The main objective of this study was to determine the relationship between occurrence of malaria infection with that of human blood group in Dar-es-Salaam Tanzania. The study was based on data collected randomly from ...The main objective of this study was to determine the relationship between occurrence of malaria infection with that of human blood group in Dar-es-Salaam Tanzania. The study was based on data collected randomly from the patients who were screened for malaria of all age groups for a period of three months at Mission Mikocheni Hospital. During this time period, a total of 430 blood samples were collected. From the study findings, it is clear that more than 50% of the patients tested were positive for malaria. Further analysis revealed that about 50% of malaria positive patients were type “O” blood group.展开更多
AIM:To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor commu...AIM:To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago. METHODS: Data on age, sex, ABO blood type and X-ray or pathological diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 patients with esophageal carcinoma (EC) and 2955 patients with cardiac cancer (CC) in Chaoshan district were retrospectively assessed for their association with ABO blood groups. RESULTS: The distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B O was 1.1415 (P【0.05) and 1.2696 (P【0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation. CONCLUSION: ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distribution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.展开更多
The successful of transplantation is determined by the shared human leukocyte antigens(HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglo...The successful of transplantation is determined by the shared human leukocyte antigens(HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulinlike receptor(KIR)] and major histocompatibility complex(MHC) class I chain-related gene molecule(i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques(e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci. These molecular techniques have several advantages because they do not depend on the availability of anti-sera, cellular expression and have greater specificity and accuracy compared with the antibody-antigen based typing. Nonetheless, these molecular techniques have limited capability to capture increasing number of markers which have been demonstrated to determine donor and recipient compatibility. It is now possible to genotype multiple markers and to the extent of a complete sequencing of the human genome using next generation sequencer(NGS). This high throughput genotyping platform has been tested for HLA, and it is expected that NGS will be used to simultaneously genotype a large number of clinically relevant transplantation genes in near future. This is not far from reality due to the bioinformatics support given by the immunogenetics community and the rigorous improvement in NGS methodology. In addition, new developments in immune tolerance based therapy, donor recruitment strategies and bioengineering are expected to provide significant advances in the field of transplantation medicine.展开更多
目的探讨抗人球蛋白试验(Antiglobulin test,AGT)在RhD、ABO血型抗原鉴定的应用效果.方法选择2018年9月-2021年11月在江门市新会区人民医院建档分娩的夫妇ABO血型不合或RhD血型不合的孕妇78例作为研究对象,所有孕妇采用经典抗人球蛋白试...目的探讨抗人球蛋白试验(Antiglobulin test,AGT)在RhD、ABO血型抗原鉴定的应用效果.方法选择2018年9月-2021年11月在江门市新会区人民医院建档分娩的夫妇ABO血型不合或RhD血型不合的孕妇78例作为研究对象,所有孕妇采用经典抗人球蛋白试验(经典法)与改良抗人球蛋白试验(改良法)进行RhD、ABO血型抗原鉴定,判定新生儿溶血病(Hemolytic disease of the newborn,HDN)发生情况.结果在78例孕妇中,改良法判断为ABO新生儿溶血病44例,RhD新生儿溶血病6例;经典法判断为ABO新生儿溶血病41例,RhD新生儿溶血病5例,对比差异无统计学意义(P>0.05).经典法的IgG抗A(B)效价阳性率为9.0%(7/78),改良法的IgG抗A(B)效价阳性率为25.6%(20/78),改良法的IgG抗A(B)效价阳性率高于经典法(χ2=7.569,P<0.05).经典法的Ig抗D效价阳性率为2.6%(2/78),改良法的Ig抗D效价阳性率为11.5%(9/78),改良法的Ig抗D效价阳性率高于经典法(χ2=4.792,P<0.05).结论不同抗人球蛋白试验在RhD、ABO血型抗原鉴定的应用都有很好的效果,其中改良法的应用能提高对于新生儿溶血病各血型效价的检测阳性率.展开更多
文摘The main objective of this study was to determine the relationship between occurrence of malaria infection with that of human blood group in Dar-es-Salaam Tanzania. The study was based on data collected randomly from the patients who were screened for malaria of all age groups for a period of three months at Mission Mikocheni Hospital. During this time period, a total of 430 blood samples were collected. From the study findings, it is clear that more than 50% of the patients tested were positive for malaria. Further analysis revealed that about 50% of malaria positive patients were type “O” blood group.
基金Supported ty the Key Teacher Fund,Ministry of Education of China and Sir Li Ka-Ching Foundation.
文摘AIM:To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago. METHODS: Data on age, sex, ABO blood type and X-ray or pathological diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 patients with esophageal carcinoma (EC) and 2955 patients with cardiac cancer (CC) in Chaoshan district were retrospectively assessed for their association with ABO blood groups. RESULTS: The distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B O was 1.1415 (P【0.05) and 1.2696 (P【0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation. CONCLUSION: ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distribution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.
文摘The successful of transplantation is determined by the shared human leukocyte antigens(HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulinlike receptor(KIR)] and major histocompatibility complex(MHC) class I chain-related gene molecule(i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques(e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci. These molecular techniques have several advantages because they do not depend on the availability of anti-sera, cellular expression and have greater specificity and accuracy compared with the antibody-antigen based typing. Nonetheless, these molecular techniques have limited capability to capture increasing number of markers which have been demonstrated to determine donor and recipient compatibility. It is now possible to genotype multiple markers and to the extent of a complete sequencing of the human genome using next generation sequencer(NGS). This high throughput genotyping platform has been tested for HLA, and it is expected that NGS will be used to simultaneously genotype a large number of clinically relevant transplantation genes in near future. This is not far from reality due to the bioinformatics support given by the immunogenetics community and the rigorous improvement in NGS methodology. In addition, new developments in immune tolerance based therapy, donor recruitment strategies and bioengineering are expected to provide significant advances in the field of transplantation medicine.
文摘目的探讨抗人球蛋白试验(Antiglobulin test,AGT)在RhD、ABO血型抗原鉴定的应用效果.方法选择2018年9月-2021年11月在江门市新会区人民医院建档分娩的夫妇ABO血型不合或RhD血型不合的孕妇78例作为研究对象,所有孕妇采用经典抗人球蛋白试验(经典法)与改良抗人球蛋白试验(改良法)进行RhD、ABO血型抗原鉴定,判定新生儿溶血病(Hemolytic disease of the newborn,HDN)发生情况.结果在78例孕妇中,改良法判断为ABO新生儿溶血病44例,RhD新生儿溶血病6例;经典法判断为ABO新生儿溶血病41例,RhD新生儿溶血病5例,对比差异无统计学意义(P>0.05).经典法的IgG抗A(B)效价阳性率为9.0%(7/78),改良法的IgG抗A(B)效价阳性率为25.6%(20/78),改良法的IgG抗A(B)效价阳性率高于经典法(χ2=7.569,P<0.05).经典法的Ig抗D效价阳性率为2.6%(2/78),改良法的Ig抗D效价阳性率为11.5%(9/78),改良法的Ig抗D效价阳性率高于经典法(χ2=4.792,P<0.05).结论不同抗人球蛋白试验在RhD、ABO血型抗原鉴定的应用都有很好的效果,其中改良法的应用能提高对于新生儿溶血病各血型效价的检测阳性率.
