A 23.75-GHz frequency comb with two low-finesse filtering cavities in series for high resolution spectroscopy

A laser frequency comb with several tens GHz level is demonstrated,based on a Yb-doped femtosecond fiber laser and two low-finesse Fabry-Perot cavities（FPCs） in series.The original 250-MHz mode-line-spacing of the source comb is filtered to 4.75 GHz and 23.75 GHz,respectively.According to the multi-beam interferences theory of FPC,the side-mode suppression rate of FPC schemes is in good agreement with our own theoretical results from 27 dB of a single FPC to43 dB of paired FPCs.To maintain long-term stable operation and determine the absolute frequency mode number in the23.75-GHz comb,the Pound-Drever-Hall（PDH） locking technology is utilized.Such stable tens GHz frequency combs have important applications in calibrating astronomical spectrographs with high resolution.

High resolution spectroscopy of Rb in magnetic field by far-detuning electromagnetically induced transparency

We have presented a high resolution spectroscopy of Rb in magnetic field by far-detuning electromagnetically induced transparency(EIT).The EIT spectrum in theΞ-type configuration is usually companied by a double resonance optical pumping(DROP)due to the strong optical coupling between the two upper states,leading to the spectral lines seriously deformed and widely broadened for complex relaxation processes in DROP.Here we demonstrate a high resolution spectroscopy by far-detuning EIT for^(87)Rb 5S_(1/2)→5P_(3/2)→5D_(5/2)in magnetic fields.The method of far-detuning eliminates the relaxation in DROP to the most extent and decreases the spectral linewidth from more than 20 MHz down to its natural linewidth limit(6 MHz).The deformation of the spectral lines also disappears and the observed spectra are well in accordance with the theoretical calculation.Our work shows that far-detuning EIT is a reliable high resolution spectroscopic method when the relaxation in DROP cannot be neglected,especially for the case of transition to low excited states.

Preliminary study in vitro brain tumor with high resolution magic angle spinning proton magnetic resonance spectroscopy

Objective： To explore water soluble metabolite features of brain tumor specimens with HRMAS-^1HMRS and its potential clinical value. Methods： There were thirty cases of pathologically proven brain tumor, including 6 Ⅰ-Ⅱ grade astrocytomas, 7 Ⅲ grade anaplastic astrocytomas, 10 IV grade glioblastomas and 7 meningiomas. Used Varian Company 600 MHz spectrometer with the Nano-probe for acquisition HRMASJHMRS, which was postprocessed with jMRUI 3.2 version software. These metabolic probability and their ratios to Cr were summed. Results： （1） HRMAS-^1HMRS could resolve NAA, PCr/Cr, GPC ± PCho ± Cho, Glu/GIn, Gly, Tau, Ala, Lac, ml and so on. All samples showed Lac, 6 samples showed unknown single peak at 3.72 ppm or 3.90 ppm. （2） The mean Cho/Cr of 6 Ⅰ-ⅡI grade astrocytomas was 2.42 ± 1.01 （P = 0.003, compared with glioblastoma）. The mean Cho/Cr of 7 anaplastic astrocytomas was 3.48 ± 0.59 （P = 0.01, compared with glioblastoma）. The Cho/Cr of 10 glioblastomas broadly ranged from 0.9 to 11.3 （mean 5.40 ± 1.23）. From Ⅰ-Ⅱ grade astrocytoma to glioblastoma, Ala/Cr, Tau/Cr and Gly/Cr trends were increased; the mean Ala/Cr of glioma was 0.31 ± 0.13. （3） Meningiomas showed higher Ala and Cho. Their Cr was lower than that of gliomas. 4/7 cases had no NAA, 3/7 patients had lower NAA. Mean Cho/Cr was 3.56 ± 1.01, Ala/Cr was 0.53 ±0.28 （P = 0.006, compared with glioma）. Conclusion： HRMAS-^1HMRS can show further details in vivo MRS, resolve in vivo spectroscopic metabolite of Cho compound and differentiate the extent of benign and malignant glioma. With the increase in the malignant degree of gliomas, Cho, ml, Ala, Tau and Gly will increase. HRMAS-^1HMRS is the only method of isotropic spectroscopy for pathological specimens.