Effects of telmisartan combined with nifedipine controlled release tablet on inflammatory factors, vascular endothelial function and left ventricular function in patients with coronary heart disease with mild to moderate hypertension

Objective: To investigate the effect of telmisartan combined with Nifedipine Controlled Release Tablet on inflammatory factors, vascular endothelial function and left ventricular function in patients with coronary heart disease with mild to moderate hypertension. Methods:A total of 92 cases of patients with coronary heart disease with mild to moderate hypertension were selected as the object of observation, according to the random data table, they were divided into the control group (n=46) and observation group (n=46), and patients in the control group were treated with Nifedipine Controlled Release Table therapy, on this basis, the observation group patients were given telmisartan treatment, two groups were treated for 6 months. The levels of the blood pressure, inflammatory factors, vascular endothelial function and left ventricular function compared between the two groups before and after treatment. Results: There were no significant differences in the levels of SBP, DBP, hs-CRP, TNF-α, NO, ET-1, LVEF, LVEDD and LVESD in the two groups before treatment. After treatment, two groups of SBP, DBP, hs-CRP, TNF-α, ET-1, LVEDD and LVESD levels were significantly lower than those in the same group before treatment, and after treatment, the levels of SBP, DBP, hs-CRP, TNF-α, ET-1 and LVESD in the observation group were significantly lower than those in the control group, while there were no significant difference in the level of LVEDD between the two groups after treatment;Compared with level in the group before treatment, the levels of NO and LVEF in the two groups were significantly increased, and the observation group [(82.13±19.01) μmol/L, (52.83±7.45)%] was significantly higher than the control group ((67.37±13.08) μmol/L, (49.47±6.96)%)Conclusion: Telmisartan combined with Nifedipine Controlled Release Table in treating coronary heart disease with mild to moderate hypertension, can effectively control blood pressure, reduce the inflammatory stress, improve vascular endothelial function and left ventricular function of patients, has an important clinical value.

Blood Pressure Variability and Its Relationship with Cognitive Function in Elderly Patients with Essential Hypertension and Type 2 Diabetes

Objective: To investigate blood pressure variability of Elder hypertensives with type 2 diabetes and its relationship with cognition. Methods: A total of 143 elderly hypertensives were enrolled and divided into diabetic group (59 cases) and non-diabetic group (84 cases). The difference of general clinical characteristics, biochemical parameters, carotid ultrasound, a neuropsychological Scales and 24-hour ambulatory blood pressure (24hABPM) parameters between the two groups of subjects were compared. Then, the two groups (diabetic group and non-diabetic group) were further divided into (Mild cognitive dysfunction) subgroup (MMSE>26) and normal cognition subgroup (MMSE≤26), respectively. On the basis of MMSE scores, the difference of the parameters of ABPM between the two subgroups was analyzed. Results: Compared with the control group, 24hSBP, 24hPP, dSBP, dPP, nSBP, nPP, 24hSSD, dSSD, nSSD, 24hSCV, dSCV and nSCV were significantly higher in the diabetic group (p<0.05). However, cognition was lower in the diabetic group. No significant difference was found in the circadian pattern of blood pressure between the two groups. 24hSSD, dSSD, nSSD, 24hSCV, dSCV, nSCV were significantly higher in the MCI subgroup than normal cognition subgroup in both diabetic and non-diabetic groups(p<0.05), and they were negatively associated with scores of MMSE, the correlation coefficient were -0.235,-0.246,-0.341,-0.158,-0.222,-0.238 (0.001≤P<0.05). Conclusion: The study showed that in the elderly with hypertension, the mean systolic blood pressure and blood pressure variability were both higher in the diabetic group, and the cognition was lower instead. Whether or not with diabetes, blood pressure variability was always higher in the MCI subgroup. Blood pressure variability increased in patients with diabetes, and was associated with cognitive decline.

Effect of Dendrobium nobile powder combined with conventional therapy on mild to moderate fatty liver

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)encompasses a variety of liver conditions impacting individuals who consume minimal or no alcohol.Recently,traditional Chinese medicine has been gradually used to treat mild to moderate fatty liver,among which Dendrobium nobile Lindl.powder has been affirmed by many doctors and patients to be effective.However,there is limited research on combining this treatment with standard therapies for mild to moderate NAFLD.AIM To survey the effect of combining Dendrobium nobile Lindl.powder with standard treatment on liver function and lipid metabolism disorder in patients with mild to moderate NAFLD.METHODS Eighty patients with mild to moderate NAFLD participated in this retrospective study,classified into two groups:The observation group(n=40)and the control group(n=40).In November 2020 and November 2022,the study was conducted at People’s Hospital of Chongqing Liang Jiang New Area.The control group received standard treatment,while the observation group received Dendrobium nobile Lindl.powder based on the control group.The study compared differences in traditional Chinese medicine clinical syndrome scores,liver fibrosis treatment,liver function indicators,lipid levels,and serum inflammatory factor levels before and after treatment,and we calculated the incidence of adverse reactions for both groups.RESULTS The total effective rate was 97.50%in the observation group and 72.5%in the control group.After 8 weeks of treatment,the main and secondary symptom scores remarkably decreased,especially in the observation group(P<0.05),and there was a significant reduction in the serum levels of hyaluronic acid(HA),laminin(LN),human rocollagen III(PC III),and collagen type IV(CIV).The levels of HA,LN,PC III,and CIV were significantly lower in the observation group(P<0.05).After 8 weeks,both groups indicated remarkable improvements in liver function and blood lipid levels,with the observation group having even lower levels(P<0.05).Serum levels of interleukin-1β,tumor necrosis factor-α,and interleukin-8 also dropped significantly.The observation group had a lower rate of adverse reactions(5.00%)compared to the control group(22.50%).CONCLUSION Adding Dendrobium nobile Lindl.powder to standard treatment has been found to remarkably improve symptoms and reduce inflammation in patients with mild to moderate fatty liver disease.It also enhances hepatic function and lipid profile,ameliorates liver fibrosis indices,and lowers the risk of side effects.Consequently,this therapeutic protocol shows promise for clinical implementation and dissemination.

The clinical efficiency and safety of bisorpolol hydrochlorothiazide in patients with mild to moderate essential hypertension

Objective To investigate the efficacy and safety of bisorpolol/hydroehlorothiazide (Lodoz) in patients with mild and moderate essential hypertension. Methods After 2 weeks of placebo run-in period, 90 hypertensive patients with sitting diastolic blood pressure (DBP) between 95 and 109 mm Hg(1 mm Hg =0. 133 kPa) and systolic blood pressure (SBP) below 180 mm Hg were treated by Lodoz(2. 5 mg/6. 25 mg/day) for 4 weeks.

Quality of life of patients with mild hypertension treated with captopril:a randomized double-blind placebo-controlled clinical trial

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MILD粉体燃烧技术研究进展与关键问题分析

MILD燃烧是一种在中度或极度低氧环境下发生的温和燃烧模式,兼具高燃烧热利用率和极低NOx排放的优势,国际燃烧领域认为它是拥有巨大应用潜力的清洁燃烧技术之一。自1990年左右开展相关研究以来,对于实现气体燃料的MILD燃烧的相关技术已相对成熟,而关于煤粉和生物质等固体燃料的MILD燃烧机制和实现条件的研究仍相对缺乏。基于高动量氧化剂射流来实现内部再循环,不再需要外部高温预热来建立MILD燃烧,极大拓宽了MILD燃烧的应用范围。从颗粒弥散、受热、着火、燃烧、污染物等方面概述了MILD粉体燃料燃烧的基础特性,由于颗粒的不均匀弥散和反应,煤粉等碳基固体燃料的MILD燃烧进程较气体燃料更复杂。高速射流MILD燃烧在增加点火延迟的同时也扩展了点火区和反应区,需要对燃烧各阶段的特征和机理开展系统研究。介绍了固体燃料MILD燃烧理论设计和装备研发领域所取得的研究成果,建议通过高精度数值模拟,改进现有燃煤锅炉燃烧器、调节工艺参数以匹配MILD燃烧模式,增加焦炭颗粒的停留时间以提高燃烬率,提高燃烧稳定性并抑制包括细颗粒物在内的各类污染物排放。基于互联能源系统的整体方法,推进MILD燃烧与各类新型燃烧技术的耦合研究,尤其加强煤粉、生物质与氢、氨等可燃气体共燃特性研究,助力能源转型。探究粉体MILD燃烧中的湍流两相流特征、湍流相间传热作用以及湍流-化学耦合作用是加深对粉体MILD燃烧理解的关键,涉及多变量分析和高精度模拟,是未来研究的重点和难点。

高速射流煤粉MILD燃烧的研究进展

开发清洁高效的煤粉燃烧技术是应对我国乃至世界范围内日益严峻的环境污染问题的重要途径,煤粉低氧稀释(MILD)燃烧技术凭借其降低NOx排放、提高热流密度均匀性等优势而被视为颇具潜力的新型燃烧方式。同时,煤粉MILD技术结合富氧燃烧技术将是未来煤炭利用过程中减少碳排放的重要方向。综述了国内外煤粉MILD燃烧的发展历程、技术特点、研究现状等,并重点针对低温预热条件下的高速射流煤粉MILD燃烧技术探讨了研究中的关键问题和研究挑战等。煤粉MILD燃烧起源于气体燃料MILD燃烧,通过增强流场对高温烟气的卷吸并稀释反应物,使高温的火焰锋面模糊甚至消失,降低燃烧峰值温度并提升温度分布的均匀性,进而显著抑制了热力型NOx和燃料型NOx的生成。煤粉MILD燃烧可通过高温预热空气或提高射流速度实现,其中后者以其在经济性和可行性上的优势而更具发展前景,然而在速度达到100 m/s左右的高速射流的强烈剪切、湍流混合条件下的煤粉MILD燃烧机理及特性研究仍有待深入开展。在高速射流强烈剪切及卷吸作用下,煤粉弥散行为与常规射流燃烧相比有明显差异,而煤粉的弥散程度又直接关系到能否实现MILD燃烧。此外,强湍流混合会改变煤粉的升温、脱挥发分、焦炭燃烧等过程,进而影响着火延迟、火焰结构和污染物生成等煤粉燃烧过程中的关键问题。基于对上述关键问题的深入了解并结合气体燃料MILD燃烧的相关研究基础,可进一步发展针对煤粉MILD燃烧的系统、准确的定义,以更好地指导煤粉MILD燃烧技术的研究与应用。

Can a Subcapital Osteotomy Fixed with an Intramedullary Locking Plate Correct all Possible Deformities of a Mild to Moderate Hallux Valgus?

Background: There are at least 5 very popular methods described for the correction of mild to moderate hallux valgus deformities. Despite of reported and self experienced good results in favorable fitting preoperative anatomical conditions of some of these methods;it seems that no one is really satisfying under “difficult” or non favorable preoperative anatomic conditions. How could an optimum operation method for a satisfying correction of a mild to moderate hallux valgus look like? The well known criteria for an optimally satisfying method to achieve full normalization of important forefoot parameters under all conditions should be a lateralization, plantarization and derotation of the Ist metatarsal head and also a normalization of the distal metatarsal articular angle (DMAA) in combination with a soft tissue correction. Methods: In order to achieve this outcome without the disadvantages of shortening or the need for unloading, we developed a new operation technique and new fixation devices. We performed a simple transverse lazy-L subcapital osteotomy and after an additional soft tissue release the Ist metatarsal head was restored to its preplaned optimum position in terms of narrowing the IM angle, plantarization, correction of the hallux valgus angle, derotation of a pronation l malrotation and improvement of the DMAA. Fixation was achieved with an intramedullary angel-stable transfixed 30 mm titanium plate. The rigidity of the implant rendered interfragmental compression or solid bone contact unnecessary. The goal was only an optimal correction. All patients were allowed to ambulate with full weightbearing immediately after the operation. Results: We retrospectively reviewed 346 patients (433 feet) who underwent subcapital osteotomy between May 2007 and December 2011;308 were women and 38 men;their mean age was 65 years. The follow-up investigation was performed on average after 6.5 years (78 months);range 5.5 to 10 years (66 to 120 months). The AOFAS Score improved from 61.18 to 96.82 (t = 55.13, p ° to 4.21° (t = 89.70, p ° to 7.75° (t = 51.68, p ° to 6.61° (t = 29.34, p < 0.001). Minimal shortening of the first metatarsal (0.33 mm) and no recurrence of the deformity was observed. Conclusion: A new access to hallux valgus surgery is presented. Our results show that interfragmental compression between the osteotomy partners or good interfragmental contact is not necessary when a rigid intramedullary fixation device is used. The goal of this approach to hallux valgus surgery was to achieve excellent correction and a very rigid intramedullary angle-stable locked implant. The procedure yielded excellent results and was associated with no recurrence of hallux valgus.

Effects of mild hypothermia irrigation fluid on nerve function and oxidative stress during intracranial hematoma irrigation

Objective: To study the effects of mild hypothermia irrigation fluid on nerve function and oxidative stress during intracranial hematoma irrigation. Methods: The patients with hypertensive cerebral hemorrhage who received hematoma aspiration in our hospital between August 2014 and November 2017 were chosen and randomly divided into the observation group who received mild hypothermia irrigation fluid and the control group who received room temperature irrigation fluid. Before treatment and 72 h after treatment, the contents of nerve injury markers, cytokines and oxidative stress mediators were measured after peripheral blood extraction and serum separation. Results: Compared with those of control group, serum neuron-specific enolase (NSE), visinin-like protein-1 (VILIP-1), glial fibrillary acidic protein (GFAP), neuropeptide Y (NPY), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), high mobility group protein B1 (HMGB1), macrophage migration inhibitory factor (MIF), interleukin-1β (IL-1β), interleukin-10 (IL-10), malondialdehyde (MDA), 8-OHdG and nitric oxide (NO) contents of observation group were significantly lower whereas serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and total antioxidant capacity (TAOC) contents were significantly higher after treatment (P<0.05). Conclusion: The application of mild hypothermia irrigation fluid during intracranial hematoma irrigation can alleviate the nerve function injury, improve the neurotrophic status and inhibit the oxidative stress response.

Jian Nao Ning for Treatment of Memory Impairment in Patients with Mild or Moderate Multi-infarct Dementia

Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.

Effects of mild hypothermia combined with minimally invasive surgery on the degree of nerve injury and the generation of toxic metabolites in patients with hypertensive cerebral hemorrhage

Objective: To explore the effects of mild hypothermia combined with minimally invasive surgery on the degree of nerve injury and the generation of toxic metabolites in patients with hypertensive cerebral hemorrhage. Methods: A total of 138 patients with hypertensive cerebral hemorrhage who received treatment in the hospital between December 2015 and March 2017 were collected and divided into control group (n=69) and mild hypothermia group (n=69) by random number table method. Control group received conventional minimally invasive surgery, and mild hypothermia group received mild hypothermia combined with minimally invasive surgery. The differences in the serum contents of nerve injury indexes, excitatory amino acids and oxidative metabolites were compared between two groups of patients before treatment and after 1 week of treatment. Results: There was no statistically significant difference in serum levels of nerve injury indexes, excitatory amino acids and oxidative metabolites between the two groups. 1 week after treatment, serum pro-BNP, h-FABP, MBP and NSE levels of mild hypothermia group were lower than those of control group;serum excitatory amino acids Glu and Asp levels were lower than those of control group;oxidative metabolites ROS, MDA, AOPPs and LHP levels were lower than those of control group. Conclusion: Mild hypothermia combined with minimally invasive surgery can effectively relieve the nerve injury and reduce the secretion of excitatory amino acids, oxidative metabolites and so on in patients with hypertensive cerebral hemorrhage.

The Mild-Moderate Case Presentation of COVID-19 in Adult Male Patient, Al Wakra Study

Background: COVID-19 is currently one of the most infectious diseases worldwide. In this study, we focused on the mild and moderate cases of COVID-19 that can present with mild respiratory symptoms or non-respiratory symptoms. Many of that cases got miss diagnoses. We aim to help emergency physicians in reaching a proper and faster diagnosis of COVID-19 cases. Method: In this retrospective cross-sectional qualitative study, we collected 100 confirmed cases of COVID-19 that were presented in April 2020 in Al Wakra Hospital, Qatar. All that cases were mild-moderate cases without severe respiratory symptoms. We reviewed the electronic files on patient presentation, emergency department physician’s note, temperature data, and chest X-ray findings. Result: Our result showed about 49% of the total COVID-19 confirmed cases had respiratory symptoms, while the remaining 51% had no respiratory symptoms. The respiratory symptoms, such as cough and sore throat, and non-respiratory symptoms like headache, vomiting, abdominal pain, and skin rash. Regarding fever presentation, we found that 66% of cases had a fever, while 34% had no fever complaints. The most frequently observed body temperature of patients was 37+ °C, followed by 38+ °C, 36+ °C, and 39+ °C. About 41% of cases had non-significant X-ray findings, and 40% cases had significant X-ray findings. The remaining 19% of cases did not undergo any X-ray examination due to mild and stable presentation. Conclusion: The presentations and symptoms of a mild-moderate case of COVID-19 are not respiratory only, there are extra-pulmonary symptoms and presentations should be considered. The most common presentation for mild-moderate COVID-19 was found to be fever. Chest X-ray may be performed depending on the patient’s condition, red flags, and abnormal findings in clinical examination, and should not be routine in cases with the mild presentation of COVID-19 suspicion in the emergency department.

八段锦联合放松功对轻中度抑郁的影响研究

【目的】探究中医行为心理疗法八段锦联合放松功干预轻中度抑郁的效果。【方法】将40例轻中度抑郁患者随机分为干预组和对照组,每组各20例。干预组给予八段锦锻炼联合放松功干预治疗,对照组给予西药氢溴酸西酞普兰片治疗,疗程为6周。观察2组患者干预前后汉密尔顿抑郁量表(HAMD)评分、蒙哥马利抑郁量表(MADRS)评分、匹兹堡睡眠质量指数(PSQI)评分以及生活质量综合评定问卷(GQOL-74)评分的变化情况,并评价2组患者的抑郁改善疗效。【结果】(1)抑郁改善疗效方面,治疗6周后,干预组的总有效率为95.0%(19/20),对照组为90.0%(18/20),组间比较(χ2检验),差异无统计学意义(P>0.05)。(2)抑郁程度方面,治疗后,2组患者的HAMD评分和MADRS评分均较治疗前明显下降(P<0.01),但治疗后组间比较,差异均无统计学意义(P>0.05)。(3)生活质量方面,治疗后,2组患者的GQOL-74的躯体功能、心理功能、社会功能、物质生活等各项评分及总分均较治疗前明显改善(P<0.01),但治疗后组间比较,差异均无统计学意义(P>0.05)。(4)睡眠质量方面,治疗后,2组患者的PSQI的睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物和日间功能等各项评分及总分均较治疗前明显改善(P<0.01),且干预组对PSQI的睡眠质量、入睡时间评分及总分的改善作用明显优于对照组(P<0.05)。【结论】八段锦锻炼联合放松功干预对轻中度抑郁症状的改善有明确的疗效,可以为轻中度抑郁症患者提供更广泛的选择可能,特别是对西药治疗不耐受的患者更具有一定的优势。

多焦点近视离焦眼镜联合阿托品滴眼液对轻中度儿童近视的治疗效果

目的:探讨多焦点近视离焦眼镜(DIMS)联合阿托品滴眼液对轻中度儿童近视的治疗效果。方法:选取90例(180眼)近视儿童为研究对象,根据治疗方法不同分为A组(n=36)、B组(n=30)和C组(n=24)。A组儿童佩戴框架眼镜治疗;B组儿童佩戴DIMS治疗;C组儿童佩戴DIMS联合0.01%阿托品滴眼液治疗,各组疗程均为12个月。比较各组患儿治疗前、治疗6个月及12个月后的裸眼视力、眼压、屈光度、眼轴长度、中央前房深度、角膜厚度及角膜曲率。结果:治疗6个月、12个月后,各组患儿裸眼视力均呈下降趋势,且C组<B组<A组(P<0.05);眼压、中央前房深度、角膜厚度、角膜曲率差异无统计学意义(P>0.05)。治疗12个月后,各组患儿屈光度、眼轴长度比较:C组<B组<A组(P<0.05)。结论:DIMS有利于延缓轻中度近视儿童近视进展,控制屈光度及眼轴增长,且与低浓度阿托品滴眼液联用效果更优。

补中益气汤联合生物反馈电刺激对中老年女性轻中度压力性尿失禁的改善效果

目的:探讨补中益气汤联合生物反馈电刺激技术对中老年女性轻中度压力性尿失禁的改善效果。方法:采用随机数字表法,将2021年5月至2023年3月该院收治的132例中老年女性轻中度压力性尿失禁患者分为对照组与联合组,每组66例。对照组患者采用生物反馈电刺激技术治疗,联合组患者在对照组的基础上联合补中益气汤治疗。连续治疗8周后,比较两组患者的临床疗效,治疗前后尿失禁问卷简表(ICI-Q-SF)评分、尿失禁生活质量量表(I-QOL)评分、1 h尿垫试验结果、尿动力学指标和盆底肌表面肌电情况,并记录不良反应。结果:联合组患者的总有效率为95.45%(63/66),较对照组的80.30%(53/66)更高,差异有统计学意义(P<0.05)。治疗后,两组患者的ICI-Q-SF评分,1 h漏尿量和漏尿次数、残余尿量,前静息阶段、后静息阶段肌电压较治疗前降低;I-QOL评分,膀胱顺应性、最大尿流率和最大尿道闭合压,快肌(Ⅱ类肌纤维)阶段、慢肌(Ⅰ类肌纤维)阶段肌电压较治疗前升高,差异均有统计学意义(P<0.05)。治疗后,联合组患者的ICI-Q-SF评分,1 h漏尿量和漏尿次数、残余尿量,前静息阶段、后静息阶段肌电压低于对照组;I-QOL评分,膀胱顺应性、最大尿流率和最大尿道闭合压,快肌(Ⅱ类肌纤维)阶段、慢肌(Ⅰ类肌纤维)阶段肌电压高于对照组,差异均有统计学意义(P<0.05)。两组患者在治疗过程中均未出现不良反应。结论:针对中老年女性轻中度压力性尿失禁患者,采用补中益气汤联合生物反馈电刺激治疗的效果显著,可改善患者尿失禁状况、生活质量、尿动力学参数和盆底肌功能,安全性好。

轻中度颅脑损伤患者认知功能障碍与血清神经特异性烯醇化酶水平相关性

目的:探讨轻中度颅脑损伤患者认知功能障碍与神经特异性烯醇化酶(NSE)水平的相关性。方法:选择2017年9月—2020年9月收治的轻中度颅脑损伤患者82例,入院时检测患者血清NSE,待患者病情平稳后采用中文版蒙特利尔认知评估量表(MoCA)评估认知功能,根据是否出现认知功能障碍分正常组和障碍组。单因素分析比较两组患者基本临床资料差异;进一步对比正常组和障碍组患者不同类型及不同部位颅脑损伤血清NSE的变化差异;相关性分析入院时患者血清NSE与患者MoCA评分相关性;多重线性回归分析探讨颅脑损伤后认知功能障碍影响因素。结果:障碍组硬膜下出血者血清NSE、蛛网膜下腔出血者血清NSE、脑挫裂伤者血清NSE,损伤部位额叶者血清NSE、颞叶者血清NSE、顶叶者血清NSE、枕叶者血清NSE,均高于正常组硬膜下出血者,差异有统计学意义(P<0.05),其中脑挫裂伤、额叶损伤患者入院时血清NSE含量最高,差异最明显;出院后1年随访45例患者MoCA评分28(24.50,30.00)分,Spearman相关性分析提示与45例患者入院时血清NSE(15.26,2.85)ng/mL之间存在负相关性(P<0.01);多重线性回归显示,根据吸烟史、损伤类型、损伤类别、头颅CT出血量和血清NSE含量预测患者认知功能障碍发生可能性。回归模型具有统计学意义(P<0.05),调整R 2=-0.732。纳入模型的5个自变量中只有血清NSE水平对颅脑损伤与认知功能障碍的相关性具有统计学意义(P<0.05)。结论:有吸烟史、脑挫裂伤、额叶损伤、CT脑出血量较高的轻中度颅脑损伤患者应警惕认知功能障碍发生可能性。轻中度颅脑损伤患者入院时血清NSE含量越高越有可能发生认知功能障碍。

微创表面活性物质注射技术联合无创通气在早产儿轻中度新生儿呼吸窘迫综合征中的应用

目的探讨微创表面活性物质注射(LISA)技术联合无创通气(NIPPV)在早产儿轻中度新生儿呼吸窘迫综合征(NRDS)中的应用效果。方法选取2022年3月至2023年3月江西省妇幼保健院收治的80例NRDS患儿为研究对象,采用随机数字表法分为常规组与研究组,每组各40例。其中常规组传统技术联合NIPPV进行治疗,研究组使用LISA技术联合NIPPV进行治疗,比较两组患儿疗效、血气指标[pH值、血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))及氧合指数(OI)]、临床指标[再次肺表面活性物质(PS)治疗例数、72 h内机械通气例数、机械通气时间、住院时间]及并发症发生情况。结果研究组总有效率(97.50%)高于常规组(80.00%),差异有统计学意义(P<0.05);治疗后,研究组pH、PaO_(2)及OI值均高于常规组,PaCO_(2)低于常规组,差异有统计学意义(P<0.05)。两组患儿再次PS发生率比较,差异无统计学意义(P>0.05)。研究组72 h内机械通气发生率低于常规组,机械通气时间及住院时间短于常规组,差异有统计学意义(P<0.05)。研究组并发症总发生率(5.00%)低于常规组(22.50%),差异有统计学意义(P<0.05)。结论在治疗早产儿轻中度NRDS患儿方面,LISA技术疗效确切,相较于传统技术其改善患儿血气指标的效果更加明显,同时可显著减少患儿机械通气次数及时间,缩短住院时间,并显著减少并发症的发生。

近代中药毒性三级分法“大毒”“有毒”“小毒”概念浅析

中药的毒性是中药药性理论的核心内容之一,古代中药毒性的含义较广,一是指药物的总称,二是指药物的偏性,三是指药物毒副作用,四是指药物作用的强弱。随着科学技术的发展,对中药研究不断深入,近现代中药毒性主要是指中药的毒副作用,历版《中国药典》、统编《中药学》教材对中药毒性有三级分法“大毒”“有毒”“小毒”,但是对三级分法“大毒”“有毒”“小毒”至今没有确切定义,笔者从2020版《中国药典》83味毒性中药的用法用量及赵学敏主编的《中药学》教材对近代中药毒性三级分法“大毒”“有毒”“小毒”进行了综合评价分析,对毒性中药“大毒”“有毒”“小毒”的概念做了梳理和定义。为中药毒性的理解和临床应用提供参考,无论从理论上还是从实践上都具有深远的现实意义。

新式盆底康复操在轻-中度盆腔器官脱垂中的临床应用研究

目的研究在轻-中度盆腔器官脱垂中采取新式盆底康复操的临床价值。方法选取105例轻-中度盆腔器官脱垂患者,随机分为三组,每组35例。对照组进行单纯的盆底肌锻炼(Kegel法),观察组1在对照组基础上采用新式盆底康复操,观察组2采用电刺激+生物反馈治疗,比较三组临床效果。结果相比对照组,观察组1与观察组2治疗后性生活质量评分、最大收缩力、收缩持续时间均更高,且盆底肌疲劳度更低,差异有统计学意义(P<0.05)。结论在轻-中度盆腔器官脱垂中采取新式盆底康复操进行干预,能够明显改善患者盆底肌力与性生活质量,值得临床推广与应用。

中等量高血压脑出血机器人辅助穿刺微创手术与保守治疗的临床研究

目的:探究中等量高血压脑出血机器人辅助穿刺微创手术与保守治疗比较。方法:选取2021年7月~2022年7月华中科技大学协和深圳医院100例中等量高血压脑出血患者,采用随机数字表法分为参照组(保守治疗)和试验组(机器人辅助穿刺微创手术)各50例,对干预效果进行比较。结果:试验组总有效率94.00%高于参照组72.00%,差异有统计学意义(P<0.05),试验组失血量、手术、血肿清除、脑脊液恢复、置管引流、住院时长均少于参照组,差异有统计学意义(P<0.05),手术后1 min、1 d、3 d试验组的颅内压小于参照组,差异有统计学意义(P<0.05),两组手术前的炎性因子比较,差异无统计学意义(P>0.05),试验组手术后的肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-6(IL-6)均小于参照组,差异有统计学意义(P<0.05),研究对象手术前的神经功能缺损(NIHSS)、日常生活能力(ADL)、格拉斯昏迷评分(GCS)、格拉斯哥预后评分(GOS)比较,差异无统计学意义(P>0.05),试验组手术后的NIHSS评分低于参照组,但ADL、GCS、GOS评分高于参照组,差异有统计学意义(P<0.05)。结论:机器人辅助穿刺微创手术能够快速降低患者颅内压,并清除血肿,缩短住院天数,促进炎性反应消失,改善患者神经功能,促进预后。