Metalens-integrated compact imaging devices for wide-field microscopy

Metasurfaces have demonstrated unprecedented capabilities in manipulating light with ultrathin and flat architectures.Although great progress has been made in the metasurface designs and function demonstrations,most metalenses still only work as a substitution of conventional lenses in optical settings,whose integration advantage is rarely manifested.We propose a highly integrated imaging device with silicon metalenses directly mounted on a complementary metal oxide semiconductor image sensor,whose working distance is in hundreds of micrometers.The imaging performances including resolution,signal-to-noise ratio,and field of view(FOV)are investigated.Moreover,we develop a metalens array with polarization-multiplexed dual-phase design for a wide-field microscopic imaging.This approach remarkably expands the FOV without reducing the resolution,which promises a non-limited space-bandwidth product imaging for wide-field microscopy.As a result,we demonstrate a centimeter-scale prototype for microscopic imaging,showing uniqueness of meta-design for compact integration.

Application of a Quality Assurance Solution Based on an Electronic Field Imaging Device in Linac

Objective To test a quality assurance(QA)DVS solution-DVS based on a linac electronic field imaging device(EPID)and evaluate its accuracy and ease of use.Methods All of the QA items that do not require the dedicated QA phantom in the DVS solution were tested.Test methods were chosen based on the test items:for the collimator rotation center,the coincidence of the radiation and mechanical,mechanical flatness/symmetry and MLC transmission were compared with the existing QA solution;for the leaf position accuracy and repeatability,the original preset beam fields and fields adjusted by 1 mm were compared.Results The collimator rotation center by the DVS solution is similar to the existing solution.For coincidence of radiation and mechanical,the DVS solution provides more data,including 3D distance.For the flatness/symmetry property,the DVS solution can display more graphics,but the overall data is less than the ion-chamber matrix solution.The DVS solution can directly obtain the MLC transmission value and quickly and intuitively measure the position accuracy of the MLC.However,the repeatability is slightly worse.Conclusion The DVS solution can improve the QA work efficiency and reduce workload,and there are more opportunities for improvement.

Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μm in diameter.The human retina is a thin and multiple layer tissue,and the layer of capillaries less than10 μm in diameter only exists in the inner nuclear layer.The layer thickness of capillaries less than 10 μm in diameter is about 40 μm and the distance range to rod＆cone cell surface is tens of micrometers,which varies from person to person.Therefore,determining reasonable capillary layer（CL） position in different human eyes is very difficult.In this paper,we propose a method to determine the position of retinal CL based on the rod＆cone cell layer.The public positions of CL are recognized with 15 subjects from 40 to 59 years old,and the imaging planes of CL are calculated by the effective focal length of the human eye.High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system（LCAOS） validate our method.All of the subjects＇ CLs have public positions from 127 μm to 147 μm from the rod＆cone cell layer,which is influenced by the depth of focus.

The Journey of SRS: An Initial Experience of Starting Sterotactic Radiosurgery Facility at Purbanchal Cancer Hospital—First in Nepal

Introduction: Radiotherapy (RT) is a vital cancer treatment modality for both curative and palliative purposes. Nepal is a developing country with a population of around 30 million people. Cancer affects 100 - 120 people out of every 100,000, and the figure is increasing. The number of radiation facility machines in the country is still countable in fingers. Purbanchal Cancer Hospital, Nepal is the first comprehensive cancer facility capable of performing stereotactic radiosurgery (SRS). Our facility has cutting-edge Varian Truebeam Linear Accelerators with millennium MLC, which makes SRS and SRT’S for intracranial lesions such as small benign and malignant tumors much easier. In addition to SRS, we are the pioneers of SBRT for lung using 4DCT, interstitial & intraluminal brachytherapy, RPM Gated & DIBH modalities in Nepal. Methods & Materials: The purpose of this study is to share our experience in establishing an SRS facility in the country, which includes training the RT team on the importance of process accuracy, patient selection, patient assessment, mould preparation, and describing image data acquisition, target, and organ at risk delineation on CT and MRI images, treatment planning process, and quality assurance. Results & Discussion: The plans for all SRS and SRT cases are based on target coverage, OAR sparing, hotspot inside the target, conformity index, heterogeneity index, and dose fall off. To select the final plan, we used strict passing criteria such as a conformity index Paddick (CIPaddick) more than 0.85, a falloff between 100% and 50% of less than 5.5 mm (maximum 6 mm in irregular targets), and a hotspot inside the target between 115 to 140 percent, as per clinical standards. In addition, we determined the CILomax and CIRTOG for each case. Passing criteria for verification plans are set as minimum of 95% for a 2% percentage dose difference (% DD) and a 2-mm distance to an agreement (DTA). We also gathered demographic data from patients treated in the first year, such as diagnosis, lesion size, dose fraction, heterogeneity index (HI), conformity index (CI) and gamma index. SRS/SRT treatment was successfully implemented, and over 40 patients were treated with positive clinical outcomes. Conclusion: SRS now has a wider range of alternatives, thanks to technology advancements in recent years. SRS’s dosimetric advantages have steadily been extended to extracranial locations. Purbanchal Cancer Hospital, Birtamode, Nepal established a comprehensive cancer facility with qualified workforce with the goal of providing high-quality treatment to the people of Nepal.

Visualization study on fluid distribution and end effects in core flow experiments with low-field mri method

Core flow experiment is an important means of simulation experiments to evaluate the effect of displacing agent, but conventionally the internal characteristics in the core cannot be intuitively observed, and then some important information can not be directly acquired by experiments. In this paper, a visualization method was used to detect the water-flooding process by using an improved low field nuclear magnetic resonance imaging（MRI） device, and the images describing the distribution of oil and water were collected. The experimental results show that the distribution of oil and water can be visually detected in an appropriate range of core porosity, and the end effect in many mechanics experiments is found to exist also in natural core flow test, and the influence range is about 0.004 m from the end of a 0.05752 m length natural core. The results also indicate that MRI is an effective tool to study the real time fluid distribution in natural core.