In this study, histopathological changes in the heart, liver, spleen, lung, kidney, intestine, brain and other organs of foxes died of parvovims infection were observed. According to the results, multiple organs of in...In this study, histopathological changes in the heart, liver, spleen, lung, kidney, intestine, brain and other organs of foxes died of parvovims infection were observed. According to the results, multiple organs of infected foxes were congested and hemorrhaged with tissue damage, inflammatory cell infiltration and a series of pathological changes, mainly exhibiting hepatic cell cord rupture, liver cell granular degeneration and fatty degeneration, small intestinal mucous mem- brane shedding, intestinal villi necrosis and shedding, severe hemorrhage of lamina pmpria with inflammatory cell infiltration, and severe small intestinal bleeding. This study laid a solid foundation for clinical diagnosis, prevention and treatment of parvovirus infection in foxes.展开更多
[ Objective] This study aimed to investigate and analyze the histopathological changes in various tissues and organs of Cynoglossus semilaevis Gunther with abdominal dropsy. [ Method] By HE staining, pathological tiss...[ Objective] This study aimed to investigate and analyze the histopathological changes in various tissues and organs of Cynoglossus semilaevis Gunther with abdominal dropsy. [ Method] By HE staining, pathological tissues of main organs of C. semilaevis Giinther with abdominal dropsy were observed. [ Result] According to the results of histopathological observation, C. semilaevis Gilnther with abdominal dropsy exhibited a large amount of ascites in the abdominal cavity; small intestinal mucosal epithelial cells were denatured and necrotic, and shed into the enteric cavity, with submucosal vascular congestion; the liver and pancreas tissues were denatured and necrotic, and the morphology of most liver cells disappeared. However, there was no remarkable pathological change in the heart, spleen and other organs. [ Conclusion] C. semilaevis Gtinther with abdominal dropsy exhibited serious pathological and histochemical lesions in the small intestine, liver and pancreas, causing metabolic disorders.展开更多
Tetrabromobisphenol A（TBBPA） and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target organisms.Considering the potential neurotoxicity ...Tetrabromobisphenol A（TBBPA） and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target organisms.Considering the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis（2-hydroxyethyl ether）（TBBPA-BHEE）, a representative TBBPA derivative, was selected for a21-day exposure experiment on neonatal Sprague Dawley（SD） rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities（p 〈 0.05）. The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int（Wnt） signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmission were influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure,which would be of great value in the biosafety evaluation of TBBPA derivatives.展开更多
基金Supported by Science and Technology Support Program of Science and Technology Department of Hebei Province(14826613D)Project of Qinhuangdao Academy of Agricultural Sciences(2014-04)Project of Qinghuangdao Municipal Science and Technology Bureau(201502A054)
文摘In this study, histopathological changes in the heart, liver, spleen, lung, kidney, intestine, brain and other organs of foxes died of parvovims infection were observed. According to the results, multiple organs of infected foxes were congested and hemorrhaged with tissue damage, inflammatory cell infiltration and a series of pathological changes, mainly exhibiting hepatic cell cord rupture, liver cell granular degeneration and fatty degeneration, small intestinal mucous mem- brane shedding, intestinal villi necrosis and shedding, severe hemorrhage of lamina pmpria with inflammatory cell infiltration, and severe small intestinal bleeding. This study laid a solid foundation for clinical diagnosis, prevention and treatment of parvovirus infection in foxes.
基金Supported by Post-award Grant Program from the Department of Science and Technology of Hebei Province(15926620H)Science and Technology Support Program of Qinhuangdao Municipal Science and Technology Bureau(201401A067201402B043)
文摘[ Objective] This study aimed to investigate and analyze the histopathological changes in various tissues and organs of Cynoglossus semilaevis Gunther with abdominal dropsy. [ Method] By HE staining, pathological tissues of main organs of C. semilaevis Giinther with abdominal dropsy were observed. [ Result] According to the results of histopathological observation, C. semilaevis Gilnther with abdominal dropsy exhibited a large amount of ascites in the abdominal cavity; small intestinal mucosal epithelial cells were denatured and necrotic, and shed into the enteric cavity, with submucosal vascular congestion; the liver and pancreas tissues were denatured and necrotic, and the morphology of most liver cells disappeared. However, there was no remarkable pathological change in the heart, spleen and other organs. [ Conclusion] C. semilaevis Gtinther with abdominal dropsy exhibited serious pathological and histochemical lesions in the small intestine, liver and pancreas, causing metabolic disorders.
基金supported by the Major International (Regional) Joint Project (No. 21461142001)the National Basic Research Program of China (No. 2015CB453102)+2 种基金the National Natural Science Foundation of China (Nos. 21621064, 21477153)the Strategic Priority Research Program of the Chinese Academy of Science (No. 14040302)the Chinese Academy of Sciences (No. QYZDJ-SSW-DQC017)
文摘Tetrabromobisphenol A（TBBPA） and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target organisms.Considering the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis（2-hydroxyethyl ether）（TBBPA-BHEE）, a representative TBBPA derivative, was selected for a21-day exposure experiment on neonatal Sprague Dawley（SD） rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities（p 〈 0.05）. The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int（Wnt） signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmission were influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure,which would be of great value in the biosafety evaluation of TBBPA derivatives.
