The oral lichenoid lesion(OLL) is response that occurs on the oral mucosa. The OLL include allergic responseto the dental materials, drugs, and on graft-vs-host disease(GVHD). OLL to dental material happen when restor...The oral lichenoid lesion(OLL) is response that occurs on the oral mucosa. The OLL include allergic responseto the dental materials, drugs, and on graft-vs-host disease(GVHD). OLL to dental material happen when restorative materials, most commonly amalgam, are in direct contact with the mucosa in sensitized individuals. Medications that produce OLL are oral hypoglycemic agents, angiotensin-converting enzyme inhibitors, and nonsteroidal anti-inflammatory agents. GVHD is a complication in bone marrow transplantation and OLL is a common lesion observed in this disease especially in chronic GVHD. The clinical and histological aspects of OLL are similar to oral lichen planus and turn it difficult to make a differential diagnosis. The purpose of this paper is review about OLL related to the dental materials, drug use and GVHD.展开更多
目的:异基因造血干细胞移植(Allo-HSCT)患者移植前后血浆中IL-17、IL-23浓度与急性移植物抗宿主病(acute graft versus host disease,aGVHD)相关性分析。方法:采用双夹心酶联免疫吸附法(ELISA)检测患者血清中IL-17和IL-23浓度,采用逆转...目的:异基因造血干细胞移植(Allo-HSCT)患者移植前后血浆中IL-17、IL-23浓度与急性移植物抗宿主病(acute graft versus host disease,aGVHD)相关性分析。方法:采用双夹心酶联免疫吸附法(ELISA)检测患者血清中IL-17和IL-23浓度,采用逆转录聚合酶链反应法(Realtime-PCR)检测IL-17mRNA和IL-2mRNA相对表达量。结果:1)移植后aGVHD阴性组和aGVHD阳性组患者在性别、年龄、疾病类型、组织类型和预处理方案差异均无统计学意义,P>0.05。2)各组血浆中IL-17与IL-23浓度检测结果,aGVHD阳性组IL-17的浓度为(330.0±11.5)ρg/mL,显著高于对照组的(109.6±7.6)ρg/mL和aGVHD阴性组的(243.1±16.4)ρg/mL,P值均<0.001;aGVHD阳性组IL-23的浓度为(250.6±14.3)ρg/mL,显著高于对照组的(101.5±9.6)ρg/mL和aGVHD阴性组的(111.0±16.3)ρg/mL,P值均<0.001。3)aGVHD阳性组血浆中IL-17与IL-23浓度检测结果,aGVHD发生当天血浆中IL-17的浓度为(330.0±11.5)ρg/mL,IL-23的浓度为(250.6±14.3)ρg/mL,显著高于aGVHD发生前2周和aGVHD发生后1、2和3周IL-17和IL-23的浓度,P值均<0.05。IL-17、IL-23的浓度在aGVHD发生当天达到高峰,随着症状的控制,逐渐下降。4)aGVHD阳性患者IL-17mRNA的相对表达量为,3.232±1.137,显著高于对照组的1.432±0.954和aGVHD阴性组的1.672±0.896,P值均<0.001;aGVHD阳性患者IL-23mRNA的相对表达量为2.142±1.194,显著高于对照组的1.242±0.752和aGVHD阴性组的1.496±0.653,P值均<0.001。结论:Allo-HSCT后血浆中IL-17、IL-23与aGVHD的发生呈正相关,动态检测allo-HSCT后IL-17和IL-23浓度的变化,可能为临床上预测或诊断aGVHD的发生提供预警或依据。展开更多
文摘The oral lichenoid lesion(OLL) is response that occurs on the oral mucosa. The OLL include allergic responseto the dental materials, drugs, and on graft-vs-host disease(GVHD). OLL to dental material happen when restorative materials, most commonly amalgam, are in direct contact with the mucosa in sensitized individuals. Medications that produce OLL are oral hypoglycemic agents, angiotensin-converting enzyme inhibitors, and nonsteroidal anti-inflammatory agents. GVHD is a complication in bone marrow transplantation and OLL is a common lesion observed in this disease especially in chronic GVHD. The clinical and histological aspects of OLL are similar to oral lichen planus and turn it difficult to make a differential diagnosis. The purpose of this paper is review about OLL related to the dental materials, drug use and GVHD.
文摘目的:异基因造血干细胞移植(Allo-HSCT)患者移植前后血浆中IL-17、IL-23浓度与急性移植物抗宿主病(acute graft versus host disease,aGVHD)相关性分析。方法:采用双夹心酶联免疫吸附法(ELISA)检测患者血清中IL-17和IL-23浓度,采用逆转录聚合酶链反应法(Realtime-PCR)检测IL-17mRNA和IL-2mRNA相对表达量。结果:1)移植后aGVHD阴性组和aGVHD阳性组患者在性别、年龄、疾病类型、组织类型和预处理方案差异均无统计学意义,P>0.05。2)各组血浆中IL-17与IL-23浓度检测结果,aGVHD阳性组IL-17的浓度为(330.0±11.5)ρg/mL,显著高于对照组的(109.6±7.6)ρg/mL和aGVHD阴性组的(243.1±16.4)ρg/mL,P值均<0.001;aGVHD阳性组IL-23的浓度为(250.6±14.3)ρg/mL,显著高于对照组的(101.5±9.6)ρg/mL和aGVHD阴性组的(111.0±16.3)ρg/mL,P值均<0.001。3)aGVHD阳性组血浆中IL-17与IL-23浓度检测结果,aGVHD发生当天血浆中IL-17的浓度为(330.0±11.5)ρg/mL,IL-23的浓度为(250.6±14.3)ρg/mL,显著高于aGVHD发生前2周和aGVHD发生后1、2和3周IL-17和IL-23的浓度,P值均<0.05。IL-17、IL-23的浓度在aGVHD发生当天达到高峰,随着症状的控制,逐渐下降。4)aGVHD阳性患者IL-17mRNA的相对表达量为,3.232±1.137,显著高于对照组的1.432±0.954和aGVHD阴性组的1.672±0.896,P值均<0.001;aGVHD阳性患者IL-23mRNA的相对表达量为2.142±1.194,显著高于对照组的1.242±0.752和aGVHD阴性组的1.496±0.653,P值均<0.001。结论:Allo-HSCT后血浆中IL-17、IL-23与aGVHD的发生呈正相关,动态检测allo-HSCT后IL-17和IL-23浓度的变化,可能为临床上预测或诊断aGVHD的发生提供预警或依据。
