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Application of High-speed Solenoid Valve to the Semi-active Control of Landing Gear 被引量:6
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作者 刘晖 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第3期232-240,共9页
To select or develop an appropriate actuator is one of the key and difficult issues in the study of semi-active controlled landing gear. Performance of the actuator may directly affect the effectiveness of semi-active... To select or develop an appropriate actuator is one of the key and difficult issues in the study of semi-active controlled landing gear. Performance of the actuator may directly affect the effectiveness of semi-active control. In this article, parallel high-speed solenoid valves are chosen to be the actuators for the semi-active controlled landing gear and being studied. A nonlinear high-speed solenoid valve model is developed with the consideration of magnetic saturation characteristics and verified by test. According to the design rule of keeping the peak load as small as possible while absorbing the specified shock energy, a fuzzy PD control rule is designed. By the rule controller parameters can be self-regulated. The simulation results indicate that the semi-active control based on high-speed solenoid valve can effectively improve the control performance and reduce impact load during landing. 展开更多
关键词 landing gear shock absorber semi-active control high-speed solenoid valve
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On the Describing Functions of PWM Pneumatic High-Speed On-Off Valves
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作者 杨树兴 汪淑兰 +1 位作者 林祥珠 曹泛 《Journal of Beijing Institute of Technology》 EI CAS 1993年第2期170-176,共7页
High-speed on-off valves are widey used in PWM electropneumatic servo sys- tems and their characteristics are generally described by their on and off delay time. This paper focuses on establishing the relationships be... High-speed on-off valves are widey used in PWM electropneumatic servo sys- tems and their characteristics are generally described by their on and off delay time. This paper focuses on establishing the relationships between their on-off switching behaviors and their frequency response characteristics. A method is proposed by which the frequency response characteristics of an analog PWM high-speed on-off valve can be calculated for inputs whose periods are certain multiples of the carrier period, based on its switching be- haviors. Thus, a simple and direct describing function for a PWM high-speed on-off valve is established. 展开更多
关键词 pulse width modulation frequency response servo valves / high--speed on--off valves
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Development of an ε-type actuator for enhancing high-speed electro-pneumatic ejector valve performance 被引量:4
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作者 Zhong XIANG Hao LIU +2 位作者 Guo-Liang TAO Jun MAN Wei ZHONG 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2008年第11期1552-1559,共8页
A novel ε-type solenoid actuator is proposed to improve the dynamic response of electro-pneumatic ejector valves by reducing moving mass weight. A finite element analysis (FEA) model has been developed to describe th... A novel ε-type solenoid actuator is proposed to improve the dynamic response of electro-pneumatic ejector valves by reducing moving mass weight. A finite element analysis (FEA) model has been developed to describe the static and dynamic operations of the valves. Compared with a conventional E-type actuator, the proposed ε-type actuator reduced the moving mass weight by almost 65% without significant loss of solenoid force, and reduced the response time (RT) typically by 20%. Prototype valves were designed and fabricated based on the proposed ε-type actuator model. An experimental setup was also established to investigate the dynamic characteristics of valves. The experimental results of the dynamics of valves agreed well with simulations, indicating the validity of the FEA model. 展开更多
关键词 ε-type actuator high-speed electro-pneumatic ejector valve Finite element method Dynamic simulation and experiment
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Development of High-Speed On-Of Valves and Their Applications 被引量:3
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作者 He Wang Zhen Chen +2 位作者 Jiahai Huang Long Quan Bin Zhao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第4期21-41,共21页
With the widespread application of the computer and microelectronic technology in the industry,digitization becomes the inevitable developing trend of the hydraulic technology.Digitization of the hydraulic components ... With the widespread application of the computer and microelectronic technology in the industry,digitization becomes the inevitable developing trend of the hydraulic technology.Digitization of the hydraulic components is critical in the digital hydraulic technology.High-speed on-of valves(HSVs)which convert a train of input pulses into the fast and accurate switching between the on and of states belong to widely used basic digital hydraulic elements.In some ways,the characteristics of the HSVs determine the performance of the digital hydraulic systems.This paper discusses the development of HSVs and their applications.First,the HSVs with innovative structures which is classifed into direct drive valves and pilot operated valves are discussed,with the emphasis on their performance.Then,an overview of HSVs with intelligent materials is presented with considering of the switching frequency and fow capacity.Finally,the applications of the HSVs are reviewed,including digital hydraulic components with the integration of the HSVs and digital hydraulic systems controlled by the HSVs. 展开更多
关键词 high-speed on-of valve Digital hydraulic component Switching frequency Flow rate Innovative structure Intelligent material
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TEST METHOD OF HIGH-SPEED ON-OFF VALVE DYNAMIC CHARACTERISTICS 被引量:2
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作者 FU Linjian KONG Xiaowu QIU Minxiu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第1期63-66,共4页
According to the valve port features of high speed on-off valve and its actions, the valve port can be simplified into an a-type half bridge construction. A method that tests the dynamic characteristics of the high sp... According to the valve port features of high speed on-off valve and its actions, the valve port can be simplified into an a-type half bridge construction. A method that tests the dynamic characteristics of the high speed on-off valve by the output pressure signal of the a-type half bridge is proposed. Having analyzed the factors related to the dynamic characteristics of an a-type half bridge, a rule for designing the outlet chamber's volume is worked out. According to the rule, a test stand is built to test the self-developed high-speed on-off valve. From the test results, it can be seen that with the outlet chamber's volume controlled by the rule the rise time of the pressure signals driven by signals with different frequencies changes very little. The test results conform to the simulation results, which nroves the correctness of the method. 展开更多
关键词 high-speed on-off valve Dynamic characteristics Test method
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Dynamic performance and temperature rising characteristic of a high-speed on/off valve based on pre-excitation control algorithm 被引量:4
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作者 Qi ZHONG Enguang XU +2 位作者 Geng XIE Xiele WANG Yanbiao LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第10期445-458,共14页
High speed on/off valve(HSV)is an essential component in aerospace digital hydraulic systems(ADHS).Dynamic performance and temperature rising characteristic are two important features,which determine the performance o... High speed on/off valve(HSV)is an essential component in aerospace digital hydraulic systems(ADHS).Dynamic performance and temperature rising characteristic are two important features,which determine the performance of HSV,and affect the response speed and reliability of ADHS.Increasing the driving voltage is an effective method for improving the dynamic performance of HSV.However,continuous high voltage excitation will lead to more wasted energy,higher temperature rising and lower reliability.To solve this problem,a pre-excitation control algorithm(PECA)is proposed in this paper based on the theoretical model of the influence of electrical parameters on dynamic performance and temperature rising characteristics.In PECA,an appropriate initial coil current is generated by pre-excitation instead of increasing driving voltage,which significantly shortens the switching delay time.Then,based on real-time current online calculation and feedback mechanism,the adaptive switching of five equivalent voltages is realized.Consequently,the coil current can be rapidly kept at the expected state without consuming more energy and generating more heat.Results indicate that compared with conventional PWM control algorithm,the PECA can improve dynamic performance of HSV,shorten the total switching time by 71.5%,and increase the maximum operation frequency.Therefore,the linear area of flow characteristic is expended by 80.0%,the adjusting time of HSV-controlled system is reduced by 23%,while shortening steady error by 46.7%.Moreover,the temperature rising characteristics of HSV are better,the maximum operation temperature is reduced by 68.6%,and the time to reach the steady state temperature is shortened by 20%.From the results,it can be concluded that the PECA is not only an effective and practical control algorithm for improving the performance of HSVs and HSV-controlled systems while reducing the heat generation and decreasing the temperature rising of HSV,but also can be a potential solution in ADHS. 展开更多
关键词 High speed on/off valve Dynamic performance Pre-excitation Temperature rising Flow characteristic
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Simulation of the piezoelectric high-speed on/off valve 被引量:11
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作者 OUYANG XiaoPing YANG HuaYong JIANG HaoYi XU Bing 《Chinese Science Bulletin》 SCIE EI CAS 2008年第17期2706-2711,共6页
The development trend and unsolved problems of the high-speed valve are given briefly, and the excellent characteristics and some key technologies of the piezoelectric high-speed on/off valve are introduced. An innova... The development trend and unsolved problems of the high-speed valve are given briefly, and the excellent characteristics and some key technologies of the piezoelectric high-speed on/off valve are introduced. An innovative high-speed on/off valve based on piezoelectric actuators is outlined, where the performance of the high frequency and high instant force is employed to kick off the poppet. The micro displacement amplification and temperature dependence of the piezoelectric actuator are solved. Furthermore, the mathematical model of the piezoelectric high-speed on/off valve is built and related simulation results are discussed. The simulation results show that the piezoelectric high-speed on/off valve can be switched by piezoelectric actuators, and the maximal flowrate of 11 L/min, pressure of 20 MPa and frequency of 200 Hz can be gained. 展开更多
关键词 压电制动器 高速电子管 数值模拟 性能
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Lumped Parameter Mass Flow Rate and Pressure Control Characteristics Model for High-Speed Pneumatic PWM on/off Valve
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作者 向忠 胡旭东 +1 位作者 刘昊 汝晶炜 《Journal of Donghua University(English Edition)》 EI CAS 2014年第3期293-303,共11页
Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the val... Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the valves time periods was well developed. With this model,the mass flow rate and dynamic pressure characteristics of constant volumes controlled by high-speed pneumatic PWM on /off valves was well described. A variable flow rate coefficient model was proposed to substitute for the constant one used in most of the prior works to investigate PWM on /off valves' dynamical pressure response, and a formula for disclosing the inherent relationship among the PWM command signal,static mass flow rate,and sonic conductance of the valve was newly derived.Finally,an extensive set of analytical experimental comparisons were implemented to verify the validity of the proposed mathematica model. With the proposed model, PWM on /off valves' characteristics,such as mass flow rate,step pressure response of the valve control system,mean pressure and ripple amplitude,not only in the linear range,but also in the nonlinear range can be wel predicted; Good agreement between measured and calculated results was obtained,which proved that the model is helpful for designing a control strategy in a closed loop control system. 展开更多
关键词 lumped parameter model pneumatic on/off valve pulse width modulation(PWM) mass flow rate pressure characteristic
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Numerical Study on Reduction in Aerodynamic Drag and Noise of High-Speed Pantograph 被引量:1
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作者 Deng Qin Xing Du +1 位作者 Tian Li Jiye Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期2155-2173,共19页
Reducing the aerodynamic drag and noise levels of high-speed pantographs is important for promoting environmentally friendly,energy efficient and rapid advances in train technology.Using computational fluid dynamics t... Reducing the aerodynamic drag and noise levels of high-speed pantographs is important for promoting environmentally friendly,energy efficient and rapid advances in train technology.Using computational fluid dynamics theory and the K-FWH acoustic equation,a numerical simulation is conducted to investigate the aerodynamic characteristics of high-speed pantographs.A component optimization method is proposed as a possible solution to the problemof aerodynamic drag and noise in high-speed pantographs.The results of the study indicate that the panhead,base and insulator are the main contributors to aerodynamic drag and noise in high-speed pantographs.Therefore,a gradual optimization process is implemented to improve the most significant components that cause aerodynamic drag and noise.By optimizing the cross-sectional shape of the strips and insulators,the drag and noise caused by airflow separation and vortex shedding can be reduced.The aerodynamic drag of insulator with circular cross section and strips with rectangular cross section is the largest.Ellipsifying insulators and optimizing the chamfer angle and height of the windward surface of the strips can improve the aerodynamic performance of the pantograph.In addition,the streamlined fairing attached to the base can eliminate the complex flow and shield the radiated noise.In contrast to the original pantograph design,the improved pantograph shows a 21.1%reduction in aerodynamic drag and a 1.65 dBA reduction in aerodynamic noise. 展开更多
关键词 high-speed pantograph aerodynamic drag aerodynamic noise REDUCTION optimizing
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High-speed penetration of ogive-nose projectiles into thick concrete targets:Tests and a projectile nose evolution model 被引量:1
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作者 Xu Li Yan Liu +4 位作者 Junbo Yan Zhenqing Shi Hongfu Wang Yingliang Xu Fenglei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期553-571,共19页
The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytic... The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit. 展开更多
关键词 high-speed penetration Concrete target EROSION Projectile nose evolution model
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Expert Experience and Data-Driven Based Hybrid Fault Diagnosis for High-SpeedWire Rod Finishing Mills 被引量:1
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作者 Cunsong Wang Ningze Tang +3 位作者 Quanling Zhang Lixin Gao Haichen Yin Hao Peng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第2期1827-1847,共21页
The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault lo... The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time monitoring.To solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this paper.First,based on its mechanical structure,time and frequency domain analysis are improved in fault feature extraction.The approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain analysis.Speed adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding sideband.Then,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault result.Finally,the proposed method is implemented in the equipment intelligent diagnosis system.By taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system. 展开更多
关键词 high-speed wire rod finishing mills expert experience DATA-DRIVEN fault diagnosis
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A review of artificial intelligence applications in high-speed railway systems 被引量:2
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作者 Xuehan Li Minghao Zhu +3 位作者 Boyang Zhang Xiaoxuan Wang Zha Liu Liang Han 《High-Speed Railway》 2024年第1期11-16,共6页
In recent years,the global surge of High-speed Railway(HSR)revolutionized ground transportation,providing secure,comfortable,and punctual services.The next-gen HSR,fueled by emerging services like video surveillance,e... In recent years,the global surge of High-speed Railway(HSR)revolutionized ground transportation,providing secure,comfortable,and punctual services.The next-gen HSR,fueled by emerging services like video surveillance,emergency communication,and real-time scheduling,demands advanced capabilities in real-time perception,automated driving,and digitized services,which accelerate the integration and application of Artificial Intelligence(AI)in the HSR system.This paper first provides a brief overview of AI,covering its origin,evolution,and breakthrough applications.A comprehensive review is then given regarding the most advanced AI technologies and applications in three macro application domains of the HSR system:mechanical manufacturing and electrical control,communication and signal control,and transportation management.The literature is categorized and compared across nine application directions labeled as intelligent manufacturing of trains and key components,forecast of railroad maintenance,optimization of energy consumption in railroads and trains,communication security,communication dependability,channel modeling and estimation,passenger scheduling,traffic flow forecasting,high-speed railway smart platform.Finally,challenges associated with the application of AI are discussed,offering insights for future research directions. 展开更多
关键词 high-speed railway Artificial intelligence Intelligent distribution Intelligent control Intelligent scheduling
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Effect of safety valve types on the gas venting behavior and thermal runaway hazard severity of large-format prismatic lithium iron phosphate batteries 被引量:2
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作者 Zhuangzhuang Jia Yuanyuan Min +5 位作者 Peng Qin Wenxin Mei Xiangdong Meng Kaiqiang Jin Jinhua Sun Qingsong Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期195-207,I0006,共14页
The safety valve is an important component to ensure the safe operation of lithium-ion batteries(LIBs).However,the effect of safety valve type on the thermal runaway(TR)and gas venting behavior of LIBs,as well as the ... The safety valve is an important component to ensure the safe operation of lithium-ion batteries(LIBs).However,the effect of safety valve type on the thermal runaway(TR)and gas venting behavior of LIBs,as well as the TR hazard severity of LIBs,are not known.In this paper,the TR and gas venting behavior of three 100 A h lithium iron phosphate(LFP)batteries with different safety valves are investigated under overheating.Compared to previous studies,the main contribution of this work is in studying and evaluating the effect of gas venting behavior and TR hazard severity of LFP batteries with three safety valve types.Two significant results are obtained:(Ⅰ)the safety valve type dominates over gas venting pressure of battery during safety venting,the maximum gas venting pressure of LFP batteries with a round safety valve is 3320 Pa,which is one order of magnitude higher than other batteries with oval or cavity safety valve;(Ⅱ)the LFP battery with oval safety valve has the lowest TR hazard as shown by the TR hazard assessment model based on gray-fuzzy analytic hierarchy process.This study reveals the effect of safety valve type on TR and gas venting,providing a clear direction for the safety valve design. 展开更多
关键词 Lithium iron phosphate battery Safety valve Thermal runaway Gas venting behavior Thermal runaway hazard severity Gray-fuzzy analytic hierarchy process
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Human intrusion detection for high-speed railway perimeter under all-weather condition 被引量:1
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作者 Pengyue Guo Tianyun Shi +1 位作者 Zhen Ma Jing Wang 《Railway Sciences》 2024年第1期97-110,共14页
Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofo... Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofobject recognition in dark and harsh weather conditions.Design/methodology/approach – This paper adopts the fusion strategy of radar and camera linkage toachieve focus amplification of long-distance targets and solves the problem of low illumination by laser lightfilling of the focus point. In order to improve the recognition effect, this paper adopts the YOLOv8 algorithm formulti-scale target recognition. In addition, for the image distortion caused by bad weather, this paper proposesa linkage and tracking fusion strategy to output the correct alarm results.Findings – Simulated intrusion tests show that the proposed method can effectively detect human intrusionwithin 0–200 m during the day and night in sunny weather and can achieve more than 80% recognitionaccuracy for extreme severe weather conditions.Originality/value – (1) The authors propose a personnel intrusion monitoring scheme based on the fusion ofmillimeter wave radar and camera, achieving all-weather intrusion monitoring;(2) The authors propose a newmulti-level fusion algorithm based on linkage and tracking to achieve intrusion target monitoring underadverse weather conditions;(3) The authors have conducted a large number of innovative simulationexperiments to verify the effectiveness of the method proposed in this article. 展开更多
关键词 high-speed rail perimeter Personnel invasion Object detection ALL-WEATHER Radar-camera fusion
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Low-temperature characteristicsof rubbers and performance testsof type 120 emergencyvalve diaphragms 被引量:1
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作者 Ming Gao Anhui Pan +5 位作者 Yi Huang Jiaqi Wang Yan Zhang Xiao Xie Huanre Han Yinghua Jia 《Railway Sciences》 2024年第1期47-58,共12页
Purpose–The type 120 emergency valve is an essential braking component of railway freight trains,butcorresponding diaphragms consisting of natural rubber(NR)and chloroprene rubber(CR)exhibit insufficientaging resista... Purpose–The type 120 emergency valve is an essential braking component of railway freight trains,butcorresponding diaphragms consisting of natural rubber(NR)and chloroprene rubber(CR)exhibit insufficientaging resistance and low-temperature resistance,respectively.In order to develop type 120 emergency valverubber diaphragms with long-life and high-performance,low-temperatureresistant CR and NR were processed.Design/methodology/approach–The physical properties of the low-temperature-resistant CR and NRwere tested by low-temperature stretching,dynamic mechanical analysis,differential scanning calorimetryand thermogravimetric analysis.Single-valve and single-vehicle tests of type 120 emergency valves werecarried out for emergency diaphragms consisting of NR and CR.Findings–The low-temperature-resistant CR and NR exhibited excellent physical properties.The elasticityand low-temperature resistance of NR were superior to those of CR,whereas the mechanical properties of thetwo rubbers were similar in the temperature range of 0℃–150℃.The NR and CR emergency diaphragms metthe requirements of the single-valve test.In the low-temperature single-vehicle test,only the low-temperaturesensitivity test of the NR emergency diaphragm met the requirements.Originality/value–The innovation of this study is that it provides valuable data and experience for futuredevelopment of type 120 valve rubber diaphragms. 展开更多
关键词 Natural rubber Chloroprene rubber Low-temperature characteristic 120 emergency valve DIAPHRAGM
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Current knowledge for the risk factors of early permanent pacemaker implantation following transcatheter aortic valve replacement and what is next for the primary prevention? 被引量:1
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作者 Gen-Min Lin Wei-Chun Huang Chih-Lu Han 《World Journal of Cardiology》 2024年第2期54-57,共4页
In this editorial,we comprehensively summarized the preoperative risk factors of early permanent pacemaker implantation after transcatheter aortic valve replacement(TAVR)among patients with severe aortic stenosis from... In this editorial,we comprehensively summarized the preoperative risk factors of early permanent pacemaker implantation after transcatheter aortic valve replacement(TAVR)among patients with severe aortic stenosis from several renowned clinical studies and focused on the primary prevention of managing the modifiable factors,e.g.,paroxysmal atrial fibrillation before the TAVR. 展开更多
关键词 Permanent pacemaker implantation Transcatheter aortic valve replacement Interventricular conduction delay DIABETES Supraventricular arrhythmia
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A novel mouse model of calcific aortic valve stenosis
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作者 Ningjing Qian Yaping Wang +12 位作者 Wangxing Hu Naifang Cao Yi Qian Jinyong Chen Juan Fang Dilin Xu Haochang Hu Shuangshuang Yang Dao Zhou Hanyi Dai Dongdong Wei Jian'an Wang Xianbao Liu 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第4期523-532,共10页
Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing prevalence.However,study of the mecha-nism and treatment of CAVS is hampered by the lack... Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing prevalence.However,study of the mecha-nism and treatment of CAVS is hampered by the lack of suitable,robust and efficient models that develop hemodynamically significant stenosis and typical calcium deposi-tion.Here,we aim to establish a mouse model to mimic the development and features of CAVS.Methods:The model was established via aortic valve wire injury(AVWI)combined with vitamin D subcutaneous injected in wild type C57/BL6 mice.Serial transthoracic echocardiography was applied to evaluate aortic jet peak velocity and mean gradi-ent.Histopathological specimens were collected and examined in respect of valve thickening,calcium deposition,collagen accumulation,osteogenic differentiation and inflammation.Results:Serial transthoracic echocardiography revealed that aortic jet peak velocity and mean gradient increased from 7 days post model establishment in a time depend-ent manner and tended to be stable at 28 days.Compared with the sham group,sim-ple AVWI or the vitamin D group,the hybrid model group showed typical pathological features of CAVS,including hemodynamic alterations,increased aortic valve thicken-ing,calcium deposition,collagen accumulation at 28 days.In addition,osteogenic dif-ferentiation,fibrosis and inflammation,which play critical roles in the development of CAVS,were observed in the hybrid model.Conclusions:We established a novel mouse model of CAVS that could be induced efficiently,robustly and economically,and without genetic intervention.It provides a fast track to explore the underlying mechanisms of CAVS and to identify more effec-tive pharmacological targets. 展开更多
关键词 animal model calcific aortic valve stenosis valve calcification
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A discussion about the limitations of the Eurocode’s high-speed load model for railway bridges
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作者 Gonçalo Ferreira Pedro Montenegro +2 位作者 JoséRui Pinto António Abel Henriques Rui Calçada 《Railway Engineering Science》 EI 2024年第2期211-228,共18页
High-speed railway bridges are subjected to normative limitations concerning maximum permissible deck accelerations.For the design of these structures,the European norm EN 1991-2 introduces the high-speed load model(H... High-speed railway bridges are subjected to normative limitations concerning maximum permissible deck accelerations.For the design of these structures,the European norm EN 1991-2 introduces the high-speed load model(HSLM)—a set of point loads intended to include the effects of existing high-speed trains.Yet,the evolution of current trains and the recent development of new load models motivate a discussion regarding the limits of validity of the HSLM.For this study,a large number of randomly generated load models of articulated,conventional,and regular trains are tested and compared with the envelope of HSLM effects.For each type of train,two sets of 100,000 load models are considered:one abiding by the limits of the EN 1991-2 and another considering wider limits.This comparison is achieved using both a bridge-independent metric(train signatures)and dynamic analyses on a case study bridge(the Canelas bridge of the Portuguese Railway Network).For the latter,a methodology to decrease the computational cost of moving loads analysis is introduced.Results show that some theoretical load models constructed within the stipulated limits of the norm can lead to effects not covered by the HSLM.This is especially noted in conventional trains,where there is a relation with larger distances between centres of adjacent vehicle bogies. 展开更多
关键词 high-speed load model Dynamic analysis high-speed railways Train signature Railway bridges Deck acceleration
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The use of fluoroscopy for detecting hypertensive lung edema due to prosthetic valve dysfunction: a case report
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作者 Yusuf Kantar Necmi Baykan 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第4期313-315,共3页
Heart valve diseases affect more than one hundred million people around the world,which are a serious cause of illness and mortality.[1]Among the valve diseases,mitral valve insufficiency ranks second in the list of v... Heart valve diseases affect more than one hundred million people around the world,which are a serious cause of illness and mortality.[1]Among the valve diseases,mitral valve insufficiency ranks second in the list of valve diseases requiring surgical repair in Europe.[2]Prosthetic valve replacement is the standard treatment in cases where repair is not sufficient for valve diseases.[3]Mechanical and bioprosthetic valves can be preferred for replacement,mechanical valves are more durable and require lifelong use of anticoagulants.The disadvantage of bioprosthetic valves is early degeneration,and infective reoperation is required due to the formation of endocarditis.[4-5]The risk of thromboembolism,lifetime anticoagulant use and complications related to anticoagulation remain disadvantages of valve surgery.[3]The most important complication requiring urgent intervention is valve dysfunction due to thrombosis.It usually occurs due to inappropriate use of the anticoagulants.[6]Surgical treatment is used for severe obstructions,such as thrombi larger than 10 mm.Thrombolytic therapy can be applied in small thrombi and in cases where surgical intervention is risky. 展开更多
关键词 valve DISADVANTAGE LIFETIME
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Animal Model of Aortic Valve Calcification: Their Methodology Helps Us Understand Aortic Valve Calcification
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作者 Yinze Wei Zhen Wang +1 位作者 Miao Chen Liang Ma 《Advances in Bioscience and Biotechnology》 CAS 2024年第4期235-268,共34页
Aortic valve calcification disease (CAVD) is the most prevalent degenerative valve disease in humans, leading to significant morbidity and mortality. Despite its common occurrence, our understanding of the underlying ... Aortic valve calcification disease (CAVD) is the most prevalent degenerative valve disease in humans, leading to significant morbidity and mortality. Despite its common occurrence, our understanding of the underlying mechanisms remains incomplete, and available treatment options are limited and risky. A more comprehensive understanding of the biology of CAVD is essential to identify new therapeutic strategies. Animal models have played a crucial role in advancing our knowledge of CAVD and exploring potential treatments. However, these models have inherent limitations as they cannot fully replicate the complex physiological mechanisms of human CAVD. In this review, we examine various CAVD models ranging from pigs to mice, highlighting the unique characteristics of each model to enhance our understanding of CAVD. While these models offer valuable insights, they also have limitations and shortcomings. We propose that the guide wire model shows promise for future CAVD research, and streamlining the methodology could enhance our understanding and expand the research scope in this field. 展开更多
关键词 Animal Model Aortic valve Stenosis CALCIFICATION CARDIOVASCULAR
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