Persistent high-risk human papillomavirus(hrHPV)infection is a necessary factor for precancerous cervical intraepithelial neoplasia and invasive cervical cancer.HPV infection and persistent infection are associated wi...Persistent high-risk human papillomavirus(hrHPV)infection is a necessary factor for precancerous cervical intraepithelial neoplasia and invasive cervical cancer.HPV infection and persistent infection are associated with poor body immunity.Human immunodeficiency virus(HIV)-positive women are susceptible to HPV infection due to the immunosuppression caused by HIV infection[1].Hence,women infected with HIV face a heightened risk of developing precancerous lesions and cervical cancers.展开更多
宫颈癌筛查显著降低其发生率及死亡率,Landy等发现定期参加筛查,可预防83%(95%CI:82%~84%)的宫颈癌死亡^([1])。50岁以上女性多数处于绝经或围绝经期,宫颈上皮相对变薄,缺乏中表层细胞,细胞学筛查中判读有一定难度。文献报道DNA倍体分...宫颈癌筛查显著降低其发生率及死亡率,Landy等发现定期参加筛查,可预防83%(95%CI:82%~84%)的宫颈癌死亡^([1])。50岁以上女性多数处于绝经或围绝经期,宫颈上皮相对变薄,缺乏中表层细胞,细胞学筛查中判读有一定难度。文献报道DNA倍体分析在敏感性、特异性方面与液基细胞学(liquid-based cytology,LBC)无显著性差异^([2-3])。本研究从DNA倍体结果异常角度结合LBC、高危型人乳头瘤病毒(high risk human papillomavirus,hrHPV)探讨其在50岁以上宫颈病变筛查中的价值。展开更多
Background: The high risk human papilloma virus (hrHPV) is largely associated with cervical cancer with identifiable dysplastic changes on cytology. The use of cervical cancer screening strategies has largely improved...Background: The high risk human papilloma virus (hrHPV) is largely associated with cervical cancer with identifiable dysplastic changes on cytology. The use of cervical cancer screening strategies has largely improved the general outcome of cervical malignancies globally. Objective: To compare cervical cytological features against human papilloma virus genotypes in non HIV positive patients presenting for cervical cancer screening in UPTH. Method: A cross sectional prospective study of 82 non HIV positive women who presented for cervical cancer screening at the University of Port Harcourt Teaching hospital. A prestructured questionnaire was used to obtain socio demographic information. Cytobrush extracts of cervical samples were subjected to cytology and human papilloma virus DNA genotyping using real-time polymerase chain reaction. The information obtained was analyzed using SSPP version 20 and results presented as frequency tables, percentages and tested for significance using student t-test and chi square with p value Results: The mean age of the women was 36.61 ± 7.75 with an age range of 22 - 58 years. The prevalence of HrHPV was 4.88%. Twenty-two of the respondent have abnormal cytological pattern. While the 4 cases of HrHPV positivity were of normal cytological pattern and occurred in respondents that were in their reproductive age, the 22 that showed abnormal cervical cytology were mainly of low grade squamous intraepithelial lesion (LGSIL). There was no case of high grade squamous cell intraepithelial lesion (HGSIL). Conclusion: HrHPV prevalence rate of 4.88% occurring in low socioeconomic class patients. All the cervical abnormalies were of LGSIL, hence the risk of transformation into cervical cancer is equally low. There may be no correlation between hrHPV and cervical cytology in low risk patients.展开更多
基金supported by grants from the UNICEF China[IR-5.2 PMTCT and Pediatric Services,Activity No.0860/A0/04/705/052/001].
文摘Persistent high-risk human papillomavirus(hrHPV)infection is a necessary factor for precancerous cervical intraepithelial neoplasia and invasive cervical cancer.HPV infection and persistent infection are associated with poor body immunity.Human immunodeficiency virus(HIV)-positive women are susceptible to HPV infection due to the immunosuppression caused by HIV infection[1].Hence,women infected with HIV face a heightened risk of developing precancerous lesions and cervical cancers.
文摘宫颈癌筛查显著降低其发生率及死亡率,Landy等发现定期参加筛查,可预防83%(95%CI:82%~84%)的宫颈癌死亡^([1])。50岁以上女性多数处于绝经或围绝经期,宫颈上皮相对变薄,缺乏中表层细胞,细胞学筛查中判读有一定难度。文献报道DNA倍体分析在敏感性、特异性方面与液基细胞学(liquid-based cytology,LBC)无显著性差异^([2-3])。本研究从DNA倍体结果异常角度结合LBC、高危型人乳头瘤病毒(high risk human papillomavirus,hrHPV)探讨其在50岁以上宫颈病变筛查中的价值。
文摘Background: The high risk human papilloma virus (hrHPV) is largely associated with cervical cancer with identifiable dysplastic changes on cytology. The use of cervical cancer screening strategies has largely improved the general outcome of cervical malignancies globally. Objective: To compare cervical cytological features against human papilloma virus genotypes in non HIV positive patients presenting for cervical cancer screening in UPTH. Method: A cross sectional prospective study of 82 non HIV positive women who presented for cervical cancer screening at the University of Port Harcourt Teaching hospital. A prestructured questionnaire was used to obtain socio demographic information. Cytobrush extracts of cervical samples were subjected to cytology and human papilloma virus DNA genotyping using real-time polymerase chain reaction. The information obtained was analyzed using SSPP version 20 and results presented as frequency tables, percentages and tested for significance using student t-test and chi square with p value Results: The mean age of the women was 36.61 ± 7.75 with an age range of 22 - 58 years. The prevalence of HrHPV was 4.88%. Twenty-two of the respondent have abnormal cytological pattern. While the 4 cases of HrHPV positivity were of normal cytological pattern and occurred in respondents that were in their reproductive age, the 22 that showed abnormal cervical cytology were mainly of low grade squamous intraepithelial lesion (LGSIL). There was no case of high grade squamous cell intraepithelial lesion (HGSIL). Conclusion: HrHPV prevalence rate of 4.88% occurring in low socioeconomic class patients. All the cervical abnormalies were of LGSIL, hence the risk of transformation into cervical cancer is equally low. There may be no correlation between hrHPV and cervical cytology in low risk patients.
