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Influence of span-to-depth ratio on dynamic response of vehicle-turnoutbridge system in high-speed railway
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作者 Chuanqing Dai Tao Xin +3 位作者 Shenlu Qiao Yanan Zhang Pengsong Wang Mahantesh M.Nadakatti 《High-Speed Railway》 2024年第1期30-41,共12页
For high-speed railways,the smoothness of the railway line significantly affects the operational speed of trains.When the train passes through the turnout on a long-span bridge,the wheel-rail impacts caused by the tur... For high-speed railways,the smoothness of the railway line significantly affects the operational speed of trains.When the train passes through the turnout on a long-span bridge,the wheel-rail impacts caused by the turnout structure irregularities,and the instability arising from the bridge's flexural deformation lead to a strong coupling effect in the vehicle-turnout-bridge system.This significantly affects both ride comfort and operational safety.For addressing this issue,the present study considered a long-span continuous rigid-frame bridge as an example and established a train-turnout-bridge coupled dynamic model of high-speed railway.Utilizing a selfdeveloped dynamic simulation program,the study analysed the dynamic response characteristics when the train passes through the turnouts on the bridge.It also investigated the influence of different span-to-depth ratios of the bridge on the vehicle dynamic response when the train passes through the main line and branch line of turnouts and then proposed a span-to-depth ratio limit value for a long-span continuous rigid-frame bridge.The research findings suggest that the changes in the span-to-depth ratio have a relatively minor impact on the train’s operational performance but significantly affect the dynamic characteristics of the bridge structure.Based on the findings and a comprehensive assessment of safety indicators,it is advisable to establish a span-to-depth ratio limit of 1/4500 for a long-span continuous rigid-frame bridge. 展开更多
关键词 Turnout on bridge Span-to-depth ratio Dynamic response Vehicle-turnout-bridge system high-speed railway
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Dynamic response and numerical simulation of Al-Sc and Al-Ti alloys under high-speed impact
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作者 张伟贵 何良菊 +3 位作者 李培杰 叶益聪 冯雪 L.S.NOVIKOV 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第2期559-570,共12页
Al-Sc and Al-Ti semi-infinite targets were impacted by high-speed projectiles at velocities of 0.8, 1.0, 1.2 and 1.5 km/s, respectively. It is found that the Al-Sc targets demonstrate more excellent ability to resist ... Al-Sc and Al-Ti semi-infinite targets were impacted by high-speed projectiles at velocities of 0.8, 1.0, 1.2 and 1.5 km/s, respectively. It is found that the Al-Sc targets demonstrate more excellent ability to resist high-speed impact. It is concluded that different microstructures of Al-Sc and Al-Ti alloys, including different grain sizes and secondary particles precipitated in the matrix, result in their greatly different capabilities of resisting impact. Furthermore, the effect of the size range ofnanoscale A13Sc precipitate in A1-Sc alloy on the resistance of high-speed impact was investigated. In addition, computer simulations and validation of these simulations were developed which fairly accurately represented residual crater shapes/geometries. Validated computer simulations allowed representative extrapolations of impact craters well beyond the laboratory where melt and solidification occurred at the crater wall, especially for hypervelocity impact (〉5 km/s). 展开更多
关键词 Al-Sc alloy Al-Ti alloy AL3SC high-speed impact dynamic response numerical simulation
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Unveiling the mechanical response and accommodation mechanism of pre-rolled AZ31 magnesium alloy under high-speed impact loading 被引量:4
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作者 Xiao Liu Hui Yang +3 位作者 Biwu Zhu Yuanzhi Wu Wenhui Liu Changping Tang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第4期1096-1108,共13页
Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommo... Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommodation mechanism of the pre-rolled AZ31 magnesium alloy under high-speed impact loading were investigated.The twin and shear band are prevailing at low temperature,and the coexistence of twins and recrystallized grains is the dominant microstructure at medium temperature,while at high temperature,dynamic recrystallization(DRX)is almost complete.The increment of temperature reduces the critical condition difference between twinning and DRX,and the recrystallized temperature decreases with increasing strain rate.The mechanical response is related to the competition among the shear band strengthen,the twin strengthen and the fine grain strengthen and determined by the prevailing grain structure.The fine grain strengthen could compensate soften caused by the temperature increase and the reduction of twin and shear band.During high-speed deformation,different twin variants,introduced by pre-rolling,induce different deformation mechanism to accommodate plastic deformation and are in favor for non-basal slip.At low temperature,the high-speed deformation is achieved by twinning,dislocation slip and the following deformation shear band at different deformation stages.At high temperature,the high-speed deformation is realized by twinning and dislocation slip of early deformation stage,transition shear band of medium deformation stage and DRX of final deformation stage. 展开更多
关键词 Mechanical response Pre-twinning Accommodation mechanism Pre-rolled AZ31 magnesium alloy high-speed impact loading
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Dynamic response limit of high-speed railway bridge under earthquake considering running safety performance of train 被引量:13
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作者 LIU Xiang JIANG Li-zhong +3 位作者 XIANG Ping LAI Zhi-peng FENG Yu-lin CAO Shan-shan 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第3期968-980,共13页
Due to the wide railway network and different characteristics of many earthquake zones in China,considering the running safety performance of trains(RSPT)in the design of high-speed railway bridge structures is very n... Due to the wide railway network and different characteristics of many earthquake zones in China,considering the running safety performance of trains(RSPT)in the design of high-speed railway bridge structures is very necessary.In this study,in order to provide the seismic design and evaluation measure of the bridge structure based on the RSPT,a calculation model of RSPT on bridge under earthquake was established,and the track surface response measure when the derailment coefficient reaches the limit value was calculated by referring to 15 commonly used ground motion(GM)intensity measures.Based on the coefficient of variation of the limit value obtained from multiple GM samples,the optimal measures were selected.Finally,the limit value of bridge seismic response based on RSPT with different train speeds and structural periods was determined. 展开更多
关键词 high-speed railway bridge seismic design running safety performance measure limit
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Dynamic responses of bridge-approach embankment transition section of high-speed rail 被引量:2
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作者 杨长卫 孙海玲 +2 位作者 张建经 朱传彬 颜利平 《Journal of Central South University》 SCIE EI CAS 2013年第10期2830-2839,共10页
Based on the vehicle track coupling dynamics theory, a new spatial dynamic numerical model of vehicle track subgrade coupling system was established considering the interaction among different structural layers in the... Based on the vehicle track coupling dynamics theory, a new spatial dynamic numerical model of vehicle track subgrade coupling system was established considering the interaction among different structural layers in the subgrade system. The dynamic responses of the coupled system were analyzed when the speed of train was 350 km/h and the transition was filled with graded broken stones mixed with 5% cement. The results indicate that the setting form of bridge-approach embankment section has little effect on the dynamic responses, thus designers can choose it on account of the practical circumstances. Because the location about 5 m from the bridge abutment has the greatest deformation, the stiffness within 0 5 m zone behind the abutment should be specially designed. The results of the study from vehicle track dynamics show that the maximum allowable track deflection angle should be 0.09% and the coefficient of subgrade reaction(K30) is greater than 190 MPa within the 0 5 m zone behind the abutment and greater than 150 MPa in other zones. 展开更多
关键词 high-speed RAIL bridge-approach EMBANKMENT section numerical model TRACK DEFLECTION angle
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Numerical modelling of vibration response in loess hills due to a high-speed train on railway viaduct
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作者 WuJian Yan Hang Zhang +2 位作者 HaiZhong Zheng ZhiJian Wu XinXin Tian 《Research in Cold and Arid Regions》 CSCD 2022年第5期329-337,共9页
In order to accurately analyze vibration characteristics and site effects of loess hills under moving load of a highspeed train,four types of loess hill models under railway viaduct was established by ABAQUS of finite... In order to accurately analyze vibration characteristics and site effects of loess hills under moving load of a highspeed train,four types of loess hill models under railway viaduct was established by ABAQUS of finite element analysis software by field test.The dynamic response and stability of loess hills under two different vibration sources under high-speed train load were studied by using two-dimensional equivalent linear response timehistory analysis,and the influence of the mechanical parameters of loess on the vibration of different types of loess hill was analyzed.Results show that there are obvious differences between peak displacement cloud maps of loess hills under the railway viaduct under gravity and train load action.We analyzed the influence of the change of elastic modulus on vibration propagation of soil of foundation and loess knoll,and found that the change of elastic modulus of soil in different position of foundation has more effect on vibration propagation than that of loess knoll soil.At the same time,the vertical acceleration cloud maps of the four types of loess hills are obviously different. 展开更多
关键词 high-speed train Moving load Loess field Finite element method Dynamic response
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Earthquake Emergency Response System of High-speed Railway by Least Square Method
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作者 Qizhou Hu Yikai Wu 《Journal of Harbin Institute of Technology(New Series)》 CAS 2023年第2期1-11,共11页
This paper studies the Least Square Method to define high-speed railway(HSR) earthquake risk and solve the problem of its emergency response mechanism. Based on the construction of a monitoring system for HSR earthqua... This paper studies the Least Square Method to define high-speed railway(HSR) earthquake risk and solve the problem of its emergency response mechanism. Based on the construction of a monitoring system for HSR earthquake emergency response, the technical operational procedures for HSR seismic emergency response are proposed. The quantity, scale, and location of HSR earthquake emergency response mechanism are defined, and the corresponding emergency response system is built. In particular, the earthquake emergency response system can conduct real-time continuous dynamic monitoring of seismic activity along the railway. When earthquake occurs, the intensity of the ground motion is detected by the system. When the earthquake monitoring value reaches the earthquake alarm threshold, it will send an alarm signal to the dispatch center, and the emergency power supply will be forced to cut off. The earthquake emergency response system will continue to monitor the follow-up ground motion acceleration. The system provides the operation scheduling center with a basis for train operation control to resume operation after stopping. The monitoring result of the system reduces the disaster, and the secondary disaster is caused by the earthquake. This paper improves the HSR response mechanism in detecting earthquake disasters. The result improves the ability of HSR to deal with earthquake disasters, and reduces casualties and economic and property loss caused by earthquake disasters. 展开更多
关键词 high-speed railway(HSR) earthquake monitoring emergency response mechanism
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Evaluation of the local inflammatory stress response and pain mediator secretion after impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator
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作者 Hong-Ju Zou Yong-Sheng Li 《Journal of Hainan Medical University》 2018年第4期95-99,共5页
Objective: To study the local inflammatory stress response and pain mediator secretion after impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator. Methods: Patients who receive... Objective: To study the local inflammatory stress response and pain mediator secretion after impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator. Methods: Patients who received impacted wisdom tooth extraction in the First People's Hospital ofYunnan Province between March 2014 and June 2017 were selected as the research objects and randomly divided into the observation group who accepted impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator and the control group who accepted impacted wisdom tooth extraction with traditional chisel. The contents of inflammatory mediators, stress mediators and pain mediators in gingival crevicular fluid were measured before surgery and 3 days after surgery. Results: Three days after surgery, PTX3, ICAM1, MPO, PGE2, PPARγ, ROS, MDA, 5-HT, CGRP, SP, Gal and ATP contents in gingival crevicular fluid of both groups were higher than those before surgery whereas GPx and T-AOC contents were significantly lower than those before surgery, and PTX3, ICAM1, MPO, PGE2, PPARγ, ROS, MDA, 5-HT, CGRP, SP, Gal and ATP contents in gingival crevicular fluid of observation group were lower than those of control group whereas GPx and T-AOC contents were significantly higher than those of control group. Conclusions: The impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator can reduce the local inflammatory stress response and inhibit the secretion of pain mediators. 展开更多
关键词 IMPACTED WISDOM tooth high-speed turbine drill ORIGINAL luxator INFLAMMATORY stress response PAIN MEDIATOR
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Dynamic Response Analysis of High-Speed Train Gearbox Housing Based on Equivalent Acceleration Amplitude Method
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作者 Xiqiao Li Xi Wang +1 位作者 Chang Xu Guangquan Li 《World Journal of Engineering and Technology》 2017年第2期254-268,共15页
Gearbox, as the crucial transmission equipment of high-speed train drive system, bears mainly the impact of wheel-rail excitation during its application, resulting in fatigue failure of the housing structure. In order... Gearbox, as the crucial transmission equipment of high-speed train drive system, bears mainly the impact of wheel-rail excitation during its application, resulting in fatigue failure of the housing structure. In order to analyze the vibration characteristics of the high-speed train gearbox housing, a test had been performed under operating condition on Wuhan-Guangzhou High-Speed Railway, where a host of vibration characteristics of different parts of housing had been obtained, and vibration signals had also been comparatively analyzed using acceleration amplitude spectrum and equivalent acceleration amplitude method. The result showed that the vibration level of the measuring point A on the joint part of the gearbox housing and axle bearing block was higher than that of the measuring point B on the upper part of the gearbox housing, both horizontally and vertically. And there existed attenuation during the transmission process of vibration from point A to Point B. Further, when a train was moving at a high speed, the gearbox vibration at the head carriage was better than that at the tail carriage. In addition, when a train slowed down from 300 km/h to 200 km/h, the horizontal equivalent acceleration amplitude dropped by 58% while the vertical one declined by 62%. Equivalent acceleration amplitude method was used to identify the vibration relations among different parts of housing, and the validity and applicability of this method were verified by data analysis. The study provided reference to ensure the operating safety of high-speed train drive system and design of new housing structure. 展开更多
关键词 high-speed TRAIN GEARBOX Wheel-Rail EXCITATION Vibration Characteristics EQUIVALENT ACCELERATION AMPLITUDE
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Influence of Random Track Irregularities on Dynamic Response of Bridge/Track Structure/High-Speed Train Systems
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作者 Marian Klasztomy Monika Podwoma 《Journal of Civil Engineering and Architecture》 2014年第10期1335-1352,共18页
Random vertical track irregularities are one of essential vibration sources in bridge, track structure and high-speed train systems. The common model of such irregularities is a stationary and ergodic Gaussian process... Random vertical track irregularities are one of essential vibration sources in bridge, track structure and high-speed train systems. The common model of such irregularities is a stationary and ergodic Gaussian process. The study presents the results of numerical dynamic analysis of advanced virtual models of composite BTT (bridge/ballasted track structure/high-speed train) systems. The analysis has been conducted for a series of types of single-span simply-supported railway composite (steel-concrete) bridges, with a symmetric platform, located on lines with ballasted track structure adapted for high-speed trains. The bridges are designed according to Polish bridge standards. A new methodology of numerical modeling and simulation of dynamic processes in BTT systems has been applied. The methodology takes into consideration viscoelastic suspensions of rail-vehicles, nonlinear Hertz wheel-rail contact stiffness and one-side wheel-rail contact, physically nonlinear elastic-damping properties of the track structure, random vertical track irregularities, approach slabs and other features. Computer algorithms of FE (finite element) modeling and simulation were programmed in Delphi. Both static and dynamic numerical investigations of the bridges forming the series of types have been carried out. It has been proved that in the case of common structural solutions of bridges and ballasted track structures, it is necessary to put certain limitations on operating speeds, macadam ballast and vertical track roughness. 展开更多
关键词 Steel-concrete composite bridge ballasted track structure high-speed passenger train random vertical track irregularities numerical analysis.
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Analysis of Wave Added Drag and Motion Response of Mid-high-speed Ship against Waves
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作者 Jing Wang Yu Zhou 《Sustainable Marine Structures》 2023年第1期1-10,共10页
In order to accurately predict the on-wave resistance and responses to hull motions of ships in actual sea conditions,the k-εmethod of the RNG model is adopted on the basis of the unsteady RANS method.The two-formula... In order to accurately predict the on-wave resistance and responses to hull motions of ships in actual sea conditions,the k-εmethod of the RNG model is adopted on the basis of the unsteady RANS method.The two-formula turbulence model deals with the viscous flow,the VOF method captures the free surface,the velocity boundary method makes waves,the artificial damping method is used to eliminate waves,and the nested grid technology is used to deal with the motion response of ships on waves.Combined with the 6-DOF motion formula,a three-dimensional numerical wave cell for regular waves is established.For one example,taking a KCS Container ship and fishing boat sailing at a mid-high-speed,the increase of wave resistance and motion response at different wavelengths are analyzed,and the simulation results are compared with the experimental value,the content of strip theory in potential flow theory and the panel method to prove the reliability of CFD method in predicting ship motion. 展开更多
关键词 CFD method Wave added resistance Motion response Numerical pool Numerical simulation
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Numerical Study on Reduction in Aerodynamic Drag and Noise of High-Speed Pantograph 被引量:1
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作者 Deng Qin Xing Du +1 位作者 Tian Li Jiye Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期2155-2173,共19页
Reducing the aerodynamic drag and noise levels of high-speed pantographs is important for promoting environmentally friendly,energy efficient and rapid advances in train technology.Using computational fluid dynamics t... Reducing the aerodynamic drag and noise levels of high-speed pantographs is important for promoting environmentally friendly,energy efficient and rapid advances in train technology.Using computational fluid dynamics theory and the K-FWH acoustic equation,a numerical simulation is conducted to investigate the aerodynamic characteristics of high-speed pantographs.A component optimization method is proposed as a possible solution to the problemof aerodynamic drag and noise in high-speed pantographs.The results of the study indicate that the panhead,base and insulator are the main contributors to aerodynamic drag and noise in high-speed pantographs.Therefore,a gradual optimization process is implemented to improve the most significant components that cause aerodynamic drag and noise.By optimizing the cross-sectional shape of the strips and insulators,the drag and noise caused by airflow separation and vortex shedding can be reduced.The aerodynamic drag of insulator with circular cross section and strips with rectangular cross section is the largest.Ellipsifying insulators and optimizing the chamfer angle and height of the windward surface of the strips can improve the aerodynamic performance of the pantograph.In addition,the streamlined fairing attached to the base can eliminate the complex flow and shield the radiated noise.In contrast to the original pantograph design,the improved pantograph shows a 21.1%reduction in aerodynamic drag and a 1.65 dBA reduction in aerodynamic noise. 展开更多
关键词 high-speed pantograph aerodynamic drag aerodynamic noise REDUCTION optimizing
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High-speed penetration of ogive-nose projectiles into thick concrete targets:Tests and a projectile nose evolution model 被引量:1
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作者 Xu Li Yan Liu +4 位作者 Junbo Yan Zhenqing Shi Hongfu Wang Yingliang Xu Fenglei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期553-571,共19页
The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytic... The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit. 展开更多
关键词 high-speed penetration Concrete target EROSION Projectile nose evolution model
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Expert Experience and Data-Driven Based Hybrid Fault Diagnosis for High-SpeedWire Rod Finishing Mills 被引量:1
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作者 Cunsong Wang Ningze Tang +3 位作者 Quanling Zhang Lixin Gao Haichen Yin Hao Peng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第2期1827-1847,共21页
The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault lo... The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time monitoring.To solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this paper.First,based on its mechanical structure,time and frequency domain analysis are improved in fault feature extraction.The approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain analysis.Speed adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding sideband.Then,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault result.Finally,the proposed method is implemented in the equipment intelligent diagnosis system.By taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system. 展开更多
关键词 high-speed wire rod finishing mills expert experience DATA-DRIVEN fault diagnosis
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A review of artificial intelligence applications in high-speed railway systems 被引量:2
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作者 Xuehan Li Minghao Zhu +3 位作者 Boyang Zhang Xiaoxuan Wang Zha Liu Liang Han 《High-Speed Railway》 2024年第1期11-16,共6页
In recent years,the global surge of High-speed Railway(HSR)revolutionized ground transportation,providing secure,comfortable,and punctual services.The next-gen HSR,fueled by emerging services like video surveillance,e... In recent years,the global surge of High-speed Railway(HSR)revolutionized ground transportation,providing secure,comfortable,and punctual services.The next-gen HSR,fueled by emerging services like video surveillance,emergency communication,and real-time scheduling,demands advanced capabilities in real-time perception,automated driving,and digitized services,which accelerate the integration and application of Artificial Intelligence(AI)in the HSR system.This paper first provides a brief overview of AI,covering its origin,evolution,and breakthrough applications.A comprehensive review is then given regarding the most advanced AI technologies and applications in three macro application domains of the HSR system:mechanical manufacturing and electrical control,communication and signal control,and transportation management.The literature is categorized and compared across nine application directions labeled as intelligent manufacturing of trains and key components,forecast of railroad maintenance,optimization of energy consumption in railroads and trains,communication security,communication dependability,channel modeling and estimation,passenger scheduling,traffic flow forecasting,high-speed railway smart platform.Finally,challenges associated with the application of AI are discussed,offering insights for future research directions. 展开更多
关键词 high-speed railway Artificial intelligence Intelligent distribution Intelligent control Intelligent scheduling
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A theory for three-dimensional response of micropolar plates 被引量:1
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作者 Dianwu HUANG Linghui HE 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第8期1403-1414,共12页
Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding throu... Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding through-thickness assumptions of the field variables are made,and the governing equations are two-dimensional,with the displacements and microrotations of the mid-plane as the unknowns.Once the deformation of the mid-plane is solved,a three-dimensional micropolar elastic field within the plate is generated,which is exact up to the second order except in the boundary region close to the plate edge.As an illustrative example,the bending of a clamped infinitely long plate caused by a uniformly distributed transverse force is analyzed and discussed in detail. 展开更多
关键词 micropolar plate TRANSFER-MATRIX asymptotic expansion three-dimensional response
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Computed tomography radiomic features and clinical factors predicting the response to first transarterial chemoembolization in intermediate-stage hepatocellular carcinoma 被引量:1
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作者 Zhong-Xing Shi Chang-Fu Li +6 位作者 Li-Feng Zhao Zhong-Qi Sun Li-Ming Cui Yan-Jie Xin Dong-Qing Wang Tan-Rong Kang Hui-Jie Jiang 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第4期361-369,共9页
Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treat... Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treatment response can help patients choose a reasonable treatment plan.This study aimed to investigate the value of the radiomic-clinical model in predicting the efficacy of the first TACE treatment for HCC to prolong patient survival.Methods:A total of 164 patients with HCC who underwent the first TACE from January 2017 to September 2021 were analyzed.The tumor response was assessed by modified response evaluation criteria in solid tumors(mRECIST),and the response of the first TACE to each session and its correlation with overall survival were evaluated.The radiomic signatures associated with the treatment response were identified by the least absolute shrinkage and selection operator(LASSO),and four machine learning models were built with different types of regions of interest(ROIs)(tumor and corresponding tissues)and the model with the best performance was selected.The predictive performance was assessed with receiver operating characteristic(ROC)curves and calibration curves.Results:Of all the models,the random forest(RF)model with peritumor(+10 mm)radiomic signatures had the best performance[area under ROC curve(AUC)=0.964 in the training cohort,AUC=0.949 in the validation cohort].The RF model was used to calculate the radiomic score(Rad-score),and the optimal cutoff value(0.34)was calculated according to the Youden’s index.Patients were then divided into a high-risk group(Rad-score>0.34)and a low-risk group(Rad-score≤0.34),and a nomogram model was successfully established to predict treatment response.The predicted treatment response also allowed for significant discrimination of Kaplan-Meier curves.Multivariate Cox regression identified six independent prognostic factors for overall survival,including male[hazard ratio(HR)=0.500,95%confidence interval(CI):0.260–0.962,P=0.038],alpha-fetoprotein(HR=1.003,95%CI:1.002–1.004,P<0.001),alanine aminotransferase(HR=1.003,95%CI:1.001–1.005,P=0.025),performance status(HR=2.400,95%CI:1.200–4.800,P=0.013),the number of TACE sessions(HR=0.870,95%CI:0.780–0.970,P=0.012)and Rad-score(HR=3.480,95%CI:1.416–8.552,P=0.007).Conclusions:The radiomic signatures and clinical factors can be well-used to predict the response of HCC patients to the first TACE and may help identify the patients most likely to benefit from TACE. 展开更多
关键词 Hepatocellular carcinoma Transarterial chemoembolization Radiomics Treatment response Prediction
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Probiotics: Shaping the gut immunological responses 被引量:1
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作者 Eirini Filidou Leonidas Kandilogiannakis +2 位作者 Anne Shrewsbury George Kolios Katerina Kotzampassi 《World Journal of Gastroenterology》 SCIE CAS 2024年第15期2096-2108,共13页
Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate amounts.Among the most popular and adequately studied probiotics are bacteria from the families Lactob... Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate amounts.Among the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae,Bifidobacteriaceae and yeasts.Most of them have been shown,both in vitro and in vivo studies of intestinal inflammation models,to provide favorable results by means of improving the gut microbiota composition,promoting the wound healing process and shaping the immunological responses.Chronic intestinal conditions,such as inflammatory bowel diseases(IBD),are characterized by an imbalance in microbiota composition,with decreased diversity,and by relapsing and persisting inflammation,which may lead to mucosal damage.Although the results of the clinical studies investigating the effect of probiotics on patients with IBD are still controversial,it is without doubt that these microorganisms and their metabolites,now named postbiotics,have a positive influence on both the host’s microbiota and the immune system,and ultimately alter the topical tissue microenvironment.This influence is achieved through three axes:(1)By dis-placement of potential pathogens via competitive exclusion;(2)by offering protection to the host through the secretion of various defensive mediators;and(3)by supplying the host with essential nutrients.We will analyze and discuss almost all the in vitro and in vivo studies of the past 2 years dealing with the possible favorable effects of certain probiotic genus on gut immunological responses,highlighting which species are the most beneficial against intestinal inflammation. 展开更多
关键词 PROBIOTICS Lactobacillaceae Bifidobacteriaceae SACCHAROMYCES Intestinal inflammation Immune responses
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Inflammation: Complexity and significance of cellular and molecular responses 被引量:1
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作者 Serdar Ozdemir 《Journal of Acute Disease》 2024年第1期3-7,共5页
Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical sig... Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical signs like redness,swelling,pain,and increased body temperature.Immune cells,notably neutrophils and macrophages,play key roles in orchestrating this response.The delicate balance between proinflammatory and anti-inflammatory mediators,including cytokines and chemokines,regulates the inflammatory cascade.While acute inflammation is crucial for tissue repair,chronic inflammation may indicate an imbalance,contributing to conditions like autoimmune diseases.Understanding these mechanisms is vital for developing therapeutic strategies and managing chronic diseases. 展开更多
关键词 INFLAMMATION C-reactive protein PLATELETS SCUBE1 ADRENOMEDULLIN CALPROTECTIN Pentraxin-3 Immune response Acute phase response Vascular function
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Human intrusion detection for high-speed railway perimeter under all-weather condition 被引量:1
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作者 Pengyue Guo Tianyun Shi +1 位作者 Zhen Ma Jing Wang 《Railway Sciences》 2024年第1期97-110,共14页
Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofo... Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofobject recognition in dark and harsh weather conditions.Design/methodology/approach – This paper adopts the fusion strategy of radar and camera linkage toachieve focus amplification of long-distance targets and solves the problem of low illumination by laser lightfilling of the focus point. In order to improve the recognition effect, this paper adopts the YOLOv8 algorithm formulti-scale target recognition. In addition, for the image distortion caused by bad weather, this paper proposesa linkage and tracking fusion strategy to output the correct alarm results.Findings – Simulated intrusion tests show that the proposed method can effectively detect human intrusionwithin 0–200 m during the day and night in sunny weather and can achieve more than 80% recognitionaccuracy for extreme severe weather conditions.Originality/value – (1) The authors propose a personnel intrusion monitoring scheme based on the fusion ofmillimeter wave radar and camera, achieving all-weather intrusion monitoring;(2) The authors propose a newmulti-level fusion algorithm based on linkage and tracking to achieve intrusion target monitoring underadverse weather conditions;(3) The authors have conducted a large number of innovative simulationexperiments to verify the effectiveness of the method proposed in this article. 展开更多
关键词 high-speed rail perimeter Personnel invasion Object detection ALL-WEATHER Radar-camera fusion
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