肝脏的低密度脂蛋白受体(LDLR)是清除血浆低密度脂蛋白(LDL)的主要途径,并且是一个非常重要的心血管系统疾病的治疗靶点。LDLR的表达量受到转录和转录后两方面的调控。这里介绍一种新近发现的、通过泛素化作用经转录后途径调控LDLR的蛋...肝脏的低密度脂蛋白受体(LDLR)是清除血浆低密度脂蛋白(LDL)的主要途径,并且是一个非常重要的心血管系统疾病的治疗靶点。LDLR的表达量受到转录和转录后两方面的调控。这里介绍一种新近发现的、通过泛素化作用经转录后途径调控LDLR的蛋白Idol(inducible degrader of the LDLR)。Idol是一个肝脏X受体(LXR)的靶分子,具有E3泛素连接酶活性,可以介导LDLR的泛素化,并在溶酶体降解。Idol还有另外两个LDLR家族的靶蛋白VLDLR和ApoER2。尽管Idol和前蛋白转化酶枯草溶菌素9(PCSK9)存在着很多相似之处,但它们在调控LDLR的途径上是不同的。最近的工作显示Idol与人类的LDL水平有关,Idol可能在人类的血脂代谢有重要作用。展开更多
目的探讨人类诱导型低密度脂蛋白受体降解蛋白(IDOL)基因多态性与成年人肥胖的相关性。方法采用病例对照研究,选择2013年8月—2019年10月期间因心血管疾病在新疆医科大学第一附属医院心脏中心住院治疗的患者1172例,根据肥胖诊断标准分...目的探讨人类诱导型低密度脂蛋白受体降解蛋白(IDOL)基因多态性与成年人肥胖的相关性。方法采用病例对照研究,选择2013年8月—2019年10月期间因心血管疾病在新疆医科大学第一附属医院心脏中心住院治疗的患者1172例,根据肥胖诊断标准分为肥胖组(n=572)和对照组(n=600),采用改进的多重连接检测反应(iMLDR)方法对诱导型低密度脂蛋白受体降解蛋白IDOL基因rs2072783、rs9370867和rs9370867位点进行基因型分型。结果诱导型低密度脂蛋白受体降解蛋白IDOL基因SNP1(rs2072783)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、隐形模型(GG vs AG+AA)的分布频率存在统计学差异。SNP2(rs9370867)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、相加模型(AG vs AA+GG)的分布频率存在统计学差异(P<0.05)。校正混杂因素后,rs2072783位点的隐形模型(GG vs AA+AG)和rs9370867位点的相加模型(AG vs AA+GG)为肥胖患者的危险因素[(rs2072783:OR=1.482,P=0.032,95%CI:1.034-2.121);(rs9370867:OR=1.849,P=0.032,95%CI:1.034-2.121)]。结论诱导型低密度脂蛋白受体降解蛋白IDOL基因多态性与成年人肥胖患病具有相关性。IDOL基因rs9370867和rs2072783位点G等位基因的人群比携带A等位基因的人罹患肥胖的可能性更高,诱导型低密度脂蛋白受体降解蛋白IDOL基因rs9370867位点AG基因型及rs2072783位点的GG基因型是肥胖的易感因素。展开更多
Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study...Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study focuses on American Idol and Super Girls,discusses their different manifestations of individualism and analyzes the reasons behind it.The analysis shows that the differences of the two countries'cultural background contribute to the different manifestations of individualism.In a word,during the process of imitating American talent shows,the problems of Chinese talent shows indicate that American individualism has its positive as well as negative effects.Consequently,Chinese people should hold a critical attitude toward American individualism.展开更多
Following the increasing interaction between China's Mainland and Taiwan,Taiwan's idol drama,may be seen as a way of cultural exchange,is very famous in the Chinese community.Not only the dramas become the hot...Following the increasing interaction between China's Mainland and Taiwan,Taiwan's idol drama,may be seen as a way of cultural exchange,is very famous in the Chinese community.Not only the dramas become the hot topic among audience,but the idols and the leading characters are popular.Meanwhile,the popularity of Taiwan's idol drama has stimulated the formation of fans or fandom in China's Mainland.Moreover,as the development of technology many practices or discussions of fans have been moved online.This paper explores the computer-mediated fan group:Summer's Desire Club in Baidu's tieba,one of the most popular fans communities in China's Mainland by using the Ethnography method.Through observing the practices of members(or fans) in this group to discover what practices appear in the computer-mediated communication of Taiwan's idol drama viewing in China's Mainland and why do fans do these practices.展开更多
Lake contamination by anthropogenic activities has become a serious threat to the aquatic ecosystem due to the presence of a high concentration of toxic heavy metals.In this study,a contaminated Lake Hussain Sagar in ...Lake contamination by anthropogenic activities has become a serious threat to the aquatic ecosystem due to the presence of a high concentration of toxic heavy metals.In this study,a contaminated Lake Hussain Sagar in India was assessed for toxic heavy metal pollutants at sites associated with industrial discharges and idol immersion activities.The observed high concentration of As,Cd,Pb,Zn,Cu,and Ni in the surface water was due to industrial effluent discharge.About 1.5 times the high concentration of the same elements were observed in surface sediments(0-10 cm)by both industrial discharges and idol immersion activities,compared to deep sediments(0-40 cm)associated only with industrial discharge.The depth-wise variation of heavy metal concentration in surface sediments is due to sorption and settling behavior of suspended solids;whereas in deep sediment,it is due to constant loading of effluents,over a period of time.The sorption capacity of surface sediments is in increasing order as Pb>Cd≥Ni>Cr>Zn>Cu,and the desorption revealed that Pb and Cu were retained to a greater extent due to high clay and organic content.By fractionation study,20-50%of Zn and 50-80%of Cd were associated with exchangeable and carbonate fraction of sediments.By risk assessment code,Zn and Cd are classified under high risk to a very high-risk category,and Cr,Pb,Ni,and Cu are classified under the medium risk category.The enrichment factor value of sediments for Cd(20.42-119.48),Zn(2.19-4.85),Cu(2.02-3.19),and Pb(2.85-7.72)signifies the significant pollution by anthropogenic activities.Therefore,this study evaluates the intensity and distribution of heavy metals in the lake environment for remediation and restoration of the lake ecosystem.展开更多
In the 1980s they rocked the cradle, now they’re fending for themselves On February 8, a gala was shown on the Beijing Television Business Channel giving awards to idols
Technophiles around the world are snapping up Apple’s new iPhone. How much longer must the Chinese wait?The iPhone, a faster and more versatile version of Apple Inc.’s original touch-based mobile handset, has been a...Technophiles around the world are snapping up Apple’s new iPhone. How much longer must the Chinese wait?The iPhone, a faster and more versatile version of Apple Inc.’s original touch-based mobile handset, has been a market hit since it went展开更多
My idol is my father. I think he is like Superman.If I want a paper plane,he will make one quickly.If l am stuck on myhomework,he will help me.Besides that,my father taught me a lot about life and told me how to be a ...My idol is my father. I think he is like Superman.If I want a paper plane,he will make one quickly.If l am stuck on myhomework,he will help me.Besides that,my father taught me a lot about life and told me how to be a betterboy.I'm quite lucky I have a great father.展开更多
文摘肝脏的低密度脂蛋白受体(LDLR)是清除血浆低密度脂蛋白(LDL)的主要途径,并且是一个非常重要的心血管系统疾病的治疗靶点。LDLR的表达量受到转录和转录后两方面的调控。这里介绍一种新近发现的、通过泛素化作用经转录后途径调控LDLR的蛋白Idol(inducible degrader of the LDLR)。Idol是一个肝脏X受体(LXR)的靶分子,具有E3泛素连接酶活性,可以介导LDLR的泛素化,并在溶酶体降解。Idol还有另外两个LDLR家族的靶蛋白VLDLR和ApoER2。尽管Idol和前蛋白转化酶枯草溶菌素9(PCSK9)存在着很多相似之处,但它们在调控LDLR的途径上是不同的。最近的工作显示Idol与人类的LDL水平有关,Idol可能在人类的血脂代谢有重要作用。
文摘目的探讨人类诱导型低密度脂蛋白受体降解蛋白(IDOL)基因多态性与成年人肥胖的相关性。方法采用病例对照研究,选择2013年8月—2019年10月期间因心血管疾病在新疆医科大学第一附属医院心脏中心住院治疗的患者1172例,根据肥胖诊断标准分为肥胖组(n=572)和对照组(n=600),采用改进的多重连接检测反应(iMLDR)方法对诱导型低密度脂蛋白受体降解蛋白IDOL基因rs2072783、rs9370867和rs9370867位点进行基因型分型。结果诱导型低密度脂蛋白受体降解蛋白IDOL基因SNP1(rs2072783)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、隐形模型(GG vs AG+AA)的分布频率存在统计学差异。SNP2(rs9370867)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、相加模型(AG vs AA+GG)的分布频率存在统计学差异(P<0.05)。校正混杂因素后,rs2072783位点的隐形模型(GG vs AA+AG)和rs9370867位点的相加模型(AG vs AA+GG)为肥胖患者的危险因素[(rs2072783:OR=1.482,P=0.032,95%CI:1.034-2.121);(rs9370867:OR=1.849,P=0.032,95%CI:1.034-2.121)]。结论诱导型低密度脂蛋白受体降解蛋白IDOL基因多态性与成年人肥胖患病具有相关性。IDOL基因rs9370867和rs2072783位点G等位基因的人群比携带A等位基因的人罹患肥胖的可能性更高,诱导型低密度脂蛋白受体降解蛋白IDOL基因rs9370867位点AG基因型及rs2072783位点的GG基因型是肥胖的易感因素。
文摘Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study focuses on American Idol and Super Girls,discusses their different manifestations of individualism and analyzes the reasons behind it.The analysis shows that the differences of the two countries'cultural background contribute to the different manifestations of individualism.In a word,during the process of imitating American talent shows,the problems of Chinese talent shows indicate that American individualism has its positive as well as negative effects.Consequently,Chinese people should hold a critical attitude toward American individualism.
文摘Following the increasing interaction between China's Mainland and Taiwan,Taiwan's idol drama,may be seen as a way of cultural exchange,is very famous in the Chinese community.Not only the dramas become the hot topic among audience,but the idols and the leading characters are popular.Meanwhile,the popularity of Taiwan's idol drama has stimulated the formation of fans or fandom in China's Mainland.Moreover,as the development of technology many practices or discussions of fans have been moved online.This paper explores the computer-mediated fan group:Summer's Desire Club in Baidu's tieba,one of the most popular fans communities in China's Mainland by using the Ethnography method.Through observing the practices of members(or fans) in this group to discover what practices appear in the computer-mediated communication of Taiwan's idol drama viewing in China's Mainland and why do fans do these practices.
基金the support from Frontier Areas of Science and Technology—Centre of Excellence(FAST-CoE)in Sustainable Development at Indian Institute of Technology Hyderabad,funded by the Ministry of Human Resource Development,India。
文摘Lake contamination by anthropogenic activities has become a serious threat to the aquatic ecosystem due to the presence of a high concentration of toxic heavy metals.In this study,a contaminated Lake Hussain Sagar in India was assessed for toxic heavy metal pollutants at sites associated with industrial discharges and idol immersion activities.The observed high concentration of As,Cd,Pb,Zn,Cu,and Ni in the surface water was due to industrial effluent discharge.About 1.5 times the high concentration of the same elements were observed in surface sediments(0-10 cm)by both industrial discharges and idol immersion activities,compared to deep sediments(0-40 cm)associated only with industrial discharge.The depth-wise variation of heavy metal concentration in surface sediments is due to sorption and settling behavior of suspended solids;whereas in deep sediment,it is due to constant loading of effluents,over a period of time.The sorption capacity of surface sediments is in increasing order as Pb>Cd≥Ni>Cr>Zn>Cu,and the desorption revealed that Pb and Cu were retained to a greater extent due to high clay and organic content.By fractionation study,20-50%of Zn and 50-80%of Cd were associated with exchangeable and carbonate fraction of sediments.By risk assessment code,Zn and Cd are classified under high risk to a very high-risk category,and Cr,Pb,Ni,and Cu are classified under the medium risk category.The enrichment factor value of sediments for Cd(20.42-119.48),Zn(2.19-4.85),Cu(2.02-3.19),and Pb(2.85-7.72)signifies the significant pollution by anthropogenic activities.Therefore,this study evaluates the intensity and distribution of heavy metals in the lake environment for remediation and restoration of the lake ecosystem.
文摘In the 1980s they rocked the cradle, now they’re fending for themselves On February 8, a gala was shown on the Beijing Television Business Channel giving awards to idols
文摘Technophiles around the world are snapping up Apple’s new iPhone. How much longer must the Chinese wait?The iPhone, a faster and more versatile version of Apple Inc.’s original touch-based mobile handset, has been a market hit since it went
文摘My idol is my father. I think he is like Superman.If I want a paper plane,he will make one quickly.If l am stuck on myhomework,he will help me.Besides that,my father taught me a lot about life and told me how to be a betterboy.I'm quite lucky I have a great father.
