期刊文献+
共找到480篇文章
< 1 2 24 >
每页显示 20 50 100
Functional gastrointestinal disorders and gut-brain axis: What does the future hold? 被引量:18
1
作者 Kashif Mukhtar Hasham Nawaz Shahab Abid 《World Journal of Gastroenterology》 SCIE CAS 2019年第5期552-566,共15页
Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underl... Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon. Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents, there need to be more studies in humans, especially to identify the therapeutic targets. This review study looks at the anatomical features of the gut-brain axis in order to discuss the different factors and underlying molecular mechanisms that may have a role in the pathogenesis of functional gastrointestinal disorders. These molecules and their receptors can be targeted in future for further studies and possible therapeutic interventions. The article also discusses the potential role of artificial intelligence and machine learning and its possible role in our understanding of these scientifically challenging disorders. 展开更多
关键词 functional gastrointestinal disorders IDIOPATHIC bowel syndrome Gut-brain axis Microbiome-gut-brain axis Machine learning Artificial intelligence
下载PDF
A Semi-analytical Method for Vibrational and Buckling Analysis of Functionally Graded Nanobeams Considering the Physical Neutral Axis Position 被引量:1
2
作者 Farzad Ebrahimi Erfan Salari 《Computer Modeling in Engineering & Sciences》 SCIE EI 2015年第6期151-181,共31页
In this paper,a semi-analytical method is presented for free vibration and buckling analysis of functionally graded(FG)size-dependent nanobeams based on the physical neutral axis position.It is the first time that a s... In this paper,a semi-analytical method is presented for free vibration and buckling analysis of functionally graded(FG)size-dependent nanobeams based on the physical neutral axis position.It is the first time that a semi-analytical differential transform method(DTM)solution is developed for the FG nanobeams vibration and buckling analysis.Material properties of FG nanobeam are supposed to vary continuously along the thickness according to the power-law form.The physical neutral axis position for mentioned FG nanobeams is determined.The small scale effect is taken into consideration based on nonlocal elasticity theory of Eringen.The nonlocal equations of motion are derived through Hamilton’s principle and they are solved applying DTM.It is demonstrated that the DTM has high precision and computational efficiency in the vibration analysis of FG nanobeams.The good agreement between the results of this article and those available in literature validated the presented approach.The detailed mathematical derivations are presented and numerical investigations are performed while the emphasis is placed on investigating the effect of the several parameters such as neutral axis position,small scale effects,the material distribution profile,mode number,thickness ratio and boundary conditions on the normalized natural frequencies and dimensionless buckling load of the FG nanobeams in detail.It is explicitly shown that the vibration and buckling behaviour of a FG nanobeams is significantly influenced by these effects. 展开更多
关键词 BUCKLING Vibration functionally GRADED nanobeam Neutral axis Differential transformation method NONLOCAL elasticity
下载PDF
Tilted Axis Rotation of ^(57)Mn in Covariant Density Functional Theory
3
作者 彭婧 徐文强 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第1期23-26,共4页
The self-consistent tilted axis cranking covariant density functional theory based on the point-coupling interaction is applied to investigate the tilted axis rotation in ^57 Mn. The observed data for band C are repro... The self-consistent tilted axis cranking covariant density functional theory based on the point-coupling interaction is applied to investigate the tilted axis rotation in ^57 Mn. The observed data for band C are reproduced well with the assigned configuration eonfig 1. The shears mechanism for magnetic rotation is examined by investigating microscopically the orientation of angular momentum and the corresponding contributions. It is found that config 1 and config 3 correspond to a rotation of high-K character. Config 2 corresponds to a rotation of magnetic character. However, due to the presence of electromagnetic transition B(M1) and B(E2), collective rotation plays an essential role in the competition with magnetic rotation. 展开更多
关键词 Tilted axis Rotation of on IS AS IT in Mn in Covariant Density functional Theory for been
下载PDF
Neuroimaging the brain-gut axis in patients with irritable bowel syndrome 被引量:8
4
作者 Kristen R Weaver Lee Anne B Sherwin +2 位作者 Brian Walitt Gail D'Eramo Melkus Wendy A Henderson 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 CAS 2016年第2期320-333,共14页
AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus... AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. 展开更多
关键词 IRRITABLE BOWEL syndrome NEUROIMAGING Brain-gut axis functional magnetic RESONANCE imaging
下载PDF
Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome 被引量:19
5
作者 Eline Margrete Randulff Hillestad Aina van der Meeren +8 位作者 Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen 《World Journal of Gastroenterology》 SCIE CAS 2022年第4期412-431,共20页
Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophy... Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. 展开更多
关键词 MICROBIOTA Neurogastroenterology Irritable bowel syndrome Microbiotagut-brain axis Structural and functional magnetic resonance imaging Machine learning Big data analysis
下载PDF
Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease 被引量:56
6
作者 Giulia Paolella Claudia Mandato +3 位作者 Luca Pierri Marco Poeta Martina Di Stasi Pietro Vajro 《World Journal of Gastroenterology》 SCIE CAS 2014年第42期15518-15531,共14页
The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease(NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and t... The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease(NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and the subsequent economic burden on healthcare systems, their prevention and treatment have become major priorities. Because standard dietary and lifestyle changes and pathogenically-oriented therapies(e.g., antioxidants, oral hypoglycemic agents, and lipid-lowering agents) often fail due to poor compliance and/or lack of efficacy, novel approaches directed toward other pathomechanisms are needed. Here we present several lines of evidence indicating that, by increasing energy extraction in some dysbiosis conditions or small intestinal bacterial overgrowth,specific gut microbiota and/or a"low bacterial richness"may play a role in obesity,metabolic syndrome,and fatty liver.Under conditions involving a damaged intestinal barrier("leaky gut"),the gut-liver axis may enhance the natural interactions between intestinal bacteria/bacterial products and hepatic receptors(e.g.,toll-like receptors),thus promoting the following cascade of events:oxidative stress,insulinresistance,hepatic inflammation,and fibrosis.We also discuss the possible modulation of gut microbiota by probiotics,as attempted in NAFLD animal model studies and in several pilot pediatric and adult human studies.Globally,this approach appears to be a promising and innovative add-on therapeutic tool for NAFLD in the context of multi-target therapy. 展开更多
关键词 PROBIOTICS Gut-liver axis INTESTINAL micro-biota B
下载PDF
适宜运动与过度训练调控肠道功能和肠-脑轴的作用机制
7
作者 余锋 贾芳芳 +2 位作者 徐帅 汪君民 王阳春 《上海体育大学学报》 北大核心 2024年第3期26-35,48,共11页
对运动介导肠道与大脑联络的相关文献进行综述,分析适宜运动与过度训练对肠道功能和肠-脑轴之间神经传导及生物信号分子的影响,以揭示其作用机制。发现:肠道与大脑之间关系密切,肠-脑轴之间的双向神经联系和相关生物信号分子是实现肠道... 对运动介导肠道与大脑联络的相关文献进行综述,分析适宜运动与过度训练对肠道功能和肠-脑轴之间神经传导及生物信号分子的影响,以揭示其作用机制。发现:肠道与大脑之间关系密切,肠-脑轴之间的双向神经联系和相关生物信号分子是实现肠道与大脑之间对话的媒介。运动可通过调控肠道与大脑之间的神经联系和相关生物分子影响肠-脑轴,介导肠道与大脑的健康及神经、精神疾病的转归。肠道微生物是实现肠-脑轴之间信息沟通的重要参与者,运动对肠道功能与肠-脑轴的调节可通过调控肠道微生态,及其介导的神经传导途径和生物信号分子的变化发挥终端效应,进而影响高级神经功能。不同强度的运动对肠道微生态及肠-脑轴的调节效应差异颇大,适宜运动和过度训练引起的干预结果截然不同。 展开更多
关键词 适宜运动 过度训练 肠道功能 肠-脑轴
下载PDF
基于下丘脑-垂体-肾上腺轴探讨电针对功能性消化不良大鼠的作用机制
8
作者 乐薇 姚函伶 +2 位作者 杨格格 吴贻森 徐派的 《世界科学技术-中医药现代化》 CSCD 北大核心 2024年第1期259-267,共9页
目的探讨电针印堂、内关、足三里对FD大鼠下丘脑-垂体-肾上腺轴的可能作用机制。方法40只SD大鼠随机分为空白组、模型组和电针组。采用夹尾、不规律饮食以及冰生理盐水灌胃法复制FD模型。造模后,电针组行针刺干预,每天1次,每次30 min,连... 目的探讨电针印堂、内关、足三里对FD大鼠下丘脑-垂体-肾上腺轴的可能作用机制。方法40只SD大鼠随机分为空白组、模型组和电针组。采用夹尾、不规律饮食以及冰生理盐水灌胃法复制FD模型。造模后,电针组行针刺干预,每天1次,每次30 min,连续14天。记录大鼠的一般状态;旷场实验检测大鼠的自主行为及紧张度;HE染色法观察大鼠胃黏膜形态及炎症反应;实时荧光定量PCR法检测大鼠下丘脑5-羟色胺3受体(5-HT3R)、促肾上腺皮质激素释放激素(CRH)的表达;蛋白免疫印迹法检测大鼠十二指肠促肾上腺皮质激素释放激素受体2(CRHR2)、NOD样受体蛋白6(NLRP6)蛋白表达;阿利新蓝染色观察大鼠十二指肠黏膜上皮形态及杯状细胞的阳性表达。结果与空白组相比,模型组大鼠一般状态、旷场自主运动距离、运动速度、十二指肠CRHR2、NLRP6蛋白均大幅下降(P<0.05),下丘脑5-HT3R、CRH mRNA明显升高(P<0.05)。与模型组相比,电针组大鼠一般状态、旷场自主运动距离、运动速度、十二指肠CRHR2、NLRP6蛋白及杯状细胞的表达均明显提高(P<0.05),下丘脑5-HT3R、CRH mRNA大幅下降(P<0.05)。模型组大鼠胃黏膜可见疏松的结缔组织,黏膜下层轻度水肿,淋巴细胞增生;空白组和电针组大鼠胃黏膜结缔组织排列紧密,胃腺间质无明显增生,未见炎症细胞。结论电针印堂、内关、足三里可能是通过提升十二指肠CRHR2、NLRP6蛋白和杯状细胞表达,抑制下丘脑5-HT3R、CRH的表达,来提高FD大鼠自主运动水平,缓解焦虑,修复缺损的肠道黏膜屏障,恢复下丘脑-垂体-肾上腺轴的正常功能。 展开更多
关键词 功能性胃肠病 电针 下丘脑-垂体-肾上腺轴 动物实验
下载PDF
脑组织GDF-15水平与脑梗死大鼠血管新生以及Th1/Th2免疫平衡轴的关系
9
作者 熊涛 《湖北医药学院学报》 CAS 2024年第2期119-124,F0002,共7页
目的:探讨脑组织GDF-15水平与脑梗死大鼠血管新生以及Th1/Th2免疫平衡轴的关系。方法:45只雄性SD大鼠随机分为脑梗死模型组、假手术组以及正常对照组,15只/组。模型组采用线栓法建立脑梗死模型,假手术组仅暴露颈内动脉后直接缝合皮肤,... 目的:探讨脑组织GDF-15水平与脑梗死大鼠血管新生以及Th1/Th2免疫平衡轴的关系。方法:45只雄性SD大鼠随机分为脑梗死模型组、假手术组以及正常对照组,15只/组。模型组采用线栓法建立脑梗死模型,假手术组仅暴露颈内动脉后直接缝合皮肤,建模成功后1周评估大鼠改良神经功能缺损(mNSS)评分。采用HE染色检测脑组织病理学变化情况,Western blot法检测大鼠脑组织中组织生长分化因子-15(GDF-15)蛋白水平,RTPCR测定脑组织中GDF-15 mRNA水平。采用ELISA法检测脑组织INF-γ、IL-4表达情况,采用Spearman相关性分析大鼠脑组织中GDF-15蛋白、mRNA表达水平分别与mNSS评分、微血管密度(MVD)、INF-γ/IL-4水平之间的相关性。结果:模型组大鼠mNSS评分明显高于假手术组和正常对照组(P<0.001),模型组脑梗死面积比为(24.45±4.15)%,假手术组和正常对照组未发现脑梗死区域。模型组大鼠脑组织GDF-15蛋白、mRNA、MVD、INF-γ/IL-4水平均明显高于假手术组和正常对照组(P<0.05)。Spearman相关性分析显示,模型组大鼠脑组织中GDF-15蛋白、mRNA表达水平分别与mNSS评分、MVD、INF-γ/IL-4水平呈正相关关系(P<0.001)。结论:脑梗死大鼠脑组织中GDF-15处于高表达状态,且与神经功能密切关联,其作用机制可能与血管新生以及调控Th1/Th2免疫平衡轴有关。 展开更多
关键词 脑梗死 组织生长分化因子-15 神经功能 血管新生 Th1/Th2免疫平衡轴
下载PDF
王雪峰教授基于“脑肠相关”理论治疗儿童功能性便秘经验探析 被引量:1
10
作者 郭天祥 张秀英 +1 位作者 王雪峰 王书钰 《中国中西医结合儿科学》 2024年第1期15-18,共4页
儿童功能性便秘作为儿科常见病之一,主要表现为排便困难、排便频次减少、排便时间延长。本病发病率、复发率较高,严重影响患儿生活质量,不利于儿童的生长发育。近年来随着社会压力的增大,本病发病率又逐年升高,除身体症状外,患儿的精神... 儿童功能性便秘作为儿科常见病之一,主要表现为排便困难、排便频次减少、排便时间延长。本病发病率、复发率较高,严重影响患儿生活质量,不利于儿童的生长发育。近年来随着社会压力的增大,本病发病率又逐年升高,除身体症状外,患儿的精神症状也逐渐受到关注,且功能性便秘患儿伴发情志异常症状多见。罗马Ⅳ中针对功能性便秘提出其发病的机制主要为“脑与肠间互动异常”,结合中医学“五脏一体”的整体观念与形神俱为一体的理论观点,故本文从“脑肠相关”理论和现代医学中的“脑-肠轴”作为切入点,对“脑肠相关”学说进行深入分析,基于脑与肠生理上相互关联、病理上相互影响的特殊联系,认为治疗功能性便秘不仅应调节胃肠功能以改善肠道症状,也应重视心脑的调神作用以改善患者焦虑、抑郁等精神症状,探究从调神以达运肠之效的治疗方法,以期找寻出治疗功能性便秘的新思路,为提高功能性便秘患儿生活质量提供新方法。 展开更多
关键词 功能性便秘 脑肠相关 脑-肠轴 儿童
下载PDF
基于“脑-肠轴”理论论治儿童功能性便秘探析
11
作者 王鹏 薛征 《中国中西医结合儿科学》 2024年第3期226-229,共4页
功能性便秘为一种排便困难、排便频次减少或排便不尽感为主要临床表现的功能性肠病,是儿科临床的常见病和多发病之一。功能性便秘会严重影响患儿的生活质量和心理健康,给患儿及家庭带来一定的困扰。近年来随着“脑-肠轴”研究逐渐深入,... 功能性便秘为一种排便困难、排便频次减少或排便不尽感为主要临床表现的功能性肠病,是儿科临床的常见病和多发病之一。功能性便秘会严重影响患儿的生活质量和心理健康,给患儿及家庭带来一定的困扰。近年来随着“脑-肠轴”研究逐渐深入,越来越多的证据表明脑与肠存在密切联系,“脑-肠轴”作为由中枢神经系统、自主神经系统和肠神经系统共同组成的联络大脑与胃肠道的双向交通机制的神经-内分泌网络系统,脑肠肽能够连接并调控“脑-肠轴”交互作用的各个环节,功能性便秘的产生也和“脑-肠轴”密切相关。在中医理论中,便秘病机为大肠传导失调,脑与肠密切相关,脑居于上,统御五脏六腑,肠腑居于下,传化糟粕,影响人体气机,肠腑通畅,则府精神明,脑肠生理相连、病理相关,脑、肠功能失调,共同导致儿童功能性便秘的发生。本文基于“脑-肠轴”理论,结合中医理论及病因病机,探讨“脑-肠轴”对儿童功能性便秘的影响,并探析基于“脑-肠轴”理论论治儿童功能性便秘。 展开更多
关键词 功能性便秘 脑-肠轴 儿童
下载PDF
基于脑-肠-菌轴探讨天枢穴治疗功能性便秘作用机制
12
作者 孙月敏 潘玫竹 +1 位作者 时静怡 王晓燕 《辽宁中医药大学学报》 CAS 2024年第2期172-175,共4页
功能性便秘(functional constipation,FC)是常见的一种胃肠功能紊乱疾病,该病发病机制复杂,脑-肠-菌轴(BGMA)在其病理生理中的作用逐渐受到关注,脑-肠与肠道菌群交互障碍可通过神经、内分泌、免疫和代谢等途径影响胃肠道运动、感觉、分... 功能性便秘(functional constipation,FC)是常见的一种胃肠功能紊乱疾病,该病发病机制复杂,脑-肠-菌轴(BGMA)在其病理生理中的作用逐渐受到关注,脑-肠与肠道菌群交互障碍可通过神经、内分泌、免疫和代谢等途径影响胃肠道运动、感觉、分泌等功能,进而引起排便异常。天枢穴具有疏调肠腑、理气行滞、健脾和胃、调神的功效,为针灸临床治疗FC的要穴。现代研究表明,针灸天枢穴对该病的影响机制可能与调节BGMA有关,包括促进中枢神经系统、肠神经系统结构与功能的正常化,改善肠道微生态失调,调节脑肠肽的分泌以及抑制促肾上腺皮质激素释放因子的过度表达等。该文从BGMA角度探究脑-肠轴、肠道菌群与FC的发病关系,总结探讨天枢穴治疗FC的内在机制,以期为针灸治疗功能性胃肠疾病提供理论依据和临床应用指导。 展开更多
关键词 功能性便秘 脑-肠-菌轴 天枢穴 针灸
下载PDF
五味子苷B调控miR-370-3p/CCL3轴对幼年肺炎小鼠免疫炎症因子水平的影响
13
作者 杨翠玲 高军铭 +2 位作者 董丽君 王丽敏 张永峰 《儿科药学杂志》 CAS 2024年第5期1-5,共5页
目的:探讨五味子苷B(Sch B)在幼年肺炎小鼠的作用机制。方法:将90只幼年雄性小鼠随机分为对照组、模型组、Sch B低剂量组(Sch BL组)、Sch B高剂量组(Sch BH组)、Sch BH+antagomir-NC组、Sch BH+miR-370-3p antagomir组各15只。Sch BL组... 目的:探讨五味子苷B(Sch B)在幼年肺炎小鼠的作用机制。方法:将90只幼年雄性小鼠随机分为对照组、模型组、Sch B低剂量组(Sch BL组)、Sch B高剂量组(Sch BH组)、Sch BH+antagomir-NC组、Sch BH+miR-370-3p antagomir组各15只。Sch BL组和Sch BH组小鼠分别灌胃20、60 mg/kg的Sch B;Sch BH+antagomir-NC组和Sch BH+miR-370-3p antagomir组,先将1 nmol的miR-370-3p antagomir、antagomir-NC用20μL的磷酸盐缓冲液(PBS)溶解,在Sch B灌胃后将miR-370-3p antagomir、antagomir-NC质粒分别经尾静脉注射到小鼠体内;对照组和模型组给予等量生理盐水。每天1次,持续给药7 d。测定各组小鼠肺组织的湿干质量比;采用苏木精-伊红(HE)染色观察各组小鼠肺组织的病理形态;检测各组小鼠肺组织中炎症因子水平;流式细胞术检测外周血T淋巴细胞亚群;实时定量反转录聚合酶链式反应(qRT-PCR)检测肺组织中miR-370-3p和CCL3的mRNA水平;双荧光素酶实验验证miR-370-3p与CCL3的靶向关系。结果:与对照组相比,模型组幼鼠肺组织结构紊乱,肺泡壁变厚,出现大量炎性细胞浸润,组织受损严重,肺组织湿干质量比、CD8^(+)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、CCL3 mRNA水平均升高,CD4^(+)、CD4^(+)/CD8^(+)、miR-370-3p水平均降低(P均<0.05)。与模型组相比,Sch BL组和Sch BH组幼鼠肺组织中肺泡壁变薄,炎性细胞浸润明显减少,损伤减轻,肺组织湿干质量比、CD8^(+)、TNF-α、IL-6、CCL3 mRNA水平均降低,CD4^(+)、CD4^(+)/CD8^(+)、miR-370-3p水平均升高(P均<0.05)。加入miR-370-3p antagomir进行回补实验,结果显示Sch B对肺炎幼鼠免疫功能和炎症保护作用被逆转,且CCL3 mRNA水平升高(P<0.05);双荧光素酶报告基因实验验证了miR-370-3p与CCL3存在靶向关系。结论:Sch B能够通过靶向调节miR-370-3p/CCL3轴来增强幼年肺炎小鼠免疫功能,并抑制炎症反应。 展开更多
关键词 五味子苷B miR-370-3p/CCL3轴 肺炎 免疫功能 炎症
下载PDF
心理应激对皮肤屏障功能的不良影响
14
作者 付梦丽 高爽 +3 位作者 叶佳滨 张凯妮 赵文刚 许诺 《生理科学进展》 CAS 北大核心 2024年第3期207-214,共8页
皮肤是机体和外界环境之间的第一道保护性屏障,在保护机体免受外界环境等危险因素造成的损伤方面起着重要的作用。心理应激是人在面对各种压力和挑战时产生的情绪和心理反应,多种因素都可以作为心理应激的应激源。长期的心理应激会造成... 皮肤是机体和外界环境之间的第一道保护性屏障,在保护机体免受外界环境等危险因素造成的损伤方面起着重要的作用。心理应激是人在面对各种压力和挑战时产生的情绪和心理反应,多种因素都可以作为心理应激的应激源。长期的心理应激会造成机体内环境稳态失衡,甚至疾病发生。迄今为止有众多研究表明心理应激可通过神经内分泌反应,导致皮肤细胞功能减弱或异常,从而深刻影响皮肤局部生理功能,引起皮肤屏障功能的显著变化,导致皮肤健康问题产生。本文主要综述心理应激影响皮肤屏障功能的相关研究进展。 展开更多
关键词 心理应激 皮肤健康 皮肤屏障功能 交感神经-肾上腺髓质系统 下丘脑-垂体-肾上腺轴
下载PDF
低复杂度永磁同步电机双矢量模型预测控制策略
15
作者 杨狂彪 陈鼎新 石坚 《电机与控制应用》 2024年第1期87-96,共10页
针对永磁同步电机模型预测电流控制中计算量大和电流波动问题,提出了一种低复杂度双矢量模型预测电压控制策略。该方法无需遍历所有的电压矢量,仅通过代价函数预测和评估三个不相邻的有效电压矢量,根据三个代价函数值的关系,即可精确快... 针对永磁同步电机模型预测电流控制中计算量大和电流波动问题,提出了一种低复杂度双矢量模型预测电压控制策略。该方法无需遍历所有的电压矢量,仅通过代价函数预测和评估三个不相邻的有效电压矢量,根据三个代价函数值的关系,即可精确快速地确定两个相邻最优有效电压矢量。最优有效的电压矢量选择可以减少预测计算量,同时引入dq轴电压差作用时间计算方法,计算最优有效电压矢量作用时间,以降低计算量。仿真结果表明,相较于占空比策略和传统双矢量模型预测电流控制策略,所提控制策略在保证系统稳态和动态性能的基础上,降低了计算复杂度和电流波动,改善了转矩脉动。 展开更多
关键词 永磁同步电机 模型预测控制 代价函数 低复杂度 dq轴电压差
下载PDF
雌孕激素治疗对围绝经期子宫肌瘤的影响
16
作者 王泉梅 王芳 仇露玲 《浙江实用医学》 2024年第1期19-22,56,共5页
目的分析雌孕激素治疗对围绝经期子宫肌瘤的影响。方法选取2022年1~12月在浙江省杭州市桐庐县第一人民医院就诊的围绝经期子宫肌瘤患者132例。按照随机数字表法分为常规治疗组和雌孕激素组,每组66例。常规治疗组给予谷维素口服,20mg/次,... 目的分析雌孕激素治疗对围绝经期子宫肌瘤的影响。方法选取2022年1~12月在浙江省杭州市桐庐县第一人民医院就诊的围绝经期子宫肌瘤患者132例。按照随机数字表法分为常规治疗组和雌孕激素组,每组66例。常规治疗组给予谷维素口服,20mg/次,2次/d;维生素B1口服,20mg/次,2次/d;治疗3个月。雌孕激素组在常规治疗组基础上给予雌孕激素治疗,给予戊酸雌二醇口服,0.5mg/次,1次/d,连用3周,第12~14天给予地屈孕酮,5mg/次,1次/d,治疗3个月。之后根据患者围绝经期症状、雌二醇(E_(2))水平并结合中华医学会绝经学组推荐的最低有效剂量以及患者个体情况调整E2使用剂量,最高剂量不超过1.5mg/d。观察两组治疗前后子宫肌瘤大小和子宫内膜厚度、血清性腺轴相关激素指标[雌二醇(E_(2))、卵泡刺激素(FSH)、黄体生成素(LH)]、围绝经期症状(潮热、盗汗、心悸、失眠积分)、Kupperman评分及生活质量评分。结果(1)治疗后,两组子宫肌瘤大小和子宫内膜厚度较治疗前差异均无统计学意义(P>0.05),且组间比较差异也无统计学意义(P>0.05)。(2)治疗后,两组血清E_(2)水平均升高(P<0.05),血清FSH、LH水平均降低(P<0.05),且雌孕激素组血清E_(2)水平高于常规治疗组(P<0.05),血清FSH、LH水平均低于常规治疗组(P<0.05)。(3)治疗后,两组潮热、盗汗、心悸、失眠积分均下降(P<0.05),且雌孕激素组潮热、盗汗、心悸、失眠积分均低于常规治疗组(P<0.05)。(4)治疗后,两组Kupperman评分均明显下降(P<0.05),生活质量评分均显著升高(P<0.05),且雌孕激素组Kupperman评分低于常规治疗组(P<0.05),生活质量评分高于常规治疗组(P<0.05)。结论小剂量雌孕激素治疗围绝经期子宫肌瘤可以调节患者性腺轴分泌功能,改善围绝经期症状,且未对子宫肌瘤产生明显影响。 展开更多
关键词 子宫肌瘤 围绝经期 雌激素 性腺轴分泌功能 生活质量
下载PDF
基于脑-肠互动观点探讨解郁复胃散对功能性消化不良的疗效及机制
17
作者 于红梅 李堃 +3 位作者 季瑜 田祖成 梅莉 葛飞 《实用临床医药杂志》 CAS 2024年第7期53-57,共5页
目的观察解郁复胃散对功能性消化不良(FD)患者的疗效。方法将海安市中医院门诊66例慢性FD(肝胃不和型)患者随机分为2组,每组33例。对照组应用多潘立酮治疗,治疗组应用解郁复胃散治疗。比较2组总有效率、中医证候积分以及血清5-羟色胺(5-... 目的观察解郁复胃散对功能性消化不良(FD)患者的疗效。方法将海安市中医院门诊66例慢性FD(肝胃不和型)患者随机分为2组,每组33例。对照组应用多潘立酮治疗,治疗组应用解郁复胃散治疗。比较2组总有效率、中医证候积分以及血清5-羟色胺(5-HT)、P物质(SP)、胃泌素(GAS)、胃动素(MTL)水平和不良反应发生率。募集2组治疗后志愿者(对照组为14例,治疗组为13例)接受门诊胃镜检查并获取活检组织,进行组织病理及GAS、MTL的免疫组化分析。结果治疗组总有效率为90.91%,高于对照组的69.70%,差异有统计学意义(P<0.05)。治疗后,治疗组两胁串通、胃脘痞满、上腹不适、嗳气、烧心反酸、急躁易怒症状积分均低于对照组,差异均有统计学意义(P<0.01)。治疗后,2组血清5-HT、SP水平下降,MTL、GAS水平升高,且治疗组血清5-HT、SP水平低于对照组,MTL、GAS水平高于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗组不良反应发生率为6.06%(2/33),对照组不良反应发生率为9.09%(3/33),差异无统计学意义(P>0.05)。活检组织苏木精-伊红(HE)染色显示2组病理无显著差异,免疫组化结果提示治疗组的GAS、MTL表达较对照组增加。结论解郁复胃散对肝胃不和型FD的疗效优于多潘立酮,其机制可能与干预脑-肠互动有关。 展开更多
关键词 解郁复胃散 肝胃不和型 功能性消化不良 脑-肠互动 脑肠轴
下载PDF
慢性心力衰竭患者心肌能量代谢变化与心脏收缩功能及左心室重构的相关性
18
作者 程进波 李红莲 张艳 《临床和实验医学杂志》 2024年第7期686-690,共5页
目的分析慢性心力衰竭患者心肌能量代谢(MEE)变化与心脏收缩功能及左心室重构的相关性。方法回顾性选取2021年3月至2022年12月南平市第一医院收治的100例慢性心力衰竭患者作为观察组,选取同期来本院进行体检的85名健康体检者作为对照组... 目的分析慢性心力衰竭患者心肌能量代谢(MEE)变化与心脏收缩功能及左心室重构的相关性。方法回顾性选取2021年3月至2022年12月南平市第一医院收治的100例慢性心力衰竭患者作为观察组,选取同期来本院进行体检的85名健康体检者作为对照组。比较两组研究对象的左心室收缩末圆周室壁应力(cESS)、MEE、血清游离脂肪酸(FFA)、血清糖类抗原125(CA125)、左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESd)、左心室质量指数(LVMI)、左心室射血分数(LVEF)、每搏输出量、短轴缩短率及射血时间水平;采用Pearson相关分析,分析慢性心力衰竭患者心肌能量代谢变化与心脏收缩功能及左心室重构的相关性。结果观察组患者cESS、MEE、FFA及CA125水平分别为(194.35±30.25)kdyne/cm^(2)、(128.37±23.69)cal/min、(850.41±150.35)μmol/L、(68.54±5.33)kU/L,均高于对照组[(79.44±50.69)kdyne/cm^(2)、(68.57±12.97)cal/min、(227.31±40.57)μmol/L、(17.25±2.70)kU/L],差异均有统计学意义(P<0.05)。观察组患者LVEDd、LVESd、LVMI分别为(71.58±12.45)mm、(67.55±12.74)mm、(140.33±25.64)g/m^(2),均高于对照组[(42.05±8.46)mm、(41.39±8.16)mm、(77.59±13.58)g/m^(2)],LVEF、每搏输出量、短轴缩短率及射血时间分别为(38.49±7.64)%、(48.69±12.46)mL、(18.53±2.14)%、(181.31±18.49)ms,均低于对照组[(68.14±12.18)%、(68.67±15.04)mL、(36.05±2.34)%、(320.45±20.14)ms],差异均有统计学意义(P<0.05)。经过Pearson相关分析,cESS、MEE、FFA均与LVEDd、LVESd、LVMI、CA125呈正相关(P<0.05),cESS、MEE、FFA均与LVEF、每搏输出量、短轴缩短率、射血时间呈负相关(P<0.05)。结论慢性心力衰竭患者MEE、心脏收缩功能及左心室重构均发生异常,且MEE与心脏收缩功能、左心室重构密切相关。 展开更多
关键词 慢性心力衰竭 心肌能量代谢 心脏收缩功能 左心室重构 左室收缩末圆周室壁应力 血清游离脂肪酸 左心室舒张末期内径 短轴缩短率
下载PDF
THE FEKETE-SZEG PROBLEM FOR CLOSE-TO-CONVEX FUNCTIONS WITH RESPECT TO THE KOEBE FUNCTION 被引量:1
19
作者 Bogumila KOWALCZYK Adam LECKO 《Acta Mathematica Scientia》 SCIE CSCD 2014年第5期1571-1583,共13页
An analytic function f in the unit disk D := {z ∈ C : |z| 〈 1}, standardly normalized, is called close-to-convex with respect to the Koebe function k(z) := z/(1-z)2, z ∈ D, if there exists δ ∈ (-π/2,... An analytic function f in the unit disk D := {z ∈ C : |z| 〈 1}, standardly normalized, is called close-to-convex with respect to the Koebe function k(z) := z/(1-z)2, z ∈ D, if there exists δ ∈ (-π/2,π/2) such that Re {eiδ(1-z)2f′(z)} 〉 0, z ∈ D. For the class C(k) of all close-to-convex functions with respect to k, related to the class of functions convex in the positive direction of the imaginary axis, the Fekete-Szego problem is studied. 展开更多
关键词 Fekete-Szego problem close-to-convex functions close-to-convex functionswith respect to the Koebe function close-to-convex functions with argumentδ functions convex in the positive direction of the imaginary axis
下载PDF
Study on the regulation of brain-gut peptide by Shenling Baizhu San in functional diarrhea rats 被引量:3
20
作者 Yuan Li Weiyue Zhang +6 位作者 Jie Ma Mindan Chen Bingqi Lin Xi Yang Feng Li Xudong Tang Fengyun Wang 《Journal of Traditional Chinese Medical Sciences》 2018年第3期283-290,共8页
Objective:To explore the therapeutic mechanism of Shenling Baizhu San (SLBZS) on functional diarrhea (FDr) by studying the brain-gut axis and related neuropeptides.Methods:Sixty male Wistar rats were randomly divided ... Objective:To explore the therapeutic mechanism of Shenling Baizhu San (SLBZS) on functional diarrhea (FDr) by studying the brain-gut axis and related neuropeptides.Methods:Sixty male Wistar rats were randomly divided into the control group,model group,SLBZS-treated group and Montmorillonite Powder-treated group (MP-treated group) (n =15/group).Rats received gavage after the establishment of functional diarrhea.An equal volume of SLBZS solution and Montmorillonite Powder (MP) solution was administered to the SLBZS-treated group and MP-treated group,respectively,and an equal volume of distilled water was administered to the control group and the model group.The chemical components and targets related to SLBZS were identified from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Traditional Chinese Medicine Integrated Database (TCMID).The effective chemical components were screened based on oral bioavailability (OB) and drug like-index (DL),and their biological functions were analyzed by GlueGO.Based on this screening,the expression of Cholecystokinin (CCK) and Ghrelin in the hypothalamus of rats was detected by real-time PCR (RT-PCR) and western blotting.Results:In this study,72 effective components and 190 core targets of SLBZS were screened.SLBZS may regulate smooth muscle contraction,energy metabolism and other biological processes.The results of RT-PCR showed that in the model group,the expression of CCK mRNA (P =.001) and Ghrelin mRNA (P =.000) increased significantly.Compared with the model group,CCK mRNA (P =.007) and Ghrelin mRNA (P =.001) levels in SLBZS-treated rats were decreased significantly.The results of western blotting showed that in the model group,the protein expression of CCK (P =.001) and Ghrelin (P =.000) increased significantly.The protein levels of CCK (P =.001) and Ghrelin (P =.005) in the SLBZS-treated group were decreased significantly compared with the model group.Conclusion:SLBZS improved functional diarrhea by regulating the brain-gut axis.Changes in the expressions of brain-gut peptide,CCK and Ghrelin might explain the pathogenesis of functional diarrhea related to brain-gut peptide and gastrointestinal hormone. 展开更多
关键词 Shenling Baizhu SAN functional DIARRHEA Brain-gut axis Brain-gut PEPTIDE
下载PDF
上一页 1 2 24 下一页 到第
使用帮助 返回顶部