Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and af...Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.展开更多
Background: Infection transmission among them occurs easily and sometimes causes outbreaks at facilities where children live in groups. Early response is necessary for infection control measures to avoid larger cluste...Background: Infection transmission among them occurs easily and sometimes causes outbreaks at facilities where children live in groups. Early response is necessary for infection control measures to avoid larger clusters. In Japan, (Nursery) School Absenteeism Surveillance System ((N)SASSy), which is a kind of school absenteeism surveillance, has activated since 2007 and covers about 60% of all schools and 40% of all nursery schools in 2017. Objective: The objective of the present paper is investigation and demonstration of how caregivers receive information related to infectious diseases in Japan and how (N)SASSy contributes health of children. Method: We randomly selected subjects with children by pre-fecture in October, 2017. The survey questionnaire asked background information and information about infectious diseases to maintain health in children. We regressed health concern variables on background information and information provision situation about community outbreaks using weighted logistic regression. Results: We received responses from 1172 people. Estimation results showed higher concern about a facility providing information about community outbreak. Caregivers whose children attend facilities provided about community outbreak or covered (N)SASSy significantly higher opportunity to arrange a schedule when a child has a high fever. Discussion: The obtained results demonstrated that activation in (N)SASSy affects the possibility of arranging a schedule when a child has a high fever. This capability might improve community health.展开更多
In this paper, exponential type regression models are considered from geometric point of view. The stochastic expansions relating to the estimate are derived and are used to study several asymptotic inference problems...In this paper, exponential type regression models are considered from geometric point of view. The stochastic expansions relating to the estimate are derived and are used to study several asymptotic inference problems. The biases and the covariances relating to the estimate may be calculated based on the expansions. The information loss of the estimate and a limit theorem connected with the observed and expected Fisher informations are obtained in terms of the curvatures.展开更多
Background: Family planning is an efficient and effective intervention that results in quick benefits for the whole family socio-economically. Differences exist in the rate of contraceptive use between male and female...Background: Family planning is an efficient and effective intervention that results in quick benefits for the whole family socio-economically. Differences exist in the rate of contraceptive use between male and female and male involvement of service uptake in Ghana. The objective of this study was to explore male direct involvement and or support to their partners in family planning service uptake. Methods: The study used a descriptive cross-sectional survey to sample 384 men of reproductive age (18 - 45 year) using cluster sampling to enlist participants from within the Suame Magazine light Industrial area in the Ashanti Region of Ghana. Data was analyzed descriptively using SPSS version 16. Results: Men showed very high knowledge (90%) about what constitutes Family Planning, with moderate level of involvement both active and passive involvement (56%) though only a few (38.9%) were presently adopting or using modern contraceptive. The study rather found only 14% (55) males were willing to be solely responsible and actively involved in Family Planning service. Family Planning services did not adequately meet the needs of men with the services centers remaining unavailable in the study area. Conclusion: The extent of male involvement in family planning programmes is marginally above average. Males showed appreciable knowledge of family planning options though misconceptions continued to exist. A more couple-oriented approach to family planning is needed including recruiting males as family planning providers, offering more family planning counseling for couples, and promoting female-oriented methods with men and vice versa.展开更多
The Information Technology at Home has caught the attention of various industries such as IT,Home Appliances,Communication,and Real Estate.Based on the information technology acceptance theories and family consumption...The Information Technology at Home has caught the attention of various industries such as IT,Home Appliances,Communication,and Real Estate.Based on the information technology acceptance theories and family consumption behaviors theories,this study summarized and analyzed four key belief variables i.e.Perceived Value,Perceived Risk,Perceived Cost and Perceived Ease of Use,which influence the acceptance of home information technology.The study also summaries three groups of external variables.They are social,industrial,and family influence factors.The social influence factors include Subjective Norm;the industry factors include the Unification of Home Information Technological Standards,the Perfection of Home Information Industry Value Chain,and the Competitiveness of Home Information Industry;and the family factors include Family Income,Family Life Cycle and Family Educational Level.The study discusses the relationship among these external variables and cognitive variables.The study provides Home Information Technology Acceptance Model based on the Technology Acceptance Model and the characteristics of home information technology consumption.展开更多
基金supported by American Diabetes Association,American Heart Association,NIH NIEHS,NIH NIA,NIH NINDS,and NIH ARRA
文摘Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.
文摘Background: Infection transmission among them occurs easily and sometimes causes outbreaks at facilities where children live in groups. Early response is necessary for infection control measures to avoid larger clusters. In Japan, (Nursery) School Absenteeism Surveillance System ((N)SASSy), which is a kind of school absenteeism surveillance, has activated since 2007 and covers about 60% of all schools and 40% of all nursery schools in 2017. Objective: The objective of the present paper is investigation and demonstration of how caregivers receive information related to infectious diseases in Japan and how (N)SASSy contributes health of children. Method: We randomly selected subjects with children by pre-fecture in October, 2017. The survey questionnaire asked background information and information about infectious diseases to maintain health in children. We regressed health concern variables on background information and information provision situation about community outbreaks using weighted logistic regression. Results: We received responses from 1172 people. Estimation results showed higher concern about a facility providing information about community outbreak. Caregivers whose children attend facilities provided about community outbreak or covered (N)SASSy significantly higher opportunity to arrange a schedule when a child has a high fever. Discussion: The obtained results demonstrated that activation in (N)SASSy affects the possibility of arranging a schedule when a child has a high fever. This capability might improve community health.
基金The project was supported by National Natural Science Foundation of China
文摘In this paper, exponential type regression models are considered from geometric point of view. The stochastic expansions relating to the estimate are derived and are used to study several asymptotic inference problems. The biases and the covariances relating to the estimate may be calculated based on the expansions. The information loss of the estimate and a limit theorem connected with the observed and expected Fisher informations are obtained in terms of the curvatures.
文摘Background: Family planning is an efficient and effective intervention that results in quick benefits for the whole family socio-economically. Differences exist in the rate of contraceptive use between male and female and male involvement of service uptake in Ghana. The objective of this study was to explore male direct involvement and or support to their partners in family planning service uptake. Methods: The study used a descriptive cross-sectional survey to sample 384 men of reproductive age (18 - 45 year) using cluster sampling to enlist participants from within the Suame Magazine light Industrial area in the Ashanti Region of Ghana. Data was analyzed descriptively using SPSS version 16. Results: Men showed very high knowledge (90%) about what constitutes Family Planning, with moderate level of involvement both active and passive involvement (56%) though only a few (38.9%) were presently adopting or using modern contraceptive. The study rather found only 14% (55) males were willing to be solely responsible and actively involved in Family Planning service. Family Planning services did not adequately meet the needs of men with the services centers remaining unavailable in the study area. Conclusion: The extent of male involvement in family planning programmes is marginally above average. Males showed appreciable knowledge of family planning options though misconceptions continued to exist. A more couple-oriented approach to family planning is needed including recruiting males as family planning providers, offering more family planning counseling for couples, and promoting female-oriented methods with men and vice versa.
文摘The Information Technology at Home has caught the attention of various industries such as IT,Home Appliances,Communication,and Real Estate.Based on the information technology acceptance theories and family consumption behaviors theories,this study summarized and analyzed four key belief variables i.e.Perceived Value,Perceived Risk,Perceived Cost and Perceived Ease of Use,which influence the acceptance of home information technology.The study also summaries three groups of external variables.They are social,industrial,and family influence factors.The social influence factors include Subjective Norm;the industry factors include the Unification of Home Information Technological Standards,the Perfection of Home Information Industry Value Chain,and the Competitiveness of Home Information Industry;and the family factors include Family Income,Family Life Cycle and Family Educational Level.The study discusses the relationship among these external variables and cognitive variables.The study provides Home Information Technology Acceptance Model based on the Technology Acceptance Model and the characteristics of home information technology consumption.
