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A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus
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作者 Ziyang Xu Qian Zhang +7 位作者 Chuanchuan Fan Meng Xiao Rong Yang Yuan Yao Yang Wu Xiongfeng Nie Hongying Wang Wenguang Liu 《Bioactive Materials》 SCIE CSCD 2023年第8期64-76,共13页
Developing a meniscus substitute mimicking the anisotropic mechanics(higher circumferential tensile modulus and lower compressive modulus)of native tissue remains a great challenge.In this work,based on the pendant gr... Developing a meniscus substitute mimicking the anisotropic mechanics(higher circumferential tensile modulus and lower compressive modulus)of native tissue remains a great challenge.In this work,based on the pendant group structure-dependent H-bonding strengthening mechanism,two kinds of amide-based H-bonding crosslinked hydrogels with distinct mechanical behaviors,that is,the flexible poly(N-acryloyl glycinamide)(PNAGA)and the ultra-stiff poly(N-acryloylsemicarbazide)(PNASC)hydrogels are employed to construct the biomimetic meniscus substitute.To this end,a gel microparticle-based self-thickening strategy is first proposed to fabricate PNASC(GMP-PNASC)high-modulus hydrogels skeleton by extrusion printing technology in mimicking the collagen fibers in native meniscus to resist the circumferential tensile stress.Then,the PNAGA hydrogel is infused into the PNASC skeleton to replicate the proteoglycan,providing a lower compressive modulus.By regulating the structural features at the interior and peripheral regions,the GMP-PNASC/PNAGA hydrogel meniscus scaffold with the higher tensile modulus(87.28±6.06 MPa)and lower compressive modulus(2.11±0.28 MPa)can be constructed.In vivo outcome at 12 weeks post-implantation of rabbit’s medial meniscectomy model confirms the effects of GMP-PNASC/PNAGA meniscus scaffold on alleviating the wear of articular cartilage and ameliorating the development of osteoarthritis(OA). 展开更多
关键词 Extrusion printing Gel microparticle high-modulus hydrogel Meniscus substitute
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