Cu,Zn SOD is a highly conserved enzyme and the controversy about its evolutionary possibility in the near future has been lively. In order to further our understanding of the future fate of human Cu,Zn SOD, we adopt...Cu,Zn SOD is a highly conserved enzyme and the controversy about its evolutionary possibility in the near future has been lively. In order to further our understanding of the future fate of human Cu,Zn SOD, we adopted a strategy relating to the directed evolution to study how the mutants of human Cu,Zn SOD respond to different oxidative stress. After five rounds of screening, we found a mutant that can survive under harsh pressures and DNA sequencing proves that it shows a mutation responsible for the phenomenon. However, under natural pressure, our screening comes to nothing. Then we may draw the following conclusions: the evolution of biological macromolecules in some respect depends on their surroundings and if they are too familiar with a certain environment, they may embody evolutionary inertia.展开更多
The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo ...The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 mon.Plasma lipid peroxides and antioxidant status were measured.For 8 capsules （containing 3.12 mg avenanthramides） groups,the levels of serum superoxide dismutase （SOD） and reduced glutathione hormone （GSH） were significantly increased by 8.4 and 17.9%,respectively （P0.05）,and malondialdehyde （MDA） level significantly decreased by 28.1%.The total cholesterol （TC）,triglyceride （TG）,and low density lipoprotein cholesterol （LDL-C） levels were lowered by 11.1,28.1,and 15.1%,respectively （P0.05）.The high density blood lipoprotein cholesterol （HDL-C） levels in the same treat was increased by 13.2%.Based on our research,it can be concluded that oats extract containing avenanthramides possessed a high antioxidative activity on humans.It indicated that oat avenanthramides could be used to prevent hyperlipemic and angiocardiopathy.展开更多
文摘Cu,Zn SOD is a highly conserved enzyme and the controversy about its evolutionary possibility in the near future has been lively. In order to further our understanding of the future fate of human Cu,Zn SOD, we adopted a strategy relating to the directed evolution to study how the mutants of human Cu,Zn SOD respond to different oxidative stress. After five rounds of screening, we found a mutant that can survive under harsh pressures and DNA sequencing proves that it shows a mutation responsible for the phenomenon. However, under natural pressure, our screening comes to nothing. Then we may draw the following conclusions: the evolution of biological macromolecules in some respect depends on their surroundings and if they are too familiar with a certain environment, they may embody evolutionary inertia.
基金supported by the Talent Fund of Chinese Academy of Agricultural Sciences,Chinathe Technology Transformation Fund,the Ministry of Sciences and Technology,China
文摘The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 mon.Plasma lipid peroxides and antioxidant status were measured.For 8 capsules （containing 3.12 mg avenanthramides） groups,the levels of serum superoxide dismutase （SOD） and reduced glutathione hormone （GSH） were significantly increased by 8.4 and 17.9%,respectively （P0.05）,and malondialdehyde （MDA） level significantly decreased by 28.1%.The total cholesterol （TC）,triglyceride （TG）,and low density lipoprotein cholesterol （LDL-C） levels were lowered by 11.1,28.1,and 15.1%,respectively （P0.05）.The high density blood lipoprotein cholesterol （HDL-C） levels in the same treat was increased by 13.2%.Based on our research,it can be concluded that oats extract containing avenanthramides possessed a high antioxidative activity on humans.It indicated that oat avenanthramides could be used to prevent hyperlipemic and angiocardiopathy.
