As a representative emerging machine learning technique, federated learning(FL) has gained considerable popularity for its special feature of “making data available but not visible”. However, potential problems rema...As a representative emerging machine learning technique, federated learning(FL) has gained considerable popularity for its special feature of “making data available but not visible”. However, potential problems remain, including privacy breaches, imbalances in payment, and inequitable distribution.These shortcomings let devices reluctantly contribute relevant data to, or even refuse to participate in FL. Therefore, in the application of FL, an important but also challenging issue is to motivate as many participants as possible to provide high-quality data to FL. In this paper, we propose an incentive mechanism for FL based on the continuous zero-determinant(CZD) strategies from the perspective of game theory. We first model the interaction between the server and the devices during the FL process as a continuous iterative game. We then apply the CZD strategies for two players and then multiple players to optimize the social welfare of FL, for which we prove that the server can keep social welfare at a high and stable level. Subsequently, we design an incentive mechanism based on the CZD strategies to attract devices to contribute all of their high-accuracy data to FL.Finally, we perform simulations to demonstrate that our proposed CZD-based incentive mechanism can indeed generate high and stable social welfare in FL.展开更多
Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients m...Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their behavior.The central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective clients.To reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize them.In this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated learning.We build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection problem.Among them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational complexity.Additionally,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively participate.Three training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in experiments.According to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.展开更多
Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various ...Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various moments or motivating users,the design of a reasonable dynamic pricing mechanism to actively engage users in demand response becomes imperative for power grid companies.For this purpose,a power grid-flexible load bilevel model is constructed based on dynamic pricing,where the leader is the dispatching center and the lower-level flexible load acts as the follower.Initially,an upper-level day-ahead dispatching model for the power grid is established,considering the lowest power grid dispatching cost as the objective function and incorporating the power grid-side constraints.Then,the lower level comprehensively considers the load characteristics of industrial load,energy storage,and data centers,and then establishes a lower-level flexible load operation model with the lowest user power-consuming cost as the objective function.Finally,the proposed method is validated using the IEEE-118 system,and the findings indicate that the dynamic pricing mechanism for peaking shaving and valley filling can effectively guide users to respond actively,thereby reducing the peak-valley difference and decreasing users’purchasing costs.展开更多
Peer-to-peer(P2P)energy trading refers to a type of decentralized transaction,where the energy from distributed energy resources is directly traded between peers.A key challenge in peer-to-peer energy trading is desig...Peer-to-peer(P2P)energy trading refers to a type of decentralized transaction,where the energy from distributed energy resources is directly traded between peers.A key challenge in peer-to-peer energy trading is designing a safe,efficient,and transparent trading model and operating mechanism.In this study,we consider a P2P trading environment based on blockchain technology,where prosumers can submit bids or offers without knowing the reports of others.We propose an Arrow-d’Aspremont-Gerard-Varet(AGV)-based mechanism to encourage prosumers to submit their real reserve price and determine the P2P transaction price.We demonstrate that the AGV mechanism can achieve Bayesian incentive compatibility and budget balance.Kernel density estimation(KDE)is used to derive the prior distribution from the historical bid/offer information of the agents.Case studies are carried out to analyze and evaluate the proposed mechanism.Simulation results verify the effectiveness of the proposed mechanism in guiding agents to report the true reserve price while maximizing social welfare.Moreover,we discuss the advantages of budget balance for decentralized trading by comparing the Vickrey-Clarke-Groves(VCG)and AGV mechanisms.展开更多
Crowdsensing,as a data collection method that uses the mobile sensing ability of many users to help the public collect and extract useful information,has received extensive attention in data collection.Since crowdsens...Crowdsensing,as a data collection method that uses the mobile sensing ability of many users to help the public collect and extract useful information,has received extensive attention in data collection.Since crowdsensing relies on user equipment to consume resources to obtain information,and the quality and distribution of user equipment are uneven,crowdsensing has problems such as low participation enthusiasm of participants and low quality of collected data,which affects the widespread use of crowdsensing.This paper proposes to apply the blockchain to crowdsensing and solve the above challenges by utilizing the characteristics of the blockchain,such as immutability and openness.An architecture for constructing a crowdsensing incentive mechanism under distributed incentives is proposed.A multi-attribute auction algorithm and a k-nearest neighbor-based sensing data quality determination algorithm are proposed to support the architecture.Participating users upload data,determine data quality according to the algorithm,update user reputation,and realize the selection of perceived data.The process of screening data and updating reputation value is realized by smart contracts,which ensures that the information cannot be tampered with,thereby encouraging more users to participate.Results of the simulation show that using two algorithms can well reflect data quality and screen out malicious data.With the help of blockchain performance,the architecture and algorithm can achieve decentralized storage and tamper-proof information,which helps to motivate more users to participate in perception tasks and improve data quality.展开更多
Background:Researchers have a higher risk of anxiety and depression than the general population,so it is important to promote researchers’mental health.Method:Based on the data from 3210 global researchers surveyed b...Background:Researchers have a higher risk of anxiety and depression than the general population,so it is important to promote researchers’mental health.Method:Based on the data from 3210 global researchers surveyed by the journal Nature in 2021,confirmatory factor analysis,OLS regression and other regressions were used to explore the research incentive dimensions and their effects on researchers’mental health.Results:(1)Material incentive factors,work-family life balance factors,good organizational environment and spiritual motivation had significant positive effects on researchers’mental health.(2)The spiritual motivation could better promote researchers’mental health than the other factors.(3)Heterogeneity analysis showed that material incentive factors and spiritual motivation created more significant stimulating effects on the mental health of humanities and social sciences researchers.Work-family life balance factors were more effective in promoting the mental health of the mid-career group and the overtime group.Conclusion:Application of the four research incentives resulted in lower likelihood of anxiety or depression among researchers,and special attention should be paid to the role of the spiritual motivation.In order to promote researchers’mental health,different incentives should be applied to different researcher groups to better improve researchers’mental health.展开更多
As 5G becomes commercial,researchers have turned attention toward the Sixth-Generation(6G)network with the vision of connecting intelligence in a green energy-efficient manner.Federated learning triggers an upsurge of...As 5G becomes commercial,researchers have turned attention toward the Sixth-Generation(6G)network with the vision of connecting intelligence in a green energy-efficient manner.Federated learning triggers an upsurge of green intelligent services such as resources orchestration of communication infrastructures while preserving privacy and increasing communication efficiency.However,designing effective incentives in federated learning is challenging due to the dynamic available clients and the correlation between clients'contributions during the learning process.In this paper,we propose a dynamic incentive and reputation mechanism to improve energy efficiency and training performance of federated learning.The proposed incentive based on the Stackelberg game can timely adjust optimal energy consumption with changes in available clients during federated learning.Meanwhile,clients’contributions in reputation management are formulated based on the cooperative game to capture the correlation between tasks,which satisfies availability,fairness,and additivity.The simulation results show that the proposed scheme can significantly motivate high-performance clients to participate in federated learning and improve the accuracy and energy efficiency of the federated learning model.展开更多
The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has b...The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively low.Moreover,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains unclear.Hence,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore platforms.To address these concerns,vibration table tests with different amplitudes and frequencies are conducted.The results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with GNSS-RTK.Furthermore,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of GNSS-PPP.Field monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN de-noising.By comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load action.The research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.展开更多
Various Cardiovascular Diseases (CVDs) can be catastrophic and can lead to irreversible outcomes. Despite improved interventions for CVD prevention awareness, there continues to be discussion and research on diet-rela...Various Cardiovascular Diseases (CVDs) can be catastrophic and can lead to irreversible outcomes. Despite improved interventions for CVD prevention awareness, there continues to be discussion and research on diet-related CVD and mortality without addressing the problem. Instead of prioritizing public guidelines and policies, policymakers should understand CVD and address population barriers to adhering to a healthy diet that decreases CVD risk. Therefore, this project aims to analyze federal healthy food incentive policies to promote healthy diet behaviors that reduce CVD risk. The method used was existing data for a comparative policy analysis that included a policy proposal process: phases of progression, measures, and a policy model with data collection and requirements. This analysis compared a current federal food incentive program versus the proposed program. Results of the final analysis derived from the literature review and collected data stated consuming foods from the Mediterranean and other low-fat and low-salt diets reduced CVD risks that also reduced other risks secondary to CVD, such as obesity, diabetes, and Cerebrovascular Accident (CVA). Comparatively, combined healthy food incentives and disincentives were more effective for improving healthy behaviors than, in some cases, even after incentives were removed. Therefore, this policy analysis supports the indication for incentive policy change. However, the lack of federal stakeholders’ response to key policy changes upon proposal submission may require other methods of proposal dissemination. Nonetheless, focusing analysis on various Food Insecurity Nutrition Incentive (FINI) programs instead of one, multi-state program, which may have improved analysis outcomes, was the lesson learned.展开更多
Natural disaster risk monitoring is an important task for disaster prevention and reduction.In the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicato...Natural disaster risk monitoring is an important task for disaster prevention and reduction.In the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicators of natural disaster risk monitoring are complex.How to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for researchers.Based on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics,this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital twin.This framework focuses on risk monitoring,including the physical entities of natural disaster risk for immovable cultural relics,monitoring indicators,and virtual entity construction.A platform for monitoring the natural disaster risk of immovable cultural relics is proposed.Using the Puzhou Ancient City Site as a test bed,the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales.展开更多
To address the issue of information asymmetry between the two parties and moral hazard among service providers in the process of service outsourcing,this paper builds the Stackelberg game model based on the principal-...To address the issue of information asymmetry between the two parties and moral hazard among service providers in the process of service outsourcing,this paper builds the Stackelberg game model based on the principal-agent framework,examines the dynamic game situation before the contract being signed,and develops four information models.The analysis reveals a Pareto improvement in the game’s Nash equilibrium when comparing the four models from the standpoint of the supply chain.In the complete information scenario,the service level of the service provider,the customer company’s incentive effectiveness,and the supply chain system’s ultimate profit are all maximized.Furthermore,a coordinating mechanism for disposable profit is built in this study.The paper then suggests a blockchain-based architecture for the service outsourcing process supervision and a distributed incentive mechanism under the coordination mechanism in response to the inadequacy of the principal-agent theory to address the information asymmetry problem and the moral hazard problem.The experiment’s end findings demonstrate that both parties can benefit from the coordination mechanism,and the application of blockchain technology can resolve these issues and effectively encourage service providers.展开更多
Based on the actual situation of the establishment of the incentive system for human resource management in universities,the constituent elements and relevant principles of the incentive system for human resources in ...Based on the actual situation of the establishment of the incentive system for human resource management in universities,the constituent elements and relevant principles of the incentive system for human resources in universities are expounded on,the current situation of the actual needs of the faculty and staff in universities is studied and analyzed,and practical plans for establishing the concept and implementing the incentive system in universities are proposed,with relevant incentive mechanisms for human resource management focusing on differentiated needs developed for reference.展开更多
Objective To provide reference for improving Chinese innovative drug research and development incentive policies.Methods Based on investigating the incentive policies for innovative drug research and development in cl...Objective To provide reference for improving Chinese innovative drug research and development incentive policies.Methods Based on investigating the incentive policies for innovative drug research and development in clinical research,evaluation and approval in China,anti-tumor drugs were taken as the research object to discuss relevant policies from the perspective of clinical trials and registration approval based on data statistics and current situation analysis.Results and Conclusion Driven by a series of incentive policies for innovative drug R&D,great achievements have been made on anti-tumor drugs.However,there are problems such as concentration of drug targets,homogenization of clinical trials,and gaps in some drugs with large clinical needs.To improve incentive policies for innovative drug R&D,China should adhere to the orientation of clinical value,focusing on basic research and translational research,improving evaluation and approval capabilities,and establishing a sound ecosystem for innovative drugs.展开更多
[Objectives]To monitor the stability of open-pit coal mine slopes in real time and ensure the safety of coal mine production.[Methods]The automatic monitoring system of coal mine slope was explored in depth,and the co...[Objectives]To monitor the stability of open-pit coal mine slopes in real time and ensure the safety of coal mine production.[Methods]The automatic monitoring system of coal mine slope was explored in depth,and the core functions of the system were designed comprehensively.According to the design function of the automatic monitoring system,the slope automatic monitoring system was constructed.Besides,in accordance with the actual situation of the slope,the monitoring frequency of slopes was set scientifically,and the key indicators such as rainfall,deep displacement and surface displacement of the slopes were monitored in an all-round and multi-angle way.[Results]During the monitoring period,the overall condition of the slope remained good,and no landslides or other geological disasters occurred.At the same time,the overall rainfall in the slope area remained low.In terms of monitoring data,the horizontal displacement and settlement of the slopes increased first and then tended to be stable.Specifically,the maximum horizontal displacement during the monitoring period was 22.74 mm,while the maximum settlement was 18.65 mm.[Conclusions]The automatic slope monitoring system has obtained remarkable achievements in practical application.It not only improves the accuracy and efficiency of slope stability monitoring,but also provides valuable reference experience for similar projects.展开更多
BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies inve...BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies investigating its accuracy has increased.However,its accuracy has not been investigated in highland populations in China.AIM To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to plains.METHODS Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 d.Throughout the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals.Moreover,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 min.The accuracy of the FGM system was evaluated according to the CGM guidelines.Subsequently,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression method.RESULTS Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and B.According to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion(LAGE)was<5.80 mmol/L but negatively correlated with blood glucose when the LAGE was≥5.80 mmol/L.CONCLUSION The FreeStyle Libre FGM system has good accuracy in patients with T2D who had recently migrated from highlands to plains.This system might be ideal for avoiding the effects of high hematocrit on blood glucose monitoring in populations that recently migrated to plains.MARD is mainly influenced by glucose levels and fluctuations,and the accuracy of the system is higher when the blood glucose fluctuation is small.In case of higher blood glucose level fluctuations,deviation in the scanned glucose levels is the highest at extremely low blood glucose levels.展开更多
Diabetic kidney disease(DKD)is a common complication of diabetes mellitus that contributes to the risk of end-stage kidney disease(ESKD).Wide glycemic var-iations,such as hypoglycemia and hyperglycemia,are broadly fou...Diabetic kidney disease(DKD)is a common complication of diabetes mellitus that contributes to the risk of end-stage kidney disease(ESKD).Wide glycemic var-iations,such as hypoglycemia and hyperglycemia,are broadly found in diabetic patients with DKD and especially ESKD,as a result of impaired renal metabolism.It is essential to monitor glycemia for effective management of DKD.Hemoglobin A1c(HbA1c)has long been considered as the gold standard for monitoring glycemia for>3 months.However,assessment of HbA1c has some bias as it is susceptible to factors such as anemia and liver or kidney dysfunction.Continuous glucose monitoring(CGM)has provided new insights on glycemic assessment and management.CGM directly measures glucose level in interstitial fluid,reports real-time or retrospective glucose concentration,and provides multiple glycemic metrics.It avoids the pitfalls of HbA1c in some contexts,and may serve as a precise alternative to estimation of mean glucose and glycemic variability.Emerging studies have demonstrated the merits of CGM for precise monitoring,which allows fine-tuning of glycemic management in diabetic patients.Therefore,CGM technology has the potential for better glycemic monitoring in DKD patients.More research is needed to explore its application and management in different stages of DKD,including hemodialysis,peritoneal dialysis and kidney transplantation.展开更多
Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information collection.The wireless communication methods adopted by sensor nodes may make the network highly vul...Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information collection.The wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various attacks.Traditional encryption and authentication mechanisms cannot prevent attacks launched by internal malicious nodes.The trust-based security mechanism is usually adopted to solve this problem in WSNs.However,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor nodes.Moreover,how to efficiently collect behavioral evidences are rarely discussed.To address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud model.First,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate uncertainty.Then,the cloud model is introduced to estimate the trust values for sensor nodes.Finally,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety assurance.Simulation results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.展开更多
The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB drugs.New strategies to facilitate drug combination...The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB drugs.New strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and recommended.Liquid chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous compounds.This technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics analysis.TDM improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target window.Based on TDM,the dose would be optimized individually to achieve favorable outcomes.Pharmacometabolomics is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome evaluation.This article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two decades.Besides,we discussed the advantages and disadvantages of this technique in practical use.The pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was highlighted.Lastly,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.展开更多
This review explores glucose monitoring and management strategies,emphasizing the need for reliable and userfriendly wearable sensors that are the next generation of sensors for continuous glucose detection.In additio...This review explores glucose monitoring and management strategies,emphasizing the need for reliable and userfriendly wearable sensors that are the next generation of sensors for continuous glucose detection.In addition,examines key strategies for designing glucose sensors that are multi-functional,reliable,and cost-effective in a variety of contexts.The unique features of effective diabetes management technology are highlighted,with a focus on using nano/biosensor devices that can quickly and accurately detect glucose levels in the blood,improving patient treatment and control of potential diabetes-related infections.The potential of next-generation wearable and touch-sensitive nano biomedical sensor engineering designs for providing full control in assessing implantable,continuous glucose monitoring is also explored.The challenges of standardizing drug or insulin delivery doses,low-cost,real-time detection of increased blood sugar levels in diabetics,and early digital health awareness controls for the adverse effects of injectable medication are identified as unmet needs.Also,the market for biosensors is expected to expand significantly due to the rising need for portable diagnostic equipment and an ever-increasing diabetic population.The paper concludes by emphasizing the need for further research and development of glucose biosensors to meet the stringent requirements for sensitivity and specificity imposed by clinical diagnostics while being cost-effective,stable,and durable.展开更多
Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance o...Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance of these activities mandatory for any experiment and professional working in this area. Assigning the severity of a research experiment is the result of an analysis of records of observations of the animal’s behavior, and clinical signs. The aim of this study was to describe the importance of carrying out a severity assessment associated with clinical and behavioral monitoring of rodents and rabbits during experimentation to maintain the welfare of these animals undergoing scientific research. Methods: The literature search was carried out using the following terms: “Monitoring”;“Humane endpoints”;“Animal welfare”, “Rodents”;“Rabbits”, and as connectors “and”;“or”, in the following databases: PubMed;LILACS/BIREME and SciELO. Results: A total of 987 articles were identified in the databases, and 20 of these studies were included in this review. Conclusions: Humane endpoint protocols and procedure severity tables are of the utmost importance, both from an ethical point and to refine the results of research conducted on laboratory animals. They should be drawn up jointly by the teams responsible for the project and the maintenance of the animals during the research period, and the data obtained should be published so that the scientific community can have access to it, helping to disseminate these practices, as well as helping to draw up new procedures. Monitoring and evaluating the welfare and clinical condition of animals undergoing scientific research procedures is the responsibility of the professors, researchers, veterinarians, and animal facility coordinators. The Ethics Committee on the Use of Animals must monitor all the activities conducted with the animals, by inspecting the experimental procedures and the physical environment of the laboratory animal facility where the animals are housed.展开更多
基金partially supported by the National Natural Science Foundation of China (62173308)the Natural Science Foundation of Zhejiang Province of China (LR20F030001)the Jinhua Science and Technology Project (2022-1-042)。
文摘As a representative emerging machine learning technique, federated learning(FL) has gained considerable popularity for its special feature of “making data available but not visible”. However, potential problems remain, including privacy breaches, imbalances in payment, and inequitable distribution.These shortcomings let devices reluctantly contribute relevant data to, or even refuse to participate in FL. Therefore, in the application of FL, an important but also challenging issue is to motivate as many participants as possible to provide high-quality data to FL. In this paper, we propose an incentive mechanism for FL based on the continuous zero-determinant(CZD) strategies from the perspective of game theory. We first model the interaction between the server and the devices during the FL process as a continuous iterative game. We then apply the CZD strategies for two players and then multiple players to optimize the social welfare of FL, for which we prove that the server can keep social welfare at a high and stable level. Subsequently, we design an incentive mechanism based on the CZD strategies to attract devices to contribute all of their high-accuracy data to FL.Finally, we perform simulations to demonstrate that our proposed CZD-based incentive mechanism can indeed generate high and stable social welfare in FL.
基金supported by Key Research and Development Program of China (No.2022YFC3005401)Key Research and Development Program of Yunnan Province,China (Nos.202203AA080009,202202AF080003)+1 种基金Science and Technology Achievement Transformation Program of Jiangsu Province,China (BA2021002)Fundamental Research Funds for the Central Universities (Nos.B220203006,B210203024).
文摘Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their behavior.The central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective clients.To reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize them.In this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated learning.We build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection problem.Among them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational complexity.Additionally,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively participate.Three training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in experiments.According to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.
基金supported in part by Technology Project of State Grid Jiangsu Electric Power Co.,Ltd.,China,under Grant J2022011.
文摘Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various moments or motivating users,the design of a reasonable dynamic pricing mechanism to actively engage users in demand response becomes imperative for power grid companies.For this purpose,a power grid-flexible load bilevel model is constructed based on dynamic pricing,where the leader is the dispatching center and the lower-level flexible load acts as the follower.Initially,an upper-level day-ahead dispatching model for the power grid is established,considering the lowest power grid dispatching cost as the objective function and incorporating the power grid-side constraints.Then,the lower level comprehensively considers the load characteristics of industrial load,energy storage,and data centers,and then establishes a lower-level flexible load operation model with the lowest user power-consuming cost as the objective function.Finally,the proposed method is validated using the IEEE-118 system,and the findings indicate that the dynamic pricing mechanism for peaking shaving and valley filling can effectively guide users to respond actively,thereby reducing the peak-valley difference and decreasing users’purchasing costs.
基金supported by National Natural Science Foundation of China(U2066211,52177124,52107134)the Institute of Electrical Engineering,CAS(E155610101)+1 种基金the DNL Cooperation Fund,CAS(DNL202023)the Youth Innovation Promotion Association of CAS(2019143).
文摘Peer-to-peer(P2P)energy trading refers to a type of decentralized transaction,where the energy from distributed energy resources is directly traded between peers.A key challenge in peer-to-peer energy trading is designing a safe,efficient,and transparent trading model and operating mechanism.In this study,we consider a P2P trading environment based on blockchain technology,where prosumers can submit bids or offers without knowing the reports of others.We propose an Arrow-d’Aspremont-Gerard-Varet(AGV)-based mechanism to encourage prosumers to submit their real reserve price and determine the P2P transaction price.We demonstrate that the AGV mechanism can achieve Bayesian incentive compatibility and budget balance.Kernel density estimation(KDE)is used to derive the prior distribution from the historical bid/offer information of the agents.Case studies are carried out to analyze and evaluate the proposed mechanism.Simulation results verify the effectiveness of the proposed mechanism in guiding agents to report the true reserve price while maximizing social welfare.Moreover,we discuss the advantages of budget balance for decentralized trading by comparing the Vickrey-Clarke-Groves(VCG)and AGV mechanisms.
基金supported by National Key R&D Program of China(2020YFB1807800).
文摘Crowdsensing,as a data collection method that uses the mobile sensing ability of many users to help the public collect and extract useful information,has received extensive attention in data collection.Since crowdsensing relies on user equipment to consume resources to obtain information,and the quality and distribution of user equipment are uneven,crowdsensing has problems such as low participation enthusiasm of participants and low quality of collected data,which affects the widespread use of crowdsensing.This paper proposes to apply the blockchain to crowdsensing and solve the above challenges by utilizing the characteristics of the blockchain,such as immutability and openness.An architecture for constructing a crowdsensing incentive mechanism under distributed incentives is proposed.A multi-attribute auction algorithm and a k-nearest neighbor-based sensing data quality determination algorithm are proposed to support the architecture.Participating users upload data,determine data quality according to the algorithm,update user reputation,and realize the selection of perceived data.The process of screening data and updating reputation value is realized by smart contracts,which ensures that the information cannot be tampered with,thereby encouraging more users to participate.Results of the simulation show that using two algorithms can well reflect data quality and screen out malicious data.With the help of blockchain performance,the architecture and algorithm can achieve decentralized storage and tamper-proof information,which helps to motivate more users to participate in perception tasks and improve data quality.
文摘Background:Researchers have a higher risk of anxiety and depression than the general population,so it is important to promote researchers’mental health.Method:Based on the data from 3210 global researchers surveyed by the journal Nature in 2021,confirmatory factor analysis,OLS regression and other regressions were used to explore the research incentive dimensions and their effects on researchers’mental health.Results:(1)Material incentive factors,work-family life balance factors,good organizational environment and spiritual motivation had significant positive effects on researchers’mental health.(2)The spiritual motivation could better promote researchers’mental health than the other factors.(3)Heterogeneity analysis showed that material incentive factors and spiritual motivation created more significant stimulating effects on the mental health of humanities and social sciences researchers.Work-family life balance factors were more effective in promoting the mental health of the mid-career group and the overtime group.Conclusion:Application of the four research incentives resulted in lower likelihood of anxiety or depression among researchers,and special attention should be paid to the role of the spiritual motivation.In order to promote researchers’mental health,different incentives should be applied to different researcher groups to better improve researchers’mental health.
文摘As 5G becomes commercial,researchers have turned attention toward the Sixth-Generation(6G)network with the vision of connecting intelligence in a green energy-efficient manner.Federated learning triggers an upsurge of green intelligent services such as resources orchestration of communication infrastructures while preserving privacy and increasing communication efficiency.However,designing effective incentives in federated learning is challenging due to the dynamic available clients and the correlation between clients'contributions during the learning process.In this paper,we propose a dynamic incentive and reputation mechanism to improve energy efficiency and training performance of federated learning.The proposed incentive based on the Stackelberg game can timely adjust optimal energy consumption with changes in available clients during federated learning.Meanwhile,clients’contributions in reputation management are formulated based on the cooperative game to capture the correlation between tasks,which satisfies availability,fairness,and additivity.The simulation results show that the proposed scheme can significantly motivate high-performance clients to participate in federated learning and improve the accuracy and energy efficiency of the federated learning model.
基金financially supported by the National Key R&D Program of China(Grant No.2022YFB4200705)the National Natural Science Foundation of China(Grant No.52109146)。
文摘The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively low.Moreover,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains unclear.Hence,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore platforms.To address these concerns,vibration table tests with different amplitudes and frequencies are conducted.The results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with GNSS-RTK.Furthermore,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of GNSS-PPP.Field monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN de-noising.By comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load action.The research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.
文摘Various Cardiovascular Diseases (CVDs) can be catastrophic and can lead to irreversible outcomes. Despite improved interventions for CVD prevention awareness, there continues to be discussion and research on diet-related CVD and mortality without addressing the problem. Instead of prioritizing public guidelines and policies, policymakers should understand CVD and address population barriers to adhering to a healthy diet that decreases CVD risk. Therefore, this project aims to analyze federal healthy food incentive policies to promote healthy diet behaviors that reduce CVD risk. The method used was existing data for a comparative policy analysis that included a policy proposal process: phases of progression, measures, and a policy model with data collection and requirements. This analysis compared a current federal food incentive program versus the proposed program. Results of the final analysis derived from the literature review and collected data stated consuming foods from the Mediterranean and other low-fat and low-salt diets reduced CVD risks that also reduced other risks secondary to CVD, such as obesity, diabetes, and Cerebrovascular Accident (CVA). Comparatively, combined healthy food incentives and disincentives were more effective for improving healthy behaviors than, in some cases, even after incentives were removed. Therefore, this policy analysis supports the indication for incentive policy change. However, the lack of federal stakeholders’ response to key policy changes upon proposal submission may require other methods of proposal dissemination. Nonetheless, focusing analysis on various Food Insecurity Nutrition Incentive (FINI) programs instead of one, multi-state program, which may have improved analysis outcomes, was the lesson learned.
基金National Natural Science Foundation of China(Nos.42171444,42301516)Beijing Natural Science Foundation Project-Municipal Education Commission Joint Fund Project(No.KZ202110016021)Beijing Municipal Education Commission Scientific Research Project-Science and Technology Plan General Project(No.KM202110016005).
文摘Natural disaster risk monitoring is an important task for disaster prevention and reduction.In the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicators of natural disaster risk monitoring are complex.How to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for researchers.Based on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics,this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital twin.This framework focuses on risk monitoring,including the physical entities of natural disaster risk for immovable cultural relics,monitoring indicators,and virtual entity construction.A platform for monitoring the natural disaster risk of immovable cultural relics is proposed.Using the Puzhou Ancient City Site as a test bed,the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales.
基金Province Keys Research and Development Program of Shandong(Soft Science Projects)[No.2021RKY01007]Major Scientific and Technological Innovation Projects in Shandong Province[No.2018CXGC0703].
文摘To address the issue of information asymmetry between the two parties and moral hazard among service providers in the process of service outsourcing,this paper builds the Stackelberg game model based on the principal-agent framework,examines the dynamic game situation before the contract being signed,and develops four information models.The analysis reveals a Pareto improvement in the game’s Nash equilibrium when comparing the four models from the standpoint of the supply chain.In the complete information scenario,the service level of the service provider,the customer company’s incentive effectiveness,and the supply chain system’s ultimate profit are all maximized.Furthermore,a coordinating mechanism for disposable profit is built in this study.The paper then suggests a blockchain-based architecture for the service outsourcing process supervision and a distributed incentive mechanism under the coordination mechanism in response to the inadequacy of the principal-agent theory to address the information asymmetry problem and the moral hazard problem.The experiment’s end findings demonstrate that both parties can benefit from the coordination mechanism,and the application of blockchain technology can resolve these issues and effectively encourage service providers.
文摘Based on the actual situation of the establishment of the incentive system for human resource management in universities,the constituent elements and relevant principles of the incentive system for human resources in universities are expounded on,the current situation of the actual needs of the faculty and staff in universities is studied and analyzed,and practical plans for establishing the concept and implementing the incentive system in universities are proposed,with relevant incentive mechanisms for human resource management focusing on differentiated needs developed for reference.
文摘Objective To provide reference for improving Chinese innovative drug research and development incentive policies.Methods Based on investigating the incentive policies for innovative drug research and development in clinical research,evaluation and approval in China,anti-tumor drugs were taken as the research object to discuss relevant policies from the perspective of clinical trials and registration approval based on data statistics and current situation analysis.Results and Conclusion Driven by a series of incentive policies for innovative drug R&D,great achievements have been made on anti-tumor drugs.However,there are problems such as concentration of drug targets,homogenization of clinical trials,and gaps in some drugs with large clinical needs.To improve incentive policies for innovative drug R&D,China should adhere to the orientation of clinical value,focusing on basic research and translational research,improving evaluation and approval capabilities,and establishing a sound ecosystem for innovative drugs.
文摘[Objectives]To monitor the stability of open-pit coal mine slopes in real time and ensure the safety of coal mine production.[Methods]The automatic monitoring system of coal mine slope was explored in depth,and the core functions of the system were designed comprehensively.According to the design function of the automatic monitoring system,the slope automatic monitoring system was constructed.Besides,in accordance with the actual situation of the slope,the monitoring frequency of slopes was set scientifically,and the key indicators such as rainfall,deep displacement and surface displacement of the slopes were monitored in an all-round and multi-angle way.[Results]During the monitoring period,the overall condition of the slope remained good,and no landslides or other geological disasters occurred.At the same time,the overall rainfall in the slope area remained low.In terms of monitoring data,the horizontal displacement and settlement of the slopes increased first and then tended to be stable.Specifically,the maximum horizontal displacement during the monitoring period was 22.74 mm,while the maximum settlement was 18.65 mm.[Conclusions]The automatic slope monitoring system has obtained remarkable achievements in practical application.It not only improves the accuracy and efficiency of slope stability monitoring,but also provides valuable reference experience for similar projects.
基金Supported by Health and Family Planning Project of Sichuan Province,No.17PJ069Tibet Autonomous Region Science and Technology Program,No.XZ202303ZY0011G.
文摘BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies investigating its accuracy has increased.However,its accuracy has not been investigated in highland populations in China.AIM To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to plains.METHODS Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 d.Throughout the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals.Moreover,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 min.The accuracy of the FGM system was evaluated according to the CGM guidelines.Subsequently,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression method.RESULTS Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and B.According to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion(LAGE)was<5.80 mmol/L but negatively correlated with blood glucose when the LAGE was≥5.80 mmol/L.CONCLUSION The FreeStyle Libre FGM system has good accuracy in patients with T2D who had recently migrated from highlands to plains.This system might be ideal for avoiding the effects of high hematocrit on blood glucose monitoring in populations that recently migrated to plains.MARD is mainly influenced by glucose levels and fluctuations,and the accuracy of the system is higher when the blood glucose fluctuation is small.In case of higher blood glucose level fluctuations,deviation in the scanned glucose levels is the highest at extremely low blood glucose levels.
基金Supported by Natural Science Foundation of Zhejiang Province,No.LY23H050005and Zhejiang Medical Technology Project,No.2022RC009.
文摘Diabetic kidney disease(DKD)is a common complication of diabetes mellitus that contributes to the risk of end-stage kidney disease(ESKD).Wide glycemic var-iations,such as hypoglycemia and hyperglycemia,are broadly found in diabetic patients with DKD and especially ESKD,as a result of impaired renal metabolism.It is essential to monitor glycemia for effective management of DKD.Hemoglobin A1c(HbA1c)has long been considered as the gold standard for monitoring glycemia for>3 months.However,assessment of HbA1c has some bias as it is susceptible to factors such as anemia and liver or kidney dysfunction.Continuous glucose monitoring(CGM)has provided new insights on glycemic assessment and management.CGM directly measures glucose level in interstitial fluid,reports real-time or retrospective glucose concentration,and provides multiple glycemic metrics.It avoids the pitfalls of HbA1c in some contexts,and may serve as a precise alternative to estimation of mean glucose and glycemic variability.Emerging studies have demonstrated the merits of CGM for precise monitoring,which allows fine-tuning of glycemic management in diabetic patients.Therefore,CGM technology has the potential for better glycemic monitoring in DKD patients.More research is needed to explore its application and management in different stages of DKD,including hemodialysis,peritoneal dialysis and kidney transplantation.
基金supported in part by the Chongqing Electronics Engineering Technology Research Center for Interactive Learningin part by the Chongqing key discipline of electronic informationin part by the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202201630)。
文摘Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information collection.The wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various attacks.Traditional encryption and authentication mechanisms cannot prevent attacks launched by internal malicious nodes.The trust-based security mechanism is usually adopted to solve this problem in WSNs.However,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor nodes.Moreover,how to efficiently collect behavioral evidences are rarely discussed.To address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud model.First,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate uncertainty.Then,the cloud model is introduced to estimate the trust values for sensor nodes.Finally,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety assurance.Simulation results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.
基金sponsored by the National Research Foundation of Korea(NRF)Grant funded by the Korean government(MSIT)(Grant No.:2018R1A5A2021242).
文摘The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB drugs.New strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and recommended.Liquid chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous compounds.This technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics analysis.TDM improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target window.Based on TDM,the dose would be optimized individually to achieve favorable outcomes.Pharmacometabolomics is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome evaluation.This article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two decades.Besides,we discussed the advantages and disadvantages of this technique in practical use.The pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was highlighted.Lastly,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (No.2022M3J7A1062940,2021R1A5A6002853,and 2021R1A2C3011585)supported by the Technology Innovation Program (20015577)funded by the Ministry of Trade,Industry&Energy (MOTIE,Korea)。
文摘This review explores glucose monitoring and management strategies,emphasizing the need for reliable and userfriendly wearable sensors that are the next generation of sensors for continuous glucose detection.In addition,examines key strategies for designing glucose sensors that are multi-functional,reliable,and cost-effective in a variety of contexts.The unique features of effective diabetes management technology are highlighted,with a focus on using nano/biosensor devices that can quickly and accurately detect glucose levels in the blood,improving patient treatment and control of potential diabetes-related infections.The potential of next-generation wearable and touch-sensitive nano biomedical sensor engineering designs for providing full control in assessing implantable,continuous glucose monitoring is also explored.The challenges of standardizing drug or insulin delivery doses,low-cost,real-time detection of increased blood sugar levels in diabetics,and early digital health awareness controls for the adverse effects of injectable medication are identified as unmet needs.Also,the market for biosensors is expected to expand significantly due to the rising need for portable diagnostic equipment and an ever-increasing diabetic population.The paper concludes by emphasizing the need for further research and development of glucose biosensors to meet the stringent requirements for sensitivity and specificity imposed by clinical diagnostics while being cost-effective,stable,and durable.
文摘Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance of these activities mandatory for any experiment and professional working in this area. Assigning the severity of a research experiment is the result of an analysis of records of observations of the animal’s behavior, and clinical signs. The aim of this study was to describe the importance of carrying out a severity assessment associated with clinical and behavioral monitoring of rodents and rabbits during experimentation to maintain the welfare of these animals undergoing scientific research. Methods: The literature search was carried out using the following terms: “Monitoring”;“Humane endpoints”;“Animal welfare”, “Rodents”;“Rabbits”, and as connectors “and”;“or”, in the following databases: PubMed;LILACS/BIREME and SciELO. Results: A total of 987 articles were identified in the databases, and 20 of these studies were included in this review. Conclusions: Humane endpoint protocols and procedure severity tables are of the utmost importance, both from an ethical point and to refine the results of research conducted on laboratory animals. They should be drawn up jointly by the teams responsible for the project and the maintenance of the animals during the research period, and the data obtained should be published so that the scientific community can have access to it, helping to disseminate these practices, as well as helping to draw up new procedures. Monitoring and evaluating the welfare and clinical condition of animals undergoing scientific research procedures is the responsibility of the professors, researchers, veterinarians, and animal facility coordinators. The Ethics Committee on the Use of Animals must monitor all the activities conducted with the animals, by inspecting the experimental procedures and the physical environment of the laboratory animal facility where the animals are housed.