Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as in...Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts.Shear stress(SS)influences the formation and development of atherosclerosis.The current review focuses on the vulnerable plaques observed in the high shear stress(HSS)regions,which localizes at the proximal region of the plaque intruding into the lumen.The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation.These results greatly challenge the established belief that low shear stress is important for expansive remodelling,which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions.展开更多
Coarse aggregates are the major infrastructure materials of concrete-faced rock-fill dams and are consolidated to bear upper and lateral loads. With the increase of dam height, high confining pressure and complex stre...Coarse aggregates are the major infrastructure materials of concrete-faced rock-fill dams and are consolidated to bear upper and lateral loads. With the increase of dam height, high confining pressure and complex stress states complicate the shear behavfor of coarse aggregates, and thus impede the high dam＇s proper construction, operation and maintenance. An experimental program was conducted to study the shear behavior of dam coarse aggregates using a large-scale triaxial shear apparatus. Through triaxial shear tests, the strain-stress behaviors of aggregates were observed under constant confining pressures： 300 kPa, 600 kPa 900 kPa and 1200 kPa. Shear strengths and aggregate breakage characteristics associated with high pressure shear processes are discussed. Stress path tests were conducted to observe and analyze coarse aggregate response under complex stress states. In triaxial shear tests, it was found that peak deviator stresses increase along with confining pressures, whereas the peak principal stress ratios decrease as confining pressures increase With increasing confining pressures, the dilation decreases and the contraction eventually prevails. Initial strength parameters （Poisson＇s ratio and tangent modulus） show a nonlinear relationship with confining pressures when the pressures are relatively low. Shear strength parameters decrease with increasing confining pressures. The failure envelope lines are convex curves, with clear curvature under low confining pressures. Under moderate confining pressures, dilation is offset by particle breakage. Under high confining pressures, dilation disappears.展开更多
With the increasing demand for lightweight and lower fuel consumption and safety of automobile industry, lightweight materials of high strength steel (HSS) are more and more widely used. The hot stamping technology, w...With the increasing demand for lightweight and lower fuel consumption and safety of automobile industry, lightweight materials of high strength steel (HSS) are more and more widely used. The hot stamping technology, which is determined by the inherent mechanical properties of high strength steel, makes molds prone to wear failure in the harsh service environments. In this paper, a finite element model is proposed for analyzing the value and distributions law of friction shear stress of contact surface of the pin disk. Through the simulation process of sliding wear, two kinds of different cladding materials of the pin specimens including H13 and Fe65, were experimented under three different loads by using the software ABAQUS. And then the pin-on- disk wear test at elevated temperature was conducted to verify the effectiveness of the simula-tion results. The results showed that the friction shear stress of pin with iron-based cladding and H13 steel was different under different loads, but the distribution was basically the same;the normal friction shear stress increased gradually along the direction of the pin movement, and the tangential shear stress increased gradually from the center of the pin to the outside of the circle;the value of the friction shear stress of the normal joints on the contact surface was periodically fluctuating in the whole dynamic analysis step, while it was basically stable in the tangential direction.展开更多
Rock joints infilled with sediments can strongly influence the strength of rock mass. As infilled joints often exist under unsaturated condition, this study investigated the influence of matric suction of infill on th...Rock joints infilled with sediments can strongly influence the strength of rock mass. As infilled joints often exist under unsaturated condition, this study investigated the influence of matric suction of infill on the overall joint shear strength. A novel technique that allows direct measurement of matric suction of infill using high capacity tensiometers(HCTs) during direct shear of infilled joints under constant normal stiffness(CNS) is described. The CNS apparatus was modified to accommodate the HCT and the procedure is explained in detail. Joint specimens were simulated by gypsum plaster using threedimensional(3D) printed surface moulds, and filled with kaolin and sand mixture prepared at different water contents. Shear behaviours of both planar infilled joints and rough joints having joint roughness coefficients(JRCs) of 8-10 and 18-20 with the ratios of infill thickness to asperity height(t/a)equal to 0.5 were investigated. Matric suction shows predominantly unimodal behaviour during shearing of both planar and rough joints, which is closely associated with the variation of unloading rate and volumetric changes of the infill material. As expected, two-peak behaviour was observed for the rough joints and both peaks increased with the increase of infill matric suction. The results suggest that the contribution of matric suction of infill on the joint peak normalised shear stress is relatively independent of the joint roughness.展开更多
基金This research program was supported by grants from the National Natural Science Foundation of China(31370949,11332003,81400329 and 11372364)Chongqing Science and Technology Commission(cstc2013kjrc-ljrccj10003)as well as the Public Experiment Center of State Bioindustrial Base(Chongqing),China.
文摘Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts.Shear stress(SS)influences the formation and development of atherosclerosis.The current review focuses on the vulnerable plaques observed in the high shear stress(HSS)regions,which localizes at the proximal region of the plaque intruding into the lumen.The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation.These results greatly challenge the established belief that low shear stress is important for expansive remodelling,which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions.
基金supported by the National Natural Science Foundation of China (Grant No. 50639050)
文摘Coarse aggregates are the major infrastructure materials of concrete-faced rock-fill dams and are consolidated to bear upper and lateral loads. With the increase of dam height, high confining pressure and complex stress states complicate the shear behavfor of coarse aggregates, and thus impede the high dam＇s proper construction, operation and maintenance. An experimental program was conducted to study the shear behavior of dam coarse aggregates using a large-scale triaxial shear apparatus. Through triaxial shear tests, the strain-stress behaviors of aggregates were observed under constant confining pressures： 300 kPa, 600 kPa 900 kPa and 1200 kPa. Shear strengths and aggregate breakage characteristics associated with high pressure shear processes are discussed. Stress path tests were conducted to observe and analyze coarse aggregate response under complex stress states. In triaxial shear tests, it was found that peak deviator stresses increase along with confining pressures, whereas the peak principal stress ratios decrease as confining pressures increase With increasing confining pressures, the dilation decreases and the contraction eventually prevails. Initial strength parameters （Poisson＇s ratio and tangent modulus） show a nonlinear relationship with confining pressures when the pressures are relatively low. Shear strength parameters decrease with increasing confining pressures. The failure envelope lines are convex curves, with clear curvature under low confining pressures. Under moderate confining pressures, dilation is offset by particle breakage. Under high confining pressures, dilation disappears.
文摘With the increasing demand for lightweight and lower fuel consumption and safety of automobile industry, lightweight materials of high strength steel (HSS) are more and more widely used. The hot stamping technology, which is determined by the inherent mechanical properties of high strength steel, makes molds prone to wear failure in the harsh service environments. In this paper, a finite element model is proposed for analyzing the value and distributions law of friction shear stress of contact surface of the pin disk. Through the simulation process of sliding wear, two kinds of different cladding materials of the pin specimens including H13 and Fe65, were experimented under three different loads by using the software ABAQUS. And then the pin-on- disk wear test at elevated temperature was conducted to verify the effectiveness of the simula-tion results. The results showed that the friction shear stress of pin with iron-based cladding and H13 steel was different under different loads, but the distribution was basically the same;the normal friction shear stress increased gradually along the direction of the pin movement, and the tangential shear stress increased gradually from the center of the pin to the outside of the circle;the value of the friction shear stress of the normal joints on the contact surface was periodically fluctuating in the whole dynamic analysis step, while it was basically stable in the tangential direction.
基金The financial support provided by the China Scholarship Council (Grant No. 201406420027)
文摘Rock joints infilled with sediments can strongly influence the strength of rock mass. As infilled joints often exist under unsaturated condition, this study investigated the influence of matric suction of infill on the overall joint shear strength. A novel technique that allows direct measurement of matric suction of infill using high capacity tensiometers(HCTs) during direct shear of infilled joints under constant normal stiffness(CNS) is described. The CNS apparatus was modified to accommodate the HCT and the procedure is explained in detail. Joint specimens were simulated by gypsum plaster using threedimensional(3D) printed surface moulds, and filled with kaolin and sand mixture prepared at different water contents. Shear behaviours of both planar infilled joints and rough joints having joint roughness coefficients(JRCs) of 8-10 and 18-20 with the ratios of infill thickness to asperity height(t/a)equal to 0.5 were investigated. Matric suction shows predominantly unimodal behaviour during shearing of both planar and rough joints, which is closely associated with the variation of unloading rate and volumetric changes of the infill material. As expected, two-peak behaviour was observed for the rough joints and both peaks increased with the increase of infill matric suction. The results suggest that the contribution of matric suction of infill on the joint peak normalised shear stress is relatively independent of the joint roughness.
