The Windows-based HEADFAST/Hunt er retrieval system in use for INSPEC Ondisc is analyzed.Its advantages in user interfa ce,search ways,search techniques and hyperlink search methods are evaluated in an objective way.
Objective: To identify the mutations of iduronate-2-sulfatase (IDS) gene, to reveal its mutation features, and to establish a basis for genetic counseling and prenatal gene diagnosis of Hunter syndrome. Methods: Urine...Objective: To identify the mutations of iduronate-2-sulfatase (IDS) gene, to reveal its mutation features, and to establish a basis for genetic counseling and prenatal gene diagnosis of Hunter syndrome. Methods: Urine glycosaminoglycans (GAGs) assay, PCR and DNA sequencing were performed to detect mutation of IDS gene of the patient and his parents. Results: The result showed that the patient was: DS(++), HS(++), KS(-), CS(-), and that both of his parents were negative. A frame-shift deletion mutation (1062 del 16) was identified in exon 7 of the patient's IDS gene. His parents' genotypes were normal. Conclusion:The patient's mutation was not inherited by his parents but a novel one. The mutation probably altered the primary structure and tertiary structure of IDS enzyme protein remarkably and lowered the activity of IDS enzyme greatly. Therefore it is supposed to be the direct cause of the disorder.展开更多
目的提出了一种用于芝麻油掺伪识别的新方法。方法为实现芝麻油中掺伪的识别,对掺入不同比例的大豆油、玉米油、棕榈油的芝麻油的40个样品进行近红外分析,并且基于主成分分析对掺入油进行识别;应用固相微萃取-气相色谱/质谱联用仪(SPME-...目的提出了一种用于芝麻油掺伪识别的新方法。方法为实现芝麻油中掺伪的识别,对掺入不同比例的大豆油、玉米油、棕榈油的芝麻油的40个样品进行近红外分析,并且基于主成分分析对掺入油进行识别;应用固相微萃取-气相色谱/质谱联用仪(SPME-GC/MS)和Mass Hunter软件,对于玉米油掺伪芝麻油的风味质谱数据进行了研究。结果 Mass Hunter解卷积软件和Agilent Mass Profiler Professional数据统计软件更加灵敏地从复杂包埋的目标物剖析分离得到了独特的标记物。倍率变化(FC=5)分析和ANOVA(P=0.05)分析的结果以火山曲线表示,确定区分芝麻油和玉米油的独特特征标记物。基于此独特的标记物,通过主成分分析,可对纯芝麻油和掺伪芝麻油进行分类。结论试验证明通过统计分析风味质谱数据寻找特征标记物可解决芝麻油掺伪的识别问题。展开更多
Nowadays,the usage of socialmedia platforms is rapidly increasing,and rumours or false information are also rising,especially among Arab nations.This false information is harmful to society and individuals.Blocking an...Nowadays,the usage of socialmedia platforms is rapidly increasing,and rumours or false information are also rising,especially among Arab nations.This false information is harmful to society and individuals.Blocking and detecting the spread of fake news in Arabic becomes critical.Several artificial intelligence(AI)methods,including contemporary transformer techniques,BERT,were used to detect fake news.Thus,fake news in Arabic is identified by utilizing AI approaches.This article develops a new hunterprey optimization with hybrid deep learning-based fake news detection(HPOHDL-FND)model on the Arabic corpus.The HPOHDL-FND technique undergoes extensive data pre-processing steps to transform the input data into a useful format.Besides,the HPOHDL-FND technique utilizes long-term memory with a recurrent neural network(LSTM-RNN)model for fake news detection and classification.Finally,hunter prey optimization(HPO)algorithm is exploited for optimal modification of the hyperparameters related to the LSTM-RNN model.The performance validation of the HPOHDL-FND technique is tested using two Arabic datasets.The outcomes exemplified better performance over the other existing techniques with maximum accuracy of 96.57%and 93.53%on Covid19Fakes and satirical datasets,respectively.展开更多
This article is concerned with the existence of global attractor of a weakly dissipative generalized two-component μ-Hunter-Saxton （gμHS2） system with viscous terms. Under the period boundary conditions and with t...This article is concerned with the existence of global attractor of a weakly dissipative generalized two-component μ-Hunter-Saxton （gμHS2） system with viscous terms. Under the period boundary conditions and with the help of the Galerkin procedure and compactness method, we first investigate the existence of global solution for the viscous weakly dissipative （gμHS2） system. On the basis of some uniformly prior estimates of the solution to the viscous weakly dissipative （gμHS2） system, we show that the semi-group of the solution operator {S（t）}t≥0 has a bounded absorbing set. Moreover, we prove that the dynamical system {S（t）}t≥0 possesses a global attractor in the Sobolev space H2（S） × H2（S）.展开更多
BACKGROUND Bow hunter’s syndrome(BHS)is a rare but surgically treatable cause of vertebrobasilar insufficiency due to dynamic rotational occlusion of the vertebral artery.Typically,patients present with posterior cir...BACKGROUND Bow hunter’s syndrome(BHS)is a rare but surgically treatable cause of vertebrobasilar insufficiency due to dynamic rotational occlusion of the vertebral artery.Typically,patients present with posterior circulation transient ischaemic symptoms such as presyncope,syncope,vertigo,diplopia,and horizontal nystagmus,but irreversible deficits,including medullary and cerebellar infarctions,have also been described.CASE SUMMARY A 70-year-old patient presented an acute onset of vertigo and gait instability triggered by right head rotation.His medical history included previous episodes of unilateral left neck and occipital pain followed by light-headedness,sweating,and blurred vision when turning his head,and these episodes were associated with severe degenerative changes in the atlanto-dens and left atlanto-axial facet joints and right rotation of the C2 cervical vertebrae.Brain magnetic resonance imaging revealed the presence of acute bilateral cerebellar ischaemic lesions,while static vascular imaging did not reveal any vertebral artery abnormalities.Dynamic ultrasonography and angiography were performed and confirmed the presence of a dynamic occlusion of the vertebral artery V3-V4 segment when the head was rotated to the right secondary to left C1-C2 bone spur compression.Surgical decompression led to complete resolution of paroxysmal symptoms without neurological sequelae.CONCLUSION BHS should be considered in cases of repeated posterior circulation transient ischaemic attack or ischaemic stroke,particularly when associated with high cervical spine abnormalities.展开更多
BACKGROUND In bow hunter’s syndrome(BHS),also known as rotational vertebral artery(VA)syndrome,there is dynamic/rotational compression of the VA producing verte-brobasilar insufficiency.Most occurrences involve atlan...BACKGROUND In bow hunter’s syndrome(BHS),also known as rotational vertebral artery(VA)syndrome,there is dynamic/rotational compression of the VA producing verte-brobasilar insufficiency.Most occurrences involve atlantoaxial rather than mid-cervical VA compromise,the latter being rarely reported.Herein,we detail successful VA decompression at mid-cervical spine,given a departure from its usual course.CASE SUMMARY The patient,a 45-year-old man,presented to our hospital with occipital headache and vertigo.Computed tomography angiography showed anomalous C4 entry of right VA,with compression upon head rotation to that side.Thyroid cartilage and anterior tubercle of C5 transverse process were visibly at fault.We opted for sur-gery,using an anterior cervical approach to remove the anterior tubercle.Patient recovery was uneventful and brought resolution of all preoperative symptoms.CONCLUSION BHS is an important consideration where aberrant coursing of VA and neurologic symptoms coexist.展开更多
A key benefit of publishing illness narratives is giving voice to sick or dying people,in order to promote a deepened understanding of patients’experiences of illness.Reading this kind of stories can also help health...A key benefit of publishing illness narratives is giving voice to sick or dying people,in order to promote a deepened understanding of patients’experiences of illness.Reading this kind of stories can also help healthcare providers to reflect about facing the difficult concept of“a good death”(a good way to die).Following considerations arise from a close reading of Franz Kafka’s incomplete short story entitled“The Hunter Gracchus”(1917)and,in particular,from the condition in which he puts the protagonist,the Hunter Gracchus.Kafka creates a completely surrealistic story concerning the artificial extension of persistently compromised vital functions of a person affected by an irreversible pathology.The protagonist,who seems to be aware of his poor condition,is really distressed by living the dying process spread over a long time and so diluted.Realistic connotations of this short story were not clear at Kafka’s time,but,nowadays,because of advances in medicine,with the availability of medications or invasive interventions developed to prolong life,many patients can experience a condition similar to hunter Gracchus’s one.We believe,therefore,that could be important reading and then reflecting on this story,especially assuming the hunter’s point of view,for the purpose of developing a new approach to the current problem of the“dehumanization”of dying.To make the reflection process as free as possible,we thought that it would have been better to give the voice to the Poet,and for this reason,we tried to avoid adding words of“wisdom”to support one thesis or another.In our opinion,reflecting upon the specific experience of a person who is practically dead but still not allowed to die could encourage health-care providers to consider meaning and consequences of serious illnesses,exploring their feelings about life-sustaining treatments and death.展开更多
Primitive man have managed to survive in the rigorous climatic conditions of the arctic regions in northeast Asia owing to the hunting for mammoth, bison, wooly rhinoceros and other Pleistocene mammals with the assist...Primitive man have managed to survive in the rigorous climatic conditions of the arctic regions in northeast Asia owing to the hunting for mammoth, bison, wooly rhinoceros and other Pleistocene mammals with the assistance of the laika, a domesticated wolf. This is how the colonization of the Arctic began. The domestic dog appeared in this region about 25 - 30 thousand years ago as a result of the severe climatic conditions in which both hunting tribes and the ancestors of the domestic dog had to live. A wolf is a predator, an able hunter. Therefore, most likely wolves were originally trained to hunt with humans—the leaders of the hunting pack. Thus, in northeast Asia, there was a direct relationship between man’s colonization of the Arctic, the appearance of the hunting dog, and a decrease in the number of mammoth, bison, and other large animals in the region, as a result of hunting when whole herds were killed.展开更多
文摘The Windows-based HEADFAST/Hunt er retrieval system in use for INSPEC Ondisc is analyzed.Its advantages in user interfa ce,search ways,search techniques and hyperlink search methods are evaluated in an objective way.
基金Project partly supported by the Ph.D. Program of the National Edu-cational Committee (No. 2000044)the Chinese Medical Board(2003), China
文摘Objective: To identify the mutations of iduronate-2-sulfatase (IDS) gene, to reveal its mutation features, and to establish a basis for genetic counseling and prenatal gene diagnosis of Hunter syndrome. Methods: Urine glycosaminoglycans (GAGs) assay, PCR and DNA sequencing were performed to detect mutation of IDS gene of the patient and his parents. Results: The result showed that the patient was: DS(++), HS(++), KS(-), CS(-), and that both of his parents were negative. A frame-shift deletion mutation (1062 del 16) was identified in exon 7 of the patient's IDS gene. His parents' genotypes were normal. Conclusion:The patient's mutation was not inherited by his parents but a novel one. The mutation probably altered the primary structure and tertiary structure of IDS enzyme protein remarkably and lowered the activity of IDS enzyme greatly. Therefore it is supposed to be the direct cause of the disorder.
文摘目的提出了一种用于芝麻油掺伪识别的新方法。方法为实现芝麻油中掺伪的识别,对掺入不同比例的大豆油、玉米油、棕榈油的芝麻油的40个样品进行近红外分析,并且基于主成分分析对掺入油进行识别;应用固相微萃取-气相色谱/质谱联用仪(SPME-GC/MS)和Mass Hunter软件,对于玉米油掺伪芝麻油的风味质谱数据进行了研究。结果 Mass Hunter解卷积软件和Agilent Mass Profiler Professional数据统计软件更加灵敏地从复杂包埋的目标物剖析分离得到了独特的标记物。倍率变化(FC=5)分析和ANOVA(P=0.05)分析的结果以火山曲线表示,确定区分芝麻油和玉米油的独特特征标记物。基于此独特的标记物,通过主成分分析,可对纯芝麻油和掺伪芝麻油进行分类。结论试验证明通过统计分析风味质谱数据寻找特征标记物可解决芝麻油掺伪的识别问题。
基金The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Small Groups Project under Grant Number(120/43)Princess Nourah bint Abdulrahman University Researchers Supporting Project Number(PNURSP2022R281)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code:(22UQU4331004DSR32).
文摘Nowadays,the usage of socialmedia platforms is rapidly increasing,and rumours or false information are also rising,especially among Arab nations.This false information is harmful to society and individuals.Blocking and detecting the spread of fake news in Arabic becomes critical.Several artificial intelligence(AI)methods,including contemporary transformer techniques,BERT,were used to detect fake news.Thus,fake news in Arabic is identified by utilizing AI approaches.This article develops a new hunterprey optimization with hybrid deep learning-based fake news detection(HPOHDL-FND)model on the Arabic corpus.The HPOHDL-FND technique undergoes extensive data pre-processing steps to transform the input data into a useful format.Besides,the HPOHDL-FND technique utilizes long-term memory with a recurrent neural network(LSTM-RNN)model for fake news detection and classification.Finally,hunter prey optimization(HPO)algorithm is exploited for optimal modification of the hyperparameters related to the LSTM-RNN model.The performance validation of the HPOHDL-FND technique is tested using two Arabic datasets.The outcomes exemplified better performance over the other existing techniques with maximum accuracy of 96.57%and 93.53%on Covid19Fakes and satirical datasets,respectively.
基金partially supported by NNSF of China(11571126,11701198)China Postdoctoral Science Foundation funded project(2017M622397)
文摘This article is concerned with the existence of global attractor of a weakly dissipative generalized two-component μ-Hunter-Saxton （gμHS2） system with viscous terms. Under the period boundary conditions and with the help of the Galerkin procedure and compactness method, we first investigate the existence of global solution for the viscous weakly dissipative （gμHS2） system. On the basis of some uniformly prior estimates of the solution to the viscous weakly dissipative （gμHS2） system, we show that the semi-group of the solution operator {S（t）}t≥0 has a bounded absorbing set. Moreover, we prove that the dynamical system {S（t）}t≥0 possesses a global attractor in the Sobolev space H2（S） × H2（S）.
文摘BACKGROUND Bow hunter’s syndrome(BHS)is a rare but surgically treatable cause of vertebrobasilar insufficiency due to dynamic rotational occlusion of the vertebral artery.Typically,patients present with posterior circulation transient ischaemic symptoms such as presyncope,syncope,vertigo,diplopia,and horizontal nystagmus,but irreversible deficits,including medullary and cerebellar infarctions,have also been described.CASE SUMMARY A 70-year-old patient presented an acute onset of vertigo and gait instability triggered by right head rotation.His medical history included previous episodes of unilateral left neck and occipital pain followed by light-headedness,sweating,and blurred vision when turning his head,and these episodes were associated with severe degenerative changes in the atlanto-dens and left atlanto-axial facet joints and right rotation of the C2 cervical vertebrae.Brain magnetic resonance imaging revealed the presence of acute bilateral cerebellar ischaemic lesions,while static vascular imaging did not reveal any vertebral artery abnormalities.Dynamic ultrasonography and angiography were performed and confirmed the presence of a dynamic occlusion of the vertebral artery V3-V4 segment when the head was rotated to the right secondary to left C1-C2 bone spur compression.Surgical decompression led to complete resolution of paroxysmal symptoms without neurological sequelae.CONCLUSION BHS should be considered in cases of repeated posterior circulation transient ischaemic attack or ischaemic stroke,particularly when associated with high cervical spine abnormalities.
文摘BACKGROUND In bow hunter’s syndrome(BHS),also known as rotational vertebral artery(VA)syndrome,there is dynamic/rotational compression of the VA producing verte-brobasilar insufficiency.Most occurrences involve atlantoaxial rather than mid-cervical VA compromise,the latter being rarely reported.Herein,we detail successful VA decompression at mid-cervical spine,given a departure from its usual course.CASE SUMMARY The patient,a 45-year-old man,presented to our hospital with occipital headache and vertigo.Computed tomography angiography showed anomalous C4 entry of right VA,with compression upon head rotation to that side.Thyroid cartilage and anterior tubercle of C5 transverse process were visibly at fault.We opted for sur-gery,using an anterior cervical approach to remove the anterior tubercle.Patient recovery was uneventful and brought resolution of all preoperative symptoms.CONCLUSION BHS is an important consideration where aberrant coursing of VA and neurologic symptoms coexist.
文摘A key benefit of publishing illness narratives is giving voice to sick or dying people,in order to promote a deepened understanding of patients’experiences of illness.Reading this kind of stories can also help healthcare providers to reflect about facing the difficult concept of“a good death”(a good way to die).Following considerations arise from a close reading of Franz Kafka’s incomplete short story entitled“The Hunter Gracchus”(1917)and,in particular,from the condition in which he puts the protagonist,the Hunter Gracchus.Kafka creates a completely surrealistic story concerning the artificial extension of persistently compromised vital functions of a person affected by an irreversible pathology.The protagonist,who seems to be aware of his poor condition,is really distressed by living the dying process spread over a long time and so diluted.Realistic connotations of this short story were not clear at Kafka’s time,but,nowadays,because of advances in medicine,with the availability of medications or invasive interventions developed to prolong life,many patients can experience a condition similar to hunter Gracchus’s one.We believe,therefore,that could be important reading and then reflecting on this story,especially assuming the hunter’s point of view,for the purpose of developing a new approach to the current problem of the“dehumanization”of dying.To make the reflection process as free as possible,we thought that it would have been better to give the voice to the Poet,and for this reason,we tried to avoid adding words of“wisdom”to support one thesis or another.In our opinion,reflecting upon the specific experience of a person who is practically dead but still not allowed to die could encourage health-care providers to consider meaning and consequences of serious illnesses,exploring their feelings about life-sustaining treatments and death.
文摘Primitive man have managed to survive in the rigorous climatic conditions of the arctic regions in northeast Asia owing to the hunting for mammoth, bison, wooly rhinoceros and other Pleistocene mammals with the assistance of the laika, a domesticated wolf. This is how the colonization of the Arctic began. The domestic dog appeared in this region about 25 - 30 thousand years ago as a result of the severe climatic conditions in which both hunting tribes and the ancestors of the domestic dog had to live. A wolf is a predator, an able hunter. Therefore, most likely wolves were originally trained to hunt with humans—the leaders of the hunting pack. Thus, in northeast Asia, there was a direct relationship between man’s colonization of the Arctic, the appearance of the hunting dog, and a decrease in the number of mammoth, bison, and other large animals in the region, as a result of hunting when whole herds were killed.
