Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment responses.AIM To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural networks.METHODS Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus.Mitochondrial genes were sourced from the MitoCarta3.0 database.The discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation cohort.Using the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were predicted.RESULTS In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy model.The average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation cohort.The average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation cohort.CONCLUSION The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

DEEP NEURAL NETWORKS COMBINING MULTI-TASK LEARNING FOR SOLVING DELAY INTEGRO-DIFFERENTIAL EQUATIONS

Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.

Opinion consensus incorporating higher-order interactions in individual-collective networks

In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this paper, a two-layer network consisting of an individual-opinion layer and a collective-opinion layer is constructed, and a dissemination model of opinions incorporating higher-order interactions(i.e. OIHOI dissemination model) is proposed. Furthermore, the dynamic equations of opinion dissemination for both individuals and groups are presented. Using Lyapunov's first method,two equilibrium points, including the negative consensus point and positive consensus point, and the dynamic equations obtained for opinion dissemination, are analyzed theoretically. In addition, for individual opinions and collective opinions,some conditions for reaching negative consensus and positive consensus as well as the theoretical expression for the dissemination threshold are put forward. Numerical simulations are carried to verify the feasibility and effectiveness of the proposed theoretical results, as well as the influence of the intra-structure, inter-connections, and higher-order interactions on the dissemination and evolution of individual opinions. The main results are as follows.(i) When the intra-structure of the collective-opinion layer meets certain characteristics, then a negative or positive consensus is easier to reach for individuals.(ii) Both negative consensus and positive consensus perform best in mixed type of inter-connections in the two-layer network.(iii) Higher-order interactions can quickly eliminate differences in individual opinions, thereby enabling individuals to reach consensus faster.

HGNN-ETC: Higher-Order Graph Neural Network Based on Chronological Relationships for Encrypted Traffic Classification

Encrypted traffic plays a crucial role in safeguarding network security and user privacy.However,encrypting malicious traffic can lead to numerous security issues,making the effective classification of encrypted traffic essential.Existing methods for detecting encrypted traffic face two significant challenges.First,relying solely on the original byte information for classification fails to leverage the rich temporal relationships within network traffic.Second,machine learning and convolutional neural network methods lack sufficient network expression capabilities,hindering the full exploration of traffic’s potential characteristics.To address these limitations,this study introduces a traffic classification method that utilizes time relationships and a higher-order graph neural network,termed HGNN-ETC.This approach fully exploits the original byte information and chronological relationships of traffic packets,transforming traffic data into a graph structure to provide the model with more comprehensive context information.HGNN-ETC employs an innovative k-dimensional graph neural network to effectively capture the multi-scale structural features of traffic graphs,enabling more accurate classification.We select the ISCXVPN and the USTC-TK2016 dataset for our experiments.The results show that compared with other state-of-the-art methods,our method can obtain a better classification effect on different datasets,and the accuracy rate is about 97.00%.In addition,by analyzing the impact of varying input specifications on classification performance,we determine the optimal network data truncation strategy and confirm the model’s excellent generalization ability on different datasets.

Pluggable multitask diffractive neural networks based on cascaded metasurfaces

Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering communities.It has been considered as one of the powerful tools in promoting the fields of imaging processing and object recognition.However,the existing optical system architecture cannot be reconstructed to the realization of multi-functional artificial intelligence systems simultaneously.To push the development of this issue,we propose the pluggable diffractive neural networks(P-DNN),a general paradigm resorting to the cascaded metasurfaces,which can be applied to recognize various tasks by switching internal plug-ins.As the proof-of-principle,the recognition functions of six types of handwritten digits and six types of fashions are numerical simulated and experimental demonstrated at near-infrared regimes.Encouragingly,the proposed paradigm not only improves the flexibility of the optical neural networks but paves the new route for achieving high-speed,low-power and versatile artificial intelligence systems.

Dynamic Multi-Graph Spatio-Temporal Graph Traffic Flow Prediction in Bangkok:An Application of a Continuous Convolutional Neural Network

The ability to accurately predict urban traffic flows is crucial for optimising city operations.Consequently,various methods for forecasting urban traffic have been developed,focusing on analysing historical data to understand complex mobility patterns.Deep learning techniques,such as graph neural networks(GNNs),are popular for their ability to capture spatio-temporal dependencies.However,these models often become overly complex due to the large number of hyper-parameters involved.In this study,we introduce Dynamic Multi-Graph Spatial-Temporal Graph Neural Ordinary Differential Equation Networks(DMST-GNODE),a framework based on ordinary differential equations(ODEs)that autonomously discovers effective spatial-temporal graph neural network(STGNN)architectures for traffic prediction tasks.The comparative analysis of DMST-GNODE and baseline models indicates that DMST-GNODE model demonstrates superior performance across multiple datasets,consistently achieving the lowest Root Mean Square Error(RMSE)and Mean Absolute Error(MAE)values,alongside the highest accuracy.On the BKK(Bangkok)dataset,it outperformed other models with an RMSE of 3.3165 and an accuracy of 0.9367 for a 20-min interval,maintaining this trend across 40 and 60 min.Similarly,on the PeMS08 dataset,DMST-GNODE achieved the best performance with an RMSE of 19.4863 and an accuracy of 0.9377 at 20 min,demonstrating its effectiveness over longer periods.The Los_Loop dataset results further emphasise this model’s advantage,with an RMSE of 3.3422 and an accuracy of 0.7643 at 20 min,consistently maintaining superiority across all time intervals.These numerical highlights indicate that DMST-GNODE not only outperforms baseline models but also achieves higher accuracy and lower errors across different time intervals and datasets.

Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach

This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.

Activation Redistribution Based Hybrid Asymmetric Quantization Method of Neural Networks

The demand for adopting neural networks in resource-constrained embedded devices is continuously increasing.Quantization is one of the most promising solutions to reduce computational cost and memory storage on embedded devices.In order to reduce the complexity and overhead of deploying neural networks on Integeronly hardware,most current quantization methods use a symmetric quantization mapping strategy to quantize a floating-point neural network into an integer network.However,although symmetric quantization has the advantage of easier implementation,it is sub-optimal for cases where the range could be skewed and not symmetric.This often comes at the cost of lower accuracy.This paper proposed an activation redistribution-based hybrid asymmetric quantizationmethod for neural networks.The proposedmethod takes data distribution into consideration and can resolve the contradiction between the quantization accuracy and the ease of implementation,balance the trade-off between clipping range and quantization resolution,and thus improve the accuracy of the quantized neural network.The experimental results indicate that the accuracy of the proposed method is 2.02%and 5.52%higher than the traditional symmetric quantization method for classification and detection tasks,respectively.The proposed method paves the way for computationally intensive neural network models to be deployed on devices with limited computing resources.Codes will be available on https://github.com/ycjcy/Hybrid-Asymmetric-Quantization.

A data-driven model of drop size prediction based on artificial neural networks using small-scale data sets

An artificial neural network(ANN)method is introduced to predict drop size in two kinds of pulsed columns with small-scale data sets.After training,the deviation between calculate and experimental results are 3.8%and 9.3%,respectively.Through ANN model,the influence of interfacial tension and pulsation intensity on the droplet diameter has been developed.Droplet size gradually increases with the increase of interfacial tension,and decreases with the increase of pulse intensity.It can be seen that the accuracy of ANN model in predicting droplet size outside the training set range is reach the same level as the accuracy of correlation obtained based on experiments within this range.For two kinds of columns,the drop size prediction deviations of ANN model are 9.6%and 18.5%and the deviations in correlations are 11%and 15%.

Multi-Scale-Matching neural networks for thin plate bending problem

Physics-informed neural networks are a useful machine learning method for solving differential equations,but encounter challenges in effectively learning thin boundary layers within singular perturbation problems.To resolve this issue,multi-scale-matching neural networks are proposed to solve the singular perturbation problems.Inspired by matched asymptotic expansions,the solution is decomposed into inner solutions for small scales and outer solutions for large scales,corresponding to boundary layers and outer regions,respectively.Moreover,to conform neural networks,we introduce exponential stretched variables in the boundary layers to avoid semiinfinite region problems.Numerical results for the thin plate problem validate the proposed method.

Multi-scale physics-informed neural networks for solving high Reynolds number boundary layer flows based on matched asymptotic expansions

Multi-scale system remains a classical scientific problem in fluid dynamics,biology,etc.In the present study,a scheme of multi-scale Physics-informed neural networks is proposed to solve the boundary layer flow at high Reynolds numbers without any data.The flow is divided into several regions with different scales based on Prandtl's boundary theory.Different regions are solved with governing equations in different scales.The method of matched asymptotic expansions is used to make the flow field continuously.A flow on a semi infinite flat plate at a high Reynolds number is considered a multi-scale problem because the boundary layer scale is much smaller than the outer flow scale.The results are compared with the reference numerical solutions,which show that the msPINNs can solve the multi-scale problem of the boundary layer in high Reynolds number flows.This scheme can be developed for more multi-scale problems in the future.

Graph neural network-based scheduling for multi-UAV-enabled communications in D2D networks

In this paper,we jointly design the power control and position dispatch for Multi-Unmanned Aerial Vehicle(UAV)-enabled communication in Device-to-Device(D2D)networks.Our objective is to maximize the total transmission rate of Downlink Users(DUs).Meanwhile,the Quality of Service(QoS)of all D2D users must be satisfied.We comprehensively considered the interference among D2D communications and downlink transmissions.The original problem is strongly non-convex,which requires high computational complexity for traditional optimization methods.And to make matters worse,the results are not necessarily globally optimal.In this paper,we propose a novel Graph Neural Networks(GNN)based approach that can map the considered system into a specific graph structure and achieve the optimal solution in a low complexity manner.Particularly,we first construct a GNN-based model for the proposed network,in which the transmission links and interference links are formulated as vertexes and edges,respectively.Then,by taking the channel state information and the coordinates of ground users as the inputs,as well as the location of UAVs and the transmission power of all transmitters as outputs,we obtain the mapping from inputs to outputs through training the parameters of GNN.Simulation results verified that the way to maximize the total transmission rate of DUs can be extracted effectively via the training on samples.Moreover,it also shows that the performance of proposed GNN-based method is better than that of traditional means.

Using deep neural networks coupled with principal component analysis for ore production forecasting at open-pit mines

Ore production is usually affected by multiple influencing inputs at open-pit mines.Nevertheless,the complex nonlinear relationships between these inputs and ore production remain unclear.This becomes even more challenging when training data(e.g.truck haulage information and weather conditions)are massive.In machine learning(ML)algorithms,deep neural network(DNN)is a superior method for processing nonlinear and massive data by adjusting the amount of neurons and hidden layers.This study adopted DNN to forecast ore production using truck haulage information and weather conditions at open-pit mines as training data.Before the prediction models were built,principal component analysis(PCA)was employed to reduce the data dimensionality and eliminate the multicollinearity among highly correlated input variables.To verify the superiority of DNN,three ANNs containing only one hidden layer and six traditional ML models were established as benchmark models.The DNN model with multiple hidden layers performed better than the ANN models with a single hidden layer.The DNN model outperformed the extensively applied benchmark models in predicting ore production.This can provide engineers and researchers with an accurate method to forecast ore production,which helps make sound budgetary decisions and mine planning at open-pit mines.

Intrusion Detection System for Smart Industrial Environments with Ensemble Feature Selection and Deep Convolutional Neural Networks

Smart Industrial environments use the Industrial Internet of Things(IIoT)for their routine operations and transform their industrial operations with intelligent and driven approaches.However,IIoT devices are vulnerable to cyber threats and exploits due to their connectivity with the internet.Traditional signature-based IDS are effective in detecting known attacks,but they are unable to detect unknown emerging attacks.Therefore,there is the need for an IDS which can learn from data and detect new threats.Ensemble Machine Learning(ML)and individual Deep Learning(DL)based IDS have been developed,and these individual models achieved low accuracy;however,their performance can be improved with the ensemble stacking technique.In this paper,we have proposed a Deep Stacked Neural Network(DSNN)based IDS,which consists of two stacked Convolutional Neural Network(CNN)models as base learners and Extreme Gradient Boosting(XGB)as the meta learner.The proposed DSNN model was trained and evaluated with the next-generation dataset,TON_IoT.Several pre-processing techniques were applied to prepare a dataset for the model,including ensemble feature selection and the SMOTE technique.Accuracy,precision,recall,F1-score,and false positive rates were used to evaluate the performance of the proposed ensemble model.Our experimental results showed that the accuracy for binary classification is 99.61%,which is better than in the baseline individual DL and ML models.In addition,the model proposed for IDS has been compared with similar models.The proposed DSNN achieved better performance metrics than the other models.The proposed DSNN model will be used to develop enhanced IDS for threat mitigation in smart industrial environments.

A Review of Computing with Spiking Neural Networks

Artificial neural networks(ANNs)have led to landmark changes in many fields,but they still differ significantly fromthemechanisms of real biological neural networks and face problems such as high computing costs,excessive computing power,and so on.Spiking neural networks(SNNs)provide a new approach combined with brain-like science to improve the computational energy efficiency,computational architecture,and biological credibility of current deep learning applications.In the early stage of development,its poor performance hindered the application of SNNs in real-world scenarios.In recent years,SNNs have made great progress in computational performance and practicability compared with the earlier research results,and are continuously producing significant results.Although there are already many pieces of literature on SNNs,there is still a lack of comprehensive review on SNNs from the perspective of improving performance and practicality as well as incorporating the latest research results.Starting from this issue,this paper elaborates on SNNs along the complete usage process of SNNs including network construction,data processing,model training,development,and deployment,aiming to provide more comprehensive and practical guidance to promote the development of SNNs.Therefore,the connotation and development status of SNNcomputing is reviewed systematically and comprehensively from four aspects:composition structure,data set,learning algorithm,software/hardware development platform.Then the development characteristics of SNNs in intelligent computing are summarized,the current challenges of SNNs are discussed and the future development directions are also prospected.Our research shows that in the fields of machine learning and intelligent computing,SNNs have comparable network scale and performance to ANNs and the ability to challenge large datasets and a variety of tasks.The advantages of SNNs over ANNs in terms of energy efficiency and spatial-temporal data processing have been more fully exploited.And the development of programming and deployment tools has lowered the threshold for the use of SNNs.SNNs show a broad development prospect for brain-like computing.

NeurstrucEnergy:A bi-directional GNN model for energy prediction of neural networks in IoT

A significant demand rises for energy-efficient deep neural networks to support power-limited embedding devices with successful deep learning applications in IoT and edge computing fields.An accurate energy prediction approach is critical to provide measurement and lead optimization direction.However,the current energy prediction approaches lack accuracy and generalization ability due to the lack of research on the neural network structure and the excessive reliance on customized training dataset.This paper presents a novel energy prediction model,NeurstrucEnergy.NeurstrucEnergy treats neural networks as directed graphs and applies a bi-directional graph neural network training on a randomly generated dataset to extract structural features for energy prediction.NeurstrucEnergy has advantages over linear approaches because the bi-directional graph neural network collects structural features from each layer's parents and children.Experimental results show that NeurstrucEnergy establishes state-of-the-art results with mean absolute percentage error of 2.60%.We also evaluate NeurstrucEnergy in a randomly generated dataset,achieving the mean absolute percentage error of 4.83%over 10 typical convolutional neural networks in recent years and 7 efficient convolutional neural networks created by neural architecture search.Our code is available at https://github.com/NEUSoftGreenAI/NeurstrucEnergy.git.

Prediction of Porous Media Fluid Flow with Spatial Heterogeneity Using Criss-Cross Physics-Informed Convolutional Neural Networks

Recent advances in deep neural networks have shed new light on physics,engineering,and scientific computing.Reconciling the data-centered viewpoint with physical simulation is one of the research hotspots.The physicsinformedneural network(PINN)is currently the most general framework,which is more popular due to theconvenience of constructing NNs and excellent generalization ability.The automatic differentiation(AD)-basedPINN model is suitable for the homogeneous scientific problem;however,it is unclear how AD can enforce fluxcontinuity across boundaries between cells of different properties where spatial heterogeneity is represented bygrid cells with different physical properties.In this work,we propose a criss-cross physics-informed convolutionalneural network(CC-PINN)learning architecture,aiming to learn the solution of parametric PDEs with spatialheterogeneity of physical properties.To achieve the seamless enforcement of flux continuity and integration ofphysicalmeaning into CNN,a predefined 2D convolutional layer is proposed to accurately express transmissibilitybetween adjacent cells.The efficacy of the proposedmethodwas evaluated through predictions of several petroleumreservoir problems with spatial heterogeneity and compared against state-of-the-art(PINN)through numericalanalysis as a benchmark,which demonstrated the superiority of the proposed method over the PINN.

RWNeRF:Robust Watermarking Scheme for Neural Radiance Fields Based on Invertible Neural Networks

As neural radiance fields continue to advance in 3D content representation,the copyright issues surrounding 3D models oriented towards implicit representation become increasingly pressing.In response to this challenge,this paper treats the embedding and extraction of neural radiance field watermarks as inverse problems of image transformations and proposes a scheme for protecting neural radiance field copyrights using invertible neural network watermarking.Leveraging 2D image watermarking technology for 3D scene protection,the scheme embeds watermarks within the training images of neural radiance fields through the forward process in invertible neural networks and extracts them from images rendered by neural radiance fields through the reverse process,thereby ensuring copyright protection for both the neural radiance fields and associated 3D scenes.However,challenges such as information loss during rendering processes and deliberate tampering necessitate the design of an image quality enhancement module to increase the scheme’s robustness.This module restores distorted images through neural network processing before watermark extraction.Additionally,embedding watermarks in each training image enables watermark information extraction from multiple viewpoints.Our proposed watermarking method achieves a PSNR(Peak Signal-to-Noise Ratio)value exceeding 37 dB for images containing watermarks and 22 dB for recovered watermarked images,as evaluated on the Lego,Hotdog,and Chair datasets,respectively.These results demonstrate the efficacy of our scheme in enhancing copyright protection.

MarkINeRV: A Robust Watermarking Scheme for Neural Representation for Videos Based on Invertible Neural Networks

Recent research advances in implicit neural representation have shown that a wide range of video data distributions are achieved by sharing model weights for Neural Representation for Videos(NeRV).While explicit methods exist for accurately embedding ownership or copyright information in video data,the nascent NeRV framework has yet to address this issue comprehensively.In response,this paper introduces MarkINeRV,a scheme designed to embed watermarking information into video frames using an invertible neural network watermarking approach to protect the copyright of NeRV,which models the embedding and extraction of watermarks as a pair of inverse processes of a reversible network and employs the same network to achieve embedding and extraction of watermarks.It is just that the information flow is in the opposite direction.Additionally,a video frame quality enhancement module is incorporated to mitigate watermarking information losses in the rendering process and the possibility ofmalicious attacks during transmission,ensuring the accurate extraction of watermarking information through the invertible network’s inverse process.This paper evaluates the accuracy,robustness,and invisibility of MarkINeRV through multiple video datasets.The results demonstrate its efficacy in extracting watermarking information for copyright protection of NeRV.MarkINeRV represents a pioneering investigation into copyright issues surrounding NeRV.

Reconfigurable optical neural networks with Plug-and-Play metasurfaces

In a very recent study,Prof.Lingling Huang and co-workers proposed and demonstrated reconfigurable optical neural networks based on cascaded metasurfaces.By fixing one metasurface and switching the other pluggable metasurfaces,the neural networks,which operate at near-infrared wavelengths,can perform distinct recognition tasks for handwritten digits and fashion products.This innovative device opens up an avenue for all-optical,high-speed,low-power,and multifunctional artificial intelligence systems.