Distributed temperature sensing is known to provide sharp signals which are very efficient for mapping hydraulically active fractures in wellbores. High-resolution temperature sensing has specifically demonstrated its...Distributed temperature sensing is known to provide sharp signals which are very efficient for mapping hydraulically active fractures in wellbores. High-resolution temperature sensing has specifically demonstrated its capacity to characterize very low flows in wellbores. But as sharp as they can be, temperature profiles are often difficult to decipher. The aim of the present work is to provide and to test the “Borehole Heat Budget Calculator” (BHB Calculator), which is implemented as a fast and easy to use tool for the quantitative analysis of depth-temperature profiles. The Calculator is suitable for most pumping and draining configurations, as the heat budget is generalized for modelling multidirectional flow systems within the same wellbore. The formatted worksheet allows the quick exploitation of temperature logs, and is applicable for the characterization of distributed fractures in long screened wellbores. Objectives of the heat modelling are to enhance the readability of complex depth-temperature data, as well as to quantify distribution of inflow intensities and temperatures with depth. The use of heat budget helps to clearly visualize how heat conduction and heat advection contributions are distributed along wellbores profiles. Calculations of inflow temperatures and their evolution through pumping duration is a prerequisite to infer about the nature of aquifer properties (i.e. conduits, distributed or discrete fractures, porous media), as well as to give insight information about the mapping of effective flow paths draining the aquifer. The efficiency and limitations of the BHB Calculator are being tested through high-resolution temperature logging, along with complementary flowmetering and televiewing logging in fractured aquifers located in the St-Lawrence Lowlands, Quebec, Canada.展开更多
This review focuses on the early diagnosis of anal cancerand its precursor lesions through routine screening. A number of risk-stratification strategies as well as screening techniques have been suggested, and current...This review focuses on the early diagnosis of anal cancerand its precursor lesions through routine screening. A number of risk-stratification strategies as well as screening techniques have been suggested, and currently little consensus exists among national societies. Much of the current clinical rationale for the prevention of anal cancer derives from the similar tumor biology of cervical cancer and the successful use of routine screening to identify cervical cancer and its precursors early in the disease process. It is thought that such a strategy of identifying early anal intraepithelial neoplasia will reduce the incidence of invasive anal cancer. The low prevalence of anal cancer in the general population prevents the use of routine screening. However, routine screening of selected populations has been shown to be a more promising strategy. Potential screening modalities include digital anorectal exam, anal Papanicolaou testing, human papilloma virus co-testing, and high-resolution anoscopy. Additional research associating high-grade dysplasia treatment with anal cancer prevention as well as direct comparisons of screening regimens is necessary to develop further anal cancer screening recommendations.展开更多
In this paper, the design of a Graphical User Interface for CAN data frame monitoring is presented. The GUI has been developed in the Qt Creator IDE. A touch screen for visualization and control is used, which in turn...In this paper, the design of a Graphical User Interface for CAN data frame monitoring is presented. The GUI has been developed in the Qt Creator IDE. A touch screen for visualization and control is used, which in turn is controlled by a development board with a SoC Cyclone V, through which a Linux operating system is executed.展开更多
Klinefelter syndrome （KS） is the set of symptoms that result from the presence of an extra X chromosome in males. Postnatal population-based KS screening will enable timely diagnosis of this common chromosomal disea...Klinefelter syndrome （KS） is the set of symptoms that result from the presence of an extra X chromosome in males. Postnatal population-based KS screening will enable timely diagnosis of this common chromosomal disease, providing the opportunity for early intervention and therapy at the time point when they are most effective and may prevent later symptoms or complications. Therefore, through this study, we introduced a simple high-resolution melting （HRM） assay for KS screening and evaluated its clinical sensitivity and specificity in three medical centers using 1373 clinical blood samples. The HRM assay utilized a single primer pair to simultaneously amplify specific regions in zinc finger protein, X-linked （ZFX） and zinc finger protein, Y-linked （ZFY）. In cases of KS, the ratios of ZFX/ZFYare altered compared to those in normal males. As a result, the specific melting profiles differ and can be differentiated during data analysis. This HRM assay displayed high analytical specificity over a wide range of template DNA amounts （5 ng-50 ng） and reproducibility, high resolution for detecting KS mosaicism, and high clinical sensitivity （100%） and specificity （98.1%）. Moreover, the HRM assay was rapid （2 h per run）, inexpensive （0.2 USD per sample）, easy to perform and automatic, and compatible with both whole blood samples and dried blood spots. Therefore, this HRM assay is an ideal postnatal population-based KS screening tool that can be used for different age groups.展开更多
基于虚拟现实(VR)技术,利用JPCT-AE三维引擎、3Ds MAX以及Open GL ES 2.0等工具,开发出应用于Android平台移动终端的工程图学移动学习系统,详细描述了系统的底层结构、功能及技术开发方案。针对工程图学课程的认知规律开发了分屏功能,...基于虚拟现实(VR)技术,利用JPCT-AE三维引擎、3Ds MAX以及Open GL ES 2.0等工具,开发出应用于Android平台移动终端的工程图学移动学习系统,详细描述了系统的底层结构、功能及技术开发方案。针对工程图学课程的认知规律开发了分屏功能,使多媒体影音讲解与立体虚拟模型同屏展示,同时实现了对虚拟模型的交互控制。展开更多
文摘Distributed temperature sensing is known to provide sharp signals which are very efficient for mapping hydraulically active fractures in wellbores. High-resolution temperature sensing has specifically demonstrated its capacity to characterize very low flows in wellbores. But as sharp as they can be, temperature profiles are often difficult to decipher. The aim of the present work is to provide and to test the “Borehole Heat Budget Calculator” (BHB Calculator), which is implemented as a fast and easy to use tool for the quantitative analysis of depth-temperature profiles. The Calculator is suitable for most pumping and draining configurations, as the heat budget is generalized for modelling multidirectional flow systems within the same wellbore. The formatted worksheet allows the quick exploitation of temperature logs, and is applicable for the characterization of distributed fractures in long screened wellbores. Objectives of the heat modelling are to enhance the readability of complex depth-temperature data, as well as to quantify distribution of inflow intensities and temperatures with depth. The use of heat budget helps to clearly visualize how heat conduction and heat advection contributions are distributed along wellbores profiles. Calculations of inflow temperatures and their evolution through pumping duration is a prerequisite to infer about the nature of aquifer properties (i.e. conduits, distributed or discrete fractures, porous media), as well as to give insight information about the mapping of effective flow paths draining the aquifer. The efficiency and limitations of the BHB Calculator are being tested through high-resolution temperature logging, along with complementary flowmetering and televiewing logging in fractured aquifers located in the St-Lawrence Lowlands, Quebec, Canada.
文摘This review focuses on the early diagnosis of anal cancerand its precursor lesions through routine screening. A number of risk-stratification strategies as well as screening techniques have been suggested, and currently little consensus exists among national societies. Much of the current clinical rationale for the prevention of anal cancer derives from the similar tumor biology of cervical cancer and the successful use of routine screening to identify cervical cancer and its precursors early in the disease process. It is thought that such a strategy of identifying early anal intraepithelial neoplasia will reduce the incidence of invasive anal cancer. The low prevalence of anal cancer in the general population prevents the use of routine screening. However, routine screening of selected populations has been shown to be a more promising strategy. Potential screening modalities include digital anorectal exam, anal Papanicolaou testing, human papilloma virus co-testing, and high-resolution anoscopy. Additional research associating high-grade dysplasia treatment with anal cancer prevention as well as direct comparisons of screening regimens is necessary to develop further anal cancer screening recommendations.
文摘In this paper, the design of a Graphical User Interface for CAN data frame monitoring is presented. The GUI has been developed in the Qt Creator IDE. A touch screen for visualization and control is used, which in turn is controlled by a development board with a SoC Cyclone V, through which a Linux operating system is executed.
文摘Klinefelter syndrome （KS） is the set of symptoms that result from the presence of an extra X chromosome in males. Postnatal population-based KS screening will enable timely diagnosis of this common chromosomal disease, providing the opportunity for early intervention and therapy at the time point when they are most effective and may prevent later symptoms or complications. Therefore, through this study, we introduced a simple high-resolution melting （HRM） assay for KS screening and evaluated its clinical sensitivity and specificity in three medical centers using 1373 clinical blood samples. The HRM assay utilized a single primer pair to simultaneously amplify specific regions in zinc finger protein, X-linked （ZFX） and zinc finger protein, Y-linked （ZFY）. In cases of KS, the ratios of ZFX/ZFYare altered compared to those in normal males. As a result, the specific melting profiles differ and can be differentiated during data analysis. This HRM assay displayed high analytical specificity over a wide range of template DNA amounts （5 ng-50 ng） and reproducibility, high resolution for detecting KS mosaicism, and high clinical sensitivity （100%） and specificity （98.1%）. Moreover, the HRM assay was rapid （2 h per run）, inexpensive （0.2 USD per sample）, easy to perform and automatic, and compatible with both whole blood samples and dried blood spots. Therefore, this HRM assay is an ideal postnatal population-based KS screening tool that can be used for different age groups.
文摘基于虚拟现实(VR)技术,利用JPCT-AE三维引擎、3Ds MAX以及Open GL ES 2.0等工具,开发出应用于Android平台移动终端的工程图学移动学习系统,详细描述了系统的底层结构、功能及技术开发方案。针对工程图学课程的认知规律开发了分屏功能,使多媒体影音讲解与立体虚拟模型同屏展示,同时实现了对虚拟模型的交互控制。
