Distribution of Terbium and Increase of Calcium Concentration in the Organs of Mice iv-Administered With Terbium Chloride

To investigate the biobeical effects of terbium (Tb), male mice were intravenously ad ministered with TbCl3 at 10, 25, or 50 mg Tb/kg. Time-course and dose-related changes in organ distributions of Tb were determined . More than 95 % of the Tb in blood was in plas ma, and the concentrations decreased rapidly. Contrary to normal pharmacokinetics, Tb con centrations in plasma were higher in the 10 mg/kg group than in the 50 mg/kg group. The concentrations after injection of 25 mg/kg were between 10 and 50 mg/kg injections. Tb was incorporated mainly in liver, lung, and spleen. In all groups more than 80% of Tb adminis tered were found in these three organs. Disappearance of Tb in these organs was very slow.Tb was also found in kidney, heart and other organs. Coincidentally, it was found that the Ca concentration was increased in organs in which Tb was incorporated. After administration of Tb (50 mg/kg) the Ca concentration, compared to the controls, was 70-fold in spleen, 20-fold in lung, and 6-fold in liver. There were highly positive correlations between Tb and Ca concentrations in organs. Excretion of Tb in urine was 0. 15 ～ 0. 3 % and that in feces was 1.7～12. 5 % for up to 7 days. These results indicate that liver, lung, and spleen are the main target organs of Tb administered intravenously, and that the increase in Ca concentrations is one of the important biological effects of Tb in target organs

Cyberattack Ramifications, The Hidden Cost of a Security Breach

In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.

Zonal disintegration phenomenon in enclosing rock mass surrounding deep tunnels—mechanism and discussion of characteristic parameters

The mechanism of the zonal disintegration phenomenon(ZDP) was realized based on the analysis of the stressedstrained state of the rock mass in the vicinity of the maximum stress zone, which resides in the creep instability failure of rock mass due to the development of a plastic zone and transfer of the maximum stress zone within the rock mass.Some characteristic parameters of the ZDP are discussed theoretically.In first instance, the analytical critical depth condition for the occurrence of ZDP was obtained, which depends on the characteristics and stress concentration coefficient of the rock mass.Secondly, based on creep theory, the expression of the outer radius of the undisturbed zones in the deep rock mass was obtained with the use of an improved Burgers rheological model, which indicated that the radius depends on the characteristics of the rock mass and the depth of excavation and increases quasi-linearly with the rise of creep compliance of the rock mass.Finally, the formula for the distance of the most remote fissured zone away from the working periphery was derived, which increases logarithmically with the increase in the ratio of the in-situ stress and ultimate strength of rock mass.The distances between fissured zones are discussed in qualitative terms.

SIMULATING THE RESPONSE OF NON-UNIFORMITY OF PRECIPITATION EXTREMES OVER CHINA TO CO_2 INCREASING BY MIROC_HIRES MODEL

The response of non-uniformity of precipitation extremes over China to doubled CO2has been analyzed using the daily precipitation simulated by a coupled general circulation model,MIROC_Hires.The major conclusions are as follows:under the CO2increasing scenario(SRES A1B),the climatological precipitation extremes are concentrated over the southern China,while they are uniformly distributed over the northern China.For interannual variability,the concentration of precipitation extremes is small over the southern China,but it is opposite over the northern China.The warming effects on the horizontal and vertical scales are different over the northern and southern part of China.Furthermore,the atmospheric stability is also different between the two parts of China.The heterogeneous warming is one of the possible reasons for the changes in non-uniformity of precipitation extremes over China.

Assessment of Heavy Metals Pollution of Some Water Resources (Kafr El-Dawar—Egypt)

Kafr El-Dawar is a major industrial city and a municipality on the Nile Delta in northern Egypt. Kafr El-Dawar area is unfortunately suffering from many factories that let out their waste water into the irrigation canal and agricultural drains. Twenty five water samples were collected from five water resources to assess their heavy pollution. The determination of heavy metals (HV) water resources content conducted to compose the following increasing HV concentration sequences;Drain Abu Qir (DA): Min (Cu)_Max (Zn), Canal Dbora Deufsho (CD): Min (Cu)_Max (Zn), Drain Dbora Abu Qir (DD): Min (Cu)_Max (Fe), Drain Kafr Dawar Deufsho (DK) : Min (Cu)_Max (Mn) and Drain Yarn and Fabric (DY) Min (Cu)_Max (Zn). Distribution patterns of HV concentration of water resources were (a) wide spread-distribution (Cr, Co, Mn), (b) moderately spread distribution pattern (Cu, Ni, Pb),and (c) narrow spread distribution pattern (Fe, Cd, Li and Zn) . The association study conducted to classify the HV concentration into three groups;positively highly correlated HV: (Pb_Cd), (Pb_Co), (Pb_Cr), (Cd_Co), (Zn_Fe), (Cr_Co), (Ni_Co) and (Ni_Fe), negatively highly correlated HV: (Pb_Mn), (Cd_Mn), (Mn_Cu) and (Co_Li) and intermediate cases (non-significant positive and negative intercorrelation) that was represented by the other cases. The low values of contamination factor, of short term use (CfiST), showed that the majority of HV concentration, of the studied water resources was at safe use level. This certainly with exception of the cases of cadmium that classified the water resources DA and CD, and DD into polluted and risky levels, respectively. The high values of contamination factor, of long term use (CfiLT), indicated that the studied water resources were mainly contaminated by Cd, Co and Cr heavy metals. Contrary, the low values of (CfiLT) of Zn, Fe, Li, Ni, Pb and Cu, all studied water resources are safe. Contamination degree index (Cd) indicated the safe use at short term of water resources (DA), (CD) and (DD), and (DY) water resources were highly contaminated. According to (Cd) values, moderate risk is expected if we use the water resource (DK), even in the short term. As for the long term use, all studied water resources were highly contaminated that they cannot be absolutely used in the long run.

The Myth of the Economic Strength of the United States

The US government constantly repeats that the country’s economy has solid foundations and that it is growing, even the current president announces that his country’s economy is the strongest in history, but the truth is that there are macroeconomic indicators that contradict it. The United States is experiencing a structural crisis of long evolution that is reflected in colossal indebtedness, in the concentration of wealth, the increase in poverty, and in the trade and budget deficits. During the second administration of President Obama, the ratio of debt to Gross Domestic Product (GDP) reached 100% and since then, the amount of debt has continued to increase. With the arrival of Donald Trump, the US economy registers historical deficits and the debt figure has already exceeded 21 trillion dollars, which augurs in the medium term a decline in GDP growth and a potential recession, but in the long term and not reversing this trend could present a financial catastrophe. This situation will negatively impact other indicators which could generate a climate of uncertainty, nervousness, and instability that will make the crises of 1929 and 2008-2009 pale.

袁家村微细粒难选磁赤混合铁矿石提铁降硅试验研究

袁家村铁矿选矿厂原生产工艺流程获得的铁精矿TFe品位仅65%左右、SiO_(2)含量达4%~5%,难以满足市场对高品质铁精矿的需求。为此,在详细分析生产流程中混合磁选精矿性质的基础上,采用卧式搅拌磨机细磨—弱磁选+强磁选—反浮选工艺流程开展了提铁降硅试验研究。对TFe品位42.44%、SiO_(2)含量35.42%的混合磁选精矿,在磨矿细度为-0.045 mm占97%情况下,全流程试验获得了产率53.87%、TFe品位67.87%、SiO_(2)含量1.96%、TFe回收率86.15%的高品质铁精矿;磨矿细度为-0.045 mm占94%情况下,适当增大捕收剂RA用量,可获得产率54.76%、TFe品位67.14%、SiO_(2)含量2.09%、TFe回收率86.63%的高品质铁精矿。研究结果可作为选矿厂提铁降硅工艺流程优化决策依据,对类似性质难选铁矿石的高效开发利用具有参考价值。

全球气候变化对稻田温室气体排放和微生物群落影响的研究进展

稻田是二氧化碳(CO_(2))、甲烷(CH_(4))和氧化亚氮(N_(2)O)等温室气体的重要排放源之一,稻田温室气体产生与排放一直是研究关注的热点和重点。IPCC预测未来全球气候变化主要表现为气候变暖、大气CO_(2)浓度和近地层臭氧(O_(3))浓度升高,三者对稻田温室气体的排放具有不同程度的影响。稻田微生物群落对全球气候变化的响应也很敏感,进而直接或间接影响温室气体的排放。通过文献综述,总结了近年来全球气候变化对稻田温室气体排放和稻田微生物群落的影响、全球气候变化背景下稻田微生物对温室气体排放的效应以及稻田关键微生物在温室气体减排中的应用,指出未来应综合考虑多因子气候变化对稻田温室气体排放的影响并加强对其机制的研究,加强稻田微生物对温室气体排放调控效应和机制研究,以及筛选减排效果显著的微生物类群用以开发成熟的稻田温室气体减排微生物产品。

基于新指南的新生儿万古霉素谷浓度达标率分析

目的:评估新生儿在不同指南推荐目标谷浓度下万古霉素谷浓度分布情况及达标率,探讨提高达标率的可能性,为临床调整给药方案提供参考。方法:回顾性分析2016年11月至2021年3月厦门大学附属妇女儿童医院新生儿科接受万古霉素治疗的128例新生儿临床资料,评估不同给药方案及给药间隔的万古霉素谷浓度达标率。结果:128例患儿中,万古霉素目标谷浓度为5~15 mg/L时达标率56.25%(72例),目标谷浓度为10~20 mg/L时达标率50.78%(65例)。早产儿和足月儿万古霉素谷浓度达标率比较差异无统计学意义。按药品说明书推荐方案给药和其他给药方案万古霉素血药谷浓度达标率比较差异无统计学意义。万古霉素目标谷浓度为5~15 mg/L时,给药间隔12小时组达标率(68.18%)高于给药间隔8小时组(43.55%)。结论:基于新指南推荐的新生儿万古霉素目标谷浓度为5~15 mg/L,既往新生儿经验给药方案可能需重新调整以提高目标谷浓度达标率。

浓度递增法程控硬膜外间歇脉冲注入罗哌卡因对产妇不同时间的镇痛效果影响分析

目的:探讨浓度递增法程控硬膜外间歇脉冲注入(PIEB)罗哌卡因对产妇不同时间的镇痛效果影响。方法:选取2021年1月—2023年1月福建医科大学附属漳州市医院收治的140例足月妊娠初产妇作为研究对象,按照随机数表法分为对照组(n=69)和观察组(n=71),两组均采用PIEB给予罗哌卡因,其中对照组给予固定浓度进行分娩镇痛,观察组给予浓度递增法进行分娩镇痛。观察两组不同时间的疼痛程度、镇痛药物消耗情况、爆发疼痛情况、不良反应发生情况。结果:观察组宫口全开后15 min及分娩时视觉模拟量表(VAS)评分均较对照组低,差异有统计学意义(P<0.05);观察组罗哌卡因总药量、舒芬太尼总药量均较对照组少,硬膜外自控镇痛(PCEA)按压次数较对照组低,差异有统计学意义(P<0.05);观察组爆发痛发生率(5.63%)较对照组(15.94%)低,追加镇痛药物次数较对照组少,差异有统计学意义(P<0.05);观察组不良反应发生率(16.90%)低于对照组(31.88%),差异有统计学意义(P<0.05)。结论:初产妇分娩镇痛采用浓度递增法PIEB注入罗哌卡因具有较好的镇痛效果,且疼痛爆发情况较少,并减少疼痛药物用量及不良反应。

个性化营养指导在妊娠糖尿病患者护理中的应用研讨

目的分析妊娠糖尿病实施个体化营养指导的价值。方法选取2022年11月—2023年11月平邑县人民医院收治的106例妊娠糖尿病患者为研究对象,采用奇偶数法分为普通组、个性组,各53例。普通组行普通指导,个性组行个性化营养指导,比较两组依从性、血糖指标、体质量增长情况、不良结局。结果个性组依从率高于普通组,差异有统计学意义(P<0.05)。指导后,两组血糖指标均降低,且个性组低于普通组,差异有统计学意义(P<0.05)。个性组体质量正常增长率高于普通组,体质量过量增长率低于普通组,不良结局总发生率低于普通组,差异有统计学意义(P均<0.05)。结论个性化营养指导可改善分娩结局,提高血糖控制效果,使体质量增长幅度控制在正常范围内,保证妊娠安全。

提高碳化中段气二氧化碳浓度可行性探讨

高效、合理提高碳化中段气二氧化碳浓度,成为纯碱生产企业提高产能、减少煤耗、石耗而达到节能、降耗、减排的主要措施之一。本文通过介绍对燃煤电厂烟道气回收利用二氧化碳的可行性,希望为行业提供一些参考和借鉴。

基于增产增效目标的多喷嘴对置式水煤浆气化技术优化改进

为实现增产增效,提高企业经济效益,灵谷化工集团有限公司对2000 t/d多喷嘴对置式水煤浆气化装置实施了煤浆提浓和耐火砖改进。介绍了多喷嘴对置式水煤浆气化工艺流程。通过采取煤种选择与煤质控制、选择合适的添加剂、优化制浆水、磨机和搅拌器等煤浆提浓措施,实施拱顶与筒身交接处、炉膛和渣口等耐火砖改造,煤浆质量分数提高了3个百分点,气化炉投煤量增加约230 t/d,单炉有效气产量从11.8万m^(3)/h增加到13.5万m^(3)/h,合成氨产量增加约200 t/d,确保了工业装置的高效优质运行。

The Concentration Degree of Nationwide Rare Earth Industry Increased Significantly

Since the'Twelfth Five Year Plan'period,China has made considerable progress in the organization and setup of large rare earth groups,layout of rare earth industry has become more rational,the concentration degree has increased significantly,the previously small,scattered,and chaotic situation has basically been reversed.

气候变化对作物产量影响的研究进展

近年来全球气候变化研究正逐步深入,气候变化对作物产量影响的研究取得了明显的进展。本文在总结气候变化对作物产量影响的研究方法后,从CO2浓度升高、温度升高、CO2浓度与温度升高的交互作用、降水变化、每日的温差变化以及极端气候事件和气候变化综合影响7个方面总结了气候变化对作物生产和产量影响的研究进展,最后指出了气候变化对作物产量影响评价尚需加强和深入研究的几个方面。

单一浓度法与梯度浓度法高渗盐水雾化诱导痰的成功率与安全性比较

目的探讨单一浓度法和梯度浓度法高渗盐水雾化在痰诱导的成功率及安全性等方面的差异。方法对20例咳嗽变异性哮喘(CVA)患者先后以单一浓度法(3%)和梯度浓度法(3%-4%-5%)各进行1次高渗盐水的雾化痰诱导。统计两种方法的诱导成功率,观察患者在诱导期间的肺通气、心率及血氧饱和度的变化,比较痰液重量、痰细胞总数及鳞状上皮细胞比例等参数。结果单一浓度法及梯度浓度法诱导成功率分别为90%和95%;两种方法咳出的痰量、痰细胞总数和鳞状上皮细胞比例无显著差异;梯度浓度法诱导后患者的PEF及SpO2均出现下降(P<0.01),单一浓度法的PEF、HR、SpO2在诱导前后均无显著变化。结论单一浓度法和梯度浓度法均为可行及有效的痰诱导方法,但在梯度浓度法雾化过程中更需要注意患者的安全性问题。

植物物候对模拟CO2浓度和温度升高的响应研究进展

以大气二氧化碳(CO2)浓度升高和全球变暖为主要特征的全球变化引起了各国政府和科学家的普遍关注.植物物候节律与气候等环境因子密切相关,已有大量研究表明,植物物候已经发生并正在发生着改变.植物物候与区域乃至全球气候变化之间存在密切关联,且其在全球碳循环中扮演着重要的角色.植物物候变化可能引起一系列生态效应.CO2浓度升高对植物物候的影响没有统一的规律,而温度升高一般加速植物物候过程,且在也同一功能群内,响应的方式有一定的趋同性,两者交互作用对植物物候影响的研究仍然匮乏.

微波场中钛精矿的温升行为及吸波特性

采用微波谐振腔法对钛精矿、焦炭、氧化钛精矿、复合添加剂的吸波特性(εr")进行研究,同时测定其温升曲线。通过对波谱图的衰减值和相对频移分析表明,钛精矿和焦炭具有良好的吸波特性,氧化钛精矿和复合添加剂对微波的吸收能力较差;钛精矿含碳球团具有良好的吸波特性,经微波还原的金属化球团吸波特性好于钛精矿含碳球团吸波特性。温升行为的结果和波谱图的检测结果相吻合。

漱口液浓度递增对扁桃体手术患儿漱口依从性的影响

目的提高扁桃体手术患儿漱口依从性,促进伤口愈合。方法将111例扁桃体手术患儿随机分为实验组(54例)和对照组(57例)。均行常规护理和采用复方硼砂溶液漱口。对照组入院即用硼砂原液漱口至出院后2周;实验组采取浓度递增的方法即入院第1天用硼砂原液与蒸馏水按1∶3配制,第2天用1∶1比例配制,第3天用硼砂原液漱口至出院后2周。结果实验组住院期间及出院后1周漱口依从性显著高于对照组(P<0.05,P<0.01),伤口愈合良好率显著高于对照组(P<0.01)。擅自减药、停药及拒绝服药为主要不依从表现,家长忘记、担心药物不良反应及患儿不配合、不愿坚持为主要原因。结论对扁桃体手术患儿采取漱口液浓度递增的方法可提高患儿漱口的依从性,从而促进伤口愈合。

地表臭氧浓度增加对南京地区冬小麦生长和产量的影响

利用改进后的开顶式气室(OTC),开展了O3浓度增加对冬小麦生长与产量影响的大田实验研究。实验设置三种处理:CK为未经处理的空气,CF100处理O3浓度为100nL/L,CF150处理O3浓度为150nL/L。结果表明,地表O3浓度增加,冬小麦生育期缩短,籽粒的灌浆期缩短,植株提前老化;同时,冬小麦的株高、生物量、叶面积等生长指标均显著下降(p<0.05),最大降幅分别达到了10.01%、36.56%和29.17%;冬小麦的穗数、穗粒数、单位面积产量等产量指标也都出现了显著下降(p<0.05),其中CF100、CF150处理的单位面积产量分别比CK下降了16.11%和39.17%。试验结果对于评估地表O3浓度增加对粮食安全的影响具有重要的指导意义。