Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas.

Construction Technology of Warm Mix Asphalt Pavement in Cold High-Altitude Areas

With the continuous development of domestic highway construction,highway civil engineering and service level quality have attracted much attention.Good pavement quality and high-quality service make people feel comfortable and smooth when traveling.High-quality pavement can significantly reduce the probability of traffic accidents.At present,there is a direct relationship between pavement quality and pavement construction operations.Carrying out pavement construction operations in cold high-altitude areas requires a reasonable selection of construction equipment and methods.The application of warm-mix asphalt pavement construction technology can ensure pavement quality.Therefore,this paper analyzes the advantages of warm-mix technology,the environmental characteristics of cold high-altitude areas,and construction preparations,and discusses the construction technology of warm-mix asphalt pavement in cold high-altitude areas in detail,to improve the overall road quality of cold high-altitude areas.

Settlement Control Technology of High Filled Soil-Rock Embankment in Alpine and High-Altitude Areas

China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of different sizes in mountainous areas are unavoidable,and the settlement of high-fill embankments is usually the most concerned issue in high-fill projects.According to the current research of highway projects,most of the high embankments in mountainous areas are soil-rock mixed embankments or rock-filled embankments,and their post-construction settlements are directly related to construction technology and the type of filler used.In this paper,the problems in the settlement control of earth-filled embankment and related factors are analyzed in detail.The settlement control technology of high-fill embankment in high-cold and high-altitude areas is also discussed,so as to ensure the overall quality of high-fill embankment.

Industrial Poverty Alleviation Model in Southwestern High-altitude Mountainous Areas of China——A Case Study of Industrial Poverty Alleviation of Xueshan Township in Luquan County of Yunnan Province through Planting Codonopsis pilosula

Due to the severe restrictions of natural conditions and ecological environment,high-altitude mountainous areas usually become the " hard bones" in the battle against poverty. Xueshan Township,Luquan Yi and Miao Autonomous County of Yunnan Province,located in the alpine valley of Jinsha River,is a major township with wide and deep poverty,and the incidence of poverty is up to 45. 00%. In recent years,Xueshan Township has insisted on the battle against poverty,made effort to develop the Codonopsis pilosula industry,and successfully developed a road to poverty alleviation through C. pilosula industry,and formed a unique industrial poverty alleviation model by the end of 2018,the incidence of poverty dropped to 0. 74%. Based on field survey and interview,this paper analyzes and summarizes the specific practices,main results,practical experience and promotion and application measures of the poverty alleviation model of C. pilosula planting industry in Xueshan Township,in the hope of providing certain reference for the targeted poverty alleviation in similar areas in Yunnan Province and other provinces of China.

Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas

BACKGROUND Colon cancer is associated with a higher incidence among residents in highaltitude areas.Hypoxic environment at high altitudes inhibits the phagocytic and oxygen-dependent killing function of phagocytes,thereby increasing the inflammatory factors,inhibiting the body’s innate immunity and increasing the risk of colon cancer.AIM To examine the effect of minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas.METHODS Ninety-two patients with colon cancer in our hospital from January 2019 to February 2021 were selected and divided into the minimally invasive surgery and laparotomy groups using the random number table method,with 46 patients in each group.Minimally invasive surgery was performed in the minimally invasive group and laparotomy in the laparotomy group.Operative conditions,inflammatory index pre-and post-surgery,immune function index and complication probability were measured.RESULTS Operative duration was significantly longer and intraoperative blood loss and recovery time of gastrointestinal function were significantly less(all P<0.05)in the minimally invasive group than in the laparotomy group.The number of lymph nodes dissected was not significantly different.Before surgery,there were no significant differences in serum C-reactive protein,interleukin-6 and tumor necrosis factor-αlevels between the groups,whereas after surgery,the levels were significantly higher in the minimally invasive group(26.98±6.91 mg/L,146.38±11.23 ng/mL and 83.51±8.69 pg/mL vs 41.15±8.39 mg/L,186.79±15.36 ng/mL and 110.65±12.84 pg/mL,respectively,P<0.05).Furthermore,before surgery,there were no significant differences in CD3+,CD4+and CD4+/CD8+levels between the groups,whereas after surgery,the levels decreased in both groups,being significantly higher in the minimally invasive group(55.61%±4.39%,35.45%±3.67%and 1.30±0.35 vs 49.68%±5.33%,31.21%±3.25%and 1.13±0.30,respectively,P<0.05).Complication probability was significantly lower in the minimally invasive group(4.35%vs 17.39%,P<0.05).CONCLUSION Laparoscopic minimally invasive procedures reduce surgical trauma and alleviate the inflammatory response and immune dysfunction caused by invasive operation.It also shortens recovery time and reduces complication probability.

TOOTH CURVES AND ENTIRE CONTACT AREA IN PROCESS OF SPLINE COLD ROLLING

In spline rolling process, the contact area between roller and workpiece plays an important role in calculating rolling-force and rolling-moment. For the purpose of studying the contact area, contact state between roller and workpiece in process of spline cold rolling based upon cross rolling is analyzed. According to the suitable hypothesis, the mathematic model of roller-tooth-curve in optional position of rolling process is established. Combing the theory of conjugate curves with the theory of envelope curve, the corresponding mathematic model of workpiece-tooth-curve is established. By utilizing establishing mathematic models, the algorithm of entire contact area in rolling process is created. On the basis of the algorithm, calculation-program is compiled under MATLAB program language environment. The calculation-program actualizes quantitative analysis and quantitative calculation of contact areas. Utilizing the calculation-program, the influence of parameters on contact area is analyzed, and the tendency is consistent with the manufacturing experience. In consideration of rolling-force optimization, the primary process parameters may be selected according to results of calculation. The result of the present study may provide basis for research on rolling-force and rolling-moment.

Effects of Nitrogen Management on the Yield of Winter Wheat in Cold Area of Northeastern China

A plot experiment including four treatments, CK （N 105 kg ha-1 as urea, including a basal N application of 35 kg ha-I and a topdressing N 70 kg ha-1 at turned green stage） and optimized N management （OPT1, OPT2 and OPT3, applied two-thirds, one-third and two-fifths N at jointing stage, respectively, total N 60 kg ha-l）, was conducted to evaluate the effects of nitrogen management on growth and N uptake of winter wheat （Triticum aestivum）, Dongnong 1, which is the first highly cold tolerant winter wheat in China. Index of population quality, N uptake and yield were determined. The ear-bearing tiller rate was increased by above 12%, and the leaf area index, biomass and N uptake were significantly decreased （P〈O.05） at jointing stage. OPT treatments increased the grain to leaf area ratio at heading stage, the dry matter weight and N uptake after heading by 14.3-27.9%, 11.6-28.7% and 118.1-161.8 %, respectively. The yield of the OPT treatments was increased by 14.2-37.5% compared with CK, and there was a significant difference （P〈0.05） between CK and OPT1 treatments. Harvest index and N partial factor productivity （PFP, kg grain yield per kg N applied） was clearly enhanced from 0.4 and 35.6 kg, respectively for CK to an average of 0.48 （P〈0.05） and 77.6 kg （P〈0.05） in the OPT treatments. These results indicated that the optimized N management increased the harvest index, yield and N use efficiency by decreasing the N application rate and postponing N application time, improved wheat population quality, controlled excessive growth in the vegetative stages and increased dry matter and N accumulation rates after heading.

Effects of Site-Specific Nitrogen Management on Yield and Dry Matter Accumulation of Rice from Cold Areas of Northeastern China

The effects of yield increase and mechanism of site-specific nitrogen management （SSNM） in five rice varieties from cold areas of northeastern China were studied. Plot experiment for critical SPAD value and experiments of two fertilization methods, SSNM and farmer＇s fertilization practice （FFP） were conducted to study their effects on the quality and dry matter accumulation of rice population, as well as N uptake. Compared with FFP, SSNM significantly decreased the average N rate by 33.8%, significantly increased average ear-bearing tiller rate and LAI for grain-filling stage by 12.3% and 14.1-27.6%, correspondingly, improved dry matter weight and N uptake after heading period by 4.3-29.1% and 11.8-55.1% （P 〈 0.05）, and heightened recovery efficiency and agronomic efficiency by 38.5-133.4% （P 〈 0.05） and 39.8-194.3% （P 〈 0.05）, respectively, as well as increased the average yield by 9.8% in 2004 and 2005. The results indicated that the accumulation rate of dry matter and N increased the rice yield and N use efficiency, because of improving rice population quality and increasing LAI after heading period.

Study on the Improvement Strategies of Physical Environment for Square in Severe Cold Regions' Rural Areas

To improve the comfortable physical environment for square in severe cold regions' rural areas. This paper applies the methods of questionnaires,field testing and statistical analysis to compare and analyze two different square cases of Qingyunpu in Liaoning Province,and conclude the main factors which affect the physical environmental comfort. The improvement strategies for physical environment of rural square are put forward from the aspects of site selection,road position,orientation,landscape design,and ground pavement material selection,aiming to provide the design basis for the physical environment of square in severe cold regions' rural areas.

Geochemical characteristics of cold-seep carbonates in Shenhu area,South China Sea

Cold seeps spread worldwide along the continental margins,which are closely related to the exploration of gas hydrates.Cold-seep carbonates have been reported to record the nature of seepage,including fluid source,sedimentary environment,and variation of seepage activity.We investigated the morphology,mineralogy,element compositions,and carbon and oxygen isotopes of 15 cold-seep carbonates collected from the Shenhu area,and compared them with 2 carbonates from the Haima cold seep,the South China Sea(SCS),to promote our knowledge of cold-seep system in SCS.Most of the Shenhu carbonates exhibit crust morphology,and some are in the form of chimneys and blocks.Their absolute(20%–65%)and relative carbonate mineral contents(mainly aragonite and calcite,with minor samples containing dolomite)vary significantly,indicating the multi-stage methane leakage in our study area.Some samples show a slight negative Ce anomaly,suggesting either the mixing of seawater or variation of the redox condition during the precipitation;the cooccurrence of strongly enriched U and Mo demonstrates anoxic condition during precipitation.The mixed genetic methane source was interpreted by δ^(13)C of the Shenhu carbonates to range from-22.34‰to-59.30‰Vienna PeeDee Belemnite(VPDB),and the slight ^(18)O-enrichment imprinted on the carbonates suggests the possible influence from hydrate dissociation.The Haima carbonates,with biogenic methane as the main gas source,were presumably formed in a stronger fluid flux by compared with our Shenhu samples.

Discussion on the model of community management of chronic diseases in cold areas

Because of the overbearing low temperature,cold areas increase the morbidity and mortality of chronic non-communicable diseases(chronic diseases)in exposed populations.With the growth of the aging population and the superposition of lifestyle risk factors,the number of people with chronic diseases in cold areas is climbing,and the family and social burdens are rising.These health-threatening circumstances in the cold areas render the general practitioners to face serious challenges and difficulties in the community management of chronic diseases.This paper summarizes the current situation of chronic disease management in cold areas and explores the relevant management models so as to provide a useful reference for regional health construction,graded diagnosis and treatment,and prevention and control of chronic diseases in China.

Thermal adaptation in overheated residential buildings in severe cold area in China

The winter in the severe cold area of China is long and cold. The mean outdoor temperature is about-10. 0 ℃ during the winter in Harbin,while the indoor air temperature is often above24 ℃. How does the indoor environment influence human thermal comfort and adaptation in such an overheated environment?A combined approach of spot-reading measurements and occupant interview s w as adopted in nine residential buildings of five communities during the heating period in 2013-2014. Tw enty residents w ere chosen as respondents. Totally 308 valid questionnaires w ere collected. The heating periods w ere separated into three phases based on the outdoor temperature.The results show that the mean indoor air temperatures in theearly-,mid-and late-heating periods w ere 23. 6 ℃,24. 3 ℃and 25. 0 ℃,respectively,w hich w ere larger than or close to the upper limit recommended by thermal comfort standards, and slightly higher than the related thermal neutral temperatures. With the heating process,the mean clothing insulation of residents decreased. Opening w indow s and reducing clothing w ere mainly taken by the residents to adapt to the overheated environment.The thermal neutral temperature has an upw ard tendency w ith the increasing indoor air temperature. On the other hand,overheating in residential buildings w ould make residents open w indow s,w hich may cause thermal discomfort and energy w aste. Therefore,the low er limit of the comfort indoor air temperature range should be suggested as the heating temperature,w hich could fully arouse residents' adaptation and achieve sustainable building designs.

Effects of Rice Yield and Quality Across Accumulated Temperature Zone Planting in Cold Area

Five rice varieties were planted to determine the variation of the yield and quality traits in five different regions in a cold area of China. The results showed that the number of the panicles, the number of grains per panicle and percentage of head-milled rice displayed quadratic curves against the accumulated temperature, and the sterile rate decreased with greater accumulated temperature. However, 1 000-grain weight had no correlation with the accumulated temperature and protein content, amylose content and taste also had no obvious relation with the accumulated temperature. The results from the accumulated temperature differed with rice variety, so the temperature insensitive type variety should be proposed for production.

Saving Strategy and Simulation Analysis of Green Log Walls in Severe Cold Area

Log house is a traditional type of vernacular dwelling in Chinese cold area. It contains distinct regional characteristics and architectural cultures. In recent years,log house has come into vogue softly with the development of wood techniques. However,log houses expend too much wood materials. There are also many negative aspects of this type of wood building which go against the criteria of energy conservation,and its high prime cost hinders the application as well. To solve these problems, the paper emphasizes using more environmental standardized techniques which save cost at the same time,and put forward technical strategy to improve the log walls. The optimization schemes are mainly divided into two categories: internal insulation and filled insulation. Each type of insulation is respectively derived two schemes through changing the thickness of main structure layers and insulation layer. Firstly,we use Weto software to calculate the timber volume of the four schemes,and it concludes that all the optimizations can save more timber than the prototype log wall with the section of 200 mm × 200 mm. Secondly,thermal comfort of each scheme is insulated in Design Builder.The results show that thermal insulation of filling type represents better than the other schemes. At last,we use thermal calculating formula to calculate thermal resistance of every scheme. Contrast to the energy efficiency standards of Heilongjiang Province, the data show that the four schemes meet the requirements of the specification.

Annual variation in Calanus sinicus abundance and population structure in the northern boundary area of the Yellow Sea Cold Water Mass

The Yellow Sea Cold Water Mass(YSCWM) was suggested as an over-summering site of the dominant copepod species Calanus sinicus in coastal Chinese seas.Population abundance and structure were investigated by monthly sampling along three transects across the northern boundary of the YSCWM during 2009–2010.Results show that thermal stratification existed from June to October and that the vertical thermal difference increased with depth.Generally,total abundance was lowest in October and highest in June,and the female/male sex ratio was highest in February and lowest in August.Evident spatial differences in abundance were observed during the existence of the YSCWM.In June,total abundance averaged 158.8 ind/m3at well-stratified stations,and 532.1 ind/m3at other stations.Similarly,high abundances of 322.0 and 324.4 ind/m3were recorded from July to August inside the YSCWM,while the abundance decreased from 50.4 to 1.9 ind/m3outside the water mass.C.sinicus distribution tended to even out over the study area in September when the YSCWM disappeared.We believe that the YSCWM may retard population recruitment in spring and preserve abundant cohorts in summer.The summer population was transported to neritic waters in autumn.In addition to low temperatures,stable vertical structure was also an essential condition for preservation of the summer population.C.sinicus can survive the summer in marginal areas in high abundance,but the population structure is completely different in terms of C5 proportion and sex ratio.

Advances in the research field of osteoporosis in cold areas

While osteoporosis is a chronic disease caused by multiple factors,it is also a risk factor for fractures.At present,numerous risk factors for osteoporosis and secondary fractures have been identified,including sunlight,physical fitness,gender,age,trauma,dietary habits,tobacco,alcohol,drugs,air quality,and genetics.Despite that factors such as long winters,short daylight hours,less daily physical activity,air pollution,low calcium and high salt diet,and sedentary lifestyle could negatively impact the bones of residents in the alpine regions of northern China,the direct effect of low-temperature stimulation on bone growth and development remains unclear.In this study,by reviewing current research progress related to osteoporosis and fracture risk in northern China,we proposed appropriate preventive measures for different risk factors to reduce the occurrence of osteoporosis and fracture in cold areas of northern China.

Contemporary understanding of the risk factors for chronic kidney disease in cold area

The management of chronic kidney disease(CKD)patients in cold areas is an important task in the daily practice of primary medical and health institutions.An important way to reduce the burden of CKD is to achieve early identification of and implement timely intervention on the relevant risk factors.Studies have shown that diet,alcohol,tobacco,air,sedentary and other factors in cold areas have negative impacts on human kidneys;yet,our current understanding of the effect of cold stimulation on CKD remains blurry.This paper introduces the research progress of risk factors related to CKD in cold areas and analytically summarizes the pathogenesis of CKD caused by cold stimulation,aiming to provide a reference work for the prevention,screening,evaluation,and management of CKD in cold areas.

Cold Agglutinin Disease Prevalence and Immunoglobulin M levels in Patients with Splenomegaly from Endemic Areas for Malaria in Rwanda

Background: Inhabitants from malaria endemic zones often present with enlarged spleen, mainly due to hyper reactive malarial splenomegaly (HMS), and it is seen more commonly associated with elevated levels of Immunoglobulin M (IgM). Cold agglutinin disease is an acquired autoimmune hemolytic anemia (AIHA) that is usually due to cold-reacting IgM autoantibodies directed against red cell antigens. The study was conducted in response to the observed high frequency of transfusion dependent anemia in patients with splenomegaly from malaria endemic zones in southern province of Rwanda. The objectives of this study were to determine the prevalence of cold agglutinin disease and to assess the distribution of IgM antibodies among these patients. Methodology: This was a descriptive, cross-sectional study conducted over a period of six months from June 2016 to December 2016. The study enrolled adult population from malaria endemic areas of the southern province of Rwanda with unexplained splenomegaly. Blood samples for testing IgM levels, cold agglutinin, FBC, and markers of hemolysis were collected from peripheral health settings and analyzed at the laboratory of Butare University Teaching Hospital. Results: During the study period, we enrolled 188 participants with enlarged spleen. One hundred twenty-five (66%) were females and 34% were males. The mean (±SD) age of the study participants was 35.6 ± 15.2 years. Out of 188 participants, only 4.8% were found with significantly positive Cold Agglutinin Titer (CAT) (≥1:64) and 84% of participants were found to have elevated serum IgM level. Hemoglobin level, white blood count and platelets count decrease with severity of splenomegaly, while IgM level increases with spleen size. Conclusion: Among patients with splenomegaly from malaria endemic areas, IgM levels correlate with the stages of splenomegaly while cold agglutinin disease plays a small role in the etiology of anemia.

Research on the Development of Green Building Technology in Hot Summer and Cold Winter Area under the Background of Carbon Neutrality:A Case Study of Zhuzhou City

Carbon sequestration and emission reduction in the construction industry plays an important role in China’s goal of achieving carbon neutrality.Research in Zhuzhou city scored 42 since the assessment of the green building project situation as the research object,in hot summer and cold winter areas of analysis and evaluation on the development of green building technology,and then sums up the carbon neutral background the priority areas and tasks for the development of green building techniques,optimization of the construction industry into a new era under the background of green development to provide the reference.

Effects of cold climate on growth and development

Climate is one of the environmental conditions on which people live.Climate conditions impact every aspect of people's daily life and production activities,even the survival of humankind.In recent years,human activities have adversely changed the climate.The emergence of global warming and extreme weather has prompted people to pay attention to the impact of climate on life.The adverse climate issues include reduced quality of air and food,facilitated spread of diseases and increased mortality of the population.Being more orientated to climate changes in the past,research has been less alerted to the negative impacts that climate changes could bring to human health.This could be ascribed to that after living in a region for a long time,the human body has"adapted"to climate.And after adaptation,routine health outcomes such as disease incidence and hospitalization rate become less obvious,making the habitants blind from the undesirable impacts of climate on the health status.This review article summarizes the impacts of cold climate on human development,including maternal/fetal factors,lifestyle factors,etc.,and delineates the relationship between cold climate and human health.