In the west,a viewpoint of evil human nature is accepted by most of critics.William Golding exposes this hideous nature in Lord of the Flies.This paper analyses the ugly human performances in details,and it also see t...In the west,a viewpoint of evil human nature is accepted by most of critics.William Golding exposes this hideous nature in Lord of the Flies.This paper analyses the ugly human performances in details,and it also see the force about justice from the novel.The force is fighting with the evilness all the time.Although the justice is in a passive position temporarily,it finally defeats the evil.展开更多
D. H. Lawrence's"Tickets, Please"displays a wartime love story between Coddy and Annie. In their love affairs, Coddy, the man of impotence deems his freedom much as before while Annie switches back to th...D. H. Lawrence's"Tickets, Please"displays a wartime love story between Coddy and Annie. In their love affairs, Coddy, the man of impotence deems his freedom much as before while Annie switches back to the traditional female role to consider marriage as the ultimate goal. In"Tickets, Please", the incidental effects of progress on humanity are shown through the Lawrentian central theme of the relationship between men and women. Here, the weaker sex and the stronger sex are respectively and ironically embodied by Annie Stone and John Thomas Raynor. This paper analyzes the wartime setting, the tram girls and the love struggle between Annie and Coddy. Through these analyses, the paper reveals the awakening of feminist consciousness in the story.展开更多
Plot Summary of The Scarlet Letter: The Scarlet Letter has as its setting Puritan Boston during the mid-17th century.Young Hester Prynne,a“fallen woman”,is sentenced towear a scarlet A,signifying“adultery,”because...Plot Summary of The Scarlet Letter: The Scarlet Letter has as its setting Puritan Boston during the mid-17th century.Young Hester Prynne,a“fallen woman”,is sentenced towear a scarlet A,signifying“adultery,”because she has a lover whenher aged husband is not with her.Consequently she is driven out of theordinary relations with humanity,and is thus able to view critically thevarious aspects of the society.Hester is not overwhelmed by the展开更多
Human cytomegalovirus(HCMV) infection is a leading cause of birth defects, primarily affecting the central nervous system and causing its maldevelopment. As the essential downstream effector of Notch signaling pathway...Human cytomegalovirus(HCMV) infection is a leading cause of birth defects, primarily affecting the central nervous system and causing its maldevelopment. As the essential downstream effector of Notch signaling pathway, Hes1, and its dynamic expression, plays an essential role on maintaining neural progenitor/stem cells(NPCs) cell fate and fetal brain development. In the present study, we reported the first observation of Hes1 oscillatory expression in human NPCs, with an approximately1.5 hour periodicity and a Hes1 protein half-life of about 17(17.6 ± 0.2) minutes. HCMV infection disrupts the Hes1 rhythm and down-regulates its expression. Furthermore, we discovered that depleting Hes1 protein disturbed NPCs cell fate by suppressing NPCs proliferation and neurosphere formation, and driving NPCs abnormal differentiation. These results suggested a novel mechanism linking disruption of Hes1 rhythm and down-regulation of Hes1 expression to neurodevelopmental disorders caused by congenital HCMV infection.展开更多
文摘In the west,a viewpoint of evil human nature is accepted by most of critics.William Golding exposes this hideous nature in Lord of the Flies.This paper analyses the ugly human performances in details,and it also see the force about justice from the novel.The force is fighting with the evilness all the time.Although the justice is in a passive position temporarily,it finally defeats the evil.
文摘D. H. Lawrence's"Tickets, Please"displays a wartime love story between Coddy and Annie. In their love affairs, Coddy, the man of impotence deems his freedom much as before while Annie switches back to the traditional female role to consider marriage as the ultimate goal. In"Tickets, Please", the incidental effects of progress on humanity are shown through the Lawrentian central theme of the relationship between men and women. Here, the weaker sex and the stronger sex are respectively and ironically embodied by Annie Stone and John Thomas Raynor. This paper analyzes the wartime setting, the tram girls and the love struggle between Annie and Coddy. Through these analyses, the paper reveals the awakening of feminist consciousness in the story.
文摘Plot Summary of The Scarlet Letter: The Scarlet Letter has as its setting Puritan Boston during the mid-17th century.Young Hester Prynne,a“fallen woman”,is sentenced towear a scarlet A,signifying“adultery,”because she has a lover whenher aged husband is not with her.Consequently she is driven out of theordinary relations with humanity,and is thus able to view critically thevarious aspects of the society.Hester is not overwhelmed by the
基金supported by the National Natural Science Foundation of China(31600145)
文摘Human cytomegalovirus(HCMV) infection is a leading cause of birth defects, primarily affecting the central nervous system and causing its maldevelopment. As the essential downstream effector of Notch signaling pathway, Hes1, and its dynamic expression, plays an essential role on maintaining neural progenitor/stem cells(NPCs) cell fate and fetal brain development. In the present study, we reported the first observation of Hes1 oscillatory expression in human NPCs, with an approximately1.5 hour periodicity and a Hes1 protein half-life of about 17(17.6 ± 0.2) minutes. HCMV infection disrupts the Hes1 rhythm and down-regulates its expression. Furthermore, we discovered that depleting Hes1 protein disturbed NPCs cell fate by suppressing NPCs proliferation and neurosphere formation, and driving NPCs abnormal differentiation. These results suggested a novel mechanism linking disruption of Hes1 rhythm and down-regulation of Hes1 expression to neurodevelopmental disorders caused by congenital HCMV infection.
