Phytosterols have received extensive attention owing to their excellent cholesterol-lowering activity and the role in cardiovascular diseases prevention. However, poor solubility in both oil and water limited the appl...Phytosterols have received extensive attention owing to their excellent cholesterol-lowering activity and the role in cardiovascular diseases prevention. However, poor solubility in both oil and water limited the application of free phytosterols in the food industry. Chemical or enzymatic modifications were effective to improve the physicochemical properties as well as the bioavailability and cholesterollowering activity of phytosterols. Higher oil solubility and lower melting point of phytosterols have been achieved by esterification and transesterification with fatty acids and triacylglycerols so as to enhance the bioavailability, reduce formation of precipitates, and improve the sensory quality of products.While the researches on the improvement on its water solubility is a hot topic. Hydrophilic phytosterol derivatives have promising applications in the food industry because most of foods belong to aqueous matrix. Hydrophilic modification is useful and meaningful for phytosterols in both industrial and commercial applications. This review mainly highlights the hydrophilic phytosterol derivatives in the following aspects:(i) hydrophilic modifications of phytosterols by coupling with various polar components;(ii) cholesterol-lowering activity and possible molecular mechanisms of hydrophilic phytosterol derivatives on reducing serum cholesterol level;and(iii) safety evaluation of hydrophilic phytosterol derivatives in cell-culture studies, animal models and clinical trials.展开更多
A silylated-terpyridine（Si TPy） derivative was newly synthesized and reacted with various transition metal ions in the solutions and self-assembled monolayers（SAMs）.Composition and morphology of the SAMs were char...A silylated-terpyridine（Si TPy） derivative was newly synthesized and reacted with various transition metal ions in the solutions and self-assembled monolayers（SAMs）.Composition and morphology of the SAMs were characterized by using absorption spectra,X-ray photoelectron spectra and atomic force microscope.The silylated-TPy compound gave off a luminescent emission at about 456 nm,which slightly shifted to 452 nm in the Zn^2＋-Si TPy and Fe^2＋-Si TPy metalated complexes.The absorbed energy can be further transferred to lanthanide ions（Tb^3＋and Eu^3＋） to give off the typical emissions of the lanthanide complexes together with an emission of the silylated-TPy at about 363 nm.展开更多
基金supported by the National Natural Science Foundation of China(No.31972110)。
文摘Phytosterols have received extensive attention owing to their excellent cholesterol-lowering activity and the role in cardiovascular diseases prevention. However, poor solubility in both oil and water limited the application of free phytosterols in the food industry. Chemical or enzymatic modifications were effective to improve the physicochemical properties as well as the bioavailability and cholesterollowering activity of phytosterols. Higher oil solubility and lower melting point of phytosterols have been achieved by esterification and transesterification with fatty acids and triacylglycerols so as to enhance the bioavailability, reduce formation of precipitates, and improve the sensory quality of products.While the researches on the improvement on its water solubility is a hot topic. Hydrophilic phytosterol derivatives have promising applications in the food industry because most of foods belong to aqueous matrix. Hydrophilic modification is useful and meaningful for phytosterols in both industrial and commercial applications. This review mainly highlights the hydrophilic phytosterol derivatives in the following aspects:(i) hydrophilic modifications of phytosterols by coupling with various polar components;(ii) cholesterol-lowering activity and possible molecular mechanisms of hydrophilic phytosterol derivatives on reducing serum cholesterol level;and(iii) safety evaluation of hydrophilic phytosterol derivatives in cell-culture studies, animal models and clinical trials.
基金supported by National Natural Science Foundation of China (No.21373058)Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1117)
文摘A silylated-terpyridine（Si TPy） derivative was newly synthesized and reacted with various transition metal ions in the solutions and self-assembled monolayers（SAMs）.Composition and morphology of the SAMs were characterized by using absorption spectra,X-ray photoelectron spectra and atomic force microscope.The silylated-TPy compound gave off a luminescent emission at about 456 nm,which slightly shifted to 452 nm in the Zn^2＋-Si TPy and Fe^2＋-Si TPy metalated complexes.The absorbed energy can be further transferred to lanthanide ions（Tb^3＋and Eu^3＋） to give off the typical emissions of the lanthanide complexes together with an emission of the silylated-TPy at about 363 nm.
