The Olfactory Receptor Pseudo-pseudogene: A Potential Therapeutic Target in Human Diseases

Recently, Prieto-Godino et al.[1] found that the olfactory receptor 75a （Ir75a） gene is a functional pseudo-pseudogene in Drosophila sechellia. For a long time, Ir75a has been regarded as an acetic acid receptor that detects acetic acid and induces obvious olfactory responses in olfactory sensory neurons （OSNs）f2J. Nonetheless, Prieto-Godino et al. confirmed that Ir75a lost its sensitivity to acetic acid in D. sechellia. Thus, the D. sechelfia Ir75a gene is generally recognized as a pseudogene in OSNs.

The Potential for Technological Advances to Promote the Human Rights Cause

Discussion and study of the relationship between technological advance and human rights development can be achieved through both their interaction and interplay. In other words, we need to research and expound on the influences of technological advances on human rights development, and vice versa. However, despite the complexity of current human rights developments, this article, given length constraints, will only generally focus on whether technological advances have a potential role in promoting human rights improvements.

Human Development Potentials and Greenhouse Gas Emissions in the Developing World

This analysis suggests that the concept of human development potentials has two dimensions: the rights and limits to human development. This conceptual understanding is supported by results from the empirical examination of the relationship between the demands for carbon emissions and the other elements of human development. As human development in the rich countries is close to its potential

Moral&Intellectual Life of the West II Summary Outline of Christianity in the Modern World for Devout Christians and Skeptics

All human beings are born from divine mercy drawing man out of unfathomable reality’s chaotic depth into the divine realm’s peaceable light.The modern sense of justice,of fair government,depends on the teachings of Jesus to which all citizens must subscribe.This is not a mere ecclesiastic doctrine but an empirically proven fact.The imperfections of a finite albeit adaptable,very large computing system,which our brain appears to be,require us to be open to the infinite beyond,its recondite wisdom,for divinity to grant us a moral life&to come to our help.Jesus puts the individual human being center stage for the first time in history.The story of abounding divine mercy:Every day we humans struggle with the difficult moral law but Jesus taught us what matters most is our soul,St.Paul’s inner man,a biological function of our left brain.Relying upon the faith of the apostles,the Council of Chalcedon(AD 451)in its Confession affirmed that Jesus was an actual person in his substance,possessing two natures,human&divine.This widely has been interpreted to apply to all mankind,the soul of each human being,the inner man,is potentially divine.Forming a practical metaphysics for devout christians&skeptics:Metaphysics is needed for the purpose of undergirding faith.Origins of humanity in the deep structures of reality:Science appears to be opposite to our human spiritual existence&requires us to search for ourselves in the realm of the logos,that can serve as our guide,being one of the names of the Christ.Jesus was deeply influenced by the gifts of the Magi,brought to him from an Armenian revival during his age,source of charismatic theology,basic concepts&historical architecture.Survival by faith in the everyday human communal world:We must have a secure grasp of the Faith,its basics,memorized or divine help won’t come.Be a lifelong winner based upon your own inner man:The essential help from divinity,in our need,is granting us a moral life.Become a lifelong winner based upon your own inner man or woman.What it takes is a willing heart,a sudden inspiration.Version 1.Piety:To be aware of our marginal competence,nobody is born as a genetic loser.Version 2.Humility:To be ready for divine help,able to receive it,we need to take a step back.Version 3.Metanoia,the Ninety Degree Turn:Repentance,betterment is the beginning of faith for all of us.Miracles can&do happen,the down-&-out guide to happiness:Constant prayer is the effective remedy for a soul that has gone lost in the temptations of the human tribal world.

TOWARDS A FOURTH ECOLOGY: Social and Environmental Sustainability with Architecture and Urban Design

The architect has always been interested in the social and cultural dimensions while creating architecture for people to last,with the help of building science and technology.Science could solve some problems,but is yet to solve many of the problems of urbanization in human history.Perhaps many of the problems can only be solved with careful under­standing of human behavior,social intercourse,and economics in relation to the urban environments and organiza­tions,and the natural environment simultaneously.There seemed to be a divide between the way an engineer and an architect think and practice in making a build­ing and a piece of architecture,where the former is highly mathematical,and the latter deals with cultural poetics and a whole range of social and technical issues of which the physics of the environment is but one dimension(Bay and Ong 2006).It may appear natural in this age of environmental crisis and rapid urban development in many cities that the current Ecologically Sustainable Design(ESD)system,which is mainly based on science of the physical world,would be readily accepted by the architect in practice and education.Many of the current ESD guidelines can contribute to the avoidance of a further decay of the earth,thus pre­venting droughts and floods,etc.,and hope to maintain the status quo of the environment for all the“business as usual”social-economic activities.With more world leaders of the developed world agreeing in principle on the need to address climate change,perhaps a lot more will be done based on the engineering models for ecologi­cally friendly planning,commerce,industry,and design.There could be a cognitive bias3 of overconfidence and systemic error that the predominantly engineering focus to keep climate change at bay will solve the problem of sustainability in various parts of the world.The current limited concept of“ecological”or the“green”design does contribute to sustainability,but is quite limited and not the whole picture of sustainability.The concept of sustainability involves the dynamic and complex balance of environmental(man-made and natural),economic and social dimensions,from many earlier sources including the theory of the Third Ecology(Chermayeff and Tzonis 1971)about social ecology directly related to the man-made urban fabric,and recently,the much accepted pervasive framework of the Brundtland Commission Report 1987:Our Common Future,which included more discussions about the interrelatedness with economic equity and the natural environment.Foremost and ultimately it is about promoting and ensuring social quality of living now and sustaining that into the future,for all nations,the rich and the poor,through solving the matrix of social,economic,and environ­mental problems.From the perspective of the theory and practice of architecture,this paper discusses the following issues:1.Belief in science,disenchantment,symbol of failure of modern architecture-Pruitt Igoe;2.An anti-thesis to Pruitt Igoe-Bedok Court;3.The cultural concerns and preparametric design thinking process of the architect;4.Architecture,social science,cultural value,social capital,behavior,and ESD;5.A Fourth Ecology,multi-disciplinary research by architects,social scientists,and engineers.