FISCO系统“ia”类隔离电源的解析与设计

依据IEC 60079-27标准对FISCO系统电源的要求,对FISCO系统"ia"类隔离电源模型进行了解析,合理地给出了适用于IIC组别的本质安全参数,针对具有梯形输出特性隔离电源进行了原理性设计和分析,针对关键器件的选择进行了分析。实验表明本FISCO系统"ia"类隔离电源不仅各项指标达到了本质安全参数要求,而且较为充分地发挥了现场总线系统(FCS)在一条通信总线上可以挂接多台现场总线设备的基本优点。

17500载重吨少压载化学品船关键技术分析

基于船东的少压载需求,对某型17500载重吨化学品船异于常规设计的主要尺度的确定和压载方案的优化进行分析。该船的压载量相比现有船型的压载量均值减少约30%。对该船的替代燃料预留设计、轴带发电机配置和锂电池应用进行详细阐述,并对其在1A级冰区航行的特殊考虑进行分析,为该船型的优化升级提供参考。

新型矿用“ia”本质安全型电源设计

通过电路计算分析常规“ia”等级本质安全型电源的基本要求和存在的缺陷,提出了利用开关电源作为本质安全电源输出电路中的功率限制设计,对新型电路进行了分析计算和试验验证,新型电路设计不仅符合了本质安全型电路的要求,同时提升了“ia”等级本质安全电源的负载驱动能力,取得了良好效果。

Investigating mechanism of Jiang-zhi-dai-pao-cha for treatment of hyperlipidemia by network pharmacology

Objective:To collect the main components and targets of Jiang-zhi-dai-pao-cha(JZDPC)and investigate the mechanism of JZDPC for the treatment of hyperlipidemia by network pharmacology.Methods:The components and targets of JZDPC were searched from ETCM databases,the targets related to hyperlipidemia were searched from DisGeNET and GeneCards databases,and then the intersection targets and corresponding key components were obtained.Cytoscape 3.8.2 software was used to construct and analyze networks,and then Metascape online database was applied for gene ontology(GO)enrichment analysis and Kyoto Encyclopedia of genes and genomes(KEGG)pathway enrichment analysis of core putative targets.Results:There were 99 overlapping targets between JZDPC and hyperlipidemia,among which NR3C1,ESR1,NR1I2,NFKB1,ESR2,ALOX5,PTGS1,PPARA,RXRA,LPL,PLA2G1B,PYGM,CYP2C9 were the core putative targets,and many members of nuclear receptor 1(NR1)subfamily were included.The core components of JZDPC,such as Ursolic Acid,β-Sitosterol,Resveratrol,Arirubic Acid,Alisol A,Oleanolic Acid,Rhein,Chrysophanol and Emodin,can regulate blood lipid by regulating a series of signaling pathways including the above core potential targets,such as non-alcoholic fatty liver disease(NAFLD)signaling pathway,pathways in cancer,arachidonic acid(AA)metabolism signaling pathway and peroxisome proliferator activated receptor(PPAR)signaling pathway,Starch and sucrose metabolism signaling pathway,etc.They play many roles in the treatment of hyperlipidemia by participating in lipid synthesis and metabolism,anti inflammation,anti oxidative stress,regulating hormone levels and carbohydrate metabolism.Conclusion:Network pharmacology provides a theoretical basis for investigating the mechanism of action of JZDPC,and the NAFLD signaling pathway is one of the most valuable pathways.

阻燃低烟无卤电线电缆在建筑工程中的应用

通过对阻燃低烟无卤绝缘电缆及其要达到的IA级阻燃低烟无卤绝缘电缆辐照交联生产工艺的介绍,提出对一类高层建筑以及重要的公共场所等防火等级高的建筑物,应按JGJ16-2008《民用建筑电气设计规范》要求使用低烟无卤辐照交联聚乙烯绝缘电力电缆。

IA型磷脂酰肌醇3-激酶与肿瘤的关系及其抑制剂分子机制研究进展

磷脂酰肌醇3-激酶(phosphatidylinositol-3 kinase,PI3K)是细胞内重要的信号分子,它具有调节细胞增殖、分化、代谢、凋亡等功能。PI3K的基因易发生突变和扩增,从而导致PI3K被激活,与肿瘤的形成和发展密切相关。IA型的PI3K及其下游的信号分子组成的通路参与调节肿瘤细胞的增殖、存活、黏附、迁移等活动。综述了IA型PI3K——PI3Kα、PI3Kβ和PI3Kδ与肿瘤发生、发展的关系,列举了20个具有代表性的IA型PI3K抑制剂,并讨论了它们的分子抑制机制。