Efficient activation of the Co/SBA-15catalyst by high-frequency AC-DBD plasma thermal effects for toluene removal

Dielectric barrier discharge(DBD)plasma excited by a high-frequency alternating-current(AC)power supply is widely employed for the degradation of volatile organic compounds(VOCs).However,the thermal effect generated during the discharge process leads to energy waste and low energy utilization efficiency.In this work,an innovative DBD thermally-conducted catalysis(DBD-TCC)system,integrating high-frequency AC-DBD plasma and its generated thermal effects to activate the Co/SBA-15 catalyst,was employed for toluene removal.Specifically,Co/SBA-15 catalysts are closely positioned to the ground electrode of the plasma zone and can be heated and activated by the thermal effect when the voltage exceeds 10 k V.At12.4 k V,the temperature in the catalyst zone reached 261℃ in the DBD-TCC system,resulting in an increase in toluene degradation efficiency of 17%,CO_(2)selectivity of 21.2%,and energy efficiency of 27%,respectively,compared to the DBD system alone.In contrast,the DBD thermally-unconducted catalysis(DBD-TUC)system fails to enhance toluene degradation due to insufficient heat absorption and catalytic activation,highlighting the crucial role of AC-DBD generated heat in the activation of the catalyst.Furthermore,the degradation pathway and mechanism of toluene in the DBD-TCC system were hypothesized.This work is expected to provide an energy-efficient approach for high-frequency AC-DBD plasma removal of VOCs.

A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of skin.However,the mechanical properties of hydrogel scaffolds and natural skin are substantially different.Here,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed Dopa-gel.The Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine functions.Furthermore,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional printing.The results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the hydrogel.Surface modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic factors.In an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound area.Mechanistically,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the Dopa-gel.Additionally,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress conditions.Taken together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration.

Jonzac Thermal Spring Water Reinforces Skin Barrier Function of Human Skin and Presents a Soothing and Regenerating Effect

The skin is a formidable physical and biological barrier which communicates continuously with the outside of the body. And the stratum corneum, the outermost layer of human epidermis, plays a central role in the interaction between the cutaneous tissue and the external environment. The horny layer, and more generally the whole skin layers, avoid the penetration of harmful exogenous agents, produce molecules named anti-microbial peptides which impact the composition of the cutaneous microbiota, regulate the internal corporal temperature, avoid the water loss from the inside of the body and constitute an incredible efficient anti-oxidant network. Nevertheless, nowadays, the skin is more and more solicited by the different elements of the cutaneous exposome, including atmospheric pollution and solar radiations, which can cause a dramatic acceleration of the skin ageing process. As a consequence, due to the multifunctional protective role of the skin, during the recent decade the cosmetic industry invested massively in the development of new raw materials and end-products (dermo-cosmetics) able to preserve an optimal state of the skin regarding the external environment. Based on their physical-chemical properties thermal spring waters, which are extremely rich in inorganics ions, are interesting and powerful candidates to be part, as integral component, of new efficient dermo-cosmetic formulations dedicated to protect the skin from the external stimuli. The aim of the present work was to investigate and characterize the activity of Jonzac thermal spring water on the skin. Using different models, we proved for the first time that Jonzac thermal spring water reinforces the barrier function of the skin by modulating the expression of key markers including filaggrin and human beta defensin 2 on ex vivo human skin. The ex vivo and in vivo hydration activity, by Raman spectroscopy and corneometry respectively, has been also demonstrated. We have also shown that Jonzac thermal spring water ameliorates significantly the cutaneous microrelief in vivo. To conclude, we characterize the soothing effect of Jonzac thermal spring water by the analysis of histamine release in Substance P treated skin explants and by measuring the redness of the skin following UV exposure of the skin in vivo. We observed that both parameters decreased following a preventive treatment of the skin with Jonzac thermal spring water. Taken together our results indicate that Jonzac thermal spring water is a promising and powerful dermo-cosmetic which can be used to preserve an optimal state of the cutaneous tissue.

Action Mechanism of Components from Gardenia jasminoides on Eye Skin Based on Network Pharmacology

[Objectives]To explore the pharmacological effects of Gardenia jasminoides and its potential benefits on eye skin.[Methods]TCMSP and SymMap databases were used to screen the active components and corresponding targets of G.jasminoides.Human eye skin-related targets were screened,and the active component-target network and protein-protein interaction(PPI)network were established.Gene ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were performed.[Results]Twenty-six active compounds were screened out from G.jasminoides,and 277 targets were obtained.From the Gencards database,26652 disease targets were retrieved and 205 related gene targets were screened.The active component-action target network of G.jasminoides constructed by Cytoscape software revealed the potential of G.jasminoides to play a role in multiple biological pathways.In addition,PPI-network analysis,GO function analysis and KEGG pathway enrichment analysis revealed that the active components of G.jasminoides mainly regulate the biological processes such as inflammatory response,oxidative stress and apoptosis,involving MAPK,NF-κB and other important signaling pathways.[Conclusions]This study provides a theoretical basis for the eye skin protection of G.jasminoides and an important clue for future drug development.

The efficacy of a novel tomato extracts formulation on skin aging and pigmentation:A randomized,double-blind,parallel-controlled trial

Background:Oxidative stress is a significant factor in skin aging and pigmentation,which can be precipitated by various circumstances.Antioxidants and tyrosinase inhibitors,such as carotenoids,yeast extract(glutathione),sodium hyaluronate,astaxanthin,and niacin,can individually protect the skin against aging through distinct mechanisms.These mechanisms potentially enhance the skin barrier and improve signs of aging and pigmentation.However,the synergistic effects of these compounds,as found in a golden tomato extract formulation,have been scarcely explored.Objective:To evaluate the effects of an orally administered formulation on the skin aging and pigmentation.Material and Methods:In this study,a randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLAB?Tomato Niacinamide beverage.Out of all participants,62 volunteers completed the experiment and were included in the statistical analysis.Results:The results indicated that after eight weeks of consuming the research product,there were no significant changes in the skin indicators within the placebo group.In contrast,the treatment group receiving the sample formulation exhibited a 35.63%increase in stratum corneum hydration and a 29.39%reduction in transepidermal water loss(TEWL),suggesting enhanced skin hydration.Visual assessments revealed improvements in skin color and gloss index by 15.03%and 11.41%,respectively,in the treatment group.Furthermore,the skin gloss and individual typology angle(ITA)value increased by 18.59%and 6.36%,respectively,leading to a lighter skin tone.Significant enhancements were also observed in skin pigmentation,color uniformity,and redness.After eight weeks of intervention with the sample,blood levels of superoxide dismutase(SOD)and glutathione peroxidase(GPx)increased,while malondialdehyde(MDA)levels decreased.Conclusion:These findings confirm that continuous intake of the tomato extract formulation over eight weeks effectively improved the volunteers'skin whitening and hydration,and visibly brightened skin tone through an antioxidant mechanism.

Investigation of Eccentric PM on High-frequency Vibration in FSCW PM Machine Considering Force Modulation Effect

This study investigates the negative influence of an eccentric permanent-magnet(PM)design on high-frequency electromagnetic vibration in fractional-slot concentrated-winding(FSCW)PM machines.First,an analytical expression for the sideband current harmonics was derived using the double Fourier series expansion method.Then,the characteristics of the flux-density harmonics are studied from the perspective of the space-time distribution and initial phase relationship.The influence of the eccentric PM design on high-frequency electromagnetic and concentrated forces was studied based on the electromagnetic force modulation effect.Consequently,an eccentric PM design is not conducive to reducing the 2pth-order high-frequency electromagnetic forces.Finally,two FSCW PM machines with conventional and eccentric PM designs are manufactured and tested to verify the theoretical analysis.The results show that the eccentric PM design worsens high-frequency vibrations.

Effects of the Reynolds number on the mean skin friction decomposition in turbulent channel flows

As the Reynolds number increases, the skin friction has been identified as the dominant drag in many practical applications. In the present paper, the effects of the Reynolds number on the mean skin friction decomposition in turbulent channel flows up to Reτ= 5 200 are investigated based on two different methods, i.e., the FukagataIwamoto-Kasagi(FIK) identity(FUKAGATA, K., IWAMOTO, K., and KASAGI, N.Contribution of Reynolds stress distribution to the skin friction in wall-bounded flows.Physics of Fluids, 14(11), L73–L76(2002)) and the Renard-Deck(RD) identity(DECK,S., RENARD, N., LARAUFIE, R., and WEISS, P.′E. Large-scale contribution to mean wall shear stress in high-Reynolds-number flat-plate boundary layers up to Reθ= 13 650.Journal of Fluid Mechanics, 743, 202–248(2014)). The direct numerical simulation(DNS) data provided by Lee and Moser(LEE, M. and MOSER, R. D. Direct numerical simulation of turbulent channel flow up to Reτ≈ 5 200. Journal of Fluid Mechanics,774, 395–415(2015)) are used. For these two skin friction decomposition methods, their decomposed constituents are discussed and compared for different Reynolds numbers.The integrands of the decomposed constituents are locally analyzed across the boundary layer to assess the actions associated with the inhomogeneity and multi-scale nature of turbulent motion. The scaling of the decomposed constituents and their integrands are presented. In addition, the boundary layer is divided into three sub-regions to evaluate the contributive proportion of each sub-region with an increase in the Reynolds number.

The‘skin effect’of subsurface damage distribution in materials subjected to high-speed machining

This paper proposes the‘skin effect’of the machining-induced damage at high strain rates.The paper first reviews the published research work on machining-induced damage and then identifies the governing factors that dominate damage formation mechanisms.Among many influential factors,such as stress-strain field,temperature field,material responses to loading and loading rate,and crack initiation and propagation,strain rate is recognized as a dominant factor that can directly lead to the‘skin effect’of material damage in a loading process.The paper elucidates that material deformation at high strain rates(>103 s−1)leads to the embrittlement,which in turn contributes to the‘skin effect’of subsurface damage.The paper discusses the‘skin effect’based on the principles of dislocation kinetics and crack initiation and propagation.It provides guidance to predicting the material deformation and damage at a high strain-rate for applications ranging from the armor protection,quarrying,petroleum drilling,and high-speed machining of engineering materials(e.g.ceramics and SiC reinforced aluminum alloys).

A Study on the Biological Effects of Laser-induced Mutation on Fibrous Roots of Yellow Skin Onion

[ Objective] This study aimed to investigate the biological effects of laser-induced mutation on fibrous roots of yellow skin onion. [ Method] Wet seeds of two yellow skin onion cultivars were irradiated by CO2 laser and He-Ne laser at three dosage levels separately. A randomized complete block design with three replications was adopted. The biological effects of laser-induced mutation on fibrous roots of Ll-generation yellow skin onion were investigated with biostatistics and physiological and biochemical methods. [Result] Significant variations in the biological effects caused by various laser treatments were observed in the length, quantity, fresh weight and activity of onion fibrous roots. Specifically, the variation in fibrous root length induced by different types of laser reached 5% significance level; significant variation was observed in fibrous roots of different onion cultivars induced by laser, while the variation among each treatment did not reach 5% sig- nifieance level ; the variation in fibrous root quantity induced by different dosage levels of laser reached 5% significance level ; laser radiation showed stimulating effect on root activity of onion. [ Conclusion] This study provided reference for laser-induced breeding of yellow skin onion.

Chemopreventive Effects of Black Tea Polyphenols in Mouse Skin Model of Carcinogenesis

In the present investigations, the antitumorigenic effect of black tea polyphenols (BTP) in twcrstage mouse skin model of carcinogenesis was studied. The animals were initiated with a single 'subcarcinogenic' topical dose (52 μg/200 μl acetone ) of 7, 12-dimethylbenzanthracene (DMBA). To evaluate the anti-tumour initiating activity, BTP was topically applied twice a week for three weeks prior to DMBA application, followed by topical treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA) (5 μg/200 μl acetone, 2x/wk. ) as promoter. For evaluation of antitumor promoting activity, BTP was applied prior to each treatment of TPA. BTP application showed marked inhibitory effect as antitumour initiator as well as antitumour promoter in mouse skin medel of two-stage carcinogenesis. Since initiation involves genetic pathway and tumour promotion involves epigenetic pathway, it seems that BTP exerts its antitumorigenic effect by altering both genetic and epigenetic pathways

Measurement of Electron Return Effect and Skin Dose Reduction by a Bolus in an Anthropomorphic Physical Phantom under a Magnetic Resonance Guided Linear Accelerator (MR-LINAC) System

Background: Magnetic resonance image-guided radiation therapy (MR-IGRT) promises more precise and effective radiation treatments compared to conventional IGRT by using real-time on-board MR imaging. Under the influence of a magnetic field, however, secondary electrons exiting a surface can be forced in a circular path and re-enter the medium, resulting in dose increase at a beam-exit surface, called the electron return effect (ERE). The purpose of the study is to compare the exit skin dose computed by Monte Carlo dose calculation with measurements using an adult anthropomorphic phantom and to measure the effect of skin dose reduction by adding 1 cm-thick bolus. Method: The plan was compared with measurements using an adult anthropomorphic phantom combined with radiochromic films and thermoluminescent dosimeters. We also measured the skin dose reduction by adding 1 cm-thick bolus on the frontal surface of the phantom. Results: We found that 1 cm-thick bolus reduced the skin dose by up to 20% both in measurements and calculations. The plan was found to overestimate the measured skin dose by about 10% and there was no significant difference in the bolus effect between the breast skin and the skin (without breast attachment) doses. Conclusion: In conclusion, we confirmed the ERE effect on the anthropomorphic phantom under the magnetic field and the exit skin dose reduction by adding a bolus. Skin dose measurements using anthropomorphic phantom may be helpful to evaluate more realistic skin dose and the bolus effect in the magnetic field.

The Effects of the Enriched Environment on Sympathetic Skin Response in Pentylenetetrazol-Kindled Rats

Epilepsy is a neurodegenerative disease that interrupts the normal electrical activity of the brain and promotes abnormal wiring in this organ.Epileptic seizures are often associated with significant changes in the functioning of the autonomic nervous system(ANS).

Study on manufacturing freeform surface parts in micro EDM based on skin effect theory

Micro fabrication of freeform surface parts made of hard and brittle materials is always a tough job in micro machining field. This paper tries to fabricate freeform surface feature by using smooth surface of tool electrode after tool wear in micro EDM. According to the skin effect theory, the tool end shape in the stage of uniform wear can be changed by adjusting the frequency of discharge pulse. The electrical energy distributing rule of tool electrode section in RC circuit has been investigated under the influence of skin effect, and the law of spark location change has been summarized. The experimental studies demonstrate that different shapes of tool ends can be achieved by varying the pulse frequencies of discharge power supply. Additionally, a micro part of freeform surface feature with high precision and good surface quality has been successfully obtained by micro EDM through adopting the smooth surface after tool wear.

Differential Effects of Butyric Acid on Mouse Skin Tumorigenesis

We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) promoter' inhi bi ted skint umors. The effect was depe n -dent on the dose of BA applied. BA showed no marked inhibitory effect on either skin tumorinitiation or complete tumorigenesis induced by dimet hyl benzant hracene (DMBA ). Si nce t u -mor promotion reportedly involves epigenetic events whereas tumor initiation or complete tu-morigenesis takes place through genetic pathways, it is Possible that BA exerts its antitumori-genic effects mainly by altering the epigenetic events responsible for tumor promotion. The re-sults of the study could further be used to study the mechanism of action and modification ofantitumorigenic effects of BA in combination with other substances

Studies on the Effects of Deltamethrin on Sodium Net Transport Through the in vivo Amphibian Skin

The action of micromolar concentrations of Deltamethrin on sodium net transport through the in vivo skin of the South American toad Bufo arenarum was studied. The effect of pure ethanolic insecticide solutions and commercial formulations when applied on the mucosal surface was assayed. Deltamethrin provoked a concentration-independent inhibition; the highest inhibition was found at the lowest concentrations. At highest concentrations of the insecticide the J Na was not altered

Peak Power Effect on Skin Rejuvenation Using IPL: Lumecca IPL Evaluation

A high peak power IPL system (Lumecca) was tested to determine the correlation between a high peak power and the successful treatment of pigmented and vascular lesions. Short pulse duration in the millisecond range and high peak power of 3.3 kW/cm2 enabled selective and effective destruction, not only of pigment, but also of vessels in a comparable manner to a pulsed dye laser. Only one treatment session at a low fluence (8 - 16 J/cm2) was sufficient to achieve the desired results.

Skin Effect of Reversely Switched Dynistor in Short Pulse Discharge Application

The skin effect in the reversely switched dynistor （RSD） devices is investigated in this paper. Based on the plasma bipolar drift model of the RSD, the current density distributions on the chip are simulated with considering the skin effect. The results indicate that the current density on the border can be several hundred to a thousand A/cm2 higher than that in the center of the chip. The skin effect becomes more prominent as the voltage increases and the inductance decreases in the main circuit. The phenomenon that most of a certain group of chips break over on the border has proved the existence of the skin effect.

A new way to construct topological invariants of non-Hermitian systems with the non-Hermitian skin effect

The non-Hermitian skin effect breaks the conventional bulk–boundary correspondence and leads to non-Bloch topological invariants.Inspired by the fact that the topological protected zero modes are immune to perturbations,we construct a partner of a non-Hermitian system by getting rid of the non-Hermitian skin effect.Through adjusting the imbalance hopping,we find that the existence of zero-energy boundary states still dictate the bulk topological invariants based on the band-theory framework.Two non-Hermitian Su–Schrieffer–Heeger(SSH)models are used to illuminate the ideas.Specially,we obtain the winding numbers in analytical form without the introduction of the generalized Brillouin zone.The work gives an alternative method to calculate the topological invariants of non-Hermitian systems.

Non-Hermitian Weyl semimetals:Non-Hermitian skin effect and non-Bloch bulk-boundary correspondence

We investigate novel features of three-dimensional non-Hermitian Weyl semimetals,paying special attention to the unconventional bulk-boundary correspondence.We use the non-Bloch Chern numbers as the tool to obtain the topological phase diagram,which is also confirmed by the energy spectra from our numerical results.It is shown that,in sharp contrast to Hermitian systems,the conventional(Bloch)bulk-boundary correspondence breaks down in non-Hermitian topological semimetals,which is caused by the non-Hermitian skin effect.We establish the non-Bloch bulk-boundary correspondence for non-Hermitian Weyl semimetals:the topological edge modes are determined by the non-Bloch Chern number of the bulk bands.Moreover,these topological edge modes can manifest as the unidirectional edge motion,and their signatures are consistent with the non-Bloch bulk-boundary correspondence.Our work establishes the non-Bloch bulk-boundary correspondence for non-Hermitian topological semimetals.

Antimicrobial Effect of Skin for Allograft and Management in Burn Wound

One of the most important functions of skins is to protect our bodies from microbes or pollutant sources. Skins containing physical substances serve as a physical barrier which protects our bodies from pathogens. A healthy skin contains a variety of antibacterial substances such as defensin, cathelicidin and psoriasin. However deep and wide burns cause the skin to lose its original functions, so our skins are exposed to various danger factors. For the burn patients, human alloskin graft serves as a very important temporary biological wound dressing. It protects the wound before autograft procedure, forms revascularization and granulation tissues and protects the wound from an invasion of microbes. This study was conducted with the aim to analyze the antimicrobial effect of cryopreserved allograft (CPA) and glycerol-preserved allograft (GPA) which was a type of allograft widely used for burn patients, and measure the difference in comparison with the fresh skin before processing it. The most common contaminants found in burn patients such as S. aureus, P. aeruginosa, C. albicans and E. coli, were used for experiment. The antimicrobial effect against S. aureus and E. coli was observed in fresh skin and some CPA. In some clinical cases, infection is frequently observed in the wounds treated with allograft, indicating the allograft completely block every kind of microbes. To prevent the infection, it is required to use antibiotics and manage wounds thoroughly.