NiH-catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular complexity.In this process,the selective generation of the desired...NiH-catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular complexity.In this process,the selective generation of the desired product can be challenging.Herein,we report that a highly chemo-,regio-and enantioselective reductive hydrocarbonylation of alkenes has been achieved using a chloroformate ester as a source of CO.A wide range of structurally diverseα-hydroxy ketones,privileged structural elements in bioactive molecules and useful building blocks,were obtained from such reactions with high enantiomeric purity.展开更多
基金Support was provided by NSFC (92156004,22271143,22271146)NSF of Jiangsu Province (BK20190281,BK20201245)+1 种基金programs for high-level entrepreneurial and innovative talents introduction of Jiangsu Province (group program),Fundamental Research Funds for the Central Universities (020514380282)Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University.Gao Deng thanks the National College Students'Innovation and Entrepreneurship Training Program (0205145031).
文摘NiH-catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular complexity.In this process,the selective generation of the desired product can be challenging.Herein,we report that a highly chemo-,regio-and enantioselective reductive hydrocarbonylation of alkenes has been achieved using a chloroformate ester as a source of CO.A wide range of structurally diverseα-hydroxy ketones,privileged structural elements in bioactive molecules and useful building blocks,were obtained from such reactions with high enantiomeric purity.
