The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical ind...The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).展开更多
In this paper, we discuss the theoretical validity of the observed partial likelihood (OPL) constructed in a Coxtype model under incomplete data with two class possibilities, such as missing binary covariates, a cure-...In this paper, we discuss the theoretical validity of the observed partial likelihood (OPL) constructed in a Coxtype model under incomplete data with two class possibilities, such as missing binary covariates, a cure-mixture model or doubly censored data. A main result is establishing the asymptotic convergence of the OPL. To reach this result, as it is difficult to apply some standard tools in the survival analysis, we develop tools for weak convergence based on partial-sum processes. The result of the asymptotic convergence shown here indicates that a suitable order of the number of Monte Carlo trials is less than the square of the sample size. In addition, using numerical examples, we investigate how the asymptotic properties discussed here behave in a finite sample.展开更多
The reflection of oblique incident waves from breakwaters with a partially-perforated front wall is investigated. The fluid domain is divided into two sub-domains and the eigenfunction expansion method is applied to e...The reflection of oblique incident waves from breakwaters with a partially-perforated front wall is investigated. The fluid domain is divided into two sub-domains and the eigenfunction expansion method is applied to expand velocity potentials in each domain. In the eigen-expansion of the velocity potential, evanescent waves are included. Numerical results of the present model are compared with experimental data. The effect of porosity, the relative chamber width, the relative water depth in the wave absorbing chamber and the water depth in front of the structure are discussed.展开更多
Wave forces induced by the interaction between the oblique incident wave and the breakwater with a partially perforated front wall is investigated. The fluid domain is divided into two sub-domains and the eigen-functi...Wave forces induced by the interaction between the oblique incident wave and the breakwater with a partially perforated front wall is investigated. The fluid domain is divided into two sub-domains and the eigen-function expansion method is applied to expanding velocity potentials in each domain. In the eigen-expansion of the velocity potential, evanescent waves are included. Numerical results of the present model are compared with other theories and a good agreement can be found between them. Experimental data have been compared with the present theoretical results. The effect of the traverse wall on wave forces has been discussed in detail. On the basis of the linear wave theory, it is shown that in the range Of engineering practice, the incident angle of wave has small influence on wave forces on the unit length of perforated caisson.展开更多
This study examines the reflection of regular and irregular waves from a partially perforated caisson breakwater located on a step bed. The step bed is treated as an idealized rubble mound foundation. Based on the lin...This study examines the reflection of regular and irregular waves from a partially perforated caisson breakwater located on a step bed. The step bed is treated as an idealized rubble mound foundation. Based on the linear potential theory, an analytical solution is developed to calculate the reflection coefficient of the structure subjected to regular waves. The matched eigenfunction expansion method is used for the solution. The regular wave method is also extended to irregular waves using a linear transfer function. The calculated results obtained for limiting cases are exactly the same as corresponding results given by the previous researchers. The present predictions also agree well with experimental data in the published literatures. Numerical experiments are conducted to examine the variations of the reflection coefficient versus its main effect factors, and some interesting results are presented.展开更多
The reflection of regular and irregular waves from a partially perforated caisson breakwater with a rock-filled core is examined. The present mathematical model is developed by means of the matched eigenfunction metho...The reflection of regular and irregular waves from a partially perforated caisson breakwater with a rock-filled core is examined. The present mathematical model is developed by means of the matched eigenfunction method. Numerical results of the present model are compared with the experimental data of different researchers. Numerical examples are given to examine the effect of rock fill on the reflection coefficient. The differences between regular and irregular waves are also investigated by means of theoretical and experimental results. It is found that the minimum reflection coefficient of irregular waves is larger than that of corresponding regular waves, but the contrary is the case for the maximum reflection coefficient.展开更多
This study examines wave reflection by a multi-chamber partially perforated caisson breakwater based on potential theory.A quadratic pressure drop boundary condition at perforated walls is adopted,which can well consi...This study examines wave reflection by a multi-chamber partially perforated caisson breakwater based on potential theory.A quadratic pressure drop boundary condition at perforated walls is adopted,which can well consider the effect of wave height on the wave dissipation by perforated walls.The matched eigenfunction expansions with iterative calculations are applied to develop an analytical solution for the present problem.The convergences of both the iterative calculations and the series solution itself are confirmed to be satisfactory.The calculation results of the present analytical solution are in excellent agreement with the numerical results of a multi-domain boundary element solution.Also,the predictions by the present solution are in reasonable agreement with experimental data in literature.Major factors that affect the reflection coefficient of the perforated caisson breakwater are examined by calculation examples.The analysis results show that the multi-chamber perforated caisson breakwater has a better wave energy dissipation function(lower reflection coefficient)than the single-chamber type over a broad range of wave frequency and may perform better if the perforated walls have larger porosities.When the porosities of the perforated walls decrease along the incident wave direction,the perforated caisson breakwater can achieve a lower reflection coefficient.The present analytical solution is simple and reliable,and it can be used as an efficient tool for analyzing the hydrodynamic performance of perforated breakwaters in preliminary engineering design.展开更多
The total horizontal and vertical forces acting on a partially-perforated caisson breakwater and their phase difference are investigated in this study. The perforated breakwater sits on the rubble tilled foundation, a...The total horizontal and vertical forces acting on a partially-perforated caisson breakwater and their phase difference are investigated in this study. The perforated breakwater sits on the rubble tilled foundation, and has a rock-filled core. An analytical solution is developed based on the eigenfunction expansion and matching method to solve the wave field around the breakwater. The finite element method is used for simulating the wave-induced tlow in the rabble-filled foundation. Experiments are also conducted to study the wave forces on the perforated caissons. Numerical predictions of the present model are compared with experimental resuhs. The phase differences between the total horizontal and vertical forces are particularly analyzed by means of experimental and numerical results. The major factors that affect the wave forces are examined.展开更多
The perforated caisson is widely applied to practical engineering because of its great advantages in effectively wave energy consumption and cost reduction. The attentions of many scientists were paid to the fluid–st...The perforated caisson is widely applied to practical engineering because of its great advantages in effectively wave energy consumption and cost reduction. The attentions of many scientists were paid to the fluid–structure interaction between wave and perforated caisson studies, but until now, most concerns have been put on theoretical analysis and experimental model set up. In this paper, interaction between the wave and the partial perforated caisson in a 2D numerical wave flume is investigated by means of the renewed SPH algorithm, and the mathematical equations are in the form of SPH numerical approximation based on Navier–Stokes equations. The validity of the SPH mathematical method is examined and the simulated results are compared with the results of theoretical models, meanwhile the complex hydrodynamic characteristics when the water particles flow in or out of a wave absorbing chamber are analyzed and the wave pressure distribution of the perforated caisson is also addressed here. The relationship between the ratio of total horizontal force acting on caisson under regular waves and its influence factors is examined. The data show that the numerical calculation of the ratio of total horizontal force meets the empirical regression equation very well. The simulations of SPH about the wave nonlinearity and breaking are briefly depicted in the paper, suggesting that the advantages and great potentiality of the SPH method is significant compared with traditional methods.展开更多
Introduction: In the last two decades, chest wall perforator flaps (CWPF) have become a versatile tissue replacement technique for partial breast reconstruction following breast-conserving surgery (BCS) in well-select...Introduction: In the last two decades, chest wall perforator flaps (CWPF) have become a versatile tissue replacement technique for partial breast reconstruction following breast-conserving surgery (BCS) in well-selected cases. We present the surgical outcome of 81 patients with chest wall perforator flaps used for breast-conserving surgery. Methods: We recorded the outcomes of three oncoplastic breast surgeons who performed partial breast reconstruction with chest wall perforator flaps from 1<sup>st</sup> January 2018 to 30<sup>th</sup> June 2022 at Sherwood Forest Hospitals NHS Foundation Trust. Data were collected on patient demographics, including age, BMI, smoking status, bra size, previous treatments, type of CWPF procedure, tumor size (measured clinically, via imaging and histologically), biopsy results, specimen weight, margins involvement, re-operation rate, surgical site infection (SSI), flap loss, flap shrinkage, hematoma, and seroma rates. Results: A total of 81 patients were included in this study, with an average age of 55.7 years and a body mass index (BMI) of 26.7 kg/m<sup>2</sup>. The bra size varied between A to FF with A (7.4%), B (28.3%), C (38.2%), D (13.6%), DD (11.1%), and FF (1.2%). 14.8% of the patients had neoadjuvant chemotherapy (NACT). For 45 patients, LICAP (lateral intercostal artery perforator), 16 AICAP (anterior intercostal artery perforator), 13 MICAP (medial intercostal artery perforator), and for seven patients, LTAP (lateral thoracic artery perforator) flaps were used. The average tumor was measured at 15.75 mm clinically, 19.1 mm via imaging, and 19.6 mm histologically. Biopsy showed that 16% of the tumors were ductal carcinoma in situ (DCIS), and 84% were invasive. 16% of patients had involved margins, and re-excision was required in 10 patients, and completion mastectomy was performed in 2 patients. A thirty-day SSI rate was 6.2%, with flap-related complications, including flap loss and shrinkage, at 3.7% and 4.9%, respectively. In addition, 3.7% had a hematoma, and 17.3% had other complications. Conclusion: Partial breast reconstruction with perforator flaps is an excellent volume replacement technique in breast-conserving surgery with acceptable complications in well-selected cases.展开更多
The finite difference method and the volume of fluid (VOF) method were used to develop a three-dimensional numerical model to study wave interaction with a perforated caisson. The partial cell method was adopted to ...The finite difference method and the volume of fluid (VOF) method were used to develop a three-dimensional numerical model to study wave interaction with a perforated caisson. The partial cell method was adopted to solve this type of problem for the first time. The validity of the present model, with and without the presence of caisson structures, was examined by comparing the model results with experimental data. Then, the numerical model was used to investigate the effects of various wave and structure parameters on the wave force and wave runup of the perforated quasi-ellipse caisson. Compared with the solid quasi-ellipse caisson, the wave force on the perforated quasi-ellipse caisson is significantly reduced with increasing porosity of the perforated quasi-ellipse caisson. Furthermore, the perforated quasi-ellipse caisson can also reduce the wave runup, and it tends to decrease with the increase of the porosity of the perforated quasi-ellipse caisson and the relative wave height.展开更多
The following paper describes patch closure (bovine pericardial sheet) of an ostium primum atrial septal defect and mitral valve repair (sutured mitral valve cleft + autologous pericardial annuloplasty + Alfieri’s me...The following paper describes patch closure (bovine pericardial sheet) of an ostium primum atrial septal defect and mitral valve repair (sutured mitral valve cleft + autologous pericardial annuloplasty + Alfieri’s method) in a 50-year-old man. He had been perfectly well until he was brought to the emergency room because of acute heart failure. Chest radiography revealed right-side heart enlargement. Electrocardiography indicated atrial flutter. Echocardiography revealed a large ostium primum atrial septal defect and moderate mitral regurgitation. The pulmonary-to-systemic blood flow ratio was 3.24. First, cardiologists performed catheter ablation of the cavotricuspid isthmus for atrial flutter. We performed patch closure of an ostium primum atrial septal defect and mitral valve repair after the patient’s heart failure was under control. The patient was discharged 13 days postoperatively in a satisfactory condition without any critical complications.展开更多
文摘The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).
文摘In this paper, we discuss the theoretical validity of the observed partial likelihood (OPL) constructed in a Coxtype model under incomplete data with two class possibilities, such as missing binary covariates, a cure-mixture model or doubly censored data. A main result is establishing the asymptotic convergence of the OPL. To reach this result, as it is difficult to apply some standard tools in the survival analysis, we develop tools for weak convergence based on partial-sum processes. The result of the asymptotic convergence shown here indicates that a suitable order of the number of Monte Carlo trials is less than the square of the sample size. In addition, using numerical examples, we investigate how the asymptotic properties discussed here behave in a finite sample.
基金by Joint Fund of the National Natural Science Foundation of China the Hong Kong Science Research Bureau (49910161985)+1 种基金the National Natural Science Foundation of China (50025924,50179004)the Research Fund for the Development of harbor engineeri
文摘The reflection of oblique incident waves from breakwaters with a partially-perforated front wall is investigated. The fluid domain is divided into two sub-domains and the eigenfunction expansion method is applied to expand velocity potentials in each domain. In the eigen-expansion of the velocity potential, evanescent waves are included. Numerical results of the present model are compared with experimental data. The effect of porosity, the relative chamber width, the relative water depth in the wave absorbing chamber and the water depth in front of the structure are discussed.
基金This project was supported by the Research Fund for the Development of Harbor Engineering Design Specification,the Ministry of Communications of Chinathe Program for Changjiang Scholars and Innovation Research Team in University of China under contract No.IRT0420the Fok Ying Tung Education Foundation of China under contract No.81068.
文摘Wave forces induced by the interaction between the oblique incident wave and the breakwater with a partially perforated front wall is investigated. The fluid domain is divided into two sub-domains and the eigen-function expansion method is applied to expanding velocity potentials in each domain. In the eigen-expansion of the velocity potential, evanescent waves are included. Numerical results of the present model are compared with other theories and a good agreement can be found between them. Experimental data have been compared with the present theoretical results. The effect of the traverse wall on wave forces has been discussed in detail. On the basis of the linear wave theory, it is shown that in the range Of engineering practice, the incident angle of wave has small influence on wave forces on the unit length of perforated caisson.
基金The Natural Science Foundation of Shandong Province under contract No Q2008F01the Specialized Research Fund for the Doctoral Program of Higher Education under contract No 200804231006the National Natural Science Foundation of China under contract Nos 40876047 and 50609001
文摘This study examines the reflection of regular and irregular waves from a partially perforated caisson breakwater located on a step bed. The step bed is treated as an idealized rubble mound foundation. Based on the linear potential theory, an analytical solution is developed to calculate the reflection coefficient of the structure subjected to regular waves. The matched eigenfunction expansion method is used for the solution. The regular wave method is also extended to irregular waves using a linear transfer function. The calculated results obtained for limiting cases are exactly the same as corresponding results given by the previous researchers. The present predictions also agree well with experimental data in the published literatures. Numerical experiments are conducted to examine the variations of the reflection coefficient versus its main effect factors, and some interesting results are presented.
文摘The reflection of regular and irregular waves from a partially perforated caisson breakwater with a rock-filled core is examined. The present mathematical model is developed by means of the matched eigenfunction method. Numerical results of the present model are compared with the experimental data of different researchers. Numerical examples are given to examine the effect of rock fill on the reflection coefficient. The differences between regular and irregular waves are also investigated by means of theoretical and experimental results. It is found that the minimum reflection coefficient of irregular waves is larger than that of corresponding regular waves, but the contrary is the case for the maximum reflection coefficient.
基金The National Natural Science Foundation of China under contract Nos 51725903 and 51490675。
文摘This study examines wave reflection by a multi-chamber partially perforated caisson breakwater based on potential theory.A quadratic pressure drop boundary condition at perforated walls is adopted,which can well consider the effect of wave height on the wave dissipation by perforated walls.The matched eigenfunction expansions with iterative calculations are applied to develop an analytical solution for the present problem.The convergences of both the iterative calculations and the series solution itself are confirmed to be satisfactory.The calculation results of the present analytical solution are in excellent agreement with the numerical results of a multi-domain boundary element solution.Also,the predictions by the present solution are in reasonable agreement with experimental data in literature.Major factors that affect the reflection coefficient of the perforated caisson breakwater are examined by calculation examples.The analysis results show that the multi-chamber perforated caisson breakwater has a better wave energy dissipation function(lower reflection coefficient)than the single-chamber type over a broad range of wave frequency and may perform better if the perforated walls have larger porosities.When the porosities of the perforated walls decrease along the incident wave direction,the perforated caisson breakwater can achieve a lower reflection coefficient.The present analytical solution is simple and reliable,and it can be used as an efficient tool for analyzing the hydrodynamic performance of perforated breakwaters in preliminary engineering design.
文摘The total horizontal and vertical forces acting on a partially-perforated caisson breakwater and their phase difference are investigated in this study. The perforated breakwater sits on the rubble tilled foundation, and has a rock-filled core. An analytical solution is developed based on the eigenfunction expansion and matching method to solve the wave field around the breakwater. The finite element method is used for simulating the wave-induced tlow in the rabble-filled foundation. Experiments are also conducted to study the wave forces on the perforated caissons. Numerical predictions of the present model are compared with experimental resuhs. The phase differences between the total horizontal and vertical forces are particularly analyzed by means of experimental and numerical results. The major factors that affect the wave forces are examined.
基金financially supported by the National Natural Science Foundation of China(Grant No.51179030)
文摘The perforated caisson is widely applied to practical engineering because of its great advantages in effectively wave energy consumption and cost reduction. The attentions of many scientists were paid to the fluid–structure interaction between wave and perforated caisson studies, but until now, most concerns have been put on theoretical analysis and experimental model set up. In this paper, interaction between the wave and the partial perforated caisson in a 2D numerical wave flume is investigated by means of the renewed SPH algorithm, and the mathematical equations are in the form of SPH numerical approximation based on Navier–Stokes equations. The validity of the SPH mathematical method is examined and the simulated results are compared with the results of theoretical models, meanwhile the complex hydrodynamic characteristics when the water particles flow in or out of a wave absorbing chamber are analyzed and the wave pressure distribution of the perforated caisson is also addressed here. The relationship between the ratio of total horizontal force acting on caisson under regular waves and its influence factors is examined. The data show that the numerical calculation of the ratio of total horizontal force meets the empirical regression equation very well. The simulations of SPH about the wave nonlinearity and breaking are briefly depicted in the paper, suggesting that the advantages and great potentiality of the SPH method is significant compared with traditional methods.
文摘Introduction: In the last two decades, chest wall perforator flaps (CWPF) have become a versatile tissue replacement technique for partial breast reconstruction following breast-conserving surgery (BCS) in well-selected cases. We present the surgical outcome of 81 patients with chest wall perforator flaps used for breast-conserving surgery. Methods: We recorded the outcomes of three oncoplastic breast surgeons who performed partial breast reconstruction with chest wall perforator flaps from 1<sup>st</sup> January 2018 to 30<sup>th</sup> June 2022 at Sherwood Forest Hospitals NHS Foundation Trust. Data were collected on patient demographics, including age, BMI, smoking status, bra size, previous treatments, type of CWPF procedure, tumor size (measured clinically, via imaging and histologically), biopsy results, specimen weight, margins involvement, re-operation rate, surgical site infection (SSI), flap loss, flap shrinkage, hematoma, and seroma rates. Results: A total of 81 patients were included in this study, with an average age of 55.7 years and a body mass index (BMI) of 26.7 kg/m<sup>2</sup>. The bra size varied between A to FF with A (7.4%), B (28.3%), C (38.2%), D (13.6%), DD (11.1%), and FF (1.2%). 14.8% of the patients had neoadjuvant chemotherapy (NACT). For 45 patients, LICAP (lateral intercostal artery perforator), 16 AICAP (anterior intercostal artery perforator), 13 MICAP (medial intercostal artery perforator), and for seven patients, LTAP (lateral thoracic artery perforator) flaps were used. The average tumor was measured at 15.75 mm clinically, 19.1 mm via imaging, and 19.6 mm histologically. Biopsy showed that 16% of the tumors were ductal carcinoma in situ (DCIS), and 84% were invasive. 16% of patients had involved margins, and re-excision was required in 10 patients, and completion mastectomy was performed in 2 patients. A thirty-day SSI rate was 6.2%, with flap-related complications, including flap loss and shrinkage, at 3.7% and 4.9%, respectively. In addition, 3.7% had a hematoma, and 17.3% had other complications. Conclusion: Partial breast reconstruction with perforator flaps is an excellent volume replacement technique in breast-conserving surgery with acceptable complications in well-selected cases.
基金supported by the National Natural Science Foundation of China (Grant No. 50921001)the Science and Technology Program for Communications Construction in West China,of the Ministry of Transport of the People’s Republic of China (Grant No. 2004-328-832-51)
文摘The finite difference method and the volume of fluid (VOF) method were used to develop a three-dimensional numerical model to study wave interaction with a perforated caisson. The partial cell method was adopted to solve this type of problem for the first time. The validity of the present model, with and without the presence of caisson structures, was examined by comparing the model results with experimental data. Then, the numerical model was used to investigate the effects of various wave and structure parameters on the wave force and wave runup of the perforated quasi-ellipse caisson. Compared with the solid quasi-ellipse caisson, the wave force on the perforated quasi-ellipse caisson is significantly reduced with increasing porosity of the perforated quasi-ellipse caisson. Furthermore, the perforated quasi-ellipse caisson can also reduce the wave runup, and it tends to decrease with the increase of the porosity of the perforated quasi-ellipse caisson and the relative wave height.
文摘The following paper describes patch closure (bovine pericardial sheet) of an ostium primum atrial septal defect and mitral valve repair (sutured mitral valve cleft + autologous pericardial annuloplasty + Alfieri’s method) in a 50-year-old man. He had been perfectly well until he was brought to the emergency room because of acute heart failure. Chest radiography revealed right-side heart enlargement. Electrocardiography indicated atrial flutter. Echocardiography revealed a large ostium primum atrial septal defect and moderate mitral regurgitation. The pulmonary-to-systemic blood flow ratio was 3.24. First, cardiologists performed catheter ablation of the cavotricuspid isthmus for atrial flutter. We performed patch closure of an ostium primum atrial septal defect and mitral valve repair after the patient’s heart failure was under control. The patient was discharged 13 days postoperatively in a satisfactory condition without any critical complications.