为探索飞船返回再入加速度过载下人体姿态对乘员动力学响应的影响,本文利用Pro-E和HyperWorks软件建立了仰姿和躺姿两种典型人体姿态的假人–座椅系统模型。模型中使用了HUMOS II (Human Model for Safety Version II)人体生物力学模型...为探索飞船返回再入加速度过载下人体姿态对乘员动力学响应的影响,本文利用Pro-E和HyperWorks软件建立了仰姿和躺姿两种典型人体姿态的假人–座椅系统模型。模型中使用了HUMOS II (Human Model for Safety Version II)人体生物力学模型。根据实际离心试验数据对假人–座椅系统模型进行了标定和验证。论证并分析了在高加速度过载(峰值为6.4 g)条件下,人体姿态对人体关键器官包括心脏、肺、膈肌、肝脏和腹部脏器过载响应的影响。仿真结果表明,膈肌的位移和变形是影响人体对再入过载耐受力的最重要因素。膈肌在卧姿时受到其他器官的作用力大于躺姿时的作用力。因此,飞船设计人员应更多地关注人体内部器官的受力状态,选择一个在飞船返回时对乘员具有更好保护作用的体位姿态,本文建议飞船乘员的姿态设计应优先选择躺姿。展开更多
1,2-Benzothiazine derivatives methyl 3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2]thiazine-3-carboxylate 1,1-dioxide（1） and methyl 2-ethyl-3-hydroxy-4-oxo-3,4-dihydro-2Hbenzo[e][1,2]thiazine-3-carboxylate 1,1-dioxid...1,2-Benzothiazine derivatives methyl 3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2]thiazine-3-carboxylate 1,1-dioxide（1） and methyl 2-ethyl-3-hydroxy-4-oxo-3,4-dihydro-2Hbenzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide（2） were synthesized, and characterized by spectroscopic techniques; 1H-NMR and infrared（IR） spectroscopy. Crystals of 1 and 2 were grown by slow evaporation of methanol and ethyl acetate, respectively and their crystal structures were investigated by single-crystal X-ray diffraction analysis. Geometric properties were calculated by the B3 LYP method of density functional theory（DFT） at the 6-31G＋（d） basis set to compare with the experimental data. Simulated properties were found in strong agreement with the experimental ones. Intermolecular forces have also been modeled in order to investigate the strength of packing and strong hydrogen bonding was observed in both compounds 1 and 2. Electronic properties such as Ionization Potential（IP）, Electron Affinities（EA） and coefficients of the highest occupied molecular orbital（HOMO） and the lowest unoccupied molecular orbital（LUMO） of com- pounds 1 and 2 were simulated for the first time.展开更多
受精是一个复杂的过程,其中精卵融合是受精过程的关键步骤。本文详细阐述精卵质膜融合过程中精子膜上相关蛋白成分,如:Izumo蛋白、ADAMs(a distintegrin and metalloprotease)基因家族蛋白、富含半胱氨酸分泌蛋白(Crisp)基因家族蛋白的...受精是一个复杂的过程,其中精卵融合是受精过程的关键步骤。本文详细阐述精卵质膜融合过程中精子膜上相关蛋白成分,如:Izumo蛋白、ADAMs(a distintegrin and metalloprotease)基因家族蛋白、富含半胱氨酸分泌蛋白(Crisp)基因家族蛋白的作用。这对于深入了解精卵融合的机制,提高临床上男性不育的诊治水平,并对避孕药物的研制具有现实意义。展开更多
文摘为探索飞船返回再入加速度过载下人体姿态对乘员动力学响应的影响,本文利用Pro-E和HyperWorks软件建立了仰姿和躺姿两种典型人体姿态的假人–座椅系统模型。模型中使用了HUMOS II (Human Model for Safety Version II)人体生物力学模型。根据实际离心试验数据对假人–座椅系统模型进行了标定和验证。论证并分析了在高加速度过载(峰值为6.4 g)条件下,人体姿态对人体关键器官包括心脏、肺、膈肌、肝脏和腹部脏器过载响应的影响。仿真结果表明,膈肌的位移和变形是影响人体对再入过载耐受力的最重要因素。膈肌在卧姿时受到其他器官的作用力大于躺姿时的作用力。因此,飞船设计人员应更多地关注人体内部器官的受力状态,选择一个在飞船返回时对乘员具有更好保护作用的体位姿态,本文建议飞船乘员的姿态设计应优先选择躺姿。
基金funded by the Saudi Basic Industries Corporation(SABIC) and the Deanship of Scientific Research(DSR),King Abdulaziz University,Jeddah,under grant no.(MS/15/396/1434)
文摘1,2-Benzothiazine derivatives methyl 3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2]thiazine-3-carboxylate 1,1-dioxide（1） and methyl 2-ethyl-3-hydroxy-4-oxo-3,4-dihydro-2Hbenzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide（2） were synthesized, and characterized by spectroscopic techniques; 1H-NMR and infrared（IR） spectroscopy. Crystals of 1 and 2 were grown by slow evaporation of methanol and ethyl acetate, respectively and their crystal structures were investigated by single-crystal X-ray diffraction analysis. Geometric properties were calculated by the B3 LYP method of density functional theory（DFT） at the 6-31G＋（d） basis set to compare with the experimental data. Simulated properties were found in strong agreement with the experimental ones. Intermolecular forces have also been modeled in order to investigate the strength of packing and strong hydrogen bonding was observed in both compounds 1 and 2. Electronic properties such as Ionization Potential（IP）, Electron Affinities（EA） and coefficients of the highest occupied molecular orbital（HOMO） and the lowest unoccupied molecular orbital（LUMO） of com- pounds 1 and 2 were simulated for the first time.
文摘受精是一个复杂的过程,其中精卵融合是受精过程的关键步骤。本文详细阐述精卵质膜融合过程中精子膜上相关蛋白成分,如:Izumo蛋白、ADAMs(a distintegrin and metalloprotease)基因家族蛋白、富含半胱氨酸分泌蛋白(Crisp)基因家族蛋白的作用。这对于深入了解精卵融合的机制,提高临床上男性不育的诊治水平,并对避孕药物的研制具有现实意义。
