基于自适应小波变换与HHT的混合储能容量配置

混合储能系统能有效缓解风电输出功率强波动性与随机性造成电网频率不稳定问题。本文以蓄电池和超级电容组成的混合储能系统为研究对象,提出了一种混合储能容量配置方法。该方法首先采用自适应小波变换对风电输出功率进行功率一次分配,得到满足条件的并网功率和储能功率。然后采用HHT变换对储能功率进行分解,得到一系列波动功率分量以及各分量的瞬时频率。再根据瞬时频率确定分界频率,将高于分界频率的功率分量分配给超级电容,剩余的功率分量分配给蓄电池。最后根据蓄电池与超级电容各自的储能功率,对储能系统的额定容量与额定功率进行配置。该仿真结果表明,本文采用自适应小波变换与HHT变换能够有效地将风电输出功率进行分解,实现风电输出功率的平抑与混合储能系统的容量与功率配置。

基于VMD-HHT的井下预裂爆破振动效应分析

云南玉溪大红山铜矿现有采矿方法为分段空场嗣后充填法,采用大爆破工艺,由于一次爆破的药量过大导致对保留岩体的损伤较大,影响采场的稳定性。为解决此问题,按照多打孔少装药的原则,在距保留岩体一定距离处布置一排较为密集的炮孔,并减小单孔装药量,在主爆区起爆之前先起爆该排炮孔,形成一条具有一定宽度的缝隙,以减弱对保留岩体的损伤。基于变分模态分解和希尔伯特黄变换(VMDHHT)方法对现场实测的爆破振动信号进行分析。结果表明:本次预裂爆破振动信号的瞬时能量分布区间主要集中在0~0.5 s内,频率分布的区间主要集中在40 Hz以内;采用3个测点的合速度进行减振率计算,得到3个测点减振率分别为21.0%、30.1%和38.5%,有效减小了爆破振动对保留岩体的损伤和破坏。

Homoharringtonine induces apoptosis of endothelium and down－regulates VEGF expression of K562 cells

Homoharringtonine (HHT) has currently been used successfully in the treatment of acute and chronic myeloid leukemias and has been shown to induce apoptosis of different types of leukemic cells in vitro. Emerging evidence suggests that angiogenesis may play an important role in hematological malignancies, such as leukemia. However, whether HHT can relieve leukemia by anti-angiogenesis is still unknown. We investigated the anti-angiogenesis potential of HHT with the human umbilical vein endothelial cell line (ECV304) and leukemic cell line (K562) in vitro. Cellular proliferation was determined by MTT assay and apoptosis was analyzed by flow cytometry, The mRNA expression of vascular endothelial growth factor (VEGF) was assessed by RT-PCR and VEGF protein production was detected by Western blot. Inhibition of cell proliferation and induction of apoptosis by HHT were discovered in ECV304 cells, and appeared in a dose- and time-dependent manner, Also, treatment with HHT caused down-regulation of VEGF mRNA expression in K562 cells in similar dose- and time-dependent manner and inhibition of VEGF protein production in K562 cells in response to the enhancing concentration of HHT. The results demonstrated that HHT could also induce apoptosis in endothelium and down-regulate VEGF expression in K562 cells. In conclusion, we believe HHT has anti-angiogenesis potential and speculate that HHT might exert its anti-leukemia effects via reduction of angiogenesis.

LONG-TERM EFFECT OF HOMOHARRINGTONINE ON CHRONIC GRANULOCYTIC LEUKEMIA

Objective: To observe the long-term effect of homoharringtonine (HHT) on chronic granulocytic leukemia (CGL) and its pharmacological mechanism. Methods: 76 patients with newly diagnosed early chronic phase CGL received treatment of merely 1.5 mg/m2 daily HHT for induction remission and long-term maintenance treatment. The apoptosis rate of bone marrow CD34+ cells induced by HHT was assayed with flow cytometer. Results: 86.8% patients achieved CHR, 13.2% patients PHR and 31.8% patients got cytogenetic response in HHT treatment group, which was longer than 31 (8-54) months in hydroxyurea (HU) group (P<0.05). The effect of apoptosis induction HHT was stronger on CGL-CP patients bone marrow CD34+ cells than on normal person bone marrow CD34+ cells. Conclusion: HHT is a very effective drug for remission induction and long-term maintenance treatment in early chronic phase CGL patients.

A phase Ⅳ study of homoharringtonine, cytarabine, aclacinomycin and G-CSF(HCAG) regimen compared with traditional IA regimen in the treatment of newly diagnosed elderly acute myeloid leukemia patients

Objective · To compare the efficacy and prognostic factors of HCAG regimen with traditional IA regimen in the treatment of newly diagnosed elderly acute myeloid leukemia(AML) patients. Methods · Forty-one patients with AML(aged 55-71 years) were randomly divided into two groups(Group HCAG and Group IA) between 2014 and 2016 for induction and consolidation therapy. Multivariate analysis was applied to identify prognostic factors for relapse-free survival(RFS). Results · A total of 29 patients(70.7%) achieved complete remission(CR). The estimated 2-year overall survival(OS) was 66.8% in Group HCAG and 75.4% in Group IA(P=0.913). The estimated 2-year RFS was 61.8% in Group HCAG and 49.1% in Group IA(P=0.411). Age remained as the unfavorable prognostic factor, leading to significant differences in OS and RFS. In addition, RFS was influenced by cytogenetic/molecular risk stratification. Conclusion · Although HCAG seemed not to particularly benefit the group, the dose reduction of anthracyclines may be applied in elderly patients with comparable short-time outcome. Furthermore, the introduction of homoharringtonine resulted in an improvement of treatment response for more than 20% compared with CAG regimen.

INDUCTION OF C-MYC GENE AMPLIFICATION BY HYDROXYUREA AND ITS INHIBITION BY HOMOHARRINGTONINE

Induction of c-myc gene amplification in L1210 cells by hydroxyurea and its inhibition by homohar-ringtonine were investigated using the DNA-DNA molecular hybridization technique. When the cells were treated with hydroxyurea 1.0 mM for 16 hours, and incubated a further 16 hours in a drug-free medium, the c-myc gene amplified 23.5-fold. If homohar-ringtonine 50 μM was used at the same time as hydroxyurea, gene amplification did not occur. Cycloheximide, an inhibitor of protein biosynthesis, produced a similar effect. Our results indicated that a (or some) protein factor(s) might be involved in gene amplification. Detailed analysis showed that the synthesis of this protein factor(s) started 4 hours before the initiation of the S phase but did not continue in the S phase. It was also found that this protein factor(s) was very labile and began to degrade 2 hours after its appearance.

Effect of Homoharringtonine on Corneal Haze after Excimer Laser Photorefractive Keratectomy in Rabbits

To evaluate the inhibiting effect of Homoharringtonine （HHT） on the corneal haze after excimer laser photorefractive keratectomy （PRK） in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups （A, B and C）. The refractive degree of ablation was - 10.0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/ mL HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution; Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group, Corneal haze, histopathology, response, ect. were investigated. The corneal haze was significantly less in group A, while the difference between group B and group C was insignificant. Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C, Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.

Effect of Homoharringtonine on Bone Morrow CD34^+CD7^+ Cells in Chronic Granulocytic Leukemia

Objective： To explore the effect of homoharringtonine （HHT） on bone morrow CD34^＋CD7^＋ cells in chronic granulocytic leukemia （CGL）. Methods： The changes of bone morrow CD34^＋CD7^＋ cells were observed after the treatment of HHT in 23 cases with CGL. The proliferation and apoptosis of CD34^＋CD7^＋ cells treated with HHT in vitro were studied. Results： The proportion of CD34^＋CD7^＋ cells in CGL （0.145±0.021） was higher than that of normal control （0.052±0.013）. The proportion of CD34^＋CD7^＋ cells in patients who got cytogenetic responses to HHT （0.072±0.020） decreased remarkably, but not in those patients who did not got cytogenetic responses to HHT, （0.137±0.023）. the proliferation of CD34^＋ cells was inhibited and the proportion of CD34^＋CD7^＋ cells decreased after cultured with HHT （0.134 in 24 h, 0.126 in 48 h and 0.102 in 72）. The apoptosis rate of CD34^＋CD7^＋ cells was higher than that in CD34^＋CDT cells （35.39%±4.39% versus 24.57%±4.01%, P〈0.05） 72 h after culture with HHT. Conclusion： The proportion of CD34^＋CD7^＋ cells in CGL was higher than that of normal control and HHT may inhibit the proliferation and induce apoptosis of bone marrow CD34^＋CD7^＋ cells.

基于HHT的典型红土区地脉动特性与场地特征关联性研究

对典型红土场地开展系统的地脉动测试,基于希尔伯特-黄变换(Hilbert-Huang transform, HHT)中的经验模态分解(empirical mode decomposition, EMD)从测试信号中分解出场地有效地脉动信号,对其进行快速傅里叶变换(fast Fourier transform, FFT)和Hilbert变换,产生功率谱曲线和Hilbert边际谱曲线,以确定场地卓越周期,进而探索与直接傅氏法和H/V谱比法不同的场地特征参数判别方法。目标场地的有效地脉动信号为EMD分解后的第4个本征模态函数(4th intrinsic mode function, IMF4),对各个测点的IMF4进行FFT和Hilbert变换,获取的地脉动卓越周期水平向在0.20~0.36 s,垂直向在0.23~0.39 s,结果表明,基于HHT的地脉动测试法来确定场地类别、划分场地岩土类型,与场地钻孔分析结果一致性高,关联性强。

基于改进HHT算法的重载铁路信号自动化解调方法设计

重载列车在铁路运行过程中,信号容易受到干扰和失真,影响列车的安全性。该文提出一种基于改进HHT算法的重载铁路信号自动化解调方法。采用小波阈值去噪方法改进HHT算法中的集成经验模态分解成多个IMF分量后,利用小波阈值去噪法对含有噪声的分量展开去噪。使用Bedrosian乘积定理获取全新的递归函数,改进HHT算法中的希尔伯特变换,将纯调频信号作为新的重载环境面的铁路信号,基于递归Hilbert变换实现重载铁路信号自动化解调。实验测试结果表明,所提方法解调后的信号频率与仿真信号频率基本吻合,频带利用率最高可达9.3%,具有良好的信号解调能力。

基于EEMD-HHT的边坡爆破振动信号分析

爆破工程所处的环境一般复杂多变,爆破振动信号大多呈现瞬时非平稳性特征。因此,为了准确分析爆破振动的信号特征以及传播规律,以首都环线高速公路承平段路基爆破工程为背景,通过引入EEMD分解方法,解决了传统EMD分解方法存在模态混叠的不足;结合HHT变换,对承平段典型路堑边坡岩体爆破振动信号进行了分析。研究结果表明:采用EEMD分解方法提取爆破振动信号中主要的IMF能量层,并对振动信号进行重构,可以达到良好的去噪效果;对施工现场爆破振动信号进行主成分分析、提取之后,瞬时能量和质点振速曲线整体平滑度显著提高,振动信号主成分提取效果良好;Hilbert能量谱可以清晰地体现时间、频率与能量三者之间的关系,展现出了爆破振动信号的时频特性和传播规律;测点振动主频主要分布在10~40 Hz的频率段范围内,近似呈现出随着传播距离的增加而衰减、随着距离的增加衰减幅度减弱的趋势。该分析成果对边坡稳定性分析和邻近建筑物的安全控制具有重要的现实意义。

VMD-HHT方法在大地电磁强人文干扰去噪中的应用

大地电磁信号具有频带范围宽、信号微弱的特点,在城市进行信号采集时,极易受到人文电磁噪声的干扰使信噪比下降,导致反演结果出现偏差。传统Hilbert-Huang变换去噪中经验模态(Empirical Mode Decomposition, EMD)分解过程中极易出现模态混叠现象,笔者提出基于变分模态分解改进的Hilbert-Huang变换(improved Hilbert-Huang transform based on Varational Mode Decomposition, VMD-HHT)方法对城市强人文干扰进行压制去噪。结果表明:改进的Hilbert-Huang变换能够有效避免模态混叠现象,明显改善电磁数据的信噪比,去噪后的数据可为后续视电阻率反演提供高质量的时间序列。

基于HHT提取昆明、下关重力固体潮的地震前兆信息

在重力固体潮地震前兆分析中引入HHT时频分析新方法.结合HHT的优越性、固体潮的特点和地震的非平稳过程特性,设计重力固体潮地震前兆分析的瞬时频率特征参数;以相应理论计算值作为参照背景,研究固体潮的震前变化特征.昆明、下关的震例分析表明,的确存在瞬时频率特征参数的震前变化,且具短期、同步正异常特征;瞬时频率特征参数具有明确的物理意义,其震前变化反映了地震非平稳过程对理论重力固体潮的影响.

Prony和HHT算法在低频振荡在线辨识中的适用性比较

Prony算法和Hilbert-Huang变换(HHT)算法是目前实际应用于低频振荡信号辨识的两种算法。Prony算法对于无噪声干扰的平稳信号的分辨率和准确性较高。HHT算法具有时频分析和滤除高频分量的能力,抗噪声性能好,计算速度快,并可以分析主导模式随时间改变的非平稳信号。从准确性、稳定性、完备性、快速性四个方面比较了两种算法在低频振荡在线辨识中的适用性,指出增加前置滤波环节的Prony算法可以满足低频振荡在线监测的要求,而实现强迫振荡扰动源定位则必须采用可进行时频分析的HHT算法。通过实际算例验证了两种算法的适用性。

HHT方法及其在地震信号处理中的应用

介绍了HHT方法和它的基本特点,并且在应用时与Fourier变换和小波分析法作了比较,说明其具有优于其他方法的明确物理意义、高度精确性和自适应性。并且通过对地震资料的处理,以实验结果说明,HHT适合应用于地震信号处理,值得进一步研究与推广。

HHT端点效应的最大Lyapunov指数边界延拓方法

针对HHT(Hilbert-Huang transfrom)的端点效应问题,提出基于最大Lyapunov指数预测模型的HHT边界延拓方法。该方法通过相空间重构,并利用时间序列相似点的演化行为,采用最大Lyapunov指数预测模型来对时间序列的端点进行预测,有效避免了不同边界条件的三次样条插值和Hilbert变换频谱泄露对HHT分析结果产生的影响。在此基础上,为了评价所提方法的有效性,提出了IMF分量归一化相关系数和IMF分量信噪比的性能评价指标,通过与标准HHT、镜像延拓HHT的仿真对比分析,结果表明所提方法抑制端点效应的性能优于二者。最后将其应用在转子油膜涡动故障试验分析中,结果表明基于最大Lyapunov指数边界延拓的HHT分析结果比镜像延拓后的分析结果更能够准确地描述油膜涡动故障特征。

HHT方法在脉搏波信号分析中的应用

目的采用HHT(Hibert-HuangTransformation)时间序列分析方法处理从人体采集到的脉搏波信号。方法通过经验模态分解(EMD)技术将一非线性、非稳态过程的原始离散数据序列分解为一组内在模态函数(IMFs),然后对每一个IMF进行HT变换,这样得到的信号幅度和瞬时频率都是时间的函数,即获得脉搏波信号幅度和频率的时间分布。再根据已获得的HH谱,进而得到边际谱。这是一种更具适应性的、新型的、基于模态分解的时间序列数据处理方法。结果首先对一系列由标准的周期函数构造而成的时间序列信号进行了EMD处理,验证HHT方法分解的可行性、有效性;然后分别对一例正常人脉搏波信号和一例典型的冠心病人脉搏波信号进行分解处理,对得到结果进行了比较。结论HHT方法在生物医学信号处理领域将会有广阔的应用前景。

基于HHT方法的爆炸应变波时频分析

为探究固体介质中爆炸应变波信号特征,采用Hilbert-Huang Transform(HHT)方法对爆炸应变波信号进行时频分析;讨论爆炸应变波信号EMD分解及时频能分布特征,并将HHT分析结果与Short Time Fourier Transform(STFT)对比;通过分析爆炸波在空气、岩石介质中传播的数值模拟结果与爆炸应变波在有机玻璃中传播的动光弹实验结果,探讨爆炸波信号多频率作用特征。结果表明,爆源近中区爆炸应变波主频率在几百千赫兹到几兆赫兹范围内;HHT方法明显表现出爆炸应变波传播的细节特征;固体介质中爆炸应变波信号波形为由不同频率波动共同作用结果。

基于HHT方法的电气化铁道谐波检测与分析

将希尔伯特-黄变换(HHT)方法用于电气化铁道谐波检测中。由于电气化铁道谐波电压、电流信号中基波能量很大,其它次数的谐波能量相对较小,使得经验模态分解(EMD)方法在应用中出现模态混叠现象,不能准确地提取任意频率的谐波信号。为改善经验模态分解过程中产生的模态混叠现象,本文采用Yang提出的基于Fourier变换的EMD方法对电气化铁道谐波信号进行筛分。通过该方法可以有效地提取出任意频率的谐波分量,进而计算其Hilbert谱。通过对电气化铁道牵引变电所实测谐波电压、电流数据进行分析,结果表明:利用改进的HHT方法可以得到电气化铁道各次谐波准确的时频分布。最后通过HHT方法计算出各次谐波电压、电流含有率及总谐波电压、电流畸变率,并对计算结果进行分析。HHT方法为电气化铁道谐波检测与分析提供了一种新的途径。