脂蛋白酯酶(Lipoprotein lipase,LPL)主要由脂肪和肌肉组织的实质细胞产生,脂解毛细血管中血浆脂蛋白的甘油三酯。多年来,关于LPL是如何从细胞间隙转运至毛细血管内皮细胞上,一直不清楚。最新研究结果表明,在LPL从细胞间隙向毛细血管内...脂蛋白酯酶(Lipoprotein lipase,LPL)主要由脂肪和肌肉组织的实质细胞产生,脂解毛细血管中血浆脂蛋白的甘油三酯。多年来,关于LPL是如何从细胞间隙转运至毛细血管内皮细胞上,一直不清楚。最新研究结果表明,在LPL从细胞间隙向毛细血管内皮细胞转运的过程中,糖基化磷脂酰肌醇锚定高密度脂蛋白结合蛋白1(Gly-cosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1,GPIHBP1)发挥着重要的作用。当GPIHBP1缺失时,LPL被错误定位于细胞间隙,导致动物机体出现严重的高甘油三酯血症。Gpihbp1基因突变可致人患高甘油三酯血症。本文就GPIHBP1分子在动物机体健康和疾病状况下的生理作用机理的研究进展进行了综述,同时也对富含甘油三酯脂蛋白脂解代谢中一些尚需解决的问题进行了讨论。展开更多
利用Apo B cDNA探针（LB 1.5）,检测13名高甘油三酯血症（HTG）患者和21名正常对照者的Apo B基因MspI限制性片段长度多态性（RFLP）等位基因频率。研究结果显示,34份标本共出现2.35kb（M_1）和2.60kb（M_2）二种不同长度的杂交片段。M_...利用Apo B cDNA探针（LB 1.5）,检测13名高甘油三酯血症（HTG）患者和21名正常对照者的Apo B基因MspI限制性片段长度多态性（RFLP）等位基因频率。研究结果显示,34份标本共出现2.35kb（M_1）和2.60kb（M_2）二种不同长度的杂交片段。M_2等位基因频率在HTG患者（0.192）和对照者（0.024）之间存在明显差异（P=0.02）。展开更多
Antiretroviral therapy in HIV patients is known for its negative effect on the cardiovascular system. One of the major adverse events in patients on lopinavir is increasing lipids. Hyperlipidaemia together with chroni...Antiretroviral therapy in HIV patients is known for its negative effect on the cardiovascular system. One of the major adverse events in patients on lopinavir is increasing lipids. Hyperlipidaemia together with chronic inflammation by HIV-infection itself makes these patients prone for cardiovascular diseases.The purpose of this study (a sub study within the FREE-study) was to determine if higher plasma lopinavir (LPV) concentrations lead to increase of serum lipids. Plasma drug concentrations were analysed up to week 24 in a prospective cohort of HIV antiretroviral therapy naive patients who started on a regimen of zidovudine, lamivudine and ritonavir-boosted lopinavir (FREE study). Prospectively we measured plasma lopinavir concentrations from baseline to week 24 in 72 naive HIV-patients starting on lopinavir (59 males and 13 females). A total of 210 samples were analysed, with at least 2 samples in every patient. Mean LPV trough concentration was 4.3 mg/L (± 2.1). The median intra-subject variation in LPV level was 38% (range 4% - 111%). Serum lipids were not correlated to LPV plasma concentrations possibly due to the wide intra-individual variability in LPV trough levels. Monitoring of plasma lopinavir and subsequent dose adjustment of LPV will not be useful to prevent hyperlipidaemia in HIV-patients treated with lopinavir.展开更多
Cerebral palsy people present movement difficulty and are liable to develop disorders associated with sedentary lifestyles such as dyslipidaemias and cardiovascular diseases. This study aimed to assess physical activi...Cerebral palsy people present movement difficulty and are liable to develop disorders associated with sedentary lifestyles such as dyslipidaemias and cardiovascular diseases. This study aimed to assess physical activity and the prevalence of lipid abnormalities in 29 children with cerebral palsy who were being treated in two care centers in the state of Guanajuato, Mexico. Physical activity was calculated using a survey. Blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides were determined. Forty-eight percent had at least one dyslipidaemia. The most frequent lipid abnormalities were hypertriglyceridaemia and low HDL-C. High prevalence of the atherogenic index was found. The physical activity of children was lower than recommended for their age. Sixty-two percent attended rehabilitation sessions, 10% attended sports classes, 14% rehabilitation plus sports and 14% did not engage in intentional physical activity. There is high frequency of lipid disorders in children with cerebral palsy. Greater participation in physical activity should be promoted in children to improve their metabolic status and quality of life, especially those suffering from cerebral palsy.展开更多
文摘脂蛋白酯酶(Lipoprotein lipase,LPL)主要由脂肪和肌肉组织的实质细胞产生,脂解毛细血管中血浆脂蛋白的甘油三酯。多年来,关于LPL是如何从细胞间隙转运至毛细血管内皮细胞上,一直不清楚。最新研究结果表明,在LPL从细胞间隙向毛细血管内皮细胞转运的过程中,糖基化磷脂酰肌醇锚定高密度脂蛋白结合蛋白1(Gly-cosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1,GPIHBP1)发挥着重要的作用。当GPIHBP1缺失时,LPL被错误定位于细胞间隙,导致动物机体出现严重的高甘油三酯血症。Gpihbp1基因突变可致人患高甘油三酯血症。本文就GPIHBP1分子在动物机体健康和疾病状况下的生理作用机理的研究进展进行了综述,同时也对富含甘油三酯脂蛋白脂解代谢中一些尚需解决的问题进行了讨论。
文摘利用Apo B cDNA探针（LB 1.5）,检测13名高甘油三酯血症（HTG）患者和21名正常对照者的Apo B基因MspI限制性片段长度多态性（RFLP）等位基因频率。研究结果显示,34份标本共出现2.35kb（M_1）和2.60kb（M_2）二种不同长度的杂交片段。M_2等位基因频率在HTG患者（0.192）和对照者（0.024）之间存在明显差异（P=0.02）。
文摘Antiretroviral therapy in HIV patients is known for its negative effect on the cardiovascular system. One of the major adverse events in patients on lopinavir is increasing lipids. Hyperlipidaemia together with chronic inflammation by HIV-infection itself makes these patients prone for cardiovascular diseases.The purpose of this study (a sub study within the FREE-study) was to determine if higher plasma lopinavir (LPV) concentrations lead to increase of serum lipids. Plasma drug concentrations were analysed up to week 24 in a prospective cohort of HIV antiretroviral therapy naive patients who started on a regimen of zidovudine, lamivudine and ritonavir-boosted lopinavir (FREE study). Prospectively we measured plasma lopinavir concentrations from baseline to week 24 in 72 naive HIV-patients starting on lopinavir (59 males and 13 females). A total of 210 samples were analysed, with at least 2 samples in every patient. Mean LPV trough concentration was 4.3 mg/L (± 2.1). The median intra-subject variation in LPV level was 38% (range 4% - 111%). Serum lipids were not correlated to LPV plasma concentrations possibly due to the wide intra-individual variability in LPV trough levels. Monitoring of plasma lopinavir and subsequent dose adjustment of LPV will not be useful to prevent hyperlipidaemia in HIV-patients treated with lopinavir.
基金funded by the State Committee for Sports and Youth Care of the State of Guanajuato and the Department of Medical Science of the University of Guanajuato.
文摘Cerebral palsy people present movement difficulty and are liable to develop disorders associated with sedentary lifestyles such as dyslipidaemias and cardiovascular diseases. This study aimed to assess physical activity and the prevalence of lipid abnormalities in 29 children with cerebral palsy who were being treated in two care centers in the state of Guanajuato, Mexico. Physical activity was calculated using a survey. Blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides were determined. Forty-eight percent had at least one dyslipidaemia. The most frequent lipid abnormalities were hypertriglyceridaemia and low HDL-C. High prevalence of the atherogenic index was found. The physical activity of children was lower than recommended for their age. Sixty-two percent attended rehabilitation sessions, 10% attended sports classes, 14% rehabilitation plus sports and 14% did not engage in intentional physical activity. There is high frequency of lipid disorders in children with cerebral palsy. Greater participation in physical activity should be promoted in children to improve their metabolic status and quality of life, especially those suffering from cerebral palsy.
