目的:探讨三维适形放疗联合盆腔热疗的疗效,安全性,以及对患者免疫功能的影响.方法:46例复发直肠癌患者按收治的时间顺序交替分为两组.A组三维适形放疗联合盆腔热疗组,B组为单纯三维适形放射治疗组,比较两组的疗效、不良反应和免疫功能...目的:探讨三维适形放疗联合盆腔热疗的疗效,安全性,以及对患者免疫功能的影响.方法:46例复发直肠癌患者按收治的时间顺序交替分为两组.A组三维适形放疗联合盆腔热疗组,B组为单纯三维适形放射治疗组,比较两组的疗效、不良反应和免疫功能.结果:A组中位局部无进展生存期较B组显著延长(16.3 mo vs 14.1 mo,P<0.05);对患者外周血T淋巴细胞亚群分析表明:A组治疗后CD3+、CD4+水平以及CD4+/CD8+比值较治疗前显著增加(CD3+:65.40%±6.18%vs 56.90%±6.16%;CD4+:32.70%±6.37%vs 28.30%±6.33%;CD4+/CD8+比值:1.24±0.23 vs 0.96±0.28,均P<0.05).B组上述指标变化无统计学差异;不良反应主要为直肠急性放射性反应,均可耐受;两组患者局部症状缓解率、1年生存率、2年生存率比较无显著差异.结论:三维适形放疗联合盆腔热疗与单纯三维适形放射治疗相比可延长患者中位局部无进展生存期,耐受性好,可明显提高患者免疫功能.展开更多
Average size of hematite and magnetite micro and nanopowders and polydispersity index, zeta potential and distribution of particles were studied. Analysis showed that average size of the obtained particles for magneti...Average size of hematite and magnetite micro and nanopowders and polydispersity index, zeta potential and distribution of particles were studied. Analysis showed that average size of the obtained particles for magnetite is 740.9 nm, for hematite particles 30 - 35 nm. Alternate current feed source was created for hyperthermia. Proceeding from the requirements of the objectives, the U type MnZn material magneto conductors were selected, in which 10.0 and 8.0 mm width gaps were cut and glass test tubes with magnetite or hematite suspensions were placed in them. Series of experiments at various field intensity and frequencies showed that for efficient magnetic hyperthermia therapy more powerful device was needed with frequency of up to 10 Mega Hertz to achieve the temperature 43°C - 45°C necessary for full activation of Neel and Brown mechanisms in particles. At the next stage, on the basis of experimental material the anticancer mono-therapeutic effect of hyperthermia and its adjuvant action in poly chemotherapeutic treatment was presented by the use of a device created by us “Lezi”. As a result of the experiment it was shown that in all animals (outbred albino mice, 3 months old) inhibition of cancer growth was fixed and intratumoral necrosis was developed, while after 7 and 10 sessions tumors were ulcerated, which refers to positive effect of the experiment (Conclusion of Pathologicanatomical Laboratory “PATGEO”, Tbilisi, Georgia ).展开更多
文摘目的:探讨三维适形放疗联合盆腔热疗的疗效,安全性,以及对患者免疫功能的影响.方法:46例复发直肠癌患者按收治的时间顺序交替分为两组.A组三维适形放疗联合盆腔热疗组,B组为单纯三维适形放射治疗组,比较两组的疗效、不良反应和免疫功能.结果:A组中位局部无进展生存期较B组显著延长(16.3 mo vs 14.1 mo,P<0.05);对患者外周血T淋巴细胞亚群分析表明:A组治疗后CD3+、CD4+水平以及CD4+/CD8+比值较治疗前显著增加(CD3+:65.40%±6.18%vs 56.90%±6.16%;CD4+:32.70%±6.37%vs 28.30%±6.33%;CD4+/CD8+比值:1.24±0.23 vs 0.96±0.28,均P<0.05).B组上述指标变化无统计学差异;不良反应主要为直肠急性放射性反应,均可耐受;两组患者局部症状缓解率、1年生存率、2年生存率比较无显著差异.结论:三维适形放疗联合盆腔热疗与单纯三维适形放射治疗相比可延长患者中位局部无进展生存期,耐受性好,可明显提高患者免疫功能.
文摘Average size of hematite and magnetite micro and nanopowders and polydispersity index, zeta potential and distribution of particles were studied. Analysis showed that average size of the obtained particles for magnetite is 740.9 nm, for hematite particles 30 - 35 nm. Alternate current feed source was created for hyperthermia. Proceeding from the requirements of the objectives, the U type MnZn material magneto conductors were selected, in which 10.0 and 8.0 mm width gaps were cut and glass test tubes with magnetite or hematite suspensions were placed in them. Series of experiments at various field intensity and frequencies showed that for efficient magnetic hyperthermia therapy more powerful device was needed with frequency of up to 10 Mega Hertz to achieve the temperature 43°C - 45°C necessary for full activation of Neel and Brown mechanisms in particles. At the next stage, on the basis of experimental material the anticancer mono-therapeutic effect of hyperthermia and its adjuvant action in poly chemotherapeutic treatment was presented by the use of a device created by us “Lezi”. As a result of the experiment it was shown that in all animals (outbred albino mice, 3 months old) inhibition of cancer growth was fixed and intratumoral necrosis was developed, while after 7 and 10 sessions tumors were ulcerated, which refers to positive effect of the experiment (Conclusion of Pathologicanatomical Laboratory “PATGEO”, Tbilisi, Georgia ).
