Evidence of Human Origins in the Himalayas

Human origins have always been a hot topic of research in academia,focusing on the controversy between“single African origin”and“multiregional evolution.”The evolution from ancient ape to modern humans was a complex process,which required the co-existence of diverse favorable factors.Based on a review of existing research findings,this paper argues that modern humans originated in the Himalayas and presents multi-dimensional evidence from the perspectives of geology,seismology,climatology,archaeology,biology,genetics,and others.The evolution from ape to man may have also existed in regions other than the Himalayas.However,such evolution falls under“invalid origin”due to the lack of essential conditions for evolution,and particularly,the evolutionary process was interrupted by the erosion of frequent Quaternary glaciations.The homo sapiens originating in the Himalayas gradually migrated and settled down across the world several times during the interglacial periods,creating local cultures and colorful civilizations in parallel.The findings of this paper provide new orientations and approaches for the studies of human origins and the development of civilizations.

The Models of Modern Human Origins:Eastern Perspective

The origin of modern humans is one of the fundamental scientific questions that has been widely debated in the international academic community.Since the 1980s,the discussion on this issue has formed two opposing camps:the""Out of Africa"hypothesis and the"Multiregional Evolution"hypothesis.With the continuous accumulation of new materials and rapid technological advancements in the new century,there have been significant adjustments in the debate over the origin models of modern humans,with materials from the East Asia playing an increasingly important role.This article reviews the major hypotheses and models regarding the origin of modern humans and the evolution of modern behavior,tracing their sources,history,and development.It also provides a comprehensive overview of some of the latest archaeological discoveries and research progress.Furthermore,it discusses the motives and directions for adjusting the models of modern human origins and behavioral evolution,emphasizing the importance of considering a vast amount of archaeological evidence in the discussion of various models and reflecting on the cultural implications of"modernity".The article calls for increased investment in research on the origin of modern humans in China and emphasizes the need to provide a solid Eastern perspective for discussing modern human origin models.

Zoonotic origins of human coronavirus 2019(HCoV-19/SARS-CoV-2):why is this work important?

The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic.

The New Contribution to the Important Discourse on Human Rights by General Secretary xi Jinping

Under the background of the fact that human rights protection has become an important part of the socialist construction with Chinese characteristics in the new era, and with the international background of the strengthened trend of mainstreaming of human rights, Xi Jinping’s series of speeches and the 19 th CPC national Congress reports comprehensively explained the construction of human rights in China and the development of the international human rights. The important discourse on human rights by General Secretary Xi Jinping is people-centered: people’s yearning for a better life is our goal and reveals the source of human rights. Chinese dream is a dream of the country, of the nation, and of everyone in China. The close integration of individual and collective human rights points out that the state and people are important parts of collective human rights and it is an effective response to the "human rights over sovereignty" of Western countries. That there are not the best human rights, but the better ones; fighting for human rights is not always done, but always doing scientifically reveals the operational form of human rights. The right of survival and development is the primary human right; to attach importance to the right of peace conforms to the reality of our country and it has the support of the vast number of developing countries. Building a community with a shared future for human beings is a new vision for the development of the international human rights. only when the perfection and implementation of Constitution and law are paid attention to, and the democratization and legalization of the international human rights cause are promoted, can the guarantee be provided for the realization of human rights. The important discourse on human rights by General Secretary Xi Jinping is guided by Marxism, carries the communist party member’s original intention of serving people and is deeply rooted in the masses of the people. It inherits the theory of "benevolence" and "harmony" in Chinese culture,stands at the height of history and times, and points out the direction for the all-round development of Chinese people and the overall progress of society, and for the liberation of all mankind. This scientific theory is successfully guiding China’s human rights construction constantly towards new achievements and has had a profound and extensive impact on the international human rights cause.

Study on the Rights to Subsistence and Development with Reference to the Origin of the Universal Declaration of Human Rights

I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason for me to use the term "source"in the discussion on the right to subsistence

New progress in understanding the origins of modern humans in China

Hypotheses concerning the origins of modern humans have been intensively debated, and two competing models, the recent "Out-of-Africa" and "Multiregional Evolution" paradigms, have dominated research and discussions for decades. Evidence from China has played a fundamental role in this debate: regional continuity and replacement by populations in-migrated from Africa have both been suggested and supported mainly by paleoanthropologists and geneticists, respectively. As more evidence has accumulated, new results obtained, and more scholars from various disciplines become involved, supporters of the recent "Out-of-Africa" model agree more or less with the "Multiregional Evolution" model regarding the complex history of modern humans and their interbreeding with other archaic populations(e.g., Neandertals). Recent discoveries of new human fossils, Paleolithic archaeological materials, and ancient DNA evidence in China have yielded a large body of information regarding the formation and development of modern humans in this region. However, controversies continue, including that most molecular biologists insist on the replacement of archaic populations by modern humans dispersed from Africa, while most paleoanthropologists and archaeologists propose an enhanced "Continuity with Hybridization" model. In this paper, we compile new results and progress in China and present the current debates and issues on the origins of modern humans. Finally, we offer several suggestions for future studies.

Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health

Objective:To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1(AOAV-1)isolates from poultry workers with respiratory symptoms.Methods:Using Illumina Mi Seq,whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates.A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools.Results:Phylogenetic analysis and genetic distance estimation suggested a close relationship among human-and avian-originated velogenic strains of genotypeⅩⅢ,sub-genotypeⅩⅢ.2.1.Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains.Conclusions:To our knowledge,this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract.Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.

Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East Asians

We investigated the distribution of Y-chromosome haplotype using 19 Y-SNPs in Han Chinese populations from 22 provinces of China. Our data indicate distinctive patterns of Y chromosome between southern and northern Han Chinese populations. The southern populations are much more polymorphic than northern populations. The latter has only a subset of the southern haplotypes. This result confirms the genetic difference observed between southern and northern ethnic populations in East Asia. It supports the hypothesis that the first settlement of modern hu-mans of African origin occurred in the southern part of East Asia during the last Ice Age, and a northward migration led to the peopling of northern China.

Revisiting the origin of modern humans in China and its implications for global human evolution

The debates over the origin of modern humans have long been centered on two competing theories:the "Out-of-Africa"(single-place origin) theory and the "Multi-regional Evolution" theory.China is an extremely important region where many ancient human fossils were collected along with numerous associated faunal remains and artefacts.These cultural remains,unearthed from different areas in the country and covering a long time span,will help clarify the controversy.The study of cultural materials in China is expected to shed important light on biological evolutionary patterns and social and technical developments of those early humans as well as their environmental conditions.Based on the analysis of Chinese fossils and associated materials,in conjunction with some genetic studies,this paper aims at evaluating each of the two theories in order to stimulate more discussions.Our study suggests that the evolutionary model of "Continuity with Hybridization" is most relevant in reflecting the current understanding of human evolutionary history in China.Furthermore,we propose that the concept of regional diversity of evolutionary models should be seriously considered to illustrate different evolutionary modes applied to different parts of the world.

Origin of modern humans in East Asia:clues from the Y chromosome

East Asia is one of the most important regions for studying modern human origin and evolution.A lot of efforts have been made to detect the genetic diversity and to reconstruct the evolutionary history of East Asians,especially using Y chromosome genetic data,in recent years.The Y chromosome data supports the African origin of modern humans in East Asia and the later migration to East Asia through the southern tropic coastline route,and then the northward migration occurred,leading to peopling of the main continent.The genetic data of the Y chromosome reflects a clear prehistoric evolution and migration course of East Asians.As well,the Y chromosome data of East Asians provides clues to elucidate modern human origins and evolution in the neighboring regions,i.e.America,Oceania and the Pacific Islands.

Erratum to: Bat origin of a new human coronavirus: there and back again

We miscalculated identities of several genes, and the corrected Table 1 should be as follows:a、 This table demonstrates identities of 2019-nCoV WIV04 (GenBank Accession No. MN996528.1) compared with bat SARSr-CoV RaTG13 (GenBank Accession No. MN996532.1) and SARS-CoV BJ01 (GenBank Accession No. AY278488.2).

IMMUNOHISTOCHEMICAL DEMONSTRATION OF CCAAT/ENHANCER BINDING PROTEIN (C/EBP) IN HUMAN LIVER TISSUES OF VARIOUS ORIGIN

C / EBP is a sequence-specific DNA-binding protein. In order to indentify its distribution and localization, immunohistochemical technique (ABC method) was done using anti-C / EBP polypeptide antibodies 1103#, 425# in liver specimens from 20 normal adults, 5 neonates, 6 patients with hepatitis, 25 with liver cirrhosis, 80 with hepatocellular carcinoma (40 cases were associated with surrounding nontumorous tissues) and 26 patients with cholangiocarcinoma (15 cases were associated with surrounding nontumorous tissues). The results showed that C / EBP was diffusely distributed in nuclei and cytoplasm of differentiated liver cells and very low or undetectable in liver cancer cells. The manifestation of C / EBP correlated with degree of differentiation of tumour cells, and was obviously weaker than that in surrounding nontumorous tussues. C / EBP positive staining has also been found in regenerating epithelial cells of bile ductules. The results suggested that C / EBP should play an important role in establishing and maintaining the differentiation of liver cells.