Hydroxyapatite coatings were directly prepared on anodized titanium by electro-deposition method in a modified simulated body fluid.The configuration,structure and bioactivity of the coating were investigated with sca...Hydroxyapatite coatings were directly prepared on anodized titanium by electro-deposition method in a modified simulated body fluid.The configuration,structure and bioactivity of the coating were investigated with scanning electron microscopy(SEM),X-ray diffraction analyzer(XRD)and Fourier transform infrared spectros-copy(FTIR)techniques.The results demonstrated that pure and homogeneous hydroxyapatite coating can be obtained without any post-treatment.The prepared coating showed good bioactivity in simulated body fluid(SBF).The time required for a fully covered dense hydroxyapatite coatings was 4 days immersion in SBF.展开更多
HA/316L stainless steel(316L SS) biocomposites were prepared by hot-pressing technique. The formation of bone-like apatite on the biocomposite surfaces in simulated body fluid(SBF) was analyzed by digital pH meter,pla...HA/316L stainless steel(316L SS) biocomposites were prepared by hot-pressing technique. The formation of bone-like apatite on the biocomposite surfaces in simulated body fluid(SBF) was analyzed by digital pH meter,plasma emission spectrometer,scanning electron microscope(SEM) and energy dispersive X-ray energy spectrometer(EDX). The results indicate that the pH value in SBF varies slightly during the immersion. It is a dynamic process of dissolution-precipitation for the formation of apatite on the surface. With prolonging immersion time,Ca and P ion concentrations increase gradually,and then approach equilibrium. The bone-like apatite layer forms on the composites surface,which possesses benign bioactivity and favorable biocompatibility and achieves osseointegration,and can provide firm fixation between HA60/316L SS composite implants and human body bone.展开更多
Excellent firm bonding between the biomaterials and bone tissue (osseointegration and osteo-conductivity) has been desired for the stability in vivo of dental implants and artificial joints. Much has been learned abou...Excellent firm bonding between the biomaterials and bone tissue (osseointegration and osteo-conductivity) has been desired for the stability in vivo of dental implants and artificial joints. Much has been learned about this concept, which has led to significant improvements in the design and surface modification of implants in the field of implant dentistry, orthopedic surgery. We have already reported that low-intensity pulsed ultrasound (LIPUS) irradiation can accelerate the bone bonding ability of the bio-conductive materials such as bioactive titanium and hydroxyapatite implant. However, it is still unclear whether the LIPUS could have same effect to different types of the bioactive-materials. Therefore, in this study, the differences of bone-like hydroxyapatite formation on some kind of hydroxyapatite surface in simulated body fluid (SBF) under the LIPUS irradiation were investigated. Two kinds of hydroxyapatite samples immersed in SBF was exposed to ultrasound waves, the bone-like apatite on the surface was analyzed by Scanning electron microscopy and X-ray diffraction. As a result, the enhancement of hydroxyapatite formation on the surface by LIPUS was confirmed, the initial epitaxial nucleation and crystal growth of apatite depended on crystal structure of the surface of matrix materials.展开更多
采用纳米羟基磷灰石(hydroxyapatite,HA)粉体与聚氨酯(polyurethane,PU)复合,制备了多孔HA/PU支架材料,通过模拟体液(simulated body fluid,SBF)浸泡试验评估支架材料的降解性和生物活性。用等离子体原子发射光谱仪测定了浸提液中钙离...采用纳米羟基磷灰石(hydroxyapatite,HA)粉体与聚氨酯(polyurethane,PU)复合,制备了多孔HA/PU支架材料,通过模拟体液(simulated body fluid,SBF)浸泡试验评估支架材料的降解性和生物活性。用等离子体原子发射光谱仪测定了浸提液中钙离子浓度变化,评估钙离子在支架材料表面的沉积;用电子天平测定了支架材料浸泡前后的质量损失,分析材料的降解性。用X射线衍射、红外光谱分析支架材料浸泡前后结构组成变化,并用扫描电镜观察其表面形貌特征。结果表明:HA/PU支架材料在SBF中,随浸泡时间的延长,材料均有不同程度的降解,PU的降解主要来自于水解。随着PU的降解,表面HA含量增加、溶液中的Ca,P离子过饱和,并与水解的基团成核,在支架材料表面形成一层结晶性较差的钙磷层,使得复合支架随着浸泡时间的延长而表现出最佳的体外生物活性。展开更多
目的 探讨不同模拟体液对HA涂层体外生物学行为的影响。方法采用等离子体喷涂法,在碳／碳复合材料表面制备HA涂层,并对涂层进行了热处理。利用X射线衍射仪(X-ray diffraction)、扫描电子显微镜(Scanning electron microscopy)等检测手段...目的 探讨不同模拟体液对HA涂层体外生物学行为的影响。方法采用等离子体喷涂法,在碳／碳复合材料表面制备HA涂层,并对涂层进行了热处理。利用X射线衍射仪(X-ray diffraction)、扫描电子显微镜(Scanning electron microscopy)等检测手段,分析该涂层的物相和形貌,观察HA涂层在模拟体液中的影响。结果XRD检测结果表明,在模拟体液浸泡过程中,涂层的主要组成相的相对含量和结晶度不断发生变化。由SEM分析结果可知,在浸泡过程中,内送粉方式下制得的HA涂层的表面沉积物呈现近似网状的结构。同时,在Ringer溶液中,可以观察到HA涂层溶解痕迹。结论通过适当的热处理可以恢复HA的结构完整性,同时提高涂层的结晶度。展开更多
基金Supported by the Young Scholars Fund of Beijing University of Chemical Technology(QN0713)
文摘Hydroxyapatite coatings were directly prepared on anodized titanium by electro-deposition method in a modified simulated body fluid.The configuration,structure and bioactivity of the coating were investigated with scanning electron microscopy(SEM),X-ray diffraction analyzer(XRD)and Fourier transform infrared spectros-copy(FTIR)techniques.The results demonstrated that pure and homogeneous hydroxyapatite coating can be obtained without any post-treatment.The prepared coating showed good bioactivity in simulated body fluid(SBF).The time required for a fully covered dense hydroxyapatite coatings was 4 days immersion in SBF.
基金Project(50774096) and project (50604017) supported by the National Natural Science Foundation of ChinaProject(1343-74334000011) supported by the Postgraduate Education and Innovation Project from Central South University, China
文摘HA/316L stainless steel(316L SS) biocomposites were prepared by hot-pressing technique. The formation of bone-like apatite on the biocomposite surfaces in simulated body fluid(SBF) was analyzed by digital pH meter,plasma emission spectrometer,scanning electron microscope(SEM) and energy dispersive X-ray energy spectrometer(EDX). The results indicate that the pH value in SBF varies slightly during the immersion. It is a dynamic process of dissolution-precipitation for the formation of apatite on the surface. With prolonging immersion time,Ca and P ion concentrations increase gradually,and then approach equilibrium. The bone-like apatite layer forms on the composites surface,which possesses benign bioactivity and favorable biocompatibility and achieves osseointegration,and can provide firm fixation between HA60/316L SS composite implants and human body bone.
文摘Excellent firm bonding between the biomaterials and bone tissue (osseointegration and osteo-conductivity) has been desired for the stability in vivo of dental implants and artificial joints. Much has been learned about this concept, which has led to significant improvements in the design and surface modification of implants in the field of implant dentistry, orthopedic surgery. We have already reported that low-intensity pulsed ultrasound (LIPUS) irradiation can accelerate the bone bonding ability of the bio-conductive materials such as bioactive titanium and hydroxyapatite implant. However, it is still unclear whether the LIPUS could have same effect to different types of the bioactive-materials. Therefore, in this study, the differences of bone-like hydroxyapatite formation on some kind of hydroxyapatite surface in simulated body fluid (SBF) under the LIPUS irradiation were investigated. Two kinds of hydroxyapatite samples immersed in SBF was exposed to ultrasound waves, the bone-like apatite on the surface was analyzed by Scanning electron microscopy and X-ray diffraction. As a result, the enhancement of hydroxyapatite formation on the surface by LIPUS was confirmed, the initial epitaxial nucleation and crystal growth of apatite depended on crystal structure of the surface of matrix materials.
文摘采用纳米羟基磷灰石(hydroxyapatite,HA)粉体与聚氨酯(polyurethane,PU)复合,制备了多孔HA/PU支架材料,通过模拟体液(simulated body fluid,SBF)浸泡试验评估支架材料的降解性和生物活性。用等离子体原子发射光谱仪测定了浸提液中钙离子浓度变化,评估钙离子在支架材料表面的沉积;用电子天平测定了支架材料浸泡前后的质量损失,分析材料的降解性。用X射线衍射、红外光谱分析支架材料浸泡前后结构组成变化,并用扫描电镜观察其表面形貌特征。结果表明:HA/PU支架材料在SBF中,随浸泡时间的延长,材料均有不同程度的降解,PU的降解主要来自于水解。随着PU的降解,表面HA含量增加、溶液中的Ca,P离子过饱和,并与水解的基团成核,在支架材料表面形成一层结晶性较差的钙磷层,使得复合支架随着浸泡时间的延长而表现出最佳的体外生物活性。
文摘目的 探讨不同模拟体液对HA涂层体外生物学行为的影响。方法采用等离子体喷涂法,在碳／碳复合材料表面制备HA涂层,并对涂层进行了热处理。利用X射线衍射仪(X-ray diffraction)、扫描电子显微镜(Scanning electron microscopy)等检测手段,分析该涂层的物相和形貌,观察HA涂层在模拟体液中的影响。结果XRD检测结果表明,在模拟体液浸泡过程中,涂层的主要组成相的相对含量和结晶度不断发生变化。由SEM分析结果可知,在浸泡过程中,内送粉方式下制得的HA涂层的表面沉积物呈现近似网状的结构。同时,在Ringer溶液中,可以观察到HA涂层溶解痕迹。结论通过适当的热处理可以恢复HA的结构完整性,同时提高涂层的结晶度。
