The single image containing only a human face not previously addressed in the literature is employed to estimate body height. The human face especially the facial vertical distribution possesses some important informa...The single image containing only a human face not previously addressed in the literature is employed to estimate body height. The human face especially the facial vertical distribution possesses some important information which strongly correlates with the stature. The vertical proportions keep up relative constancy during the human growth. Only a few facial features such as the eyes, the lip and the chin are necessary to extract. The metric stature is estimated according to the statistical measurement sets and the facial vertical golden proportion. The estimated stature is tested with some individuals with only a single facial image. The performance of the proposed method is compared with some similar methods, which shows the proposal performs better. The experimental results highlight that the developed method estimates stature with high accuracy.展开更多
Copy number variation （CNV） is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we perf...Copy number variation （CNV） is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height （with borderline significant p value： 0.013, 0.011, 0.024, 0.049; respectively）. However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number （more than 2 copies） at 8p23.3-23.2 was associated with lower height （normal copy number vs. gain of copy number： 161.2 cm vs. 153.7 cm, p = 0.011）, which accounted for 0.9% of height variation. Loss of copy number （less than 2 copies） at 6p21.3 was associated with 0.8% lower height （loss of copy number vs. normal copy number： 154.5 cm vs. 161.1 cm, p = 0.013）. Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height.展开更多
Summary: Ten girls with Turner syndrome were treated with a combination therapy of recombinant human growth hormone (R hGH) and low dose stanozolol for a period of 8 to 36 months. The results showed that when compare...Summary: Ten girls with Turner syndrome were treated with a combination therapy of recombinant human growth hormone (R hGH) and low dose stanozolol for a period of 8 to 36 months. The results showed that when compared with the growth rate before the treatment, the growth rates after treatment with R hGH and stanozolol showed a sustained increase, reaching 9.0±1.9 cm/year during the first year of treatment; the height age increase by 2.5±0.8 years while the bone age increase were 1.0±0.7 years; and the predicted final adult height at the end of the first year of the treatment increased to 149.4±6.1 cm compared to their original mean of 142.8±4.2 cm. We are led to conclude that therapy with R hGH in combination with stanozolol can increase the growth velocity and significantly increase the predicted adult height of children with Turner syndrome.展开更多
通过临床检查、生化指标检测、全外显子组检测及遗传分析,确诊1例假假性甲状旁腺功能减退症(pseudo-pseudohypoparathyroidism,PPHP)患儿。在不违背生长激素治疗禁忌证的情况下,每日皮下注射基因重组人生长激素(recombinant human growt...通过临床检查、生化指标检测、全外显子组检测及遗传分析,确诊1例假假性甲状旁腺功能减退症(pseudo-pseudohypoparathyroidism,PPHP)患儿。在不违背生长激素治疗禁忌证的情况下,每日皮下注射基因重组人生长激素(recombinant human growth hormone,rhGH)粉剂6 IU,治疗时间持续7个月。治疗开始4个月患儿身高增长4.3 cm,治疗7个月身高总共增长6.7 cm。治疗过程中监测血糖、血脂、胰岛素、胰岛素样生长因子-1、甲状腺功能、电解质8项(包括钙磷)、25羟维生素D及雌激素、雄激素均没有明显异常。可见,rhGH不仅对生长激素缺乏的矮小患者有效,对本例PPHP矮小患儿的身高增长也有效。展开更多
文摘The single image containing only a human face not previously addressed in the literature is employed to estimate body height. The human face especially the facial vertical distribution possesses some important information which strongly correlates with the stature. The vertical proportions keep up relative constancy during the human growth. Only a few facial features such as the eyes, the lip and the chin are necessary to extract. The metric stature is estimated according to the statistical measurement sets and the facial vertical golden proportion. The estimated stature is tested with some individuals with only a single facial image. The performance of the proposed method is compared with some similar methods, which shows the proposal performs better. The experimental results highlight that the developed method estimates stature with high accuracy.
基金supported by Natural Science Foundation of China (Nos. 30600364, 30771222, and 30900810)NSFC-Canadian Institutes of Health Research(CIHR) Joint Health Research Initiative Proposal (No.30811120436)+3 种基金NSFC/RGC Joint Research Scheme (No.30731160618)Shanghai Leading Academic Discipline Project (No. S30501)startup fund from Shanghai University of Science and Technologysupported by grants from NIH (Nos. P50AR055081,R01AG026564, R01AR050496, RC2DE020756,R01AR057049, and R03TW008221)
文摘Copy number variation （CNV） is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height （with borderline significant p value： 0.013, 0.011, 0.024, 0.049; respectively）. However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number （more than 2 copies） at 8p23.3-23.2 was associated with lower height （normal copy number vs. gain of copy number： 161.2 cm vs. 153.7 cm, p = 0.011）, which accounted for 0.9% of height variation. Loss of copy number （less than 2 copies） at 6p21.3 was associated with 0.8% lower height （loss of copy number vs. normal copy number： 154.5 cm vs. 161.1 cm, p = 0.013）. Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height.
文摘Summary: Ten girls with Turner syndrome were treated with a combination therapy of recombinant human growth hormone (R hGH) and low dose stanozolol for a period of 8 to 36 months. The results showed that when compared with the growth rate before the treatment, the growth rates after treatment with R hGH and stanozolol showed a sustained increase, reaching 9.0±1.9 cm/year during the first year of treatment; the height age increase by 2.5±0.8 years while the bone age increase were 1.0±0.7 years; and the predicted final adult height at the end of the first year of the treatment increased to 149.4±6.1 cm compared to their original mean of 142.8±4.2 cm. We are led to conclude that therapy with R hGH in combination with stanozolol can increase the growth velocity and significantly increase the predicted adult height of children with Turner syndrome.
