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The Impact of Health Information Technology on Hospital Performance: A Systematic Integrative Literature Review
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作者 Alisa Westerhof Cokky Hilhorst Willem Jan Bos 《Health》 2024年第4期257-279,共23页
Objective: To review, categorise, and synthesise findings from literature on health information technology (HIT) functionalities, HIT use, and the impact of HIT on hospital performance. Materials and Methods: We condu... Objective: To review, categorise, and synthesise findings from literature on health information technology (HIT) functionalities, HIT use, and the impact of HIT on hospital performance. Materials and Methods: We conducted a systematic integrative literature review based on a compre-hensive database search. To organise, categorise and synthesise the ex-isting literature, we adopted the affordance actualization theory. To align the literature with our research framework, we used four categories: 1) the functionalities of HIT and how these functionalities are measured;2) use and immediate outcomes of HIT functionalities;3) different perfor-mance indicators and how HIT functionalities affect them;and 4) what hospital characteristics influence the outcome of hospital performance. Results: Fifty-two studies were included. We identified four types of HIT. Only ten studies (19.2%) define the use of HIT by explicitly meas-uring the use rate of HIT. We identified five dimensions of hospital per-formance indicators. Every dimension showed mixed results;however, in general, HIT has a positive impact on mortality and patient readmis-sions. We found several hospital characteristics that may affect the rela-tionship between HIT and hospital-level outcomes. Discussion: Further efforts should focus on embedded research on HIT functionalities, use and effects of HIT implementations with more performance indicators and adjusted for hospital characteristics. Conclusion: The proposed framework could help hospitals and researchers make decisions regard-ing the functionalities, use and effects of HIT implementation in hospi-tals. Given our research outcomes, we suggest future research opportuni-ties to improve understanding of how HIT affects hospital performance. . 展开更多
关键词 Health information technology HIT Functionalities Hospital Performance Indicators
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The Influence of Information Technology(IT)on Accrual Accounting Adoption:The Case of the Jordanian Public Sector
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作者 Moawiah Awad Alghizzawi Rosnia Masruki 《Journal of Modern Accounting and Auditing》 2024年第2期40-48,共9页
Jordan is one of many countries that intends to reform its public sector by adopting accrual accounting,which is primarily carried out through the International Public Sector Accounting Standards(IPSAS)implementation ... Jordan is one of many countries that intends to reform its public sector by adopting accrual accounting,which is primarily carried out through the International Public Sector Accounting Standards(IPSAS)implementation plan,scheduled to be completed by 2021.Considering the difficulties of adoption,this process cannot be completed without an appropriate Information Technology(IT)system capable of providing the accounting information required for this reform.Therefore,this study aims to examine the influence of IT on accrual accounting adoption in the Jordanian public sector.The study employed the quantitative survey approach.Based on 331 usable questionnaires,the descriptive findings showed that the use of IT in the Jordanian public sector is relevant to daily accounting transactions in general and to accrual accounting in particular.The regression analysis showed a positive,significant relationship between IT use and accrual accounting practice.The IT specialist should be able to understand the needs of public sector in adopting accrual-based accounting.In line with today’s digitalization age,which integrates advanced technologies and numerous techniques,this study suggests that a combination of accounting and IT experts is a value added to sharpen the competitiveness of public sector reform.This study contributes to the extant literature in public sector,concerning the relationship between IT and accrual accounting adoption in the context of Jordan. 展开更多
关键词 public sector accrual accounting adoption information technology JORDAN
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Influence of Quantum Information Technology on International Security
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作者 ZHAO Dongqian 《International Relations and Diplomacy》 2024年第1期26-33,共8页
Humanity is currently undergoing the fourth industrial revolution,characterized by advancements in artificial intelligence,clean energy,quantum information technology,virtual reality,and biotechnology.This technologic... Humanity is currently undergoing the fourth industrial revolution,characterized by advancements in artificial intelligence,clean energy,quantum information technology,virtual reality,and biotechnology.This technological revolution is poised to have a profound impact on the world.Quantum information technology encompasses both quantum computing and the transmission of quantum information.This article aims to integrate quantum information technology with international security concerns,exploring its implications for international security and envisioning its groundbreaking significance. 展开更多
关键词 quantum information technology quantum communication quantum computing international security
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IAM Excellence: Exploring Saviynt’s Role in Modern Information Technology
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作者 Sampath Talluri 《Journal of Information Security》 2024年第1期40-52,共13页
Organizations may increase data security and operational efficiency by connecting Salesforce with Identity and Access Management (IAM) systems like Saviynt. This study delves deeply into the details of this revolution... Organizations may increase data security and operational efficiency by connecting Salesforce with Identity and Access Management (IAM) systems like Saviynt. This study delves deeply into the details of this revolution that is being encouraged to shift towards IAM software and potential drawbacks such as excessive provisioning and implementation issues. The study illuminated excellent practices and emphasized the importance of constant monitoring by using secondary theme analysis and qualitative research as proof. The findings indicate Saviynt as a viable solution and provide detailed information for firms seeking a smooth and secure integration path. 展开更多
关键词 information technology (IT) Identity and Access Management (IAM) Saviynt User Identities Access Privileges Authentication Processes Risk Management
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Exploration of Innovation Strategy in the Deep Integration of Information Technology and Education and Teaching
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作者 Lingyan Meng 《Journal of Contemporary Educational Research》 2024年第6期261-267,共7页
The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to ... The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education. 展开更多
关键词 information technology Education and teaching Deep integration Innovation strategy
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Exploration of the Integrated Training Model for Information Technology Teachers
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作者 Haitao Sang Bo Chen +1 位作者 Zongliang Ye Jing Cai 《Journal of Contemporary Educational Research》 2024年第1期31-38,共8页
With the acceleration of the social information process,information awareness and information skills have become the basic qualities of every citizen.The establishment of the training mechanism for scientific and tech... With the acceleration of the social information process,information awareness and information skills have become the basic qualities of every citizen.The establishment of the training mechanism for scientific and technological innovation talents from the beginning of higher education is insufficient to meet the needs of the development of the times.It is imperative to improve the training of information technology innovation talents and explore a new training model.This paper describes the general situation of the development of education in the field of information technology from a domestic and international perspective.It then analyzes the existing problems,explores new exploration models and implementation suggestions,and puts forward prospects at the end of the paper. 展开更多
关键词 information technology discipline Personnel training Model exploration
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The Model of“Post,Course,Competition,Certificate”Integrated Education for Electronic Information Engineering Technology Major in Higher Vocational Colleges
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作者 Qinqin Jing Yun Liu Xinyu Zheng 《Journal of Contemporary Educational Research》 2024年第5期223-229,共7页
The core education function of higher vocational colleges is to train technical talents with high quality,so as to meet the needs of talents in the development stage of our society.Under the guidance of talent trainin... The core education function of higher vocational colleges is to train technical talents with high quality,so as to meet the needs of talents in the development stage of our society.Under the guidance of talent training,higher vocational colleges need to pay attention to establishing an all-round and three-dimensional education model,and promote innovation of higher vocational education on the basis of this.It is also a way to promote the innovation of higher vocational education to vigorously promote the construction of“post,course,competition,certificate”mode in the construction of education mode.Through the construction of“post,course,competition,certificate”mode,the education mode of higher vocational colleges is gradually improved,so as to strengthen the effectiveness of talent training in higher vocational colleges.Therefore,in this paper,the author puts forward some suggestions to promote the construction of the integrated education mode of the electronic information engineering technology major in higher vocational colleges,so as to help improve the talent training level of higher vocational colleges. 展开更多
关键词 Higher vocational education Electronic information engineering technology major “Post course competition certificate” Integrated education model
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Application of Mobile Technology and Information Management in Emergency Pre- Examination and Triage
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作者 Zhongqing Yang Ruihua Zhu +1 位作者 Li Shen Bei Zhu 《Journal of Clinical and Nursing Research》 2024年第3期147-151,共5页
The primary objective of emergency pre-examination and triage is to provide the most appropriate clinical service to patients with acute and critical illnesses while ensuring the optimal utilization of limited medical... The primary objective of emergency pre-examination and triage is to provide the most appropriate clinical service to patients with acute and critical illnesses while ensuring the optimal utilization of limited medical resources.With the advancement of medical information technology,mobile technology,and information management,these features have been gradually incorporated into emergency pre-examination and triage and have shown promising outcomes.In this article,the benefits of implementing mobile technology and the current status of integrated information management to provide a reference for the future development and enhancement of emergency pre-examination and triage are reviewed. 展开更多
关键词 Pre-examination and triage EMERGENCY Mobile technology
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Application of Information Technology in Institutions and Challenges of Human Resources-Case Study: Administration of the Municipality of Ferizaj
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作者 Egzona Selimi 《Journal of Computer and Communications》 2023年第5期84-92,共9页
This study aims to investigate how information technology is applied in the administration of the municipality of Ferizaj and what are the challenges with human resources, the work was carried out through a case study... This study aims to investigate how information technology is applied in the administration of the municipality of Ferizaj and what are the challenges with human resources, the work was carried out through a case study in the municipality. This paper highlights that the use of information technology provides higher efficiency for the performance of daily work in the municipality, thus also the provision of better services to citizens. However, the level of use of information technology in the Municipality of Ferizaj leaves much to be desired in terms of efficiency because a significant number of employees have not attended adequate training for the effective and efficient use of various IT applications and have not are still adapted to the digital environment in the municipality. Therefore, the recommendation derived from this paper is that the information technology environment in the municipality of Ferizaj needs to be improved by providing staff with adequate qualifications, while for those who are currently engaged in the municipality and who do not have adequate qualifications, training should be provided in a way that all users of IT applications are fully integrated into the digitized environment in order to be effective and efficient in providing services to citizens. This simultaneously gives the municipal staff job security and motivation for better services for citizens. Also, information technology enables a better control over the activity of the municipality because every action is recorded as data which can then be used to analyze the performance of the municipality. 展开更多
关键词 information technology Human Resources Administration of the Municipality of Ferizaj DIGITALIZATION
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Factors Influencing Employees on Compliance with Cybersecurity Policies and Their Implications for Protection of Information and Technology Assets in Saudi Arabia
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作者 Sami Saad Alsemairi 《Intelligent Information Management》 2023年第4期259-283,共25页
In the current digital era, it is difficult to preserve the confidentiality, integrity, and availability of an organization’s information and technology assets against cyber attacks. Organizations cannot rely solely ... In the current digital era, it is difficult to preserve the confidentiality, integrity, and availability of an organization’s information and technology assets against cyber attacks. Organizations cannot rely solely on technical solutions for defense, since many cyber attacks attempt to exploit non-technical vulnerabilities such as how well employees comply with the organization’s cybersecurity policies. This study surveyed 245 randomly selected employees of government organizations in the Kingdom of Saudi Arabia with an electronically distributed questionnaire about factors that influence employees’ compliance with cybersecurity policies. The study found that ethical factors had the most influence on employee compliance with cybersecurity policies, followed in decreasing order of influence by legislative factors, technical factors, and administrative factors. 展开更多
关键词 Cybersecurity Policies COMPLIANCE PROTECTION information and technology Assets
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The Impact of Information Technology on Service Quality,Satisfaction,and Customer Relationship Management(Case Study:IT Organization Individuals)
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作者 Hojjat Talebi Amid Khatibi Bardsiri 《Journal of Management Science & Engineering Research》 2023年第2期24-31,共8页
Recent research and studies have shown that Information Technology(IT)has a significant impact on service quality,customer satisfaction,and customer relationship development.With the proliferation and penetration of t... Recent research and studies have shown that Information Technology(IT)has a significant impact on service quality,customer satisfaction,and customer relationship development.With the proliferation and penetration of technology in all aspects of life,organizations are responding to the implications and opportunities that IT creates in relation to customer services.The main objective of using information technology in organizations is to increase customer satisfaction,service quality,and customer relationship management,which the authors will focus on here.Enhancing service quality,improving customer satisfaction,and establishing close and sustainable customer relationships are key advantages of leveraging information technology in this field.This article examines the impact of information technology on service quality,customer satisfaction,and customer relationship development and provides strategies and models for organizations to improve customer satisfaction and establish closer connections with them through the use of information technology.Seventy individuals from the IT field were used to evaluate the proposed model.The proposed model was compared with three models:SEM,regression,and decision tree,and the results demonstrated better performance of this approach. 展开更多
关键词 information technology Service quality Customer relationship Customer satisfaction Improvement and development
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A Systematic Review of Blockchain Technology for Government Information Sharing
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作者 Lu Zhang Jiarong Mao +4 位作者 Yuting An Tianshuo Zhang Jixin Ma Chen Feng Xiaoyi Zhou 《Computers, Materials & Continua》 SCIE EI 2023年第1期1161-1181,共21页
Government information sharing(GIS)refers to that act of required or provided for duty government information,commercial information and public welfare information,and it is a basic issue of government services.Howeve... Government information sharing(GIS)refers to that act of required or provided for duty government information,commercial information and public welfare information,and it is a basic issue of government services.However,the existing GIS has low transparency and is lack of flexibility between different departments.Aiming at such problems,this paper takes blockchain as a solusion,and systematically summarizes the development of digital GIS,the advantages and challenges of blockchain and its theoretical research and practical applications.Specifically,it reviews e-government interactive structure,big data and other solutions,analyses their imperfections,and puts forward blockchain-based solutions.The blockchain improves government service efficiency and data security,meanwhile it faces challenges in throughput and supervision.In order to meet these challenges,researchers propose solutions based on three data exchange scenarios:government-to-government,government-to-enterprise and government-toindividual.In addition to researches,blockchain-based GIS is put into use.The electronic licensing project of Nanjing(China)government is taken as an example to illustrate that blockchain has the ability to openly and securely verify,track,and exchange data,so as to improve management ability and public service level of government agencies. 展开更多
关键词 Blockchain information sharing GOVERNMENT cross-chain
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Advantages and Development Prospects of Building Information Modelling(BIM)Technology Application in Highway Engineering 被引量:1
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作者 Hongmei Wang Ying Lin Xiaolin Gan 《Journal of Architectural Research and Development》 2023年第6期1-5,共5页
Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the applica... Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the application of BIM technology in practice,and approaches from the integration of BIM design-construction.This paper also puts forward the integration of cross-stage information based on the BIM+Geographic Information System(GIS)construction information management system to realize the BIM whole life cycle management,and provides directional support for the continuous and efficient application of BIM technology in engineering practice. 展开更多
关键词 BIM technology Highway engineering Application advantages Development prospects
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Critical Reflections on the Deconvergence of Information and Communications Technology
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作者 Zhaoxun Song Yuk Tai Siu Kwok-Wai Cheung 《Intelligent Information Management》 2023年第4期243-258,共16页
In recent years, information and communications technology (ICT) has gone through a process of convergence due to dynamic marketing and technological development. However, signs of deconvergence have emerged during th... In recent years, information and communications technology (ICT) has gone through a process of convergence due to dynamic marketing and technological development. However, signs of deconvergence have emerged during this ongoing process of ICT convergence, which requires close attention and critical reflection by ICT practitioners and educators. This article seeks to identify and critique the seemingly paradoxical trend of market convergence/deconvergence, technological convergence/deconvergence, and audience convergence/deconvergence in ICT. To achieve this goal, a focus group discussion with eight selected participants was adopted as the research method for this study. The data were then analysed using qualitative thematic analysis. The themes revealed in the focus group discussion not only reflect the trends in ICT convergence but also, from various perspectives, highlight the increasingly obvious phenomena of deconvergence. The findings should inform industrial practitioners about the rapidly changing ICT landscape and shed light on future ICT policy and industry directions. 展开更多
关键词 ICT Deconvergence Market Deconvergence technological Deconvergence Audience Deconvergence
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Research on Technology Development of Traditional Chinese Medicine Extraction Based on Patent Information
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作者 Liu Yue Fu Nan +1 位作者 Shen Manzhu Yuan Hongmei 《Asian Journal of Social Pharmacy》 2023年第1期49-56,共8页
Objective To understand the development status of traditional Chinese medicine extraction technology,so as to provide a reference for enterprises and scientific research institutions to determine the direction of tech... Objective To understand the development status of traditional Chinese medicine extraction technology,so as to provide a reference for enterprises and scientific research institutions to determine the direction of technological innovation.Besides,the government can formulate scientific and technological innovation strategies.Methods Based on patent information,statistical methods were applied to analyze the development of traditional Chinese medicine extraction technology.Then,the core technology was identified by constructing a patent citation network.Finally,the main path analysis method was applied to discover the technological evolution path.Results and Conclusion The extraction technology of traditional Chinese medicine is still in the growth stage.At present,its R&D is based on enterprises,supplemented by scientific research institutions.The core technologies are ultrasonic extraction and enzymatic extraction.The main path represented by enzymatic extraction technology reveals the evolution process of traditional Chinese medicine extraction technology.Based on this,relevant suggestions are put forward.Firstly,technological innovation cooperation should be strengthened to explore new models of achievement transformation and cooperation.Secondly,key enterprises of technology clusters should be cultivated to accelerate breakthroughs in core technologies.Thirdly,combined technologies can achieve high-efficiency enzyme-assisted extraction and open up new ways of extracting traditional Chinese medicine.Fourthly,traditional techniques should be improved to develop innovative modern techniques. 展开更多
关键词 traditional Chinese medicine extraction technology technological innovation patent information technology evolution enzymatic extraction technology
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A Practical Study of Big Data Technology in Computer Network Information Security Processing
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作者 Kongduo Xing 《Journal of Electronic Research and Application》 2023年第6期36-41,共6页
In recent years,China has witnessed continuous development and progress in its scientific and technological landscape,with widespread utilization of computer networks.Concurrently,issues related to computer network in... In recent years,China has witnessed continuous development and progress in its scientific and technological landscape,with widespread utilization of computer networks.Concurrently,issues related to computer network information security,such as information leakage and virus invasions,have become increasingly prominent.Consequently,there is a pressing need for the implementation of effective network security measures.This paper aims to provide a comprehensive summary and analysis of the challenges associated with computer network information security processing.It delves into the core concepts and characteristics of big data technology,exploring its potential as a solution.The study further scrutinizes the application strategy of big data technology in addressing the aforementioned security issues within computer networks.The insights presented in this paper are intended to serve as a valuable reference for individuals involved in the relevant fields,offering guidance on effective approaches to enhance computer network information security through the application of big data technology. 展开更多
关键词 Big data technology Computer network information security
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Implementation of a Comprehensive Information Management Platform for Public Security Based on Java Technology
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作者 Jin Xue Yali Yuan 《计算机科学与技术汇刊(中英文版)》 2023年第1期11-16,共6页
Due to the rapid development of electronic information technology,the development of Internet technology and system software development technology has become more and more common.Especially,along with the development... Due to the rapid development of electronic information technology,the development of Internet technology and system software development technology has become more and more common.Especially,along with the development of public security,there are more and more provisions for standard administrative department management system,improving office efficiency and enhancing decision encouragement.Therefore,it is of great practical value to design and complete a comprehensive public security business information system.Based on java technology,this paper designs and builds a comprehensive information management platform for public security through the analysis of comprehensive public security business,and also gets good feedback during the actual test,which confirms the feasibility of the system. 展开更多
关键词 Public Security Comprehensive Business information System JAVA WORKFLOW Web information Security
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Analysis of the Standardization of Administrative Management in Colleges and Universities Under the Background of Information Technology
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作者 Wei Wang 《Journal of Contemporary Educational Research》 2023年第4期72-77,共6页
In the development of the information age,universities should recognize the significant impact of information technology on their own development.In practice,it is possible to effectively improve the efficiency and qu... In the development of the information age,universities should recognize the significant impact of information technology on their own development.In practice,it is possible to effectively improve the efficiency and quality of work by dealing with and constructing information-based methods,innovating administrative management models,and adopting more efficient and scientific methods to address various problems and shortcomings encountered in work.As an important part of university management,administrative management is a complex task.Establishing a standardized management model through information technology can further improve the comprehensive efficiency of administrative management.In this regard,the administrative standardization in universities under the background of information technology is analyzed and studied in this paper. 展开更多
关键词 information background UNIVERSITIES Administrative management Standardization Online publication:April 27 2023
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A frequency servo SoC with output power stabilization loop technology for miniaturized atomic clocks 被引量:1
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作者 Hongyang Zhang Xinlin Geng +3 位作者 Zonglin Ye Kailei Wang Qian Xie Zheng Wang 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期13-22,共10页
A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL... A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL)technique,incorporating an off-chip power detector(PD),ensures that the output power of the FS-SoC remains stable,mitigating the impact of power fluctuations on the atomic clock's stability.Additionally,a one-pulse-per-second(1PPS)is employed to syn-chronize the clock with GPS.Fabricated using 65 nm CMOS technology,the measured phase noise of the FS-SoC stands at-69.5 dBc/Hz@100 Hz offset and-83.9 dBc/Hz@1 kHz offset,accompanied by a power dissipation of 19.7 mW.The Cs atomic clock employing the proposed FS-SoC and PSL obtains an Allan deviation of 1.7×10^(-11) with 1-s averaging time. 展开更多
关键词 CMOS technology atomic clock phase-locked loop output power stabilization 1PPS
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Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis 被引量:1
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作者 Xing-Nian Zhou Quan Zhang +6 位作者 Hong Peng Yu-Jie Qin Yu-Hong Liu Lu Wang Ming-Liang Cheng Xin-Hua Luo Hong Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第11期1588-1608,共21页
BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple b... BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and inflammation.AIM To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.METHODS This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce ALF.Gasdermin D(GSDMD)^(-/-)mice were used as an experimental group.Histological changes in liver tissue were monitored by hematoxylin and eosin staining.ALT,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial kits.Ferroptosis-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction.SIRT1,p53,and GSDMD were assessed by immunofluorescence analysis.RESULTS Serum AST and ALT levels were elevated in patients with ALF.SIRT1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver tissue.In the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated.In mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were detected.In vitro,knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels,the cytostatic rate,and GSDMD expression,restoring SLC7A11 depletion.Moreover,SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group,accompanied by reduced p53,GSDMD,and ACSL4,and increased SLC7A11 and GPX4.Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalNinduced in vitro and in vivo models.CONCLUSION SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF. 展开更多
关键词 Silent information regulator sirtuin 1 Ferroptosis PYROPTOSIS p53/glutathione peroxidase 4/gasdermin D Acute liver failure
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