EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine tar...EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.展开更多
As commercial memristors are still unavailable in the market, mathematic models and emulators which can imitate the features of the mernristor are meaningful for further research. In this paper, based on the analyses ...As commercial memristors are still unavailable in the market, mathematic models and emulators which can imitate the features of the mernristor are meaningful for further research. In this paper, based on the analyses of characteristics of the q-φ curve, an exponential flux-controlled model, which has the quality that its memductance (memristance) will keep monotonically increasing or decreasing unless the voltage's polarity reverses (if not approach the boundaries), is constructed. A new approach to designing the floating emulator of the memristor is also proposed. This floating structure can flexibly meet various demands for the current through the memristor (especially the demand for a larger current). The simulations and experiments are presented to confirm the effectiveness of this model and its floating emulator.展开更多
In this paper,the transmission performances are studied in cognitive radio networks with primary user emulator and relay existence.In the proposed network,the users include primary users,secondary users and primary us...In this paper,the transmission performances are studied in cognitive radio networks with primary user emulator and relay existence.In the proposed network,the users include primary users,secondary users and primary user emulators.The decreasing access priority of the users are primary users,primary user emulators and secondary users.Different user access to the network results in different transmission effects.We impose interference power constraints on the secondary users to protect the primary users from being interfered.We also adopt the transmission mechanism that transits among more than one secondary transmitters,secondary receivers and relays.The transition models of the transmission states are proposed to describe the transmission mechanism.To investigate the transmission performances,the theory of effective capacity is adopted.The transmission performances in terms of effective capacity are expressed and demonstrated under different transmission policies.The overall effective capacity,as the overall data traffic in the cognitive radio network,is calculated.Besides,the overall effective capacity is demonstrated under different transmission strategies.The results show the greedy transmission strategy outperforms the rest of the transmission 8 policies in the overall effective capacity.For a larger number of the users,the effective capacity converges to a certain value.展开更多
The mathematical physics model of mine methane and coal dust explosion propagation was established in the research,by using continuous phase,combustion,par- ticulate equations of mathematical physics.Based upon the da...The mathematical physics model of mine methane and coal dust explosion propagation was established in the research,by using continuous phase,combustion,par- ticulate equations of mathematical physics.Based upon the data from mine methane drainage roadway explosion,and mine methane and coal dust explosion propagation ex- perimental studies,the numerical emulator system of mine methane and coal dust explo- sion software was developed by using prevalent flow simulation platform,which can be used to simulate the explosion accidents process effectively.In addition,the system can also be used to determine whether coal dust involved in the explosion,and to simulate accurately the transition from deflagration to detonation in methane explosion,propagation velocity of explosion shock,attenuation pattern,and affected area of explosion.展开更多
This paper presents the modeling, simulation and practical implementation of an inverter-based diesel generator emulator. The main purpose of this emulator is for the study of frequency variations in diesel-based auto...This paper presents the modeling, simulation and practical implementation of an inverter-based diesel generator emulator. The main purpose of this emulator is for the study of frequency variations in diesel-based autonomous power systems in a laboratory environment where the operation of a real diesel generator is not possible. The emulator basically consists in a voltage source inverter with a second order output filter which voltage references are given by the model of the diesel generator. The control of the emulator is based on the digital signal processor TMS320F2812, where the mathematical models of the diesel generator and the control of the inverter are computed in real-time. Parameters for the model were obtained from commercially available components. Experimental results for different values of speed droop showed that the emulator achieves a satisfactory performance in the transient and stationary response. For the stationary response, the measured frequency deviates from theoretical values with a mean absolute error of: 0.06 Hz for 0% droop, 0.037 Hz for 3% droop, and 0.087 Hz for 5% droop. For the transient response, the measured frequency nadir deviates from simulations in: 0.05 Hz for 0% droop, 0.02 Hz for 3% droop, and 0.1 Hz for 5% droop.展开更多
This paper investigates the subjective assessment of QoE of web and video services over a mobile network. To achieve this, the authors used the network emulator (NetEm) traffic control functionality to simulate the dy...This paper investigates the subjective assessment of QoE of web and video services over a mobile network. To achieve this, the authors used the network emulator (NetEm) traffic control functionality to simulate the dynamic behaviour of a mobile network. Experiments were conducted in a laboratory setting and test conditions were varied to ascertain the QoE, with a focus on QoE metrics such as delay and packet loss ratio. From the experiments conducted, it was observed that there was a negative correlation between delay and average mean opinion score (MOS), and between packet loss ratio and average MOS. The results obtained can be adopted by network operators to provide better services which would lead to improved subscriber base and profitability for the operators and better QoE for the end users.展开更多
Power system inherently consists of capacitance and inductance in its components. Equipment with saturable inductance and circuit capacitance provides circumstances of generating ferroresonance, resulting in overvolta...Power system inherently consists of capacitance and inductance in its components. Equipment with saturable inductance and circuit capacitance provides circumstances of generating ferroresonance, resulting in overvoltage and overcurrent in the connected system. The effects of ferroresonance result in insulation failure and hence damage to the equipment is unavoidable. Though many devices are proposed for mitigating such circumstances, a promising technology of using memristors may provide better performance than others in the future. A memristor emulator using the N-channel JFET J310 is used in this work. Unlike other electronic components that replicate memristor properties, the chosen memristor emulator is a passive device since it does not need any external power supply. Simulation and experimental results verify the design of a memristor emulator and the characteristics of an ideal memristor. Experimental results prove that the memristor emulator can suppress the fundamental ferroresonance induced in a prototype single phase transformer. The results of the harmonic analysis also validate the memristor performance against the conventional technique.展开更多
In this article,novel emulation strategies for the sectored multiple probe anechoic chamber(SMPAC)are proposed to enable the reliable evaluation of the massive multiple-input multiple-output(MIMO)device operating at b...In this article,novel emulation strategies for the sectored multiple probe anechoic chamber(SMPAC)are proposed to enable the reliable evaluation of the massive multiple-input multiple-output(MIMO)device operating at beamforming mode,which requires a realistic non-stationary channel environment.For the dynamic propagation emulation,an efficient closed-form probe weighting strategy minimizing the power angular spectrum(PAS)emulation errors is derived,substantially reducing the associated computational complexity.On the other hand,a novel probe selection algorithm is proposed to reproduce a more accurate fading environment.Various standard channel models and setup configurations are comprehensively simulated to validate the capacity of the proposed methods.The simulation results show that more competent active probes are selected with the proposed method compared to the conventional algorithms.Furthermore,the derived closedform probe weighting strategy offers identical accuracy to that obtained with complicated numerical optimization.Moreover,a realistic dynamic channel measured in an indoor environment is reconstructed with the developed methodologies,and 95.6%PAS similarity can be achieved with 6 active probes.The satisfactory results demonstrate that the proposed algorithms are suitable for arbitrary channel emulation.展开更多
Emulating massively parallel computer architectures represents a very important tool for the parallel programmers. It allows them to implement and validate their algorithms. Due to the high cost of the massively paral...Emulating massively parallel computer architectures represents a very important tool for the parallel programmers. It allows them to implement and validate their algorithms. Due to the high cost of the massively parallel real machines, they remain unavailable and not popular in the parallel computing community. The goal of this paper is to present an elaborated emulator of a 2-D massively parallel re-configurable mesh computer of size n x n processing elements (PE). Basing on the object modeling method, we develop a hard kernel of a parallel virtual machine in which we translate all the physical properties of its different components. A parallel programming language and its compiler are also devel-oped to edit, compile and run programs. The developed emulator is a multi platform system. It can be installed in any sequential computer whatever may be its operating system and its processing unit technology (CPU). The size n x n of this virtual re-configurable mesh is not limited;it depends just on the performance of the sequential machine supporting the emulator.展开更多
This work aims at developing an automatic system for the control of the APS (air plasma spraying) plasma process in which some instability phenomena are present. APS is a versatile technique to produce coatings of p...This work aims at developing an automatic system for the control of the APS (air plasma spraying) plasma process in which some instability phenomena are present. APS is a versatile technique to produce coatings of powder material at high deposition rates. Using this technique, powder particles are injected into a plasma jet, where they are melted and accelerated towards a substrate. The coating microstructures and properties depend strongly on the characteristics of the plasma jet, which can be controlled by the adjustment of the process parameters. However, the imeractions among the spray variables, render optimization and control of this process are quite complex. Understanding relationships between coating properties and process parameters is mandatory to optimize the process technique and the product quality. We are interested in this work to build an on-line control model for the APS process based on the elements of artificial intelligence and to build an emulator that replicates the dynamic behavior of the process as closely as possible.展开更多
In this paper a fuel cell emulator model suitable for each fuel cell type and power level is proposed. A power interface to the electronic load and a digital section are provided. The fuel cell steady-state, dynamic a...In this paper a fuel cell emulator model suitable for each fuel cell type and power level is proposed. A power interface to the electronic load and a digital section are provided. The fuel cell steady-state, dynamic and thermal behaviour is modeled by the digital controller. The emulator architecture is deeply analyzed and remarks on hardware implementation algorithms are provided for further applications. The system is tested on a 10 W Proton Exchange Membrane (PEM) fuel cell and the high accuracy of the proposed emulator is shown by the comparison between experimental and simulation results.展开更多
Internet of things(IoT)devices are being increasingly used in numerous areas.However,the low priority on security and various IoT types have made these devices vulnerable to attacks.To prevent this,recent studies have...Internet of things(IoT)devices are being increasingly used in numerous areas.However,the low priority on security and various IoT types have made these devices vulnerable to attacks.To prevent this,recent studies have analyzed firmware in an emulation environment that does not require actual devices and is efficient for repeated experiments.However,these studies focused only on major firmware architectures and rarely considered exotic firmware.In addition,because of the diversity of firmware,the emulation success rate is not high in terms of large-scale analyses.In this study,we propose the adaptive emulation framework for multi-architecture(AEMA).In the field of automated emulation frameworks for IoT firmware testing,AEMA considers the following issues:(1)limited compatibility for exotic firmware architectures,(2)emulation instability when configuring an automated environment,and(3)shallow testing range resulting from structured inputs.To tackle these problems,AEMAcan emulate not onlymajor firmware architectures but also exotic firmware architectures not previously considered,such as Xtensa,ColdFire,and reduced instruction set computer(RISC)version five,by implementing a minority emulator.Moreover,we applied the emulation arbitration technique and input keyword extraction technique for emulation stability and efficient test case generation.We compared AEMA with other existing frameworks in terms of emulation success rates and fuzz testing.As a result,AEMA succeeded in emulating 864 out of 1,083 overall experimental firmware and detected vulnerabilities at least twice as fast as the experimental group.Furthermore,AEMAfound a 0-day vulnerability in realworld IoT devices within 24 h.展开更多
文摘EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.
基金supported by the National Natural Science Foundation of China(Grant Nos.51377124 and 51221005)the Foundation for the Author of National Excellent Doctoral Dissertation of China(Grant No.201337)+1 种基金the Program for New Century Excellent Talents in University of China(Grant No.NCET-13-0457)the Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2012JQ7026)
文摘As commercial memristors are still unavailable in the market, mathematic models and emulators which can imitate the features of the mernristor are meaningful for further research. In this paper, based on the analyses of characteristics of the q-φ curve, an exponential flux-controlled model, which has the quality that its memductance (memristance) will keep monotonically increasing or decreasing unless the voltage's polarity reverses (if not approach the boundaries), is constructed. A new approach to designing the floating emulator of the memristor is also proposed. This floating structure can flexibly meet various demands for the current through the memristor (especially the demand for a larger current). The simulations and experiments are presented to confirm the effectiveness of this model and its floating emulator.
基金supported by National Natural Science Foundation of China(No.61379016)
文摘In this paper,the transmission performances are studied in cognitive radio networks with primary user emulator and relay existence.In the proposed network,the users include primary users,secondary users and primary user emulators.The decreasing access priority of the users are primary users,primary user emulators and secondary users.Different user access to the network results in different transmission effects.We impose interference power constraints on the secondary users to protect the primary users from being interfered.We also adopt the transmission mechanism that transits among more than one secondary transmitters,secondary receivers and relays.The transition models of the transmission states are proposed to describe the transmission mechanism.To investigate the transmission performances,the theory of effective capacity is adopted.The transmission performances in terms of effective capacity are expressed and demonstrated under different transmission policies.The overall effective capacity,as the overall data traffic in the cognitive radio network,is calculated.Besides,the overall effective capacity is demonstrated under different transmission strategies.The results show the greedy transmission strategy outperforms the rest of the transmission 8 policies in the overall effective capacity.For a larger number of the users,the effective capacity converges to a certain value.
文摘The mathematical physics model of mine methane and coal dust explosion propagation was established in the research,by using continuous phase,combustion,par- ticulate equations of mathematical physics.Based upon the data from mine methane drainage roadway explosion,and mine methane and coal dust explosion propagation ex- perimental studies,the numerical emulator system of mine methane and coal dust explo- sion software was developed by using prevalent flow simulation platform,which can be used to simulate the explosion accidents process effectively.In addition,the system can also be used to determine whether coal dust involved in the explosion,and to simulate accurately the transition from deflagration to detonation in methane explosion,propagation velocity of explosion shock,attenuation pattern,and affected area of explosion.
文摘This paper presents the modeling, simulation and practical implementation of an inverter-based diesel generator emulator. The main purpose of this emulator is for the study of frequency variations in diesel-based autonomous power systems in a laboratory environment where the operation of a real diesel generator is not possible. The emulator basically consists in a voltage source inverter with a second order output filter which voltage references are given by the model of the diesel generator. The control of the emulator is based on the digital signal processor TMS320F2812, where the mathematical models of the diesel generator and the control of the inverter are computed in real-time. Parameters for the model were obtained from commercially available components. Experimental results for different values of speed droop showed that the emulator achieves a satisfactory performance in the transient and stationary response. For the stationary response, the measured frequency deviates from theoretical values with a mean absolute error of: 0.06 Hz for 0% droop, 0.037 Hz for 3% droop, and 0.087 Hz for 5% droop. For the transient response, the measured frequency nadir deviates from simulations in: 0.05 Hz for 0% droop, 0.02 Hz for 3% droop, and 0.1 Hz for 5% droop.
文摘This paper investigates the subjective assessment of QoE of web and video services over a mobile network. To achieve this, the authors used the network emulator (NetEm) traffic control functionality to simulate the dynamic behaviour of a mobile network. Experiments were conducted in a laboratory setting and test conditions were varied to ascertain the QoE, with a focus on QoE metrics such as delay and packet loss ratio. From the experiments conducted, it was observed that there was a negative correlation between delay and average mean opinion score (MOS), and between packet loss ratio and average MOS. The results obtained can be adopted by network operators to provide better services which would lead to improved subscriber base and profitability for the operators and better QoE for the end users.
文摘Power system inherently consists of capacitance and inductance in its components. Equipment with saturable inductance and circuit capacitance provides circumstances of generating ferroresonance, resulting in overvoltage and overcurrent in the connected system. The effects of ferroresonance result in insulation failure and hence damage to the equipment is unavoidable. Though many devices are proposed for mitigating such circumstances, a promising technology of using memristors may provide better performance than others in the future. A memristor emulator using the N-channel JFET J310 is used in this work. Unlike other electronic components that replicate memristor properties, the chosen memristor emulator is a passive device since it does not need any external power supply. Simulation and experimental results verify the design of a memristor emulator and the characteristics of an ideal memristor. Experimental results prove that the memristor emulator can suppress the fundamental ferroresonance induced in a prototype single phase transformer. The results of the harmonic analysis also validate the memristor performance against the conventional technique.
基金supported by National Natural Science Foundation of China(No.62090015,No.61821001)BUPT Excellent Ph.D.Students Foundation under Grant(CX2021216)。
文摘In this article,novel emulation strategies for the sectored multiple probe anechoic chamber(SMPAC)are proposed to enable the reliable evaluation of the massive multiple-input multiple-output(MIMO)device operating at beamforming mode,which requires a realistic non-stationary channel environment.For the dynamic propagation emulation,an efficient closed-form probe weighting strategy minimizing the power angular spectrum(PAS)emulation errors is derived,substantially reducing the associated computational complexity.On the other hand,a novel probe selection algorithm is proposed to reproduce a more accurate fading environment.Various standard channel models and setup configurations are comprehensively simulated to validate the capacity of the proposed methods.The simulation results show that more competent active probes are selected with the proposed method compared to the conventional algorithms.Furthermore,the derived closedform probe weighting strategy offers identical accuracy to that obtained with complicated numerical optimization.Moreover,a realistic dynamic channel measured in an indoor environment is reconstructed with the developed methodologies,and 95.6%PAS similarity can be achieved with 6 active probes.The satisfactory results demonstrate that the proposed algorithms are suitable for arbitrary channel emulation.
文摘Emulating massively parallel computer architectures represents a very important tool for the parallel programmers. It allows them to implement and validate their algorithms. Due to the high cost of the massively parallel real machines, they remain unavailable and not popular in the parallel computing community. The goal of this paper is to present an elaborated emulator of a 2-D massively parallel re-configurable mesh computer of size n x n processing elements (PE). Basing on the object modeling method, we develop a hard kernel of a parallel virtual machine in which we translate all the physical properties of its different components. A parallel programming language and its compiler are also devel-oped to edit, compile and run programs. The developed emulator is a multi platform system. It can be installed in any sequential computer whatever may be its operating system and its processing unit technology (CPU). The size n x n of this virtual re-configurable mesh is not limited;it depends just on the performance of the sequential machine supporting the emulator.
文摘This work aims at developing an automatic system for the control of the APS (air plasma spraying) plasma process in which some instability phenomena are present. APS is a versatile technique to produce coatings of powder material at high deposition rates. Using this technique, powder particles are injected into a plasma jet, where they are melted and accelerated towards a substrate. The coating microstructures and properties depend strongly on the characteristics of the plasma jet, which can be controlled by the adjustment of the process parameters. However, the imeractions among the spray variables, render optimization and control of this process are quite complex. Understanding relationships between coating properties and process parameters is mandatory to optimize the process technique and the product quality. We are interested in this work to build an on-line control model for the APS process based on the elements of artificial intelligence and to build an emulator that replicates the dynamic behavior of the process as closely as possible.
文摘In this paper a fuel cell emulator model suitable for each fuel cell type and power level is proposed. A power interface to the electronic load and a digital section are provided. The fuel cell steady-state, dynamic and thermal behaviour is modeled by the digital controller. The emulator architecture is deeply analyzed and remarks on hardware implementation algorithms are provided for further applications. The system is tested on a 10 W Proton Exchange Membrane (PEM) fuel cell and the high accuracy of the proposed emulator is shown by the comparison between experimental and simulation results.
基金This work was supported by the Ministry of Science and ICT(MSIT)Korea,under the Information Technology Research Center(ITRC)support program(IITP-2022-2018-0-01423)+2 种基金supervised by the Institute for Information&Communications Technology Planning&Evaluation(IITP)by MSIT,Korea under the ITRC support program(IITP-2021-2020-0-01602)supervised by the IITP.
文摘Internet of things(IoT)devices are being increasingly used in numerous areas.However,the low priority on security and various IoT types have made these devices vulnerable to attacks.To prevent this,recent studies have analyzed firmware in an emulation environment that does not require actual devices and is efficient for repeated experiments.However,these studies focused only on major firmware architectures and rarely considered exotic firmware.In addition,because of the diversity of firmware,the emulation success rate is not high in terms of large-scale analyses.In this study,we propose the adaptive emulation framework for multi-architecture(AEMA).In the field of automated emulation frameworks for IoT firmware testing,AEMA considers the following issues:(1)limited compatibility for exotic firmware architectures,(2)emulation instability when configuring an automated environment,and(3)shallow testing range resulting from structured inputs.To tackle these problems,AEMAcan emulate not onlymajor firmware architectures but also exotic firmware architectures not previously considered,such as Xtensa,ColdFire,and reduced instruction set computer(RISC)version five,by implementing a minority emulator.Moreover,we applied the emulation arbitration technique and input keyword extraction technique for emulation stability and efficient test case generation.We compared AEMA with other existing frameworks in terms of emulation success rates and fuzz testing.As a result,AEMA succeeded in emulating 864 out of 1,083 overall experimental firmware and detected vulnerabilities at least twice as fast as the experimental group.Furthermore,AEMAfound a 0-day vulnerability in realworld IoT devices within 24 h.