Invariance and Noises of Shannon Entropy for Information on Oxidative Activity of DNA in All Living Cells for Medical Diagnostics

We analyze oxidative activity of DNA due to fluorescence of chromosomes inside cells, using flow cytometry method with nanometer spatial resolution. Statistics of fluorescence is presented in histogram as frequency distributions of flashes in the dependence on their intensity and in distributions of Shannon entropy, which was defined on the base of normalized distribution of information in original histogram for frequency of flashes. We show that overall sum of entropy, i.e. total entropy E , for any histogram is invariant and has identical trends of changes all values of E(r) = lnr at reduction of histogram’ rank r. This invariance reflects informational homeostasis of chromosomes activity in multi-scale networks of entropy inside all cells in various samples of blood for DNA inside neutrophils, lymphocytes, inside all leukocytes of human and inside chicken erythrocytes for various dyes, colors and various excitations of fluorescence. Informational homeostasis of oxidative activity of 3D DNA in the full set of chromosomes inside living cells exists for any Shannon-Weaver index of biodiversity of cells, at any state of health different beings. Regulation perturbations in information activity DNA provides informational adaptability and vitality of cells at homeostasis support. Noises of entropy, during regulation of informational homeostasis, depend on the states of health in real time. The main structural reconstructions of chromosomal correlations, corresponding to self-regulation of homeostasis, occur in the most large-scale networks of entropy, for rank r<32. We show that stability of homeostasis is supported by activity of all 46 chromosomes inside cells. Patterns, hidden switching and branching in sequences of averages of H?lder and central moments for noises in regulation of homeostasis define new opportunities in diagnostics of health and immunity. All people and all aerobic beings have one overall homeostatic level for countdown of information activity of DNA inside cells. We noted very bad and dangerous properties of artificial cells with other levels of informational homeostasis for all aerobic beings in foods, medical treatment and in biotechnologies.

Study on Plant Radiation Signal Transduction for Human Self-Healing

We selected 450 patients with chronic and difficult diseases as receptors, and selected edible and medicinal plant combinations as biological signal donors, and randomly participated in a new experiment. After adjusting the patient’s biological field, the compensating bio information energy (CBE) high-tech is applied to transmit the signal of plant radiation to the patient’s body. The physical therapy of this health care mode has the characteristics of no contact, no drugs, no intervention, no toxic side effects, no pain, and no electromagnetic radiation and so on. Before and after the experiment, the main function test, cell function, cell biochemistry and body temperature of each patient were used for the same body control and data statistical analysis, and then the comprehensive integration method was used to evaluate the effect. We found that after 1 - 4 courses of treatment (7 - 28 dx 2h), the potential disease risk of patients was significantly reduced, the relevant medical indicators improved rapidly, and the cell function and symptoms improved simultaneously. The effective rate was up to 90%, the significant efficiency was up to 57%. This experiment shows that this new physical therapy can treat both symptoms and root causes, make chronic and difficult diseases self-healing and rehabilitation, and has no ethical problems. It also shows that information on plant health can play an important role in reversing cell aging and restoring cell function. Therefore, it opens up a new field of natural therapy, which can be called cell information therapy.

Stimulus discrimination via responses of retinal ganglion cells and dopamine-dependent modulation

Neighboring retinal ganglion cells（RGCs）fire with a high degree of correlation.It has been increasingly realized that visual perception of the environment relies on neuronal population activity to encode and transmit the information contained in stimuli.Understanding how neuronal population activity contributes to visual information processing is essential for understanding the mechanisms of visual coding.Here we simultaneously recorded spike discharges from groups of RGCs in bullfrog retina in response to visual patterns（checkerboard,horizontal grating,and full-field illumination）using a multi-electrode array system.To determine the role of synchronous activity mediated by gap junctions,we measured the correct classification rates of single cells＇firing patterns as well as the synchronization patterns of multiple neurons.We found that,under normal conditions,RGC population activity exhibited distinct response features with exposure to different stimulus patterns and had a higher rate of correct stimulus discrimination than the activity of single cells.Dopamine（1μmol/L）application did not significantly change the performance of single neuron activity,but enhanced the synchronization of the RGC population activity and decreased the rate of correct stimulus pattern discrimination.These findings suggest that the synchronous activity of RGCs plays an important role in the information coding of different types of visual patterns,and a dopamine-induced increase in synchronous activity weakens the population performance in pattern discrimination,indicating the potential role of the dopaminergic pathway in modulating the population coding process.