Age-related macular degeneration（AMD） is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race...Age-related macular degeneration（AMD） is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species（ROS） which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium（RPE）,endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide（H2S） acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals＇ inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity.展开更多
This study presents the use of chicken eggshells waste utilizing palm kernel shell based activated carbon（PKSAC） through the modification of their surface to enhance the adsorption capacity of H2S. Response surface ...This study presents the use of chicken eggshells waste utilizing palm kernel shell based activated carbon（PKSAC） through the modification of their surface to enhance the adsorption capacity of H2S. Response surface methodology technique was used to optimize the process conditions and they were found to be： 500 mg/L for H2S initial concentration, 540 min for contact time and 1 g for adsorbent mass. The impacts of three arrangement factors（calcination temperature of impregnated activated carbon（IAC）, the calcium solution concentration and contact time of calcination） on the H2S removal efficiency and impregnated AC yield were investigated. Both responses IAC yield（IACY, %） and removal efficiency（RE, %） were maximized to optimize the IAC preparation conditions. The optimum preparation conditions for IACY and RE were found as follows： calcination temperature of IAC of 880 ℃, calcium solution concentration of 49.3% and calcination contact time of 57.6 min, which resulted in 35.8% of IACY and 98.2% RE. In addition, the equilibrium and kinetics of the process were investigated. The adsorbent was characterized using TGA, XRD, FTIR, SEM/EDX, and BET. The maximum monolayer adsorption capacity was found to be 543.47 mg/g. The results recommended that the composite of PKSAC and Ca O could be a useful material for H2S containing wastewater treatment.展开更多
A full-scale integrated-bioreactor consisting of a suspended zone and an immobilized zone was employed to treat the ordours emitted from a wastewater treatment plant. The inlet concentrations of H,S and NH3 were 1.6-3...A full-scale integrated-bioreactor consisting of a suspended zone and an immobilized zone was employed to treat the ordours emitted from a wastewater treatment plant. The inlet concentrations of H,S and NH3 were 1.6-38.6 mg.m-3 and 0.1 6.7 mg.m-3 respectively, while the steady-state outlet concentrations were reduced to 0-2.8mg.m - for H2S and 0-0.5mg.m for NH3. BothH2SandNH3 were eliminated effectively by the integrated-bioreactor. The removal efficiencies of H2S and NH3 differed between the two zones. Four species of microorganisms related to the degradation of H2S and NH3 were isolated. The characteristics and distributions of the microbes in the bioreactor depended on the inlet concentration of substrates and the micro-environmental conditions in the individual zones. Product analysis indicated that most of the H2S was oxidized into sulfate in the immobilized zone but was dissolved into the liquid phase in the suspended zone. A large amount of NH3 was converted into nitrate and nitrite by nitration in the suspended zone, whereas only a small amount of NH3 was transferred to the aqueous phase mainly by absorption or chemical neutralization in the immobilized zone. Different microbial populations dominated the individual zones, and the major biodegradation products varied accordingly.展开更多
基金Supported in part by NIH Heart,Lung,and Blood Institute(No.HLO74815)Institute of Neurological Disorders and Stroke(No.NS-084823)
文摘Age-related macular degeneration（AMD） is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species（ROS） which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium（RPE）,endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide（H2S） acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals＇ inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity.
基金Funded by the Faculty of Chemical&Natural Resources Engineering,Universiti Malaysia Pahang through a Local Research Grant Scheme
文摘This study presents the use of chicken eggshells waste utilizing palm kernel shell based activated carbon（PKSAC） through the modification of their surface to enhance the adsorption capacity of H2S. Response surface methodology technique was used to optimize the process conditions and they were found to be： 500 mg/L for H2S initial concentration, 540 min for contact time and 1 g for adsorbent mass. The impacts of three arrangement factors（calcination temperature of impregnated activated carbon（IAC）, the calcium solution concentration and contact time of calcination） on the H2S removal efficiency and impregnated AC yield were investigated. Both responses IAC yield（IACY, %） and removal efficiency（RE, %） were maximized to optimize the IAC preparation conditions. The optimum preparation conditions for IACY and RE were found as follows： calcination temperature of IAC of 880 ℃, calcium solution concentration of 49.3% and calcination contact time of 57.6 min, which resulted in 35.8% of IACY and 98.2% RE. In addition, the equilibrium and kinetics of the process were investigated. The adsorbent was characterized using TGA, XRD, FTIR, SEM/EDX, and BET. The maximum monolayer adsorption capacity was found to be 543.47 mg/g. The results recommended that the composite of PKSAC and Ca O could be a useful material for H2S containing wastewater treatment.
基金The authors express their sincerely Acknowledgments to ShineWrite and Editage services center of professional editing support for the English revision of the manuscript. This work was financially supported by the National Nature Science Foundation of China （Grant No. 51478456）, Scientific Research Foundation of Beijing University of Civil Engineering and Architecture （No. 00331615020） and Beijing Municipal Science and Technology Commission （D 151100005115002）.
文摘A full-scale integrated-bioreactor consisting of a suspended zone and an immobilized zone was employed to treat the ordours emitted from a wastewater treatment plant. The inlet concentrations of H,S and NH3 were 1.6-38.6 mg.m-3 and 0.1 6.7 mg.m-3 respectively, while the steady-state outlet concentrations were reduced to 0-2.8mg.m - for H2S and 0-0.5mg.m for NH3. BothH2SandNH3 were eliminated effectively by the integrated-bioreactor. The removal efficiencies of H2S and NH3 differed between the two zones. Four species of microorganisms related to the degradation of H2S and NH3 were isolated. The characteristics and distributions of the microbes in the bioreactor depended on the inlet concentration of substrates and the micro-environmental conditions in the individual zones. Product analysis indicated that most of the H2S was oxidized into sulfate in the immobilized zone but was dissolved into the liquid phase in the suspended zone. A large amount of NH3 was converted into nitrate and nitrite by nitration in the suspended zone, whereas only a small amount of NH3 was transferred to the aqueous phase mainly by absorption or chemical neutralization in the immobilized zone. Different microbial populations dominated the individual zones, and the major biodegradation products varied accordingly.
