Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit model...Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10^6 human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.展开更多
This paper presents a customized design method for ergonomic products via additive manufacturing(AM)con-sidering joint biomechanics.An ergonomic customized design model can be built based on kinesiology involving huma...This paper presents a customized design method for ergonomic products via additive manufacturing(AM)con-sidering joint biomechanics.An ergonomic customized design model can be built based on kinesiology involving human joint biomechanics.Manifolds of the human bone can be reconstructed from X-rays,computed tomog-raphy(CT),magnetic resonance imaging(MRI),and direct 3D scanning.The conceptual and detailed design of customized products were implemented on ergonomic shoes and insoles.A lightweight lattice structure with vari-able porosity was generated via structural topology optimization for an ergonomic customized design.Notably,the upper surface of the custom-made insole may adhere perfectly to the plantar surface of the patient,resulting in a lower peak plantar pressure.Finite element analysis(FEA)can be employed to simulate the static or dynamic biomechanical characteristics.The conceptual ergonomic products were forwarded to the machine and fabricated via AM,driven by visual digital twin techniques.The experiments proved that a customized design suitability method for wearable ergonomic products via 3D printing is specifically tailored to the rehabilitation needs of individual customers,while consuming the least cost,time,and materials.展开更多
基金supported by a grant from Science and Technology Development Program of Jilin Province of China,No.20110492
文摘Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10^6 human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.
基金supported by National Key Research and Development Project of China(Grant No.2022YFB3303303)Open Fund of State Key Laboratory of Mechanical Transmissions of China(Grant No.SKLMT-ZDKFKT-202202)+2 种基金Ng Teng Fong Charitable Foundation in the Form of ZJU-SUTD IDEA of China(Grant No.188170-11102)Zhejiang Univer-sity President Special Fund of China(Grant No.2021XZZX008)National Natural Science Foundation of China(Grant Nos.U22A6001,51935009).
文摘This paper presents a customized design method for ergonomic products via additive manufacturing(AM)con-sidering joint biomechanics.An ergonomic customized design model can be built based on kinesiology involving human joint biomechanics.Manifolds of the human bone can be reconstructed from X-rays,computed tomog-raphy(CT),magnetic resonance imaging(MRI),and direct 3D scanning.The conceptual and detailed design of customized products were implemented on ergonomic shoes and insoles.A lightweight lattice structure with vari-able porosity was generated via structural topology optimization for an ergonomic customized design.Notably,the upper surface of the custom-made insole may adhere perfectly to the plantar surface of the patient,resulting in a lower peak plantar pressure.Finite element analysis(FEA)can be employed to simulate the static or dynamic biomechanical characteristics.The conceptual ergonomic products were forwarded to the machine and fabricated via AM,driven by visual digital twin techniques.The experiments proved that a customized design suitability method for wearable ergonomic products via 3D printing is specifically tailored to the rehabilitation needs of individual customers,while consuming the least cost,time,and materials.
