Cement mortar with carbon fiber(CFc)and resin-cement mortar with carbon fiber(CFrc)were used as inner and outer cores of smart aggregate with Z shape,respectively,which was used as the basic perception units to prepar...Cement mortar with carbon fiber(CFc)and resin-cement mortar with carbon fiber(CFrc)were used as inner and outer cores of smart aggregate with Z shape,respectively,which was used as the basic perception units to prepare smart concrete aggregate with a mosaic structure(SAMS).The hydroxpropyl methylcellulose(HPMC)was taken into consideration to improve the properties of mortar;by using HPMC,the structure of SAMS was optimized and its mechanical and electrical properties were evaluated.The experimental results show that the toughness of mortar could be improved by the complex that formed by epoxy resin,and the effect of HPMC on the flexibility of CFc was greater than that on the flexibility of CFrc;the feasible designing indicates that the CFc-Z core and CFrc-Z core could be used as inner and outer cores of SAMS.When the proposed dosages of HPMC in inner and outer cores are 0.35wt%and 0.2wt%,respectively,it could give an effective prediction for the damage of concrete during the loading process.展开更多
The aims of this study were to prepare and characterize hydroxypropyl methylcellulose(HPMC)/polycarbophil(PC) mucoadhesive blend films saturated with propranolol hydrochloride(PNL)-loaded nanoparticles to improve perm...The aims of this study were to prepare and characterize hydroxypropyl methylcellulose(HPMC)/polycarbophil(PC) mucoadhesive blend films saturated with propranolol hydrochloride(PNL)-loaded nanoparticles to improve permeability of drugs that undergo firstpass metabolism. An ionic cross-linking method and film casting technique was used to prepare nanoparticles and mucoadhesive blend films, respectively. Increasing concentrations of PNL(70, 80, 90 mg/film) in HPMC/PC blend films containing PNL-loaded nanoparticles(PN-films) and HPMC/PC blend films containing PNL(80 mg/film) without nanoparticles(PPfilms) were prepared to test swelling, mucoadhesiveness, release, permeation and physicochemical properties. Scanning electron microscope(SEM) images showed a partially smooth surface with a wrinkled occurrence and spherically shaped, well-dispersed nanoparticles on the surface of PN-films containing PNL 80 mg/film(PN-films-80). The size of the nanoparticles on the surface of PN-films-80 was around 100 nm, which was similar to the nanoparticle size observed using light scattering technique. The swelling index(SI)of all PN-films and PP-films increased greatly in the first period time(10–20 min) and reached swelling equilibrium at 20 min and 30 min, respectively. For the PN-films, the concentration of PNL influenced the mucoadhesive properties and tended to be higher when the amount of PNL increased. Immediate release of all blend film formulations was found in early time points(10–30 min). After 120 min, the release of PN-films-70 was lower than the other PNfilms. Permeation studies using porcine buccal mucosa showed that inclusion of nanoparticles in the films increased the permeability of PNL compared to PP-films. Therefore, buccal administration of mucoadhesive blend films containing PNL-loaded nanoparticles could be a promising approach for drugs that undergo first-pass metabolism.展开更多
基金Funded by the Natural Science Foundation of Fujian Province(No.2016J01241)the National Natural Science Foundation of China(No.51608212)。
文摘Cement mortar with carbon fiber(CFc)and resin-cement mortar with carbon fiber(CFrc)were used as inner and outer cores of smart aggregate with Z shape,respectively,which was used as the basic perception units to prepare smart concrete aggregate with a mosaic structure(SAMS).The hydroxpropyl methylcellulose(HPMC)was taken into consideration to improve the properties of mortar;by using HPMC,the structure of SAMS was optimized and its mechanical and electrical properties were evaluated.The experimental results show that the toughness of mortar could be improved by the complex that formed by epoxy resin,and the effect of HPMC on the flexibility of CFc was greater than that on the flexibility of CFrc;the feasible designing indicates that the CFc-Z core and CFrc-Z core could be used as inner and outer cores of SAMS.When the proposed dosages of HPMC in inner and outer cores are 0.35wt%and 0.2wt%,respectively,it could give an effective prediction for the damage of concrete during the loading process.
基金the financial support provided by Thammasat University under the TU Research Scholar,Contract No.TP 2/68/2556
文摘The aims of this study were to prepare and characterize hydroxypropyl methylcellulose(HPMC)/polycarbophil(PC) mucoadhesive blend films saturated with propranolol hydrochloride(PNL)-loaded nanoparticles to improve permeability of drugs that undergo firstpass metabolism. An ionic cross-linking method and film casting technique was used to prepare nanoparticles and mucoadhesive blend films, respectively. Increasing concentrations of PNL(70, 80, 90 mg/film) in HPMC/PC blend films containing PNL-loaded nanoparticles(PN-films) and HPMC/PC blend films containing PNL(80 mg/film) without nanoparticles(PPfilms) were prepared to test swelling, mucoadhesiveness, release, permeation and physicochemical properties. Scanning electron microscope(SEM) images showed a partially smooth surface with a wrinkled occurrence and spherically shaped, well-dispersed nanoparticles on the surface of PN-films containing PNL 80 mg/film(PN-films-80). The size of the nanoparticles on the surface of PN-films-80 was around 100 nm, which was similar to the nanoparticle size observed using light scattering technique. The swelling index(SI)of all PN-films and PP-films increased greatly in the first period time(10–20 min) and reached swelling equilibrium at 20 min and 30 min, respectively. For the PN-films, the concentration of PNL influenced the mucoadhesive properties and tended to be higher when the amount of PNL increased. Immediate release of all blend film formulations was found in early time points(10–30 min). After 120 min, the release of PN-films-70 was lower than the other PNfilms. Permeation studies using porcine buccal mucosa showed that inclusion of nanoparticles in the films increased the permeability of PNL compared to PP-films. Therefore, buccal administration of mucoadhesive blend films containing PNL-loaded nanoparticles could be a promising approach for drugs that undergo first-pass metabolism.
