Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared dr...Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared drug implant prototype consists of a doublelayer structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX. The release test in vivo revealed that LVFX was released in the early stage; no RFP was detected until 8th day; both of them continuously released more than 6 weeks. Therefore, 3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.展开更多
The effect of external constraints on Li diffusion in high-capacity Li-ion battery electrodes is investigated using a coupled finite deformation theory. It is found that thinfilm electrodes on rigid substrates experie...The effect of external constraints on Li diffusion in high-capacity Li-ion battery electrodes is investigated using a coupled finite deformation theory. It is found that thinfilm electrodes on rigid substrates experience much slower diffusion rates compared with free-standing films with the same material properties and geometric dimensions. More importantly, the study reveals that mechanical driving forces tend to retard diffusion in highly-constrained thin films when lithiation-induced softening is considered, in contrast to the fact that mechanical driving forces always enhance diffusion when deformation is fully elastic. The results provide further proof that nano-particles are a better design option for nextgeneration alloy-based electrodes compared with thin films.展开更多
The performance of the Ordered-Statistic Smallest Of (OSSO) Constant False Alarm Rate (CFAR) with binary integration in Weibull background with known shape parameter is analyzed, in the cases that the processor operat...The performance of the Ordered-Statistic Smallest Of (OSSO) Constant False Alarm Rate (CFAR) with binary integration in Weibull background with known shape parameter is analyzed, in the cases that the processor operates in homogeneous background and non-homogeneous situation caused by multiple targets and clutter edge. The analytical models of this scheme for the performance evaluation are given. It is shown that the OSSO-CFAR with binary integration can greatly improve the detection performance with respect to the single pulse processing case. As the clutter background becomes spiky, a high threshold S of binary integration (S/M) is required in order to obtain a good detection performance in homogeneous background. Moreover, the false alarm performance of the OSSO-CFAR with binary integration is more sensitive to the changes of shape parameter or power level of the clutter background.展开更多
基金Funded by the Graduate Innovation Fund of the Huazhong University of Science and Technology, the "863" Key Project of the National High Technology Research and Development Program of China (No.2006AA02A124)the Program for New Century Excellent Talents in University from the Ministry of Education of China( NCET-05-0647)
文摘Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared drug implant prototype consists of a doublelayer structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX. The release test in vivo revealed that LVFX was released in the early stage; no RFP was detected until 8th day; both of them continuously released more than 6 weeks. Therefore, 3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.
基金supported by the National Research Foundation of Korea through WCU(R31-2009-000-10083-0)
文摘The effect of external constraints on Li diffusion in high-capacity Li-ion battery electrodes is investigated using a coupled finite deformation theory. It is found that thinfilm electrodes on rigid substrates experience much slower diffusion rates compared with free-standing films with the same material properties and geometric dimensions. More importantly, the study reveals that mechanical driving forces tend to retard diffusion in highly-constrained thin films when lithiation-induced softening is considered, in contrast to the fact that mechanical driving forces always enhance diffusion when deformation is fully elastic. The results provide further proof that nano-particles are a better design option for nextgeneration alloy-based electrodes compared with thin films.
基金Supported by the National Natural Science Foundation of China (No.61179016)
文摘The performance of the Ordered-Statistic Smallest Of (OSSO) Constant False Alarm Rate (CFAR) with binary integration in Weibull background with known shape parameter is analyzed, in the cases that the processor operates in homogeneous background and non-homogeneous situation caused by multiple targets and clutter edge. The analytical models of this scheme for the performance evaluation are given. It is shown that the OSSO-CFAR with binary integration can greatly improve the detection performance with respect to the single pulse processing case. As the clutter background becomes spiky, a high threshold S of binary integration (S/M) is required in order to obtain a good detection performance in homogeneous background. Moreover, the false alarm performance of the OSSO-CFAR with binary integration is more sensitive to the changes of shape parameter or power level of the clutter background.
