BACKGROUND Both tenofovir alafenamide(TAF)and tenofovir disoproxil fumarate(TDF)are the first-line treatments for chronic hepatitis B(CHB).We have showed switching from TDF to TAF for 96 weeks resulted in further alan...BACKGROUND Both tenofovir alafenamide(TAF)and tenofovir disoproxil fumarate(TDF)are the first-line treatments for chronic hepatitis B(CHB).We have showed switching from TDF to TAF for 96 weeks resulted in further alanine aminotransferase(ALT)improvement,but data remain lacking on the long-term benefits of TDF switching to TAF on hepatic fibrosis.AIM To assess the benefits of TDF switching to TAF for 3 years on ALT,aspartate aminotransferase(AST),and hepatic fibrosis improvement in patients with CHB.METHODS A single center retrospective study on 53 patients with CHB who were initially treated with TDF,then switched to TAF to determine dynamic patterns of ALT,AST,AST to platelet ratio index(APRI),fibrosis-4(FIB-4)scores,and shear wave elastography(SWE)reading improvement at switching week 144,and the associated factors.RESULTS The mean age was 55(28-80);45.3%,males;15.1%,clinical cirrhosis;mean baseline ALT,24.8;AST,25.7 U/L;APRI,0.37;and FIB-4,1.66.After 144 weeks TDF switching to TAF,mean ALT and AST were reduced to 19.7 and 21,respectively.From baseline to switching week 144,the rates of ALT and AST<35(male)/25(female)and<30(male)/19(female)were persistently increased;hepatic fibrosis was also improved by APRI<0.5,from 79.2%to 96.2%;FIB-4<1.45,from 52.8%to 58.5%,respectively;mean APRI was reduced to 0.27;FIB-4,to 1.38;and mean SWE reading,from 7.05 to 6.30 kPa after a mean of 109 weeks switching.The renal function was stable and the frequency of patients with glomerular filtration rate>60 mL/min was increased from 86.5%at baseline to 88.2%at switching week 144.CONCLUSION Our data confirmed that switching from TDF to TAF for 3 years results in not only persistent ALT/AST improvement,but also hepatic fibrosis improvement by APRI,FIB-4 scores,as well as SWE reading,the important clinical benefits of long-term hepatitis B virus antiviral treatment with TAF.展开更多
The fatty acid derivatives, prepared from renewable natural oils, can be used as highly promising and potential substitutes for petrochemicals. The study of process improvement and stereochemical mechanism for prepari...The fatty acid derivatives, prepared from renewable natural oils, can be used as highly promising and potential substitutes for petrochemicals. The study of process improvement and stereochemical mechanism for preparing these derivatives would be beneficial for their industrial production. Conjugated linoleic acid (CLA) containing 9<em>cis</em>-11<em>trans</em> (9<em>c</em>, 11<em>t</em>) and 10<em>trans</em>-12<em>cis</em> (10<em>t</em>, 12<em>c</em>) isomers was prepared from <em>Salicornia herbacea</em> seed oil. Maleic anhydride cycloadduct of CLA (MAC) was prepared by an improved process, and it was characterized by FTIR, <sup>1</sup>H and <sup>13</sup>C NMR, <em>etc</em>. A new method to calculate conformers-ratio of CLA or MAC was also developed. Furthermore, the stereochemical mechanism for the improved preparation of MAC was proposed primarily by the calculation method above. The following observations were made: 1) The yield of MAC could reach as high as 96.7% under mild reaction conditions and with an easy and efficient product separation;2) The <em>trans-trans</em> CLA in the<em> s-cis</em> conformation acted as a predominant reactant to <em>Diels-Alder</em> [4 + 2] cycloaddition of maleic anhydride, which was the main reaction occurred simultaneously with catalytic configurational isomerizations of CLA in one step;3) From all studied CLA conformers, the most stable conformation was the s-trans conformation of trans-trans CLA, while the <em>s-cis</em> conformation of <em>trans-trans</em> CLA had the most favorable structural parameters for cyclohexenyl ring formation;4) Four MAC conformers derived from 9<em>c</em>, 11<em>t</em>- and 10<em>t</em>, 12c-CLA, were obtained as final main products that were determined to be <em>cis</em>-cycloadducts;5) The <em>endo/exo</em> ratios of the <em>cis</em>- cycloadducts derived from 9<em>c</em>, 11<em>t</em>- and 10<em>t</em>, 12<em>c</em>-CLA, were 2.14:1 and 1.99:1, respectively;and 6) The results obtained from the calculation method above were in excellent accordance with those from our experiments.展开更多
It is essential to precisely predict the crack growth,especially the near-threshold regime crack growth under different stress ratios,for most engineering structures consume their fatigue lives in this regime under ra...It is essential to precisely predict the crack growth,especially the near-threshold regime crack growth under different stress ratios,for most engineering structures consume their fatigue lives in this regime under random loading.In this paper,an improved unique curve model is proposed based on the unique curve model,and the determination of the shape exponents of this model is provided.The crack growth rate curves of some materials taken from the literature are evaluated using the improved model,and the results indicate that the improved model can accurately predict the crack growth rate in the nearthreshold and Paris regimes.The improved unique curve model can solve the problems about the shape exponents determination and weak ability around the near-threshold regime meet in the unique curve model.In addition,the shape exponents in the improved model at negative stress ratios are discussed,which can directly adopt that in the unique curve model.展开更多
Optimization of antenna array pattern used in a spaceborne Synthetic Aperture Radar (SAR) system is considered in this study. A robust evolutionary algorithm, Non-dominated Sorting Genetic Algorithms (the improved NS...Optimization of antenna array pattern used in a spaceborne Synthetic Aperture Radar (SAR) system is considered in this study. A robust evolutionary algorithm, Non-dominated Sorting Genetic Algorithms (the improved NSGA-Ⅱ), is applied on a spaceborne SAR antenna pattern design. The system consists of two objective functions with two constraints. Pareto fronts are generated as a result of multi-objective optimization. After being validated by a test problem ZDT4, the algorithms are used to synthesize spaceborne SAR antenna radiation pattern. The good results with low Ambi- guity-to-Signal Ratio (ASR) and high directivity are obtained in the paper.展开更多
To improve the training speed of support vector machine （SVM）, a method called improved center distance ratio method （ICDRM） with determining thresholds automatically is presented here without reduce the identific...To improve the training speed of support vector machine （SVM）, a method called improved center distance ratio method （ICDRM） with determining thresholds automatically is presented here without reduce the identification rate. In this method border vectors are chosen from the given samples by comparing sample vectors with center distance ratio in advance. The number of training samples is reduced greatly and the training speed is improved. This method is used to the identification for license plate characters. Experimental resuhs show that the improved SVM method-ICDRM does well at identification rate and training speed.展开更多
文摘BACKGROUND Both tenofovir alafenamide(TAF)and tenofovir disoproxil fumarate(TDF)are the first-line treatments for chronic hepatitis B(CHB).We have showed switching from TDF to TAF for 96 weeks resulted in further alanine aminotransferase(ALT)improvement,but data remain lacking on the long-term benefits of TDF switching to TAF on hepatic fibrosis.AIM To assess the benefits of TDF switching to TAF for 3 years on ALT,aspartate aminotransferase(AST),and hepatic fibrosis improvement in patients with CHB.METHODS A single center retrospective study on 53 patients with CHB who were initially treated with TDF,then switched to TAF to determine dynamic patterns of ALT,AST,AST to platelet ratio index(APRI),fibrosis-4(FIB-4)scores,and shear wave elastography(SWE)reading improvement at switching week 144,and the associated factors.RESULTS The mean age was 55(28-80);45.3%,males;15.1%,clinical cirrhosis;mean baseline ALT,24.8;AST,25.7 U/L;APRI,0.37;and FIB-4,1.66.After 144 weeks TDF switching to TAF,mean ALT and AST were reduced to 19.7 and 21,respectively.From baseline to switching week 144,the rates of ALT and AST<35(male)/25(female)and<30(male)/19(female)were persistently increased;hepatic fibrosis was also improved by APRI<0.5,from 79.2%to 96.2%;FIB-4<1.45,from 52.8%to 58.5%,respectively;mean APRI was reduced to 0.27;FIB-4,to 1.38;and mean SWE reading,from 7.05 to 6.30 kPa after a mean of 109 weeks switching.The renal function was stable and the frequency of patients with glomerular filtration rate>60 mL/min was increased from 86.5%at baseline to 88.2%at switching week 144.CONCLUSION Our data confirmed that switching from TDF to TAF for 3 years results in not only persistent ALT/AST improvement,but also hepatic fibrosis improvement by APRI,FIB-4 scores,as well as SWE reading,the important clinical benefits of long-term hepatitis B virus antiviral treatment with TAF.
文摘The fatty acid derivatives, prepared from renewable natural oils, can be used as highly promising and potential substitutes for petrochemicals. The study of process improvement and stereochemical mechanism for preparing these derivatives would be beneficial for their industrial production. Conjugated linoleic acid (CLA) containing 9<em>cis</em>-11<em>trans</em> (9<em>c</em>, 11<em>t</em>) and 10<em>trans</em>-12<em>cis</em> (10<em>t</em>, 12<em>c</em>) isomers was prepared from <em>Salicornia herbacea</em> seed oil. Maleic anhydride cycloadduct of CLA (MAC) was prepared by an improved process, and it was characterized by FTIR, <sup>1</sup>H and <sup>13</sup>C NMR, <em>etc</em>. A new method to calculate conformers-ratio of CLA or MAC was also developed. Furthermore, the stereochemical mechanism for the improved preparation of MAC was proposed primarily by the calculation method above. The following observations were made: 1) The yield of MAC could reach as high as 96.7% under mild reaction conditions and with an easy and efficient product separation;2) The <em>trans-trans</em> CLA in the<em> s-cis</em> conformation acted as a predominant reactant to <em>Diels-Alder</em> [4 + 2] cycloaddition of maleic anhydride, which was the main reaction occurred simultaneously with catalytic configurational isomerizations of CLA in one step;3) From all studied CLA conformers, the most stable conformation was the s-trans conformation of trans-trans CLA, while the <em>s-cis</em> conformation of <em>trans-trans</em> CLA had the most favorable structural parameters for cyclohexenyl ring formation;4) Four MAC conformers derived from 9<em>c</em>, 11<em>t</em>- and 10<em>t</em>, 12c-CLA, were obtained as final main products that were determined to be <em>cis</em>-cycloadducts;5) The <em>endo/exo</em> ratios of the <em>cis</em>- cycloadducts derived from 9<em>c</em>, 11<em>t</em>- and 10<em>t</em>, 12<em>c</em>-CLA, were 2.14:1 and 1.99:1, respectively;and 6) The results obtained from the calculation method above were in excellent accordance with those from our experiments.
文摘It is essential to precisely predict the crack growth,especially the near-threshold regime crack growth under different stress ratios,for most engineering structures consume their fatigue lives in this regime under random loading.In this paper,an improved unique curve model is proposed based on the unique curve model,and the determination of the shape exponents of this model is provided.The crack growth rate curves of some materials taken from the literature are evaluated using the improved model,and the results indicate that the improved model can accurately predict the crack growth rate in the nearthreshold and Paris regimes.The improved unique curve model can solve the problems about the shape exponents determination and weak ability around the near-threshold regime meet in the unique curve model.In addition,the shape exponents in the improved model at negative stress ratios are discussed,which can directly adopt that in the unique curve model.
文摘Optimization of antenna array pattern used in a spaceborne Synthetic Aperture Radar (SAR) system is considered in this study. A robust evolutionary algorithm, Non-dominated Sorting Genetic Algorithms (the improved NSGA-Ⅱ), is applied on a spaceborne SAR antenna pattern design. The system consists of two objective functions with two constraints. Pareto fronts are generated as a result of multi-objective optimization. After being validated by a test problem ZDT4, the algorithms are used to synthesize spaceborne SAR antenna radiation pattern. The good results with low Ambi- guity-to-Signal Ratio (ASR) and high directivity are obtained in the paper.
基金Sponsored by the National Natural Science Foundation of China(60472110)
文摘To improve the training speed of support vector machine （SVM）, a method called improved center distance ratio method （ICDRM） with determining thresholds automatically is presented here without reduce the identification rate. In this method border vectors are chosen from the given samples by comparing sample vectors with center distance ratio in advance. The number of training samples is reduced greatly and the training speed is improved. This method is used to the identification for license plate characters. Experimental resuhs show that the improved SVM method-ICDRM does well at identification rate and training speed.
