目的探讨高压氧（hyperbaricoxygen，HBO）不同介入时机治疗对轻中度颅脑损伤后认知功能及日常活动能力的影响。方法将165例轻中度颅脑损伤后认知功能障碍患者随机分为3组．年龄17～53岁．平均年龄32．0岁．分别于伤后7天～1个月（A组...目的探讨高压氧（hyperbaricoxygen，HBO）不同介入时机治疗对轻中度颅脑损伤后认知功能及日常活动能力的影响。方法将165例轻中度颅脑损伤后认知功能障碍患者随机分为3组．年龄17～53岁．平均年龄32．0岁．分别于伤后7天～1个月（A组）、伤后1～3个月（B组）和伤后3个月（C组）介入高压氧治疗。治疗前后分别采用神经行为认知状态检查表（neurobehavioral cognitive status examination，NCSE）、Barthel指数评定法评定3组患者的认知功能、日常生活活动能力。结果3组患者治疗前后和组间的NCSE和Barthel指数评定法评分比较差异有统计学意义（P〈0．05）．且评分的变化均数比较显示伤后7天～1个月介入高压氧治疗患者的ADL和认知功能恢复显著优于后两组（P〈0．01）。结论早期介入高压氧治疗能明显改善轻中度颅脑损伤后认知功能和日常活动能力。展开更多
Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) t...Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.展开更多
文摘目的探讨高压氧（hyperbaricoxygen，HBO）不同介入时机治疗对轻中度颅脑损伤后认知功能及日常活动能力的影响。方法将165例轻中度颅脑损伤后认知功能障碍患者随机分为3组．年龄17～53岁．平均年龄32．0岁．分别于伤后7天～1个月（A组）、伤后1～3个月（B组）和伤后3个月（C组）介入高压氧治疗。治疗前后分别采用神经行为认知状态检查表（neurobehavioral cognitive status examination，NCSE）、Barthel指数评定法评定3组患者的认知功能、日常生活活动能力。结果3组患者治疗前后和组间的NCSE和Barthel指数评定法评分比较差异有统计学意义（P〈0．05）．且评分的变化均数比较显示伤后7天～1个月介入高压氧治疗患者的ADL和认知功能恢复显著优于后两组（P〈0．01）。结论早期介入高压氧治疗能明显改善轻中度颅脑损伤后认知功能和日常活动能力。
基金supported by Natural Science Research of Jiangsu Higher Education Institutions of China(No.19KJB320002)the Science and Technology Project of Nantong City China(No.JC2020010)+4 种基金a Research Startup Fund of Nantong UniversityYihua Wang was supported by the UK Medical Research Council(No.MR/S025480/1)the UK Royal Society(No.IEC/NSFC/191030)Zhenglin Jiang was supported by the National Natural Science Foundation of China(No.82171869 and 81671859)Xia Li was supported by the Science and Technology Project of Nantong City China(No.MS12020019 and JC2021079).
文摘Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.
