An InP optical 90°hybrid based on a×4 MMI coupler with a deep ridged waveguide is designed and fabricated.The working principle of the 90°hybrid is systematically introduced.Three-dimensional beam ropag...An InP optical 90°hybrid based on a×4 MMI coupler with a deep ridged waveguide is designed and fabricated.The working principle of the 90°hybrid is systematically introduced.Three-dimensional beam ropagation method(3D BPM)is used to optimize the structure parameters of the 90°hybrid.The designed compact structure is demonatrated to have a low excess loss less than-0.15 dB,a high common mode rejection ratio better than 40 dB,and a low relative phase deviation less than±2.5°.The designed hybrid is manufactured on a sandwitched structure deposited on an InP substrate.The measured results show that the common mode rejection ratios are larger than 20 dB in a range from 1520 nm to 1580 nm.The phase deviations are less than±5°in a range from 1545 nm to 1560 nm and less than±7°across the C band.The designed 90°optical hybrid is suitable well for realizing miniaturization,high-properties,and high bandwidth of coherent receiver.展开更多
Multiple maneuvedng targets signal processing in high frequency radar is challenging due to the following difficulties： the interference between signals is severe because of significant spread of the target Doppler s...Multiple maneuvedng targets signal processing in high frequency radar is challenging due to the following difficulties： the interference between signals is severe because of significant spread of the target Doppler spectrum, the low signal to clutter ratio （SCR） environment degrades the performance of signal process- ing algorithms. This paper addresses this challenging problem by using an S2-method and an adaptive clutter rejection scheme. The proposed S2-method improves the S-method by eliminating inter- ference between signals, and thus it enables multi-target signals to be reconstructed individually. The proposed adaptive clutter rejec- tion scheme is based on an adaptive notch filter, which is designed according to the envelop of the clutter spectrum. Experiments with simulated targets added into radar sea clutter echo and real air target data illustrate the effectiveness of the proposed method.展开更多
To identify acute renal allograft rejection biomarkers in human serum, two-dimensional differential in-gel electrophoresis （2-D DIGE） and reversed phase high-performance liquid chromatography （RP-HPLC） followed by...To identify acute renal allograft rejection biomarkers in human serum, two-dimensional differential in-gel electrophoresis （2-D DIGE） and reversed phase high-performance liquid chromatography （RP-HPLC） followed by electrospray ionization mass spectrometry （ESI-MS） were used. Serum samples from renal allograft patients and normal volunteers were divided into three groups： acute rejec- tion （AR）, stable renal function （SRF） and normal volunteer （N）. Serum samples were firstly processed using Multiple Affinity Removal Column to selectively remove the highest abundance proteins. Differentially expressed proteins were analyzed using 2-D DIGE. These differential protein spots were excised, digested by trypsin, and identified by RP-HPLC-ESI/MS. Twenty-two differentially expressed proteins were identified in serum from AR group. These proteins included complement C9 precursor, apolipoprotein A-IV precursor, vitamin D-binding protein precursor, beta-2-glycoprotein 1 precursor, etc. Vitamin D-binding protein, one of these proteins, was confirmed by ELISA in the independent set of serum samples. In conclusion, the differentially expressed proteins as serum biomarker candidates may provide the basis of acute rejection noninvasive diagnosis. Confirmed vitamin D-binding protein may be one of serum biomarkers of acute rejection. Furthermore, it may provide great insights into understanding the mechanisms and potential treatment strategy of acute rejection.展开更多
In this paper, a practical decoupling control scheme for fighter aircraft is proposed to achieve high angle of attack(AOA)tracking and super maneuver action by utilizing the thrust vector technology. Firstly, a six de...In this paper, a practical decoupling control scheme for fighter aircraft is proposed to achieve high angle of attack(AOA)tracking and super maneuver action by utilizing the thrust vector technology. Firstly, a six degree-of-freedom(DOF) nonlinear model with 12 variables is given. Due to low sufficiency of the aerodynamic actuators at high AOA, a thrust vector model with rotatable engine nozzles is derived. Secondly, the active disturbance rejection control(ADRC) is used to realize a three-channel decoupling control such that a strong coupling between different channels can be treated as total disturbance, which is estimated by the designed extended state observer. The control surface allocation is implemented by the traditional daisy chain method. Finally,the effectiveness of the presented control strategy is demonstrated by some numerical simulation results.展开更多
Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privileg...Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in "low-risk" settings. Furthermore, although corneal graft survival in "lowrisk" recipients is favourable, the prognosis in "high-risk" recipients for corneal graft is poor. In "high-risk" grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of "high-risk" recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in "high-risk" recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both "low-risk" and "high-risk" hosts.展开更多
随着可再生能源接入电网比例的逐步增大,热力发电厂需要应对更加频繁、更大范围的负荷变化,给电厂的高阶大惯性过热汽温过程的控制带来严峻的挑战。为此,文中针对一类高阶大惯性过热汽温过程,提出一种基于相位补偿的自抗扰控制(phase co...随着可再生能源接入电网比例的逐步增大,热力发电厂需要应对更加频繁、更大范围的负荷变化,给电厂的高阶大惯性过热汽温过程的控制带来严峻的挑战。为此,文中针对一类高阶大惯性过热汽温过程,提出一种基于相位补偿的自抗扰控制(phase compensation based active disturbance rejection control,PC-ADRC)方法。首先,阐述过热汽温系统的工作原理和控制难点。然后,采用低频近似法详细推导相位补偿(phase compensation,PC)网络模型,提出采用PC网络对模型动态特性进行补偿,得到等效降阶模型的简化思路。为便于工程应用,给出PC-ADRC系统的简单实现方法和等效模型分析。最后,对PC-ADRC系统的稳定性和鲁棒性进行研究。理论分析和仿真结果表明,所提出的PC-ADRC系统能有效提升高阶过程控制系统的鲁棒性和快速响应能力。展开更多
基金Project supported by the National Key Research and Development Program of China(Grant No.2016YFB0402404)the Beijing Natural Science Foundation,China(Grant No.4194093)the National Natural Science Foundation of China(Grant Nos.61635010,61674136,and 61435002).
文摘An InP optical 90°hybrid based on a×4 MMI coupler with a deep ridged waveguide is designed and fabricated.The working principle of the 90°hybrid is systematically introduced.Three-dimensional beam ropagation method(3D BPM)is used to optimize the structure parameters of the 90°hybrid.The designed compact structure is demonatrated to have a low excess loss less than-0.15 dB,a high common mode rejection ratio better than 40 dB,and a low relative phase deviation less than±2.5°.The designed hybrid is manufactured on a sandwitched structure deposited on an InP substrate.The measured results show that the common mode rejection ratios are larger than 20 dB in a range from 1520 nm to 1580 nm.The phase deviations are less than±5°in a range from 1545 nm to 1560 nm and less than±7°across the C band.The designed 90°optical hybrid is suitable well for realizing miniaturization,high-properties,and high bandwidth of coherent receiver.
基金supported by the State Key Program of National Natural Science Foundation of China(61032011)
文摘Multiple maneuvedng targets signal processing in high frequency radar is challenging due to the following difficulties： the interference between signals is severe because of significant spread of the target Doppler spectrum, the low signal to clutter ratio （SCR） environment degrades the performance of signal process- ing algorithms. This paper addresses this challenging problem by using an S2-method and an adaptive clutter rejection scheme. The proposed S2-method improves the S-method by eliminating inter- ference between signals, and thus it enables multi-target signals to be reconstructed individually. The proposed adaptive clutter rejec- tion scheme is based on an adaptive notch filter, which is designed according to the envelop of the clutter spectrum. Experiments with simulated targets added into radar sea clutter echo and real air target data illustrate the effectiveness of the proposed method.
基金supported by a grant from National Basic Research 973 Program of China (No.2009CB522407)
文摘To identify acute renal allograft rejection biomarkers in human serum, two-dimensional differential in-gel electrophoresis （2-D DIGE） and reversed phase high-performance liquid chromatography （RP-HPLC） followed by electrospray ionization mass spectrometry （ESI-MS） were used. Serum samples from renal allograft patients and normal volunteers were divided into three groups： acute rejec- tion （AR）, stable renal function （SRF） and normal volunteer （N）. Serum samples were firstly processed using Multiple Affinity Removal Column to selectively remove the highest abundance proteins. Differentially expressed proteins were analyzed using 2-D DIGE. These differential protein spots were excised, digested by trypsin, and identified by RP-HPLC-ESI/MS. Twenty-two differentially expressed proteins were identified in serum from AR group. These proteins included complement C9 precursor, apolipoprotein A-IV precursor, vitamin D-binding protein precursor, beta-2-glycoprotein 1 precursor, etc. Vitamin D-binding protein, one of these proteins, was confirmed by ELISA in the independent set of serum samples. In conclusion, the differentially expressed proteins as serum biomarker candidates may provide the basis of acute rejection noninvasive diagnosis. Confirmed vitamin D-binding protein may be one of serum biomarkers of acute rejection. Furthermore, it may provide great insights into understanding the mechanisms and potential treatment strategy of acute rejection.
基金supported by the National Natural Science Foundation of China(61973175,61973172)。
文摘In this paper, a practical decoupling control scheme for fighter aircraft is proposed to achieve high angle of attack(AOA)tracking and super maneuver action by utilizing the thrust vector technology. Firstly, a six degree-of-freedom(DOF) nonlinear model with 12 variables is given. Due to low sufficiency of the aerodynamic actuators at high AOA, a thrust vector model with rotatable engine nozzles is derived. Secondly, the active disturbance rejection control(ADRC) is used to realize a three-channel decoupling control such that a strong coupling between different channels can be treated as total disturbance, which is estimated by the designed extended state observer. The control surface allocation is implemented by the traditional daisy chain method. Finally,the effectiveness of the presented control strategy is demonstrated by some numerical simulation results.
基金Supported by Saving Sight in Grampian,Development Trust of University of Aberdeen,United KingdomAction Medical Research United Kingdom(grant SP4328)Link?ping University,Sweden
文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in "low-risk" settings. Furthermore, although corneal graft survival in "lowrisk" recipients is favourable, the prognosis in "high-risk" recipients for corneal graft is poor. In "high-risk" grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of "high-risk" recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in "high-risk" recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both "low-risk" and "high-risk" hosts.
文摘随着可再生能源接入电网比例的逐步增大,热力发电厂需要应对更加频繁、更大范围的负荷变化,给电厂的高阶大惯性过热汽温过程的控制带来严峻的挑战。为此,文中针对一类高阶大惯性过热汽温过程,提出一种基于相位补偿的自抗扰控制(phase compensation based active disturbance rejection control,PC-ADRC)方法。首先,阐述过热汽温系统的工作原理和控制难点。然后,采用低频近似法详细推导相位补偿(phase compensation,PC)网络模型,提出采用PC网络对模型动态特性进行补偿,得到等效降阶模型的简化思路。为便于工程应用,给出PC-ADRC系统的简单实现方法和等效模型分析。最后,对PC-ADRC系统的稳定性和鲁棒性进行研究。理论分析和仿真结果表明,所提出的PC-ADRC系统能有效提升高阶过程控制系统的鲁棒性和快速响应能力。
