The all-wheel drive(AWD)hybrid system is a research focus on high-performance new energy vehicles that can meet the demands of dynamic performance and passing ability.Simultaneous optimization of the power and economy...The all-wheel drive(AWD)hybrid system is a research focus on high-performance new energy vehicles that can meet the demands of dynamic performance and passing ability.Simultaneous optimization of the power and economy of hybrid vehicles becomes an issue.A unique multi-mode coupling(MMC)AWD hybrid system is presented to realize the distributed and centralized driving of the front and rear axles to achieve vectored distribution and full utilization of the system power between the axles of vehicles.Based on the parameters of the benchmarking model of a hybrid vehicle,the best model-predictive control-based energy management strategy is proposed.First,the drive system model was built after the analysis of the MMC-AWD’s drive modes.Next,three fundamental strategies were established to address power distribution adjustment and battery SOC maintenance when the SOC changed,which was followed by the design of a road driving force observer.Then,the energy consumption rate in the average time domain was processed before designing the minimum fuel consumption controller based on the equivalent fuel consumption coefficient.Finally,the advantage of the MMC-AWD was confirmed by comparison with the dynamic performance and economy of the BYD Song PLUS DMI-AWD.The findings indicate that,in comparison to the comparative hybrid system at road adhesion coefficients of 0.8 and 0.6,the MMC-AWD’s capacity to accelerate increases by 5.26%and 7.92%,respectively.When the road adhesion coefficient is 0.8,0.6,and 0.4,the maximum climbing ability increases by 14.22%,12.88%,and 4.55%,respectively.As a result,the dynamic performance is greatly enhanced,and the fuel savings rate per 100 km of mileage reaches 12.06%,which is also very economical.The proposed control strategies for the new hybrid AWD vehicle can optimize the power and economy simultaneously.展开更多
Mining shovel is a crucial piece of equipment for high-efficiency production in open-pit mining and stands as one of the largest energy consumption sources in mining.However,substantial energy waste occurs during the ...Mining shovel is a crucial piece of equipment for high-efficiency production in open-pit mining and stands as one of the largest energy consumption sources in mining.However,substantial energy waste occurs during the descent of the hoisting system or the deceleration of the slewing platform.To reduce the energy loss,an innovative hydrau-lic-electric hybrid drive system is proposed,in which a hydraulic pump/motor connected with an accumulator is added to assist the electric motor to drive the hoisting system or slewing platform,recycling kinetic and potential energy.The utilization of the kinetic and potential energy reduces the energy loss and installed power of the min-ing shovel.Meanwhile,the reliability of the mining shovel pure electric drive system also can be increased.In this paper,the hydraulic-electric hybrid driving principle is introduced,a small-scale testbed is set up to verify the feasibil-ity of the system,and a co-simulation model of the proposed system is established to clarify the system operation and energy characteristics.The test and simulation results show that,by adopting the proposed system,compared with the traditional purely electric driving system,the peak power and energy consumption of the hoisting electric motor are reduced by 36.7%and 29.7%,respectively.Similarly,the slewing electric motor experiences a significant decrease in peak power by 86.9%and a reduction in energy consumption by 59.4%.The proposed system expands the application area of the hydraulic electric hybrid drive system and provides a reference for its application in over-sized and super heavy equipment.展开更多
This paper develops a parallel hybrid electric vehicle(PHEV)propor-tional integral controller with driving cycle.To improve fuel efficiency and reduce hazardous emissions in hybrid electric vehicles(HEVs)combine an ele...This paper develops a parallel hybrid electric vehicle(PHEV)propor-tional integral controller with driving cycle.To improve fuel efficiency and reduce hazardous emissions in hybrid electric vehicles(HEVs)combine an electric motor(EM),a battery and an internal combustion engine(ICE).The electric motor assists the engine when accelerating,driving longer highways or climbing hills.This enables the use of a smaller,more efficient engine.It also makes use of the concept of regenerative braking to maximize energy efficiency.In a Hybrid Electric Vehicle(HEV),energy dissipated while braking is utilized to charge the battery.The proportional integral controller was used in this paper to analyze engine,motor performance and the New European Driving Cycle(NEDC)was used in the vehicle driving test using Matlab/Simulink.The proportional integral controllers were designed to track the desired vehicle speed and manage the vehi-cle’s energyflow.The Sea Lion Optimization(SLnO)methods were created to reduce fuel consumption in a parallel hybrid electric vehicle and the results were obtained for the New European Driving Cycle.展开更多
The superconducting tokamak HT-7U [1] has been designed by the Institute of Plasma Physics since 1998 and will be set up before 2003. The 1.2 MW /2.45 GHz HT-7U LHCD (Lower hybrid current drive) system which being the...The superconducting tokamak HT-7U [1] has been designed by the Institute of Plasma Physics since 1998 and will be set up before 2003. The 1.2 MW /2.45 GHz HT-7U LHCD (Lower hybrid current drive) system which being the most efficient non-induction device can heat the plasma and drive the plasma current has been efficiently in operation 'owl and a particular design of the 2.8 MW/-35 kV high-voltage DC power supply has been already completed and will apply to the klystron of LHCD on HT-7 and the future HT-7U, and the project of the power supply has been examined and approved professionally by an authorized group of high-level specialist in the institute of Plasma Physics. The detailed design of the power supply and the simulation results are referred in the paper.展开更多
?Fundamental experiments on lower hybrid current drive (LHCD) have been undertaken on HT-7 superconducting tokamak. The experiments on LHCD efficiency reveal its depen- deuce on plasma density and the toroidal magnet...?Fundamental experiments on lower hybrid current drive (LHCD) have been undertaken on HT-7 superconducting tokamak. The experiments on LHCD efficiency reveal its depen- deuce on plasma density and the toroidal magnetic field. Furthermore, the experiments on HT-7 successfully demonstrate the ability for LHCD to sustain long pulse tokamak discharges, such as discharges with full non-inductive current drive for several seconds. The experimental study to improve plasma confinements by LHCD suggests that the improvement should be due to the change o f current profile. It has also been demonstrated by the experiments that the lower hybrid wave may lead to an enhanced ionization of particles in the region where the wave is deposited.展开更多
The effect of the wave accessibility condition on the lower hybrid cm'rent drive in the experimental advanced superconductor Tokamak (EAST) plasma with H-mode operation is studied. Based on a simplified model, a mo...The effect of the wave accessibility condition on the lower hybrid cm'rent drive in the experimental advanced superconductor Tokamak (EAST) plasma with H-mode operation is studied. Based on a simplified model, a mode conversion layer of the lower hybrid wave between the fast wave branch and the slow wave branch is proved to exist in the plasma periphery for typical EAST H-mode parameters. Under the framework of the lower hybrid wave simulation code (LSC), the wave ray trajectory and the associated current drive are calculated numerically. The results show that the wave accessibility condition plays an important role on the lower hybrid current drive in EAST plasma. For wave rays with parallel refractive index n||= 2.1 or n|| = 2.5 launched from the outside midplane, the wave rays may penetrate the core plasma due to the toroida] geometry effect, while numerous reflections of the wave ray trajectories in the plasma periphery occur. However, low current drive efficiency is obtained. Meanwhile, the wave accessibility condition is improved if a higher confined magnetic field is applied. The simulation results show that for plasma parameters under present EAST H-mode operation, a significant lower hybrid wave current drive could be obtained for the wave spectrum with peak value n|| = 2.1 if a toroidal magnetic field BT =2.5 T is applied.展开更多
H-mode discharges with lower hybrid current drive (LHCD) alone are achieved in EAST divertor plasma over a wide parameter range. These H-mode discharges are characterized by a sudden drop in Da emission and a sponta...H-mode discharges with lower hybrid current drive (LHCD) alone are achieved in EAST divertor plasma over a wide parameter range. These H-mode discharges are characterized by a sudden drop in Da emission and a spontaneous rise in main plasma density. Good lower hybrid (LH) coupling during H-mode is obtained by putting the plasma close to the antenna and by injecting D2 gas from a pipe near the grill mouse. The analysis of lower hybrid current drive properties shows that the LH deposition profile shifts off axis during H-mode, and current drive (CD) efficiency decreases due to the increase in density. Modeling results of H-mode discharges with a general ray trueing code GENRAY are reported.展开更多
For the effect of the collisional dissipation of fast electrons driven by the lower-hybrid waves, a predictive simulation is made for the HT-7 plasma. The simulation results show that the dissipation of fast electrons...For the effect of the collisional dissipation of fast electrons driven by the lower-hybrid waves, a predictive simulation is made for the HT-7 plasma. The simulation results show that the dissipation of fast electrons counteracts the effect of radial diffusion to some extent, thereby making the lower-hybrid driven current profile closer to the power deposition profile. So, in the case of an off-axis lower-hybrid wave power launching, the dissipation is helpful in maintaining a center-hollowed current profile in lower hybrid current drive (LHCD) plasmas, and thus possibly maintains the desired reversed magnetic shear.展开更多
The effects of trapped electrons on off-axis lower hybrid current drive (LHCD) in tokamaks are studied, A computer code for solving the Fokker-Planck equation in a toroidal geometry is developed and employed. The co...The effects of trapped electrons on off-axis lower hybrid current drive (LHCD) in tokamaks are studied, A computer code for solving the Fokker-Planck equation in a toroidal geometry is developed and employed. The code is suitable for various auxiliary heating and current drive schemes in tokamak plasmas. The influence of the resonance regime on the current drive efficiency as well as the influence of trapped particle fraction on the current drive efficiency are emphasized. It is shown that, as an electrostatic force, the lower hybrid wave causes some of the trapped electrons to be untrapped and lose their energy, which can cut the LHCD efficiency by about 30%. The ITER scaling law is also used to estimate the trapped electron effects.展开更多
Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's dis...Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related dementia.Our previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease synapses.This study investigated a new molecular relationship between miR-502-3p and GABAergic synapse function.In vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and antagomiRs.In silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 mRNA.Luciferase assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase activity.Furthermore,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 protein.Notably,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be increased.The whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse function.Additionally,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p suppression.The present study provides insight into the molecular mechanism of regulation of GABAergic synapses by miR-502-3p.We propose that micro-RNA,in particular miR-502-3p,could be a potential therapeutic to rget to modulate GABAergic synapse function in neurological disorders,including Alzheimer's disease and Alzheimer's diseaserelated dementia.展开更多
A perpendicular neutral particle analyzer (NPA) is used on HT-7 tokamak experiment to provide the measurements of neutral particle flux and ion temperature. The measured results were compared with calculated data by ...A perpendicular neutral particle analyzer (NPA) is used on HT-7 tokamak experiment to provide the measurements of neutral particle flux and ion temperature. The measured results were compared with calculated data by Monte-carlo method for ohmic heating. In lower hybrid current drive (LHCD) experiments, the ion heating of LHCD was identified. The chargeexchange neutral particle flux enhanced was observed. The energy spectrum clearly showed a high-energy ions tail. The bulk ion temperature increased by 0.4-0.5 keV after the onset of LHCD. Efficient ion heating of 1 eV. kW-1 was obtained.展开更多
Ramp-up experiments by means of lower hybrid wave on HT-7 superconducting tokamak have been performed and analyzed. A ramp-up rate of over 300 kA/s is obtained and a conversion efficiency of over 1.0% has been achieve...Ramp-up experiments by means of lower hybrid wave on HT-7 superconducting tokamak have been performed and analyzed. A ramp-up rate of over 300 kA/s is obtained and a conversion efficiency of over 1.0% has been achieved during the ramp-up phase. The study of the dependence of conversion efficiency on plasma density shows that the conversion efficiency is affected by the driven current, which is mainly dominated by the competition of impurity concentration with wave accessibility condition. In addition, the effect of current profile may play an important role in determining the conversion efficiency.展开更多
The high-speed reciprocating motion of a detaching roller limits the velocity of a cotton comber and affects the quality of comber slivers. The article has proposed a controllable time-sharing unidirectional hybrid dr...The high-speed reciprocating motion of a detaching roller limits the velocity of a cotton comber and affects the quality of comber slivers. The article has proposed a controllable time-sharing unidirectional hybrid drive mechanism after analyzing detaching roller's current numerical control drive method. The analysis focuses on the detaching roller motion required according to cotton comber's velocity and process. The double-servo motors of the mechanism consists of differential gear trains. The mechanism addresses the problem of increased servo motor power,and failure of promptly responded to the positive inversion process of mechanism driven by servo motors. A velocity calculation model of the detaching roller controllable drive mechanism will be generated by using superposition method and design of differential gear trains. The accuracy of the model will be verified using the test platform. This study has presented a reliable and practical high-speed drive mechanism and can be a reference to future studies on high-speed reciprocating motion drive.展开更多
An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo2O4 battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device...An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo2O4 battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device.By designing three-dimensional hierarchical NiCo2O4 arrays as faradic electrode,with capacitive electrode of active carbon(AC),BSHs were assembled with energy density of 16.6 Wh kg-1,power density of 7285 W kg-1,long-term stability with 100% retention after 15,000 cycles,and rather low self-discharge.The NiCo2O4//AC BSH was charged to 1.6 V in 1 s by solar cells and acted as reliable sources for powering LEDs.The integrated system is rational for operation,having an overall efficiency of 8.1% with storage efficiency of 74.24%.The integrated system demonstrates a stable solar power conversion,outstanding energy storage behavior,and reliable light emitting.Our study offers a precious strategy to design a self-driven integrated system for highly efficient energy utilization.展开更多
The optimized synergy conditions between electron cyclotron current drive (ECCD) and lower hybrid current drive (LHCD) with normal parameters of the EAST tokamak are studied by using the C3PO/LUKE code based on th...The optimized synergy conditions between electron cyclotron current drive (ECCD) and lower hybrid current drive (LHCD) with normal parameters of the EAST tokamak are studied by using the C3PO/LUKE code based on the under- standing of the synergy mechanisms so as to obtain a higher synergistic current and provide theoretical reference for the synergistic effect in the EAST experiment. The dependences of the synergistic effect on the parameters of two waves (lower hybrid wave (LHW) and electron cyclotron wave (ECW)), including the radial position of the power deposition, the power value of the LH and EC waves, and the parallel refractive indices of the LHW (Nr) are oresented and discussed.展开更多
基金Supported by Hebei Provincial Natural Science Foundation of China(Grant Nos.E2020203174,E2020203078)S&T Program of Hebei Province of China(Grant No.226Z2202G)Science Research Project of Hebei Provincial Education Department of China(Grant No.ZD2022029).
文摘The all-wheel drive(AWD)hybrid system is a research focus on high-performance new energy vehicles that can meet the demands of dynamic performance and passing ability.Simultaneous optimization of the power and economy of hybrid vehicles becomes an issue.A unique multi-mode coupling(MMC)AWD hybrid system is presented to realize the distributed and centralized driving of the front and rear axles to achieve vectored distribution and full utilization of the system power between the axles of vehicles.Based on the parameters of the benchmarking model of a hybrid vehicle,the best model-predictive control-based energy management strategy is proposed.First,the drive system model was built after the analysis of the MMC-AWD’s drive modes.Next,three fundamental strategies were established to address power distribution adjustment and battery SOC maintenance when the SOC changed,which was followed by the design of a road driving force observer.Then,the energy consumption rate in the average time domain was processed before designing the minimum fuel consumption controller based on the equivalent fuel consumption coefficient.Finally,the advantage of the MMC-AWD was confirmed by comparison with the dynamic performance and economy of the BYD Song PLUS DMI-AWD.The findings indicate that,in comparison to the comparative hybrid system at road adhesion coefficients of 0.8 and 0.6,the MMC-AWD’s capacity to accelerate increases by 5.26%and 7.92%,respectively.When the road adhesion coefficient is 0.8,0.6,and 0.4,the maximum climbing ability increases by 14.22%,12.88%,and 4.55%,respectively.As a result,the dynamic performance is greatly enhanced,and the fuel savings rate per 100 km of mileage reaches 12.06%,which is also very economical.The proposed control strategies for the new hybrid AWD vehicle can optimize the power and economy simultaneously.
基金Supported by National Natural Science Foundation of China(Grant No.U1910211)National Key Research and Development Program of China(Grant No.2021YFB2011903).
文摘Mining shovel is a crucial piece of equipment for high-efficiency production in open-pit mining and stands as one of the largest energy consumption sources in mining.However,substantial energy waste occurs during the descent of the hoisting system or the deceleration of the slewing platform.To reduce the energy loss,an innovative hydrau-lic-electric hybrid drive system is proposed,in which a hydraulic pump/motor connected with an accumulator is added to assist the electric motor to drive the hoisting system or slewing platform,recycling kinetic and potential energy.The utilization of the kinetic and potential energy reduces the energy loss and installed power of the min-ing shovel.Meanwhile,the reliability of the mining shovel pure electric drive system also can be increased.In this paper,the hydraulic-electric hybrid driving principle is introduced,a small-scale testbed is set up to verify the feasibil-ity of the system,and a co-simulation model of the proposed system is established to clarify the system operation and energy characteristics.The test and simulation results show that,by adopting the proposed system,compared with the traditional purely electric driving system,the peak power and energy consumption of the hoisting electric motor are reduced by 36.7%and 29.7%,respectively.Similarly,the slewing electric motor experiences a significant decrease in peak power by 86.9%and a reduction in energy consumption by 59.4%.The proposed system expands the application area of the hydraulic electric hybrid drive system and provides a reference for its application in over-sized and super heavy equipment.
文摘This paper develops a parallel hybrid electric vehicle(PHEV)propor-tional integral controller with driving cycle.To improve fuel efficiency and reduce hazardous emissions in hybrid electric vehicles(HEVs)combine an electric motor(EM),a battery and an internal combustion engine(ICE).The electric motor assists the engine when accelerating,driving longer highways or climbing hills.This enables the use of a smaller,more efficient engine.It also makes use of the concept of regenerative braking to maximize energy efficiency.In a Hybrid Electric Vehicle(HEV),energy dissipated while braking is utilized to charge the battery.The proportional integral controller was used in this paper to analyze engine,motor performance and the New European Driving Cycle(NEDC)was used in the vehicle driving test using Matlab/Simulink.The proportional integral controllers were designed to track the desired vehicle speed and manage the vehi-cle’s energyflow.The Sea Lion Optimization(SLnO)methods were created to reduce fuel consumption in a parallel hybrid electric vehicle and the results were obtained for the New European Driving Cycle.
文摘The superconducting tokamak HT-7U [1] has been designed by the Institute of Plasma Physics since 1998 and will be set up before 2003. The 1.2 MW /2.45 GHz HT-7U LHCD (Lower hybrid current drive) system which being the most efficient non-induction device can heat the plasma and drive the plasma current has been efficiently in operation 'owl and a particular design of the 2.8 MW/-35 kV high-voltage DC power supply has been already completed and will apply to the klystron of LHCD on HT-7 and the future HT-7U, and the project of the power supply has been examined and approved professionally by an authorized group of high-level specialist in the institute of Plasma Physics. The detailed design of the power supply and the simulation results are referred in the paper.
文摘?Fundamental experiments on lower hybrid current drive (LHCD) have been undertaken on HT-7 superconducting tokamak. The experiments on LHCD efficiency reveal its depen- deuce on plasma density and the toroidal magnetic field. Furthermore, the experiments on HT-7 successfully demonstrate the ability for LHCD to sustain long pulse tokamak discharges, such as discharges with full non-inductive current drive for several seconds. The experimental study to improve plasma confinements by LHCD suggests that the improvement should be due to the change o f current profile. It has also been demonstrated by the experiments that the lower hybrid wave may lead to an enhanced ionization of particles in the region where the wave is deposited.
基金Supported by the National Natural Science Foundation of China under Grant No 11347002the National Magnetic Confinement Fusion Science Program of China under Grant No 2013GB111000+2 种基金the Outstanding Youth Fund of Hunan Province Education Department of China under Grant No 12B107the JSPS-NRF-NSFC A3 Foresight Program in the field of Plasma Physics under Grant No 11261140328the National Research Foundation 2012K2A2A6000443
文摘The effect of the wave accessibility condition on the lower hybrid cm'rent drive in the experimental advanced superconductor Tokamak (EAST) plasma with H-mode operation is studied. Based on a simplified model, a mode conversion layer of the lower hybrid wave between the fast wave branch and the slow wave branch is proved to exist in the plasma periphery for typical EAST H-mode parameters. Under the framework of the lower hybrid wave simulation code (LSC), the wave ray trajectory and the associated current drive are calculated numerically. The results show that the wave accessibility condition plays an important role on the lower hybrid current drive in EAST plasma. For wave rays with parallel refractive index n||= 2.1 or n|| = 2.5 launched from the outside midplane, the wave rays may penetrate the core plasma due to the toroida] geometry effect, while numerous reflections of the wave ray trajectories in the plasma periphery occur. However, low current drive efficiency is obtained. Meanwhile, the wave accessibility condition is improved if a higher confined magnetic field is applied. The simulation results show that for plasma parameters under present EAST H-mode operation, a significant lower hybrid wave current drive could be obtained for the wave spectrum with peak value n|| = 2.1 if a toroidal magnetic field BT =2.5 T is applied.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10875149 and 10805057)the National Magnetic Confinement Fusion Science Program of China (Grant No. 2010GB105004)
文摘H-mode discharges with lower hybrid current drive (LHCD) alone are achieved in EAST divertor plasma over a wide parameter range. These H-mode discharges are characterized by a sudden drop in Da emission and a spontaneous rise in main plasma density. Good lower hybrid (LH) coupling during H-mode is obtained by putting the plasma close to the antenna and by injecting D2 gas from a pipe near the grill mouse. The analysis of lower hybrid current drive properties shows that the LH deposition profile shifts off axis during H-mode, and current drive (CD) efficiency decreases due to the increase in density. Modeling results of H-mode discharges with a general ray trueing code GENRAY are reported.
基金supportcd by National Natural Science Foundation of China(No.10425526)
文摘For the effect of the collisional dissipation of fast electrons driven by the lower-hybrid waves, a predictive simulation is made for the HT-7 plasma. The simulation results show that the dissipation of fast electrons counteracts the effect of radial diffusion to some extent, thereby making the lower-hybrid driven current profile closer to the power deposition profile. So, in the case of an off-axis lower-hybrid wave power launching, the dissipation is helpful in maintaining a center-hollowed current profile in lower hybrid current drive (LHCD) plasmas, and thus possibly maintains the desired reversed magnetic shear.
基金Project supported by the National Natural Science Foundation of China (Grant Nos 10675043, 10575031 and 10675042).
文摘The effects of trapped electrons on off-axis lower hybrid current drive (LHCD) in tokamaks are studied, A computer code for solving the Fokker-Planck equation in a toroidal geometry is developed and employed. The code is suitable for various auxiliary heating and current drive schemes in tokamak plasmas. The influence of the resonance regime on the current drive efficiency as well as the influence of trapped particle fraction on the current drive efficiency are emphasized. It is shown that, as an electrostatic force, the lower hybrid wave causes some of the trapped electrons to be untrapped and lose their energy, which can cut the LHCD efficiency by about 30%. The ITER scaling law is also used to estimate the trapped electron effects.
基金supported by the National Institute on Aging (NIA)National Institutes of Health (NIH)+3 种基金Nos.K99AG065645,R00AG065645R00AG065645-04S1 (to SK)NIH research grants,NINDS,No.R01 NS115834NINDS/NIA,No.R01 NS115834-02S1 (to LG)。
文摘Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related dementia.Our previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease synapses.This study investigated a new molecular relationship between miR-502-3p and GABAergic synapse function.In vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and antagomiRs.In silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 mRNA.Luciferase assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase activity.Furthermore,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 protein.Notably,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be increased.The whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse function.Additionally,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p suppression.The present study provides insight into the molecular mechanism of regulation of GABAergic synapses by miR-502-3p.We propose that micro-RNA,in particular miR-502-3p,could be a potential therapeutic to rget to modulate GABAergic synapse function in neurological disorders,including Alzheimer's disease and Alzheimer's diseaserelated dementia.
文摘A perpendicular neutral particle analyzer (NPA) is used on HT-7 tokamak experiment to provide the measurements of neutral particle flux and ion temperature. The measured results were compared with calculated data by Monte-carlo method for ohmic heating. In lower hybrid current drive (LHCD) experiments, the ion heating of LHCD was identified. The chargeexchange neutral particle flux enhanced was observed. The energy spectrum clearly showed a high-energy ions tail. The bulk ion temperature increased by 0.4-0.5 keV after the onset of LHCD. Efficient ion heating of 1 eV. kW-1 was obtained.
文摘Ramp-up experiments by means of lower hybrid wave on HT-7 superconducting tokamak have been performed and analyzed. A ramp-up rate of over 300 kA/s is obtained and a conversion efficiency of over 1.0% has been achieved during the ramp-up phase. The study of the dependence of conversion efficiency on plasma density shows that the conversion efficiency is affected by the driven current, which is mainly dominated by the competition of impurity concentration with wave accessibility condition. In addition, the effect of current profile may play an important role in determining the conversion efficiency.
基金National Basic Research Program of China(973 Program)(No.2010CB334711)the Applied Basic Research of China National Textile and Apparel Council (Textile Vision Science and Education Fund of China in 2012)
文摘The high-speed reciprocating motion of a detaching roller limits the velocity of a cotton comber and affects the quality of comber slivers. The article has proposed a controllable time-sharing unidirectional hybrid drive mechanism after analyzing detaching roller's current numerical control drive method. The analysis focuses on the detaching roller motion required according to cotton comber's velocity and process. The double-servo motors of the mechanism consists of differential gear trains. The mechanism addresses the problem of increased servo motor power,and failure of promptly responded to the positive inversion process of mechanism driven by servo motors. A velocity calculation model of the detaching roller controllable drive mechanism will be generated by using superposition method and design of differential gear trains. The accuracy of the model will be verified using the test platform. This study has presented a reliable and practical high-speed drive mechanism and can be a reference to future studies on high-speed reciprocating motion drive.
基金the support of National Natural Science Foundation of China (Nos. 51702284 and 21878270)Zhejiang Provincial Natural Science Foundation of China (LR19B060002)+5 种基金the Startup Foundation for Hundred-Talent Program of Zhejiang University(112100-193820101/001/022)the support of Shenzhen Science and Technology Project of China (JCYJ20170412105400428)the support of Zhejiang Provincial Natural Science Foundation of China (LR16F040001)Open Project of Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang Universitythe support of Innovation Platform of Energy Storage Engineering and New Material in Zhejiang University (K19-534202-002)Provincial Innovation Team on Hydrogen Electric Hybrid Power Systems in Zhejiang Province
文摘An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo2O4 battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device.By designing three-dimensional hierarchical NiCo2O4 arrays as faradic electrode,with capacitive electrode of active carbon(AC),BSHs were assembled with energy density of 16.6 Wh kg-1,power density of 7285 W kg-1,long-term stability with 100% retention after 15,000 cycles,and rather low self-discharge.The NiCo2O4//AC BSH was charged to 1.6 V in 1 s by solar cells and acted as reliable sources for powering LEDs.The integrated system is rational for operation,having an overall efficiency of 8.1% with storage efficiency of 74.24%.The integrated system demonstrates a stable solar power conversion,outstanding energy storage behavior,and reliable light emitting.Our study offers a precious strategy to design a self-driven integrated system for highly efficient energy utilization.
基金supported by the National Magnetic Confinement Fusion Science Program of China(Grant Nos.2011GB102000,2012GB103000,2013GB106001,and2015GB102003)the National Natural Science Foundation of China(Grant Nos.11175206 and 11305211)+1 种基金the JSPS-NRF-NSFC A3 Foresight Program in the Field of Plasma Physics(Grant No.11261140328)the Fundamental Research Funds for the Central Universities of China(Grant No.JZ2015HGBZ0472)
文摘The optimized synergy conditions between electron cyclotron current drive (ECCD) and lower hybrid current drive (LHCD) with normal parameters of the EAST tokamak are studied by using the C3PO/LUKE code based on the under- standing of the synergy mechanisms so as to obtain a higher synergistic current and provide theoretical reference for the synergistic effect in the EAST experiment. The dependences of the synergistic effect on the parameters of two waves (lower hybrid wave (LHW) and electron cyclotron wave (ECW)), including the radial position of the power deposition, the power value of the LH and EC waves, and the parallel refractive indices of the LHW (Nr) are oresented and discussed.