In a typical discrete manufacturing process,a new type of reconfigurable production line is introduced,which aims to help small-and mid-size enterprises to improve machine utilization and reduce production cost.In ord...In a typical discrete manufacturing process,a new type of reconfigurable production line is introduced,which aims to help small-and mid-size enterprises to improve machine utilization and reduce production cost.In order to effectively handle the production scheduling problem for the manufacturing system,an improved multi-objective particle swarm optimization algorithm based on Brownian motion(MOPSO-BM)is proposed.Since the existing MOPSO algorithms are easily stuck in the local optimum,the global search ability of the proposed method is enhanced based on the random motion mechanism of the BM.To further strengthen the global search capacity,a strategy of fitting the inertia weight with the piecewise Gaussian cumulative distribution function(GCDF)is included,which helps to maintain an excellent convergence rate of the algorithm.Based on the commonly used indicators generational distance(GD)and hypervolume(HV),we compare the MOPSO-BM with several other latest algorithms on the benchmark functions,and it shows a better overall performance.Furthermore,for a real reconfigurable production line of smart home appliances,three algorithms,namely non-dominated sorting genetic algorithm-II(NSGA-II),decomposition-based MOPSO(dMOPSO)and MOPSO-BM,are applied to tackle the scheduling problem.It is demonstrated that MOPSO-BM outperforms the others in terms of convergence rate and quality of solutions.展开更多
BACKGROUND Advanced glycation end products(AGEs)are diabetic metabolic toxic products that cannot be ignored.Nε-(carboxymethyl)lysine(CML),a component of AGEs,could increase macrophage lipid uptake,promote foam cell ...BACKGROUND Advanced glycation end products(AGEs)are diabetic metabolic toxic products that cannot be ignored.Nε-(carboxymethyl)lysine(CML),a component of AGEs,could increase macrophage lipid uptake,promote foam cell formation,and thereby accelerate atherosclerosis.The receptor for AGEs(RAGE)and cluster of differentiation 36(CD36)were the receptors of CML.However,it is still unknown whether RAGE and CD36 play key roles in CML-promoted lipid uptake.AIM Our study aimed to explore the role of RAGE and CD36 in CML-induced macrophage lipid uptake.METHODS In this study,we examined the effect of CML on lipid uptake by Raw264.7 macrophages.After adding 10 mmol/L CML,the lipid accumulation in macrophages was confirmed by oil red O staining.Expression changes of CD36 and RAGE were detected with immunoblotting and quantitative real-time polymerase chain reaction.The interaction between CML with CD36 and RAGE was verified by immunoprecipitation.We synthesized a novel N-succinimidyl-4-18Ffluorobenzoate-CML radioactive probe.Radioactive receptor-ligand binding assays were performed to test the binding affinity between CML with CD36 and RAGE.The effects of blocking CD36 or RAGE on CML-promoting lipid uptake were also detected.RESULTS The study revealed that CML significantly promoted lipid uptake by macrophages.Immunoprecipitation and radioactive receptor-ligand binding assays indicated that CML could specifically bind to both CD36 and RAGE.CML had a higher affinity for CD36 than RAGE.ARG82,ASN71,and THR70 were the potential interacting amino acids that CD36 binds to CML Anti-CD36 and anti-RAGE could block the uptake of CML by macrophages.The lipid uptake promotion effect of CML was significantly attenuated after blocking CD36 or RAGE.CONCLUSION Our results suggest that the binding of CML with CD36 and RAGE promotes macrophage lipid uptake.展开更多
The production cycle of open-cast coal mines generally in eludes drilling, blasting, loading, hauling and coal preparation activities. Individual optimization of these activities does not mean that the whole system is...The production cycle of open-cast coal mines generally in eludes drilling, blasting, loading, hauling and coal preparation activities. Individual optimization of these activities does not mean that the whole system is optimized. This paper proposes a cost model considering all activities in mining cycle and system-wide approach to minimize the total mining cost of bench production. Since the fragmentation size and blast-hole diameter are linked to all activities of mining system, they are considered as decision variables in the problem form ul at io n. The operatio n costs are then minimized by using the evolutionary algorithm. Moreover, the impact of the change in the explosive price, and the hourly unit cost of equipment on total mining cost is quantified by sensitivity analysis. A case study is implemented to demonstrate the developed model.展开更多
Recently,both the importance and awareness relating to food safety relating to agrochemicals,chemical fertilizers,the pollution of ecosystem and unwholesome foods are growing rapidly.For the same reason,the purchaser&...Recently,both the importance and awareness relating to food safety relating to agrochemicals,chemical fertilizers,the pollution of ecosystem and unwholesome foods are growing rapidly.For the same reason,the purchaser's curiosity increases to know about the production process which can be accomplished by production traceability system.The traceability system can store and superintend the specific attribute information about products regarding the productive centre,producer and production finish data.The products undergo various circulation processes and they are being managed by individually constructed traceability system.Thus,it is difficult for the producer and the consumer to guarantee the safety from transpirable issues about the falsification of production traceability because the traceability information can be re-produced by forging through various ways.So in this paper,we proposed a system for integrated management of agro-fishery products based on quick response code(QR-code)for forgery prevention which may help to solve these issues.The proposed system makes QR-code using production information provided by producer.And then it is provided to the distributor and the consumer through integrated service model using the QR-code.Therefore,this system make sure to provide the same production traceability about the products to the distributor and the consumer and always keeps both updated with the same information.展开更多
The spatial and temporal distributions of new production vary largely in different sea areas. To understand the level of new production in the sea area studied better, an estimate of new production must be obtained in...The spatial and temporal distributions of new production vary largely in different sea areas. To understand the level of new production in the sea area studied better, an estimate of new production must be obtained in large spatial and temporal scales. The ~234Th/ ~238U disequilibrium is an effective method for the study of new production. Two sampling strategies, vertically integrated sampling ap proach based on trapezoidal integration principle and discrete layer sampling approach, were compared in the studies of the xiamen Bay and the northern South China Sea. The scavenging fluxes and removal fluxes of ~234Th and the residence times for dissolved and particulate ~234Th were calculated. The coinci dent results from two Sampling approach suggest that vertically integrated sampling approach is not only effective and reliable, but also significantly reduces the number and volume of samples. It allows us to study new production by ba ^(234)Th - ^(238)U disequilibria in large spatial scale.展开更多
Smart home-based care for elderly is the product of the “Internet+” era, along with the information technology and the growing needs for a better elderly life. In order to understand the influencing factors of smart...Smart home-based care for elderly is the product of the “Internet+” era, along with the information technology and the growing needs for a better elderly life. In order to understand the influencing factors of smart home care in Hengshui city, this paper selected 183 elderly people through a questionnaire survey. The conclusion of the study showed that education level, economic status, sleep quality and residence conditions are the influencing factors affecting the needs of smart home care of the elderly (p 0.05). Smart home care products for the elderly have a high willingness to use them, especially in terms of life care, medical services and emotional talk, but the compliance still needs to be improved. Development countermeasures suitable for Hengshui city can be put forward through the publicity of smart elderly care services, promoting the construction of demand-oriented big data, and promoting the participation of various forces.展开更多
The real smart home is not merely moving from the original remote control and panel to a smart phone app to make products intelligent or to control consumer electronics in one way,but is built based on interconnection...The real smart home is not merely moving from the original remote control and panel to a smart phone app to make products intelligent or to control consumer electronics in one way,but is built based on interconnection and automation.The smart home of the future can not only achieve integrated control,remote control,scene control,timing control,intelligent linkage and security measures,but also support“selflearning”and“self-optimization”,and will“manual”and“automatic”control.This paper aims to change the value of smart home products into“active”.Therefore,this paper relies on the realization of the value of smart home products,describes the principles of smart home products and product interaction design,analyzes the needs of the target users,and proposes a product design scheme for reference by relevant personnel.展开更多
Based upon broad-band CCD observation data of comet Hale-Bopp obtained by a 60cm telescope at Xinglong Station of Beijing Astronomical Observatory during March-August, 1996, the photometric results of comet Hale-Bopp ...Based upon broad-band CCD observation data of comet Hale-Bopp obtained by a 60cm telescope at Xinglong Station of Beijing Astronomical Observatory during March-August, 1996, the photometric results of comet Hale-Bopp are reported. Using the photometric results, the dust production rate, radius and mass of nucleus of comet Hale-Bopp are estimated as follows: dM/dt~1.5×10 5 kgs -1, R n~35.5km, and M n~5.65×10 16kg.展开更多
This study was conducted to investigate the in-vitro production technology of embryos from young Dorper sheep, so as to provide technical support for the utilization of ovarian follicles in young Dorper sheep. Tests w...This study was conducted to investigate the in-vitro production technology of embryos from young Dorper sheep, so as to provide technical support for the utilization of ovarian follicles in young Dorper sheep. Tests were conducted from the induction of Dorper sheep of 4 to 8 weeks old using follicle stimulating hormone(FSH) and pregnant horse serum(PMSG), collection of oocytes, in-vitro oocyte maturation-fertilization-zygote cultivation and 2-4-cell-stage fertilized ovum transfer. The results showed that 585 oocytes were collected from eight Dorper sheep at the age of 4 and 8 weeks, with an average of 73.13 oocytes/sheep. 346 of the 2-4-cell-stage fertilized eggs were obtained, whose cleavage rate was 59.15%. 77 in-vitro fertilized eggs at 2-4-cell stage were transplanted into 17 recipient sheep, seven of which were pregnant and gave birth to 13 "test-tube sheep" with a conception rate of 41.18%. It is indicated that the hormone induction technique, in-vitro oocyte maturation-fertilization-zygote cultivation technique and 2-4-cell-stage fertilized ovum transfer technique used in this study can serve as effective techniques for the in-vitro production of embryos from Dorper sheep of 4-8 weeks old.展开更多
Conscious consumption is a trend that is here to stay since consumers are becoming more aware of their purchasing decision and its impact on their health & environment. To sustain in the market on the move towards...Conscious consumption is a trend that is here to stay since consumers are becoming more aware of their purchasing decision and its impact on their health & environment. To sustain in the market on the move towards sustainability and meet the demands, companies need to re-examine their footprints and incorporate green practices in their products and organization. Using eco-friendly material & processes is one of the remedies to come up with this, and bamboo is one of the most versatile, green and renewable natural resources on planet earth. Traditionally bamboo has been exploited to a large extent but cutting-edge options available for bamboo are still limited and have a scope of indulging fully in the lifestyle of people in India. The global market size of bamboo was valued at UED 53.28 billion in 2020, and it is expected to grow at compound annual growth rate of 5.7% from 2022 to 2028. There is increasing demand for sustainable construction, and furniture and handicraft products also have considerable weightage. Manny brands and craft clusters of bamboo are realizing and promoting this green quotient of bamboo to the market to attract the eco-conscious audience and trying to cope up with the advancement of sustainability, like certifications of being a green organisation. Despite the exceptional qualities of bamboo, it is considered as a marginalized material due to low production rate, high competition with the non-eco-friendly or cheaper alternatives, aesthetics and marketing gaps. There is a gap between willingness to purchase and an actual purchase when it comes to the sustainable products and marketing plays a major role in conversions. The main purpose of the research is to study and understand the product, craft, design, production processes and marketing practices of bamboo lifestyle products and how conscious consumption patterns influence the bamboo products and the industry in relevance to the sustainability. Exploratory research method was applied with the literature survey and reviewing of the research papers from the peer reviewed journals. They were classified and reviewed based on the areas relevant to the bamboo products. The research outcome revealed the research gaps and the results were discussed and presented with the perspectives of product design, conscious consumption and marketing strategies in relevant to the sustainability of bamboo lifestyle products.展开更多
During the China International Trade Fair for Home textiles and Accessories(Intertextile Shanghai Home textile),held from Aug.24th to 26 th,2010,in the city of Shanghai,the Intertextile Direction Trend Committee relea...During the China International Trade Fair for Home textiles and Accessories(Intertextile Shanghai Home textile),held from Aug.24th to 26 th,2010,in the city of Shanghai,the Intertextile Direction Trend Committee released the latest home textile trends for Autumn and Winter 2011 and 2012.展开更多
基金supported by the National Natural Science Foundation of China(71871203,52005447,L1924063)Zhejiang Provincial Natural Science Foundation of China(LY18G010017,LQ21E050014).
文摘In a typical discrete manufacturing process,a new type of reconfigurable production line is introduced,which aims to help small-and mid-size enterprises to improve machine utilization and reduce production cost.In order to effectively handle the production scheduling problem for the manufacturing system,an improved multi-objective particle swarm optimization algorithm based on Brownian motion(MOPSO-BM)is proposed.Since the existing MOPSO algorithms are easily stuck in the local optimum,the global search ability of the proposed method is enhanced based on the random motion mechanism of the BM.To further strengthen the global search capacity,a strategy of fitting the inertia weight with the piecewise Gaussian cumulative distribution function(GCDF)is included,which helps to maintain an excellent convergence rate of the algorithm.Based on the commonly used indicators generational distance(GD)and hypervolume(HV),we compare the MOPSO-BM with several other latest algorithms on the benchmark functions,and it shows a better overall performance.Furthermore,for a real reconfigurable production line of smart home appliances,three algorithms,namely non-dominated sorting genetic algorithm-II(NSGA-II),decomposition-based MOPSO(dMOPSO)and MOPSO-BM,are applied to tackle the scheduling problem.It is demonstrated that MOPSO-BM outperforms the others in terms of convergence rate and quality of solutions.
基金Supported by The National Natural Science Foundation of China,No.82070455Natural Science Foundation of Jiangsu Province,No.BK20201225Medical Innovation Team Project of Jiangsu Province,No.CXTDA2017010。
文摘BACKGROUND Advanced glycation end products(AGEs)are diabetic metabolic toxic products that cannot be ignored.Nε-(carboxymethyl)lysine(CML),a component of AGEs,could increase macrophage lipid uptake,promote foam cell formation,and thereby accelerate atherosclerosis.The receptor for AGEs(RAGE)and cluster of differentiation 36(CD36)were the receptors of CML.However,it is still unknown whether RAGE and CD36 play key roles in CML-promoted lipid uptake.AIM Our study aimed to explore the role of RAGE and CD36 in CML-induced macrophage lipid uptake.METHODS In this study,we examined the effect of CML on lipid uptake by Raw264.7 macrophages.After adding 10 mmol/L CML,the lipid accumulation in macrophages was confirmed by oil red O staining.Expression changes of CD36 and RAGE were detected with immunoblotting and quantitative real-time polymerase chain reaction.The interaction between CML with CD36 and RAGE was verified by immunoprecipitation.We synthesized a novel N-succinimidyl-4-18Ffluorobenzoate-CML radioactive probe.Radioactive receptor-ligand binding assays were performed to test the binding affinity between CML with CD36 and RAGE.The effects of blocking CD36 or RAGE on CML-promoting lipid uptake were also detected.RESULTS The study revealed that CML significantly promoted lipid uptake by macrophages.Immunoprecipitation and radioactive receptor-ligand binding assays indicated that CML could specifically bind to both CD36 and RAGE.CML had a higher affinity for CD36 than RAGE.ARG82,ASN71,and THR70 were the potential interacting amino acids that CD36 binds to CML Anti-CD36 and anti-RAGE could block the uptake of CML by macrophages.The lipid uptake promotion effect of CML was significantly attenuated after blocking CD36 or RAGE.CONCLUSION Our results suggest that the binding of CML with CD36 and RAGE promotes macrophage lipid uptake.
文摘The production cycle of open-cast coal mines generally in eludes drilling, blasting, loading, hauling and coal preparation activities. Individual optimization of these activities does not mean that the whole system is optimized. This paper proposes a cost model considering all activities in mining cycle and system-wide approach to minimize the total mining cost of bench production. Since the fragmentation size and blast-hole diameter are linked to all activities of mining system, they are considered as decision variables in the problem form ul at io n. The operatio n costs are then minimized by using the evolutionary algorithm. Moreover, the impact of the change in the explosive price, and the hourly unit cost of equipment on total mining cost is quantified by sensitivity analysis. A case study is implemented to demonstrate the developed model.
基金The MSIP(Ministry of Science,ICT&Future Planning),Korea,under the ITRC(Information Technology Research Center)support program(NIPA-2013-H0301-13-2006)supervised by the NIPA(National IT Industry Promotion Agency)
文摘Recently,both the importance and awareness relating to food safety relating to agrochemicals,chemical fertilizers,the pollution of ecosystem and unwholesome foods are growing rapidly.For the same reason,the purchaser's curiosity increases to know about the production process which can be accomplished by production traceability system.The traceability system can store and superintend the specific attribute information about products regarding the productive centre,producer and production finish data.The products undergo various circulation processes and they are being managed by individually constructed traceability system.Thus,it is difficult for the producer and the consumer to guarantee the safety from transpirable issues about the falsification of production traceability because the traceability information can be re-produced by forging through various ways.So in this paper,we proposed a system for integrated management of agro-fishery products based on quick response code(QR-code)for forgery prevention which may help to solve these issues.The proposed system makes QR-code using production information provided by producer.And then it is provided to the distributor and the consumer through integrated service model using the QR-code.Therefore,this system make sure to provide the same production traceability about the products to the distributor and the consumer and always keeps both updated with the same information.
基金National Natural Science Foundation of China! 49676296National Scientific and Technical Project! 97-926-04-02.
文摘The spatial and temporal distributions of new production vary largely in different sea areas. To understand the level of new production in the sea area studied better, an estimate of new production must be obtained in large spatial and temporal scales. The ~234Th/ ~238U disequilibrium is an effective method for the study of new production. Two sampling strategies, vertically integrated sampling ap proach based on trapezoidal integration principle and discrete layer sampling approach, were compared in the studies of the xiamen Bay and the northern South China Sea. The scavenging fluxes and removal fluxes of ~234Th and the residence times for dissolved and particulate ~234Th were calculated. The coinci dent results from two Sampling approach suggest that vertically integrated sampling approach is not only effective and reliable, but also significantly reduces the number and volume of samples. It allows us to study new production by ba ^(234)Th - ^(238)U disequilibria in large spatial scale.
文摘Smart home-based care for elderly is the product of the “Internet+” era, along with the information technology and the growing needs for a better elderly life. In order to understand the influencing factors of smart home care in Hengshui city, this paper selected 183 elderly people through a questionnaire survey. The conclusion of the study showed that education level, economic status, sleep quality and residence conditions are the influencing factors affecting the needs of smart home care of the elderly (p 0.05). Smart home care products for the elderly have a high willingness to use them, especially in terms of life care, medical services and emotional talk, but the compliance still needs to be improved. Development countermeasures suitable for Hengshui city can be put forward through the publicity of smart elderly care services, promoting the construction of demand-oriented big data, and promoting the participation of various forces.
基金Tutor system research project of Huashang School of Guangdong University of Finance and Economics(Number:2019HSDS21).
文摘The real smart home is not merely moving from the original remote control and panel to a smart phone app to make products intelligent or to control consumer electronics in one way,but is built based on interconnection and automation.The smart home of the future can not only achieve integrated control,remote control,scene control,timing control,intelligent linkage and security measures,but also support“selflearning”and“self-optimization”,and will“manual”and“automatic”control.This paper aims to change the value of smart home products into“active”.Therefore,this paper relies on the realization of the value of smart home products,describes the principles of smart home products and product interaction design,analyzes the needs of the target users,and proposes a product design scheme for reference by relevant personnel.
文摘Based upon broad-band CCD observation data of comet Hale-Bopp obtained by a 60cm telescope at Xinglong Station of Beijing Astronomical Observatory during March-August, 1996, the photometric results of comet Hale-Bopp are reported. Using the photometric results, the dust production rate, radius and mass of nucleus of comet Hale-Bopp are estimated as follows: dM/dt~1.5×10 5 kgs -1, R n~35.5km, and M n~5.65×10 16kg.
基金Supported by Earmarked Fund for Construction of National Wool Sheep Industry Technology Research System(CARS-39-24)Program for Science and Technology Development of Shanxi Province(20120311024-1)+1 种基金Fund for Science and Technology Innovation Team in Shanxi Province(201705D131028-20)Shanxi Agricultural Industry Development Technology Leading Fund(2017CYYL-08)
文摘This study was conducted to investigate the in-vitro production technology of embryos from young Dorper sheep, so as to provide technical support for the utilization of ovarian follicles in young Dorper sheep. Tests were conducted from the induction of Dorper sheep of 4 to 8 weeks old using follicle stimulating hormone(FSH) and pregnant horse serum(PMSG), collection of oocytes, in-vitro oocyte maturation-fertilization-zygote cultivation and 2-4-cell-stage fertilized ovum transfer. The results showed that 585 oocytes were collected from eight Dorper sheep at the age of 4 and 8 weeks, with an average of 73.13 oocytes/sheep. 346 of the 2-4-cell-stage fertilized eggs were obtained, whose cleavage rate was 59.15%. 77 in-vitro fertilized eggs at 2-4-cell stage were transplanted into 17 recipient sheep, seven of which were pregnant and gave birth to 13 "test-tube sheep" with a conception rate of 41.18%. It is indicated that the hormone induction technique, in-vitro oocyte maturation-fertilization-zygote cultivation technique and 2-4-cell-stage fertilized ovum transfer technique used in this study can serve as effective techniques for the in-vitro production of embryos from Dorper sheep of 4-8 weeks old.
文摘Conscious consumption is a trend that is here to stay since consumers are becoming more aware of their purchasing decision and its impact on their health & environment. To sustain in the market on the move towards sustainability and meet the demands, companies need to re-examine their footprints and incorporate green practices in their products and organization. Using eco-friendly material & processes is one of the remedies to come up with this, and bamboo is one of the most versatile, green and renewable natural resources on planet earth. Traditionally bamboo has been exploited to a large extent but cutting-edge options available for bamboo are still limited and have a scope of indulging fully in the lifestyle of people in India. The global market size of bamboo was valued at UED 53.28 billion in 2020, and it is expected to grow at compound annual growth rate of 5.7% from 2022 to 2028. There is increasing demand for sustainable construction, and furniture and handicraft products also have considerable weightage. Manny brands and craft clusters of bamboo are realizing and promoting this green quotient of bamboo to the market to attract the eco-conscious audience and trying to cope up with the advancement of sustainability, like certifications of being a green organisation. Despite the exceptional qualities of bamboo, it is considered as a marginalized material due to low production rate, high competition with the non-eco-friendly or cheaper alternatives, aesthetics and marketing gaps. There is a gap between willingness to purchase and an actual purchase when it comes to the sustainable products and marketing plays a major role in conversions. The main purpose of the research is to study and understand the product, craft, design, production processes and marketing practices of bamboo lifestyle products and how conscious consumption patterns influence the bamboo products and the industry in relevance to the sustainability. Exploratory research method was applied with the literature survey and reviewing of the research papers from the peer reviewed journals. They were classified and reviewed based on the areas relevant to the bamboo products. The research outcome revealed the research gaps and the results were discussed and presented with the perspectives of product design, conscious consumption and marketing strategies in relevant to the sustainability of bamboo lifestyle products.
文摘During the China International Trade Fair for Home textiles and Accessories(Intertextile Shanghai Home textile),held from Aug.24th to 26 th,2010,in the city of Shanghai,the Intertextile Direction Trend Committee released the latest home textile trends for Autumn and Winter 2011 and 2012.