Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg.,a dominant microorganism from the post fermentation process of ripe Pu-er tea.Their structures were eluci...Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg.,a dominant microorganism from the post fermentation process of ripe Pu-er tea.Their structures were elucidated by extensive spectroscopic methods.Among them,trypostatins C(1)and D(2)featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds,while 3 and 4 were obtained for the first time from nature source.The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40μM.展开更多
基金supported by the National Natural Science Foundation of China(No.21672223).
文摘Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg.,a dominant microorganism from the post fermentation process of ripe Pu-er tea.Their structures were elucidated by extensive spectroscopic methods.Among them,trypostatins C(1)and D(2)featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds,while 3 and 4 were obtained for the first time from nature source.The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40μM.
