Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relations...Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day- old （P35） FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram （EEG） power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.展开更多
Chronic experiments with rabbits have shown that electrical destruction of dorsal amygdalofugal pathways leads to complete and persisted blockade of hippocampal theta rhythm in contrast to ventral one. In intact anima...Chronic experiments with rabbits have shown that electrical destruction of dorsal amygdalofugal pathways leads to complete and persisted blockade of hippocampal theta rhythm in contrast to ventral one. In intact animals, electro- and chemostimulation of amygdala nuclei, hypothalamus, reticular formation and medial septum nucleus lead to the formation of well pronounced theta rhythm in hippocampus, but after destruction of the amygdalofugal pathway any theta-rhythm in this structure is not observed. Restoration of hippocampal EEG took place under intrahippocampal application of carbocholine and strychnine. It is proposed that one of the necessary conditions for the regulation of excitability of hippocampal neurons is the integrity of dorsal amygdalofugal pathways by means of which regulatory influence of amygdale on the hippotalamic neurosecretory cells is realized.展开更多
基金supported by the National Natural Science Foundation of China (91332202, 81273506, 81273492)the Program for Zhejiang Leading Team of S&T Innovation, China (2011R50014)
文摘Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day- old （P35） FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram （EEG） power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.
文摘Chronic experiments with rabbits have shown that electrical destruction of dorsal amygdalofugal pathways leads to complete and persisted blockade of hippocampal theta rhythm in contrast to ventral one. In intact animals, electro- and chemostimulation of amygdala nuclei, hypothalamus, reticular formation and medial septum nucleus lead to the formation of well pronounced theta rhythm in hippocampus, but after destruction of the amygdalofugal pathway any theta-rhythm in this structure is not observed. Restoration of hippocampal EEG took place under intrahippocampal application of carbocholine and strychnine. It is proposed that one of the necessary conditions for the regulation of excitability of hippocampal neurons is the integrity of dorsal amygdalofugal pathways by means of which regulatory influence of amygdale on the hippotalamic neurosecretory cells is realized.
