To investigate whether aberration of the APC gene play any role in the development of Chinese sporadic colorectal carcinomas,we used a polymorphic site located in exon 11 which creted a new restriction site for RsaI t...To investigate whether aberration of the APC gene play any role in the development of Chinese sporadic colorectal carcinomas,we used a polymorphic site located in exon 11 which creted a new restriction site for RsaI to analyze LOH for the APC gene.We found that 20/29(68.9%) patients with colorectal cancer were informative for the APC exon 11 site and loss of one allele was detected in 40% of 20 informativc cascs.These data suggested that loss of heterozygosity of APC gene(APC-LOH) play a role in the pathogenesis of Chinese colorectal cancer.APC-LOH is a earlier event of colorectal tumorigenesis and may be of diagnostic value in Patient suffering colorectal cancer.展开更多
文摘To investigate whether aberration of the APC gene play any role in the development of Chinese sporadic colorectal carcinomas,we used a polymorphic site located in exon 11 which creted a new restriction site for RsaI to analyze LOH for the APC gene.We found that 20/29(68.9%) patients with colorectal cancer were informative for the APC exon 11 site and loss of one allele was detected in 40% of 20 informativc cascs.These data suggested that loss of heterozygosity of APC gene(APC-LOH) play a role in the pathogenesis of Chinese colorectal cancer.APC-LOH is a earlier event of colorectal tumorigenesis and may be of diagnostic value in Patient suffering colorectal cancer.
